Pharmacogenomics in lung cancer: an analysis of DNA repair gene expression in patients treated with platinum-based chemotherapy

2005 ◽  
Vol 6 (12) ◽  
pp. 2015-2026 ◽  
Author(s):  
Rosario García-Campelo ◽  
Guillermo Alonso-Curbera ◽  
LM Antón Aparicio ◽  
Rafael Rosell
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Dna Repair ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Platinum Based Chemotherapy

scholarly journals Influence of DNA repair gene polymorphisms on prognosis in inoperable non-small cell lung cancer patients treated with radiotherapy and platinum-based chemotherapy

2012 ◽  
Vol 131 (7) ◽  
pp. E1100-E1108 ◽  
Author(s):  
Dorota Butkiewicz ◽  
Anna Drosik ◽  
Rafał Suwiński ◽  
Małgorzata Krześniak ◽  
Marek Rusin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Patients ◽  
Gene Polymorphisms ◽  
Small Cell ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Lung Cancer Patients ◽  
Dna Repair Gene ◽  
Platinum Based Chemotherapy

DNA repair gene expression level in peripheral blood and tumour tissue from non-small cell lung cancer and head and neck squamous cell cancer patients

DNA Repair ◽  
2012 ◽  
Vol 11 (4) ◽  
pp. 374-380 ◽  
Author(s):  
Marina Schena ◽  
Simonetta Guarrera ◽  
Lucio Buffoni ◽  
Angelica Salvadori ◽  
Floriana Voglino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Dna Repair ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Neck Squamous Cell Cancer

scholarly journals Pattern of Antioxidant and DNA Repair Gene Expression in Normal Airway Epithelium Associated with Lung Cancer Diagnosis

2009 ◽  
Vol 69 (22) ◽  
pp. 8629-8635 ◽  
Author(s):  
T. Blomquist ◽  
E. L. Crawford ◽  
D. Mullins ◽  
Y. Yoon ◽  
D.-A. Hernandez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Diagnosis ◽  
Airway Epithelium ◽  
Repair Gene ◽  
Lung Cancer Diagnosis ◽  
Normal Airway ◽  
Dna Repair Gene

Regulation of DNA repair gene expression in human cancer cell lines

2006 ◽  
Vol 97 (5) ◽  
pp. 1121-1136 ◽  
Author(s):  
Claire J. McGurk ◽  
Michele Cummings ◽  
Beate Köberle ◽  
John A. Hartley ◽  
R. Timothy Oliver ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Repair ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Repair Gene ◽  
Human Cancer Cell Lines ◽  
Dna Repair Gene

scholarly journals DNA Repair Gene Expression Adjusted by the PCNA Metagene Predicts Survival in Multiple Cancers

2019 ◽  
Author(s):  
Leif Peterson ◽  
Tatiana Kovyrshina
Keyword(s):  
Gene Expression ◽  
Dna Repair ◽  
Gene Selection ◽  
P Value ◽  
Survival Prediction ◽  
Dna Repair Genes ◽  
Repair Gene ◽  
A Genome ◽  
Dna Repair Gene ◽  
Repair Genes

Removal of the proliferation component of gene expression by PCNA adjustment has been addressed in numerous survival prediction studies for breast cancer and all cancers in the TCGA. These studies indicate that widespread co-regulation of proliferation upwardly biases survival prediction when gene selection is performed on a genome-wide basis. In addition, removal of the correlative effects of proliferation does not reduce the random bias associated with survival prediction using random gene selection. Since most cancers become addicted to DNA repair as a result of forced cellular replication, increased oxidation, and repair deficiencies from oncogenic loss or genetic polymorphisms, we pursued an investigation to remove the proliferation component of expression in DNA repair genes to determine survival prediction. This translational hypothesis-driven focus on DNA repair genes is directly amenable to finding new sets of DNA repair genes that could potentially be studied for inhibition therapy. Overall survival (OS) prediction was evaluated in 18 cancers by using normalized RNA-Seq data for 126 DNA repair genes with expression available in TCGA. Transformations for normality and adjustments for age at diagnosis, stage, and PCNA metagene expression were performed for all DNA repair genes. We also analyzed genomic event rates (GER) for somatic mutations, deletions, and amplification in driver genes and DNA repair genes. After performing empirical p-value testing with use of randomly selected gene sets, it was observed that OS could be predicted significantly by sets of DNA repair genes for 61% (11/18) of the cancers. Interestingly, PARP1 was not a significant predictor of survival for any of the 11 cancers. Results from cluster analysis of GERs indicates that the most opportunistic cancers for inhibition therapy may be AML, colorectal, and renal papillary, because of potentially less confounding due to lower GERs for mutations, deletions, and amplifications in DNA repair genes. However, the most opportunistic cancer for inhibition therapy is likely to be AML, since it showed the lowest GERs for mutations, deletions, and amplifications in DNA repair genes. In conclusion, our hypothesis-driven focus to target DNA repair gene expression adjusted for the PCNA metagene as a means of predicting OS in various cancers resulted in statistically significant sets of genes.

Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells

2011 ◽  
Vol 28 (10) ◽  
pp. 579-587 ◽  
Author(s):  
Kuo-Ching Liu ◽  
Heng-Chien Ho ◽  
An-Cheng Huang ◽  
Bin-Chuan Ji ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Dna Damage ◽  
Dna Repair ◽  
Gallic Acid ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Repair Gene ◽  
Dna Repair Gene

Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women

2009 ◽  
Vol 188 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Jiaoyang Yin ◽  
Ulla Vogel ◽  
Yegang Ma ◽  
Rong Qi ◽  
Huiwen Wang
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Cancer Susceptibility ◽  
Chinese Women ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Lung Cancer Susceptibility

scholarly journals SIRT6, a Mammalian Deacylase with Multitasking Abilities

2020 ◽  
Vol 100 (1) ◽  
pp. 145-169 ◽  
Author(s):  
Andrew R. Chang ◽  
Christina M. Ferrer ◽  
Raul Mostoslavsky
Keyword(s):  
Gene Expression ◽  
Dna Repair ◽  
Cellular Metabolism ◽  
Multiple Roles ◽  
Biological Processes ◽  
Repair Gene ◽  
Cellular Homeostasis ◽  
Chromatin Dynamics ◽  
Open Questions ◽  
Dna Repair Gene

Mammalian sirtuins have emerged in recent years as critical modulators of multiple biological processes, regulating cellular metabolism, DNA repair, gene expression, and mitochondrial biology. As such, they evolved to play key roles in organismal homeostasis, and defects in these proteins have been linked to a plethora of diseases, including cancer, neurodegeneration, and aging. In this review, we describe the multiple roles of SIRT6, a chromatin deacylase with unique and important functions in maintaining cellular homeostasis. We attempt to provide a framework for such different functions, for the ability of SIRT6 to interconnect chromatin dynamics with metabolism and DNA repair, and the open questions the field will face in the future, particularly in the context of putative therapeutic opportunities.

Sign in / Sign up

Export Citation Format

Share Document