Bioassay-Guided Separation of an α-Amylase Inhibitor Anthocyanin from Vaccinium arctostaphylos Berries
2010 ◽
Vol 65
(9-10)
◽
pp. 567-570
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Keyword(s):
Vaccinium arctostaphylos is a traditional medicinal plant in Iran used for the treatment of diabetes mellitus. In our search for antidiabetic compounds from natural sources, we found that the extract obtained from V. arctostaphylos berries showed an inhibitory effect on pancreatic α-amylase in vitro [IC50 = 1.91 (1.89 -1.94) mg/mL]. The activity-guided purification of the extract led to the isolation of malvidin-3-O-β-glucoside as an α-amylase inhibitor. The compound demonstrated a dose-dependent enzyme inihibitory activity [IC50 = 0.329 (0.316 - 0.342) mM].
1996 ◽
Vol 63
(2)
◽
pp. 257-267
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Keyword(s):
2013 ◽
pp. 519-536
Keyword(s):
2016 ◽
Vol 22
(1)
◽
pp. 127-133
◽
1994 ◽
Vol 1
(4)
◽
pp. 193-197
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Keyword(s):