TSH-regulation and goitrogenesis in severe iodine deficiency

1983 ◽  
Vol 103 (1) ◽  
pp. 21-27 ◽  
Author(s):  
H. Bachtarzi ◽  
M. Benmiloud
Keyword(s):  
Iodine Deficiency ◽  
Age Groups ◽  
Serum Levels ◽  
Endemic Goitre ◽  
Age Related ◽  
Gradual Development ◽  
Tsh Regulation ◽  
Group A ◽  
Goitre Prevalence ◽  
Group B

Abstract. Since goitre prevalence increases sharply during the first two decades of life, age-related changes in the adaptation of the thyroid to iodine deficiency may occur. In order to study this, we have measured serum levels of TSH, T4 and T3 in 247 subjects (age range 5 to 60 years) living in an endemic goitre area of North Algeria (group A) and in 64 control subjects living in the non-iodine deficient city of Algiers (group B). TRH tests were also performed in 88 subjects from the goitrous area and in 30 controls. Patients from group A had significantly higher serum TSH and T3 and lower serum T4 than those from group B. Analysis of group A by age groups revealed significantly higher TSH concentrations in the 2–9 years group and a moderate but significant decrease in the group from 50–59 years. No significant changes were demonstrated for T4 and T3. In the goitrous area, the response of TSH to TRH was exaggerated and prolonged. ΔTSH20 was inversely correlated with age. The different age groups showed a significantly progressive and continuous decrease of ΔTSH20, ΔTSH60, ΔTSH120 from age 10–19 to age 50–59 years. Our findings thus show a sharp increase of TSH during the first decades of life, which coincides with the phase of maximal growth of the thyroid gland. These results suggest that TSH plays a definite role in the genesis of endemic goitre. The subsequent progressive decrease of TSH secretion and reserve, with unchanged T4 and T3, imply a gradual development of autonomous activity in longstanding multinodular goitre.

Age related volume of cadaver-prostates in Bangladesh

1970 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Rukshana Ahmed ◽  
Shamim Ara
Keyword(s):  
Prostate Gland ◽  
Age Groups ◽  
Clinical Settings ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Key Words Prostate ◽  
The Mean ◽  
Group B

Pathological changes in the prostate gland occur commonly with advancing age including inflammation, atrophy, hyperplasia and carcinoma and a change in volume is also evident. Estimation of volume of prostate may be useful in a variety of clinical settings. A cross-sectional descriptive study was designed to see the changes in volume of the prostate with advancing age and done in the Department of Anatomy, Dhaka Medical College, Dhaka from August 2006 to June 2007. The study was performed on 70 post-mortem human prostates collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age groups; group A (10-20 years), group B (21-40 years) and group C (41-70 years). Volume of the sample was measured by using the ellipsoid formula. The mean ± SD volume of prostate was 7.68 ± 3.64 cm3 in group A, 10.61 ± 3.99 cm3 in group B and 15.40 ± 6.31 cm3 in group C. Mean difference in volume between group A and group C, group B and group C were statistically significant (p<0.001). Statistically significant positive correlation was found between age and volume of prostate (r = + 0.579, p < 0.001). Key Words: Prostate; volume; Bangladeshi. DOI: 10.3329/imcj.v4i2.6501Ibrahim Med. Coll. J. 2010; 4(2): 74-77

scholarly journals Microscopic Study on the Diameter of the Pineal Calcification of Bangladeshi Cadavers

2013 ◽  
Vol 9 (2) ◽  
pp. 71-74
Author(s):  
Halima Afroz ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Shamim Ara ◽  
Mushfika Rahman ◽  
Tahamida Yesmin ◽  
...  
Keyword(s):  
Histological Study ◽  
Age Groups ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Microscopic Features ◽  
Group A ◽  
Group B ◽  
Group D ◽  
Age Related Changes

Context: The human pineal gland is characterized by the presence of calcified concretions, called ‘pineal acervuli’ or brain sand. These are basophilic extracellular bodies. The study was carried out to describe the microscopic features of pineal calcifications and to find out age related changes. Study Design: Cross sectional descriptive type of study. Place and period of study: Department of Anatomy, Dhaka Medical College, Dhaka, from July 2009 to June 2010. Materials: 60 postmortem human pineal glands were collected from unclaimed dead bodies that were under examination in the morgue of Department of Forensic Medicine, Dhaka Medical College, Dhaka. Methods: The samples were divided into four different age groups, i.e. Group-A (15-30 years), Group-B (31-40 years), Group-C (41-50 years) and Group-D (>50 years). Histological study was carried out on relatively 27 fresh samples. Results: The mean diameter of the pineal calcifications were 351.14±111.69 ?m in group A, 600.00±232.69 ?m in group B, 909.43±124.18 ?m in group C and 1541.67±224.54 ?m in group D. The differences in diameter of the pineal calcifications between group A & C, A & D, B & C, B & D and C & D were statistically significant. Conclusion: Age related changes were found in the diameter of pineal calcifications. DOI: http://dx.doi.org/10.3329/bja.v9i2.15220 Bangladesh Journal of Anatomy 2011 Vol.9(2) pp.71-74

scholarly journals Weight of the Human Kidney – A Study on 70 Autopsy Cases

2016 ◽  
Vol 4 (1) ◽  
pp. 31-34
Author(s):  
Fatema Zohora ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Dilruba Siddiqua ◽  
Hasna Hena ◽  
Hosna Ara Perven ◽  
...  
Keyword(s):  
Age Groups ◽  
Human Kidney ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Bangladeshi Population ◽  
Group B ◽  
The Right

Background: Variations in weight of the kidney in different populations and in different age groups are evident.Objective: The aim of the present study was to find out age related changes in weight of the kidney in a Bangladeshi population and compare with previous local and foreign studies.Materials and method: This cross-sectional study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, Bangladesh from July 2008 to June 2009, based on collection of 140 post mortem human kidneys collected from 70 unclaimed dead bodies which were in the morgue under examination in the Department of Forensic Medicine of same institute. All the samples were divided into three different age groups - A (10-19 years), B (20-39 years) and C (40-59 years), and the weight of each kidney was measured by using a digital balance and recorded.Results: The weight of the right and left kidneys were found 86.18±0.32 gm and 86.10±0.10 gm in group A, 102.25±7.64 gm and 101.96±7.27 gm in group B, 95.59±0.75 gm and 95.19±1.24 gm in group C respectively. No difference was found between the right and left kidneys in any group. However, statistically significant differences were evident among age groups.Conclusion: The weight of the kidney was found to increase up to 4th decade of life and then declined with further advancing age.Delta Med Col J. Jan 2016 4(1): 31-34

LT4-monopreparation versus LT4- LT3-compound preparation in the treatment of diffuse endemic goitre

1986 ◽  
Vol 113 (2) ◽  
pp. 242-248 ◽  
Author(s):  
H. Bongers ◽  
L. A. Hotze ◽  
R. Schmitz ◽  
K. Joseph
Keyword(s):  
Thyroid Volume ◽  
Serum Levels ◽  
Double Blind Study ◽  
Endemic Goitre ◽  
Weak Correlation ◽  
Normal Range ◽  
Double Blind ◽  
Blood Samples ◽  
Group A ◽  
Group B

Abstract. Fifty-four patients with diffuse non-toxic goitre were observed before and under therapy either with 125 μg LT4 (group A) or 75 μg LT4 + 15 μg LT3 (group B) in a prospective double blind study, using 1-, 3- and 6-months controls. Changes in goitre size have been estimated by ultrasonic scanning. Both treatment forms provided a significant reduction of goitre size, even after 1 month of therapy: a 20%-decrease in group A and 16% in group B. The 6-month reduction was about 30% in group A and 27% in group B. Between the 2 groups there were no differences in the reduction of volume. The suppression of the TSH-response to TRH was identical in both groups, too. In group A there was a predominant increase of the TT4-and FT4-serum levels, both reaching the hyperthyroid range. In group B there was a predominant increase of the TT3- and FT3-serum levels and a slight increase of the FT4-levels. The TT3- and FT3-serum levels also exceeded the upper normal range. As the blood samples were drawn about 2 h after medication, acute hormone resorption influenced these data. In the 3-month controls only there was a significant correlation between the reduction of the thyroid volume and the suppression of TSH-release. In the 6-month controls we found a weak correlation of the reduction of volume and the decrease of the pertechnetate uptake value. No correlation was found between the relative changes of FT3- and FT4-serum levels and the reduction of goitre size. There were no indications of possible side effects in group A or B during treatment. So this study showed the compared treatment forms to be equivalent in the therapy of diffuse non-toxic goitre, both yielding excellent results.

scholarly journals Study of Morphology of the Ovary as a Determinant of Reproductive Age

2014 ◽  
Vol 11 (2) ◽  
pp. 77-80
Author(s):  
Shamima Yesmin ◽  
Selina Anwar ◽  
Anjum Ara Begum ◽  
Narayan Chandra Saha ◽  
Md Khalilur Rahman
Keyword(s):  
Age Groups ◽  
Physical Method ◽  
The Other ◽  
Reproductive Age ◽  
Cross Sectional ◽  
Age Related ◽  
Group A ◽  
The Difference ◽  
Group B ◽  
The Right

Context and rationale: The age related infertility due to early ovarian ageing is one of the problems for women who want to become pregnant in late age in our country. Ovarian ageing reflects in its morphology. So this study was aimed at determining the gross morphology of the ovary in different age groups of Bangladeshi female (cadaver) to assess the possible relationships among different morphological variable of ovaries in different age groups. The present study would serve as a baseline data for the gynecologist, obstetricians and endocrinologist about the onset of infertility in the context of Bangladesh. Materials and methods: Cross sectional analytical type of study was conducted at the department of Anatomy, Rangpur Medical College, Rangpur. Fifty pairs postmortem human ovaries from Bangladeshi female aged between 15 and 45 years were examined for morphological study. The morphological parameters such as length, breadth, circumference, weight and volume of the right and left ovaries determined by physical method and the data were compared between different age groups. Result: Mean length, circumference and volume were significantly higher in group A than the other groups in both right and left sides. The difference reached a significant level (P< 0.05) in both ovaries in between and within groups for all mentioned parameter. The mean breadth of right ovary in group B and mean breadth of left ovary in group A were larger than the other groups but was not significant. Conclusion: The values of the morphological measurements fall from younger to older women. This may be due to depletion of the ovarian non-growing follicles thus reflecting fall in the ovarian reserve. DOI: http://dx.doi.org/10.3329/bja.v11i2.20675 Bangladesh Journal of Anatomy, July 2013, Vol. 11 No. 2 pp 77-80

scholarly journals Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258362
Author(s):  
Zsófia Gregor ◽  
Anna Réka Kiss ◽  
Liliána Erzsébet Szabó ◽  
Attila Tóth ◽  
Kinga Grebur ◽  
...  
Keyword(s):  
Age Groups ◽  
Left Ventricular ◽  
Reference Ranges ◽  
Age Group ◽  
Myocardial Mass ◽  
Functional Parameters ◽  
Normal Reference ◽  
Age Related ◽  
Group A ◽  
Group B

Background The threshold-based (TB) trabeculated and papillary muscle mass (TPM) quantification method for cardiac MRI (CMR) calculates different values than conventional contouring techniques. We aimed to identify the sex- and age-related normal reference ranges for left ventricular (LV) myocardial mass values, volumetric and functional parameters and the correspondence of these parameters using the TB method. Methods Healthy European adults (n = 200, age: 39.4 ± 12 years, males: 100) were examined with CMR and evaluated with a TB postprocessing method. They were stratified by sex and age (Group A: 18–29, Group B: 30–39, Group C: 40–49, Group D: >50 years). The calculated parameters were indexed to body surface area (i). Results The normal reference ranges for the studied parameters were assessed in each age group. Significant biometric differences in LV parameters and mass-to-volume ratios were found between males and females, and the left ventricular compacted myocardial mass (LVCMi) and TPMi differences remained significant after stratification by age. Unlike other LV volumetric and functional parameters and mass-to-volume ratios, the TPMi, the LVCMi and the TPMi-to-LVCMi ratio did not differ among age groups in males or females. This finding was strengthened by the lack of correlation between TPMi and age. Conclusions Age- and sex-related normal reference ranges for LV volumetric and functional parameters and LVCMi and TPMi values were established using a TB postprocessing method. TPMi, LVCMi and their ratio did not change over time. The TPMi-to-LVCMi and the mass-to-volume ratios might have clinical utility in the differential diagnosis of conditions with LV hypertrabeculation.

scholarly journals Age-related changes of vitamin C levels in aqueous humour

2015 ◽  
Vol 72 (9) ◽  
pp. 823-826 ◽  
Author(s):  
Vladimir Canadananovic ◽  
Slobodanka Latinovic ◽  
Sava Barisic ◽  
Nikola Babic ◽  
Sandra Jovanovic
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Aqueous Humor ◽  
High Performance ◽  
Age Groups ◽  
Common Disease ◽  
Age Related ◽  
Senior Population ◽  
Group A ◽  
Group B

Background/Aim. Age-related cataract is a common disease among senior population. Vitamin C is the most effective reducing hydrosoluble antioxidant causing reduction in the levels of free radicals in crystaline lens. The aim of this study was to evaluate the age-related change of vitamin C (L-ascorbic acid) level in the aqueous humor of patients with senile cataract. Methods. This prospective study included 74 patients, divided into 3 age groups, with age-related cataract, underwent routine phaco cataract surgery with intraocular lens implantation. Aqueous humor was aspirated from 74 eyes at the beginning of phacoemulsification. The levels of vitamin C (L-ascorbic acid) in aqueous humor were determined with high-performance liquid chromatography (HPLC). Results. The average age of patients included in the study was 65 ? 9.85 years (54-87 years). The level of vitamin C in aqueous humor was 152.78 ? 7.0125 ?g/mL in the group A (50-59 years), 134.15 ? 5.1569 ?g/mL in the group B (60-69 years) and 106.51 ? 5.44 ?g/mL in the group C (over 70 years). Conclusion. The amount of vitamin C in aqueous humor of patients with age-related cataract is decreasing with age. There was a statistically significant change (p < 0.001) of vitamin C aqueous concentration in the patients of different age. This decrease could play a role in susceptibility to cataract formation in older population.

scholarly journals Microscopic study on the total number of follicles of ovary in Bangladeshi female cadavers

2014 ◽  
Vol 3 (1) ◽  
pp. 12-17
Author(s):  
Rubina Qasim ◽  
Humaira Naushaba ◽  
Md Enayet Ullah ◽  
Hasna Hena ◽  
Laila Farzana Khan
Keyword(s):  
Age Groups ◽  
Cross Sectional ◽  
Group 13 ◽  
Age Related ◽  
Group A ◽  
The Mean ◽  
Group 5 ◽  
Group B ◽  
The Right ◽  
Group D

Context: The ovaries are paired female reproductive and endocrine glands. It is an unique organ in the female body. It undergoes various changes under the influence of hormones which started from prepubertal period and continue up to post menopausal period. Reproductive life span is determined by the histological changes of ovarian follicles. The study was carried out to counting the total number of follicles in relation to age. Study design: Cross sectional, descriptive type of study. Place and period of study: Department of Anatomy, Sir Salimullah Medical College (SSMC), Dhaka from July 2010 to June 2011. Materials: 65 ovaries of Bangladeshi female cadavers age ranging from 5 years to 65 years. Methods: The samples were divided into four different age groups. They were group A or prepubertal group (5-12years), group B or reproductive group (13-45 years), group C or perimenopausal group (46-51years) and group D or postmenopausal group (52-65years). Histological studies were carried out only in right ovary on 24 fresh samples, 6 samples from each group. RESULTS: The mean (±SD) total number of the follicles in the right ovaries were 82.67±2.07, 43.33±8.17, 10.00± 5.47 and 1.17±1.94 per square millimeter in group A, B, C & D respectively. The differences of the mean (±SD) number of the follicles were highly significant (P<0.001) among the all age groups and was significant (P<0.01) when compared between group C with group D. CONCLUSION: Age related changes were observed in the total number of follicles of the ovary. DOI: http://dx.doi.org/10.3329/updcj.v3i1.17979 Update Dent. Coll. j: 2013; 3 (1): 12-17

Hypercoagulable State in the Watanabe Heritable Hyperlipidemic Rabbit, an Animal Model for the Progression of Atherosclerosis

1989 ◽  
Vol 61 (01) ◽  
pp. 140-143 ◽  
Author(s):  
Yoshitaka Mori ◽  
Hideo Wada ◽  
Yutaka Nagano ◽  
Katsumi Deguch ◽  
Toru Kita ◽  
...  
Keyword(s):  
Vitamin K ◽  
Fibrinogen Level ◽  
Plasma Cholesterol ◽  
Age Groups ◽  
Clotting Factor ◽  
Clotting Factors ◽  
Group A ◽  
Hyperlipidemic Rabbit ◽  
Group B ◽  
Progression Of Atherosclerosis

SummaryBlood coagulation in a strain of rabbits designated as Watanabe heritable hyperlipidemic (WHHL) rabbits was examined. The activities of vitamin K-dependent clotting factors, contact factors and clotting factor VIII (F VIII) and the fibrinogen level were significantly higher in WHHL rabbits than in normolipidemic rabbits (all age groups). Values for vitamin Independent clotting factor were already higher at 2 months of age. Contact factors and fibrinogen levels increased age after 5 to 8 months. F VIII increased between 5 and 8 months and then decreased. At 2 months of age, WHHL rabbits were divided into two groups. Group A was fed standard rabbit chow and group B standard rabbit chow containing 1% probucol. Probucol prevented the progression of atherosclerosis in group B in the absence of a significant reduction in plasma cholesterol level. F VIII and fibrinogen levels were statistically decreased in all rabbits at all ages in group B (P<0.05). These differences in clotting factors between the two groups were most obvious at 8 months (P<0.02).We conclude that vitamin K-dependent clotting factors may increase with hyperlipemia and that increases in F VIII and fibrinogen may be closely related to the progression of throm- boatherosclerosis.

Histological Study of Human Thyroid Gland Relative Proportion of Parenchyma and Stroma in Thyroid Glands of Bangladeshi People

2013 ◽  
Vol 1 (2) ◽  
pp. 17-20
Author(s):  
Md Enayet Ullah ◽  
Hasna Hena ◽  
Rubina Qasim
Keyword(s):  
Thyroid Gland ◽  
Histological Study ◽  
Relative Proportion ◽  
Age Groups ◽  
Human Thyroid ◽  
Structural Units ◽  
Thyroid Glands ◽  
Group A ◽  
Group B ◽  
Connective Tissue Sheath

Deep cervical fascia forms a connective tissue sheath around the thyroid gland. Delicate trabeculae and septa penetrate the gland indistinctly dividing the gland into lobes and lobules which in turn composed of follicles.1,2,3 These follicles are structural units of thyroid gland which varies greatly in size and shape.4 The number of follicles varies in different age groups. The study was carried out to see the percentage of area occupied by follicles in the stained section of thyroid glands in different age groups. The collected samples were grouped as A (3.5 – 20yrs), B (21- 40yrs) & C (41 – 78yrs). Percentage of area occupied by follicles was (58.55±10.72) in group A, (63.79±12.35) in group B + (63.39±8.29) in group C.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13981 Update Dent. Coll. j. 2011: 1(2): 17-20

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