scholarly journals Factors associated with delayed diagnosis of breast cancer; a study in North-West of Iran

2019 ◽  
Vol 6 (1) ◽  
pp. e02-e02 ◽  
Author(s):  
Nasrin Fouladi ◽  
Maedeh Barahman ◽  
Firouz Amani ◽  
Mohammad Bahadoram ◽  
Sevda Eghbali
Keyword(s):  
Breast Cancer ◽  
Clinical Symptoms ◽  
Delayed Diagnosis ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Related Factors ◽  
Cross Sectional ◽  
Surgical Interventions ◽  
North West ◽  
Factors Associated

Introduction: Delayed diagnosis and treatment of breast cancer leads to the presentation of the disease in advanced stages necessitating more invasive surgical interventions, increasing health care costs and mortality rate, and finally reduced patients’ survival. Objectives: This study aimed to investigate the factors associated with delayed diagnosis of breast cancer in the north-west of Iran. Patients and Methods: This retrospective cross-sectional study was conducted on 70 breast cancer patients referred to the cancer registry of Ardabil city, north-west of Iran. The time from the presentation of clinical symptoms to the initiation of treatment was determined by interviews to identify the system and patients’ delays. The data was analyzed in SPSS 19 with the level of significance as P<0.05. Results: The mean age of the patients was 43.3 ± 13.2 years. The means of total, patient, and system related delays were 9.4±1.6 weeks, 6.3 ± 9.9 weeks, and 3.1 ± 2.8 weeks respectively. Regression analysis showed that age, marital status, educational level, monthly income, fear of cancer, and residency were significantly associated with patients’ delay. Conclusion: Our results highlighted the important role of patients’ related factors in delayed diagnosis of breast cancer. Therefore, it is essential to educate individuals for timely referrals to physicians.

scholarly journals Risk of Anastrozole-related Mood Disturbances and Dizziness among Breast Cancer Patients taking Anastrozole

2020 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Adverse Reactions ◽  
Cross Sectional Study ◽  
Mood Disturbance ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Factors Associated ◽  
Induced Mood ◽  
Post Menopausal

Background: Anastrozole has been widely utilized in the management of endocrine sensitive post-menopausal breast cancer; however, there is high variability in the adverse reactions associated with its use. Anastrozole-associated mood disturbances and dizziness occur less frequently. However, they can still affect the quality of life of breast cancer patients. The aim of this study was to determine the clinical and demographic factors associated with Anastrozole's adverse events. Materials/Methods: This is a cross-sectional study of oestrogen receptor positive post-menopausal women (n = 97) with stages I to III breast cancer receiving Anastrozole (1mg daily). Multivariate analyses were performed to establish the factors associated with Anastrozole-induced mood disturbance and dizziness. Results: Approximately 20.6% and 13.4% of the subjects experienced mood disturbance and dizziness respectively. Patients who are on Anastrozole treatment for more than three years had higher odds of having mood disturbance (adjusted odds ratio 20.31, confidence interval 1.75 to 235.31, p = 0.016). No significant association was established between serum oestrogen levels and development of mood disturbance and dizziness. Conclusion: Our study confirmed that although mood disturbances and dizziness are not the most commonly reported adverse reactions, the duration of Anastrozole treatment may be a predictor of mood disturbance in these patients.

scholarly journals Evaluation of sexual function and its related factors in women with breast cancer undergoing chemotherapy referred to Iran-Mehr Medical Center in Birjand, 2018

2020 ◽  
pp. 366-375
Keyword(s):  
Breast Cancer ◽  
Sexual Function ◽  
Cancer Patients ◽  
Medical Center ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Related Factors ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Age Of Marriage

Background and Aim: The Breast cancer is very common. These patients develop sexual dysfunction following chemotherapy. The aim of this study was to evaluate the effect of chemotherapy in breast cancer patients on their sexual function. Materials and Methods: This descriptive-analytical cross-sectional study was performed on patients with breast cancer referred to Iran-Mehr Medical Center in winter 2018 undergoing chemotherapy. 119 patients were enrolled in the study under census. The Rosen’s Sexual Function Questionnaire was used to collect data. Data were analyzed by using SPSS (Version 16) and Smirnov-Kolmogorov, Kruskal-Wallis and Mann-Whitney tests at the significant level of (P<0.05). Results: In terms of sexual function, the lowest score was 2.40 and the highest score was 14.90. In the study of sexual function components, patients were in the worst condition in terms of pain, 0.84±0.75 and humidity 0.85±0.73. The mean scores of other components included orgasm 1.13±0.64, irritability 1.05±0.84, satisfaction 1.23±0.30 and sexual desire 1.66±0.66, respectively. The only factor affecting sexual function Location, age of marriage and age of patients. Conclusion: The score of sexual function was less than the minimum; the most disorders were recorded for the components of pain and humidity. Factors affecting sexual function were included: location, years of menopause, type of treatment, age of patients and years of marriage. It is recommended that the sexual status of breast cancer patients be evaluated before and during treatment and that the necessary training be provided to inform patients about this disorder and the necessary treatments to improve sexual function.

scholarly journals The prevalence and risk factors associated with Leptospira in donkeys in Ngaka Modiri Molema District, North West Province, South Africa

2020 ◽  
Vol 13 (9) ◽  
pp. 2020-2027
Author(s):  
Kibambe Kiayima Daddy ◽  
Mulunda Mwanza ◽  
James Wabwire Oguttu ◽  
Lubanza Ngoma
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
Agricultural Activities ◽  
Binary Logistic Regression Model ◽  
Public Health Importance ◽  
Related Factors ◽  
Cross Sectional ◽  
North West ◽  
Factors Associated

Background and Aim: Leptospirosis is one of the major emerging global economic and health problems affecting donkeys, thereby reducing their work output. Furthermore, the disease has public health importance because of its zoonotic nature. Despite the significant contribution donkeys make to the national economy, less attention is given to diseases that afflict donkeys and reduce their productivity and performance. A cross-sectional study was conducted to investigate the seroprevalence of Leptospira and identify risk factors associated with the occurrence of the disease among donkeys in the study area. Materials and Methods: A questionnaire survey was used to collect the following data: Demographic, environmental, management, and health-related factors. Blood samples were aseptically collected from 365 randomly selected donkeys from 19 villages. The sera were tested using the microscopic agglutination test. Categorical variables were summarized and presented as proportions and their 95% confidence interval (CI). A binary logistic regression model was fitted to the data to identify risk factors associated with Leptospira seroprevalence in donkeys within the study areas. Results: The majority of the donkeys (29.6%; n=108/365) were from Mafikeng local municipality, and the rest (19.7%; n=72/365) were from Ratlou. Just over half (58.1%; n=212/365) of the donkeys tested were female, and the remaining (41.9%; n=153/365) were males. In addition, most donkeys (42.7%; n=156/365) were between 6 and 12 years old, followed by those between 0 and 5 years (37%; n=135/365), and only 20.3% (n=74/365) were above 12 years. Out of the donkeys tested, 11.5% (95% CI: 4.86-18.14) donkeys tested positive for Leptospira antibodies. The most common serovar was Bratislava (81%; n=34/42), followed by Tarassovi (19.04%; n=8/42). While gender was positively associated with seroprevalence of the disease (Adjusted Odds Ratio [AOR]=4.88; p=0.0001), the presence of horses (AOR=0.226; p=0.002) and agricultural activities (AOR=0.093; p=0.0001) in the vicinity of the dwellings of the donkeys were negatively associated with Leptospira seropositivity in the study area. Conclusion: Findings reported here show that donkeys in the study area are reservoirs for the predominant serovar Bratislava and the less dominant serovar Tarassovi. The gender of the donkey was a risk factor for Leptospira seroprevalence. Further studies are needed to investigate the role of agricultural activities in the vicinity of the dwellings of donkeys on the occurrence of Leptospira in the study area.

Assessment of the quality of life of breast cancer patients after one year of treatment

2021 ◽  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Related Factors ◽  
Cross Sectional ◽  
Life Score ◽  
One Year

Introduction: Breast cancer is the most commonly diagnosed malignancy and the leading cause of death among women worldwide. The incidence of breast cancer is on the rise in developing countries. Breast cancer patients not only experience physical pain from treatment but may also face mental crises, impaired social function, and impaired quality of life. However, there are not many studies on the quality of life (QoL) of post - treatment breast cancer patients. Therefore, we carried out the study “assessment the quality of life of breast cancer patients after one year of treatment” with aims to evaluate the quality of life of breast cancer patients after one year of treatment using the scales EQ-5D-5L and QLQ-BR23 and to find out related factors to the quality of life of these subjects. Methods: A cross - sectional study was conducted on 100 breast cancer patients after one year of treatment at the Hue University of Medicine and Pharmacy Hospital to examine the quality of life using the scales EQ-5D-5L and QLQ-BR23 and to detect the associated factors. Results: The mean quality of life score of breast cancer patients after one year of treatment on the EQ- 5D-5L scale was 0.6436 ± 0.2098. By QLQ-BR23, the quality of life score on function was 74.75 ± 20.78 while the score on symptoms was 28.80 ± 12.79. The quality of life from both scales was found to be statistically significant related to social work participation, self - reported health, risk of depression, anxiety, and stress. Conclusions: The quality of life of breast cancer patients in the study was at a moderate level. This suggests more supports to be done continuously after long - term post - diagnosing especially psychological and social aspects for these subjects.

Association of CYP2D6*10 (c. 100 C>T) Genotype with Z-END Concentration in Patients with Breast Cancer Receiving Tamoxifen Therapy in Indonesian Population

2019 ◽  
Vol 19 (8) ◽  
pp. 1198-1206 ◽  
Author(s):  
Yenny ◽  
Sonar S. Panigoro ◽  
Denni J. Purwanto ◽  
Adi Hidayat ◽  
Melva Louisa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Steady State ◽  
Ultra Performance Liquid Chromatography ◽  
Cross Sectional Study ◽  
Threshold Concentration ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Liquid Chromatography Tandem Mass

Background: Tamoxifen (TAM) is a frequently used hormonal prodrug for patients with breast cancer that needs to be activated by cytochrome P450 2D6 (CYP2D6) into Zusammen-endoxifen (Z-END). Objective: The purpose of the study was to determine the association between CYP2D6*10 (c.100C>T) genotype and attainment of the plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women with breast cancer. Methods: A cross-sectional study was performed in 125 ambulatory patients with breast cancer consuming TAM at 20 mg/day for at least 4 months. The frequency distribution of CYP2D6*10 (c.100C>T) genotypes (C/C: wild type; C/T: heterozygous mutant; T/T: homozygous mutant) was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), the results of which were subsequently confirmed by sequencing. The genotypes were categorized into plasma Z- END concentrations of <5.9 ng/mL and ≥5.9 ng/mL, which were measured using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results: Percentages of C/C, CT, and T/T genotypes were 22.4%, 29.6%, and 48.8%, respectively. Median (25-75%) Z-END concentrations in C/C, C/T, and T/T genotypes were 9.58 (0.7-6.0), 9.86 (0.7-26.6), and 3.76 (0.9-26.6) ng/mL, respectively. Statistical analysis showed a significant difference in median Z-END concentration between patients with T/T genotype and those with C/C or C/T genotypes (p<0.001). There was a significant association between CYP2D6*10 (c.100C>T) genotypes and attainment of plasma steady-state Z-END MTC (p<0.001). Conclusion: There was a significant association between CYP2D6*10 (c.100C>T) and attainment of plasma steady-state Z-END MTC in Indonesian breast cancer patients receiving TAM at a dose of 20 mg/day.

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