A New Triterpenoid Alkaloid from Buxus sempervirens

2011 ◽  
Vol 66 (10) ◽  
pp. 1076-1078 ◽  
Author(s):  
Yu-Xin Yan ◽  
Yun Sun ◽  
Jian-Chao Chen ◽  
Jia Su ◽  
Yan Li ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Spectral Data ◽  
Human Cell ◽  
Spectral Methods ◽  
Inhibitory Activity ◽  
Human Cell Lines ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Buxus Sempervirens ◽  
Mcf 7

A new triterpenoid alkaloid, 16-deacetoxy-hyrcamine (1), together with six analogs, was isolated from the leaves and stems of Buxus sempervirens. Their structures were elucidated based on spectral methods and by comparison of the spectral data with those reported previously. All isolated compounds were evaluated for their growth inhibitory activity against human cell lines HL-60, SMMC-7721, A-549,MCF-7, and SW480. Compounds 1 - 4 and 6 showed modest cytotoxic activity against A-549, MCF-7, and SW480.

Obtusifoliol related steroids from Euphorbia sogdiana with cell growth inhibitory activity and apoptotic effects on breast cancer cells (MCF-7 and MDA-MB231)

Steroids ◽  
2016 ◽  
Vol 115 ◽  
pp. 90-97 ◽  
Author(s):  
Mahmoud Aghaei ◽  
Zeinab Yazdiniapour ◽  
Mustafa Ghanadian ◽  
Behzad Zolfaghari ◽  
Virginia Lanzotti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Breast Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Apoptotic Effects ◽  
Mcf 7

scholarly journals New Humulenes from Hyptis incana (Labiatae)

2013 ◽  
Vol 8 (12) ◽  
pp. 1934578X1300801
Author(s):  
Mitsuru Satoh ◽  
Yoshio Satoh ◽  
Yasuhiro Anzai ◽  
Daisuke Ajisawa ◽  
Keiichi Matsuzaki ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Inhibitory Activity ◽  
Leukemia Cells ◽  
Moderate Activity ◽  
Mouse Leukemia ◽  
Aerial Parts ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Potent Growth

Two new humulene-type sesquiterpenes, named hyptishumulene I (1) and II (2), have been isolated, together with eight known compounds, a humulene-type sesquiterpene (3), a monoterpene (4) and six abietane-type diterpenoids (5–10) from the aerial parts of Hyptis incana (Labiatae). The cytotoxic activity of the isolated compounds against mouse leukemia cells (L1210) was examined. The abietane-type diterpenoids (5–10) showed rather potent growth inhibitory activity (IC50<15 μM), while the new humulene-type compounds (1 and 2) exhibited moderate activity (IC50>50 μM).

Cationic liposomes as efficient nanocarriers for the drug delivery of an anticancer cholesterol-based ruthenium complex

2015 ◽  
Vol 3 (15) ◽  
pp. 3011-3023 ◽  
Author(s):  
Giuseppe Vitiello ◽  
Alessandra Luchini ◽  
Gerardino D'Errico ◽  
Rita Santamaria ◽  
Antonella Capuozzo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Ruthenium Complex ◽  
Human Cancer ◽  
High Growth ◽  
Human Cancer Cells ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Mcf 7

Cationic nanovectors loaded with Ru-based nucleolipids exert a high growth-inhibitory activity against human cancer cells (MCF-7 (A), WiDr (B), and HeLa (C)).

scholarly journals Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of Phytophthora infestans

Pathogens ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 558
Author(s):  
Mary L. McKee ◽  
Limian Zheng ◽  
Elaine C. O’Sullivan ◽  
Roberta A. Kehoe ◽  
Barbara M. Doyle Prestwich ◽  
...  
Keyword(s):  
Phytophthora Infestans ◽  
Natural Product ◽  
Human Cell ◽  
Inhibitory Activity ◽  
Human Cell Line ◽  
Crop Damage ◽  
Apparent Lack ◽  
Lead Compounds ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

The pathogen Phytophthora infestans is responsible for worldwide catastrophic crop damage and discovery of new inhibitors of this organism is of paramount agricultural and industrial importance. Current strategies for crop treatment are inadequate with limitations of efficacy and market alternatives. Ellipticines have recently been reported to have fungicidal properties and have been assessed against P. infestans growth with promising results. We hereby report a probe of the ellipticine framework to investigate the alkyl subunit and screen a set ellipticines and derivatives to identify new lead compounds to act against P. infestans. A series of ellipticinium salt derivatives have been identified with exceptional growth inhibitory activity and apparent lack of toxicity towards a human cell-line surpassing the effect of known and marketed fungicides. This report identifies the potential of this natural product derivative as a novel fungicide.

Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells

2008 ◽  
Vol 377 (1) ◽  
pp. 242-247 ◽  
Author(s):  
Hong-Nu Yu ◽  
Eun-Mi Noh ◽  
Young-Rae Lee ◽  
Si-Gyun Roh ◽  
Eun-Kyung Song ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Mcf 7

New pyrimidines and triazolopyrimidines as antiproliferative and antioxidants with cyclooxygenase-1/2 inhibitory potential

2019 ◽  
Vol 11 (13) ◽  
pp. 1583-1603
Author(s):  
Ashraf M Omar ◽  
Heba A Abd El Razik ◽  
Aly A Hazzaa ◽  
Maryam AZ El-Attar ◽  
Maha A El Demellawy ◽  
...  
Keyword(s):  
Free Radicals ◽  
Inhibitory Activity ◽  
Docking Studies ◽  
Cyclooxygenase 1 ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Cox 2 ◽  
Inhibitory Potential ◽  
Cox 1 ◽  
Mcf 7

Aim: Cyclooxygenase-2 (COX-2) inhibition and scavenging-free radicals are important targets in cancer treatment. Materials & methods: Sulfanylpyrimidines and triazolopyrimidines were synthesized and evaluated as anticancer and antioxidant COX-1/2 inhibitors. Results: Compound 7 showed the same growth inhibitory activity as 5-fluorouracil against MCF-7. Compound 6f displayed broad-spectrum anticancer activity against the four tested cancer cell lines. Compounds 5b, 6a, 6c, 6d and 8 were found to be more active antioxidants than trolox. Compounds 6a, 6c, 6f and 8 revealed high COX-2 inhibitory activity and selectivity, which was confirmed by docking studies. Conclusion: Compound 6f could be considered as promising anticancer and antioxidant structural lead with COX-2 inhibition that deserve further derivatization and investigation.

scholarly journals Two New Alkylresorcinols from Homalomena wendlandii and Their Cytotoxic Activity

2012 ◽  
Vol 7 (8) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Luis A. Sánchez ◽  
Dionisio Olmedo ◽  
José Luis López-Pérez ◽  
Todd D. Williams ◽  
Mahabir P. Gupta
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Human Cell ◽  
2D Nmr ◽  
Human Cell Lines ◽  
Ir Spectroscopic ◽  
Mcf 7

In the course of our search for antineoplasic agents from Panamanian Flora, two new alkylresorcinols: 1-(2,6-dihydroxyphenyl)octan-1-one (1) and (+)-1-(3-(1-(2,6-dihydroxyphenyl)butyl)-2,6-dihydroxyphenyl)octan-1-one (2), together with three known compounds, (1 R, 2 R)-1-(benzo[ d][1,3]dioxol-5-yl)propane-1,2,3-triol (3), (+)-aptosimon (4) and (-)-sesamin (5), were identified from the leaves of Homalomena wendlandii Schott (Araceae). Their structures were established by 1D and 2D NMR and IR spectroscopic, and MS methods. Compound 2 exhibited IC50 values of 3.3, 5.8 and 4.0 μg/mL against MCF-7, SF-268 and H-460 cancer human cell lines, respectively.

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