scholarly journals Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS

2018 ◽  
Vol 7 (1) ◽  
pp. 115-123 ◽  
Author(s):  
Signe Frøssing ◽  
Malin Nylander ◽  
Caroline Kistorp ◽  
Sven O Skouby ◽  
Jens Faber
Keyword(s):  
Insulin Resistance ◽  
Heart Rate ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Visceral Fat ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Increased Risk ◽  
Risk Biomarkers ◽  
Atrial Natriuretic

Context Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease (CVD), and biomarkers can be used to detect early subclinical CVD. Midregional-pro-adrenomedullin (MR-proADM), midregional-pro-atrial natriuretic peptide (MR-proANP) and copeptin are all associated with CVD and part of the delicate system controlling fluid and hemodynamic homeostasis through vascular tonus and diuresis. The GLP-1 receptor agonist liraglutide, developed for treatment of type 2 diabetes (T2D), improves cardiovascular outcomes in patients with T2D including a decrease in particular MR-proANP. Objective To investigate if treatment with liraglutide in women with PCOS reduces levels of the cardiovascular biomarkers MR-proADM, MR-proANP and copeptin. Methods Seventy-two overweight women with PCOS were treated with 1.8 mg/day liraglutide or placebo for 26 weeks in a placebo-controlled RCT. Biomarkers, anthropometrics, insulin resistance, body composition (DXA) and visceral fat (MRI) were examined. Results Baseline median (IQR) levels were as follows: MR-proADM 0.52 (0.45–0.56) nmol/L, MR-proANP 44.8 (34.6–56.7) pmol/L and copeptin 4.95 (3.50–6.50) pmol/L. Mean percentage differences (95% CI) between liraglutide and placebo group after treatment were as follows: MR-proADM −6% (−11 to 2, P = 0.058), MR-proANP −25% (−37 to −11, P = 0.001) and copeptin +4% (−13 to 25, P = 0.64). Reduction in MR-proANP concentration correlated with both increased heart rate and diastolic blood pressure in the liraglutide group. Multiple regression analyses with adjustment for BMI, free testosterone, insulin resistance, visceral fat, heart rate and eGFR showed reductions in MR-proANP to be independently correlated with an increase in the heart rate. Conclusion In an RCT, liraglutide treatment in women with PCOS reduced levels of the cardiovascular risk biomarkers MR-proANP with 25% and MR-proADM with 6% (borderline significance) compared with placebo. The decrease in MR-proANP was independently associated with an increase in the heart rate.

Relationship between status of plasma atrial natriuretic peptide and heart rate variability in human subjects

2012 ◽  
Vol 28 (2) ◽  
pp. 208-214 ◽  
Author(s):  
Yuji Kasamaki ◽  
Yoichi Izumi ◽  
Yukio Ozawa ◽  
Masakatsu Ohta ◽  
Ayako Tano ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Human Subjects ◽  
Plasma Atrial Natriuretic Peptide ◽  
Atrial Natriuretic

Release of atrial natriuretic peptide by atrial distension

1985 ◽  
Vol 63 (6) ◽  
pp. 739-742 ◽  
Author(s):  
J. R. Ledsome ◽  
N. Wilson ◽  
C. A. Courneya ◽  
A. J. Rankin
Keyword(s):  
Heart Rate ◽  
Atrial Natriuretic Peptide ◽  
Pulmonary Vein ◽  
Natriuretic Peptide ◽  
Coronary Sinus ◽  
Femoral Artery ◽  
Left Atrial ◽  
Cervical Vagotomy ◽  
Atrial Receptors ◽  
Atrial Natriuretic

A heterologous radioimmunoassay was used to measure the concentration of immunoreactive atrial natriuretic peptide (iANP) in plasma from the femoral artery of eight chloralose anaesthetized dogs. Mitral obstruction which increased left atrial pressure by 11 cmH2O increased plasma iANP from 97 ± 10.3 (mean ± SE) to 135 ± 14.3 pg/mL. Pulmonary vein distension increased heart rate but did not increase plasma iANP. Bilateral cervical vagotomy and administration of atenolol (2 mg/kg) did not prevent the increase in iANP with mitral obstruction. Samples of blood from the coronary sinus had plasma iANP significantly higher than simultaneous samples from the femoral artery confirming the cardiac origin of the iANP. Release of iANP depends on direct stretch of the atrium rather than on a reflex involving left atrial receptors.

Circadian Rhythms of Atrial Natriuretic Peptide, Blood Pressure and Heart Rate in Normal Subjects

Cardiology ◽  
1989 ◽  
Vol 76 (6) ◽  
pp. 428-432 ◽  
Author(s):  
Francesco Portaluppi ◽  
Loris Montanari ◽  
Bruno Bagni ◽  
Ettore degli Uberti ◽  
Giorgio Trasforini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Circadian Rhythms ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Normal Subjects ◽  
Atrial Natriuretic

Secretion of Atrial Natriuretic Peptide (Anp), Heart Reconditioning and Remolding in Elite Endurance Trained Athletes

2021 ◽  
Vol 15 (11) ◽  
pp. 3305-3312
Author(s):  
Hafeezullah Wazir Ali ◽  
Mohammad Aslam ◽  
Sohail Aziz ◽  
Muhammad Mazhar Hussain
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cardiac Remodeling ◽  
Maximal Exercise ◽  
Elite Athletes ◽  
Athlete’S Heart ◽  
Athlete's Heart ◽  
Atrial Natriuretic

Aim / Objective: The aim of this study was to evaluate the effect of maximal exercise on the level of cardiac remolding and Atrial Natriuretic Peptide (ANP) in elite athletes as compared to sedentary healthy subjects and correlation of ANP with the adaptation of athlete’s heart and cardiac remodeling (if any) Place and Duration of Study: The present study was carried out at the Department of Physiology, Army Medical College, with collaboration of Armed Forces Institute of Cardiology (AFIC) Rawalpindi from June 2003 to May 2004. Methodology: A total number of 44 subjects were included in this study. These comprised of 22 elite endurance athletes and 22 healthy sedentary volunteers as controls. All subjects were examined clinically to rule out the cardiovascular and pulmonary diseases on the basis of medical history, physical examination, and echocardiography. All the selected subjects were examined on a Toshiba Power Vision 6000 echocardiograph for assessing and measuring their LV end-diastolic internal diameter (LVIDd), Diastolic interventricular septal thickness (IVSTd), diastolic posterior wall thickness (PWTd). The left ventricular mass was (LVM) was calculated by using the Devereux formula. They were subject to go for ergometer cycle exercise before breakfast. The Blood samples were drawn before and after exercise to assess the level of ANP in their samples. Results: It was found that LVIDd, IVSTd, PWTd, LVM were higher in athletes as compared to their age, sex and BMI matched controls. The ANP levels in athlete’s plasma were also high in post and pre exercise sample as compared to controls. Conclusion: Systolic blood pressure, Diastolic Blood Pressure and heart rate are lower in endurance elite athletes than matched sedentary controls. The maximal Exercise increases the level of Atrial Natriuretic Peptide (ANP) in elite athletes significantly as compared to sedentary healthy controls. There was a Positive correlations between ANP and LVIDd, IVSTd, PWTd, and LVM while there was negative correlation between ANP and heart rate, ANP and Blood pressure. However, none of correlation was found to be statistically significant. Keywords: Athlete’s Heart, ANP, Cardiac remodeling in athletes, Echocardiography of heart

scholarly journals Low Plasma Atrial Natriuretic Peptide: A New Piece in the Puzzle of Polycystic Ovary Syndrome

2013 ◽  
Vol 98 (12) ◽  
pp. 4882-4889 ◽  
Author(s):  
Patricia B. M. Lauria ◽  
Helen L. Del Puerto ◽  
Adelina M. Reis ◽  
Ana L. Candido ◽  
Fernando M. Reis
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Plasma Atrial Natriuretic Peptide ◽  
Atrial Natriuretic

Response to dynamic exercise in cardiac transplant recipients: implications for control of the sodium regulatory hormone atrial natriuretic peptide

1990 ◽  
Vol 78 (2) ◽  
pp. 159-163 ◽  
Author(s):  
D. R. J. Singer ◽  
N. R. Banner ◽  
A. Cox ◽  
N. Patel ◽  
M. Burdon ◽  
...  
Keyword(s):  
Heart Rate ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Control Group ◽  
Cardiac Transplant ◽  
Cardiac Innervation ◽  
Transplant Recipients ◽  
Plasma Atrial Natriuretic Peptide ◽  
Control Subjects ◽  
Atrial Natriuretic

1. To study the importance of cardiac innervation in the regulation of atrial natriuretic peptide, plasma atrial natriuretic peptide levels were measured during symptom-limited, graded exercise on a cycle ergometer in seven male orthotopic cardiac transplant recipients. 2. Resting plasma atrial natriuretic peptide was significantly higher in the transplant recipients than in two control groups, one matched to the transplant recipients (group 1) and the other to the age of the donor heart (group II). 3. The response to exercise of the cardiac transplant recipients was compared with the response of control group II. Mean maximal work load achieved with exercise was around 40% lower in the cardiac transplant recipients. During exercise, plasma atrial natriuretic peptide levels increased in both the cardiac transplant recipients and the control subjects. The increase in plasma atrial natriuretic peptide with exercise was greater in absolute, but less in percentage, terms in transplant recipients than in the control subjects. 4. The increase in mean arterial pressure with exercise was similar in patients and in control subjects; however, heart rate increased in the patients by only 33% compared with a rise of 151% in the control group. 5. These results provide insight into the control of the sodium regulatory hormone atrial natriuretic peptide. First, factors other than a change in heart rate appear of importance in the regulation of atrial natriuretic peptide. Secondly, these findings suggest that cardiac innervation is not of dominant importance in the modulation of atrial natriuretic peptide secretion.

Effect of posture on plasma immunoreactive atrial natriuretic peptide concentrations in man

1986 ◽  
Vol 71 (3) ◽  
pp. 299-305 ◽  
Author(s):  
L. R. Solomon ◽  
J. C. Atherton ◽  
H. Bobinski ◽  
R. Green
Keyword(s):  
Heart Rate ◽  
Renal Function ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Positive Pressure ◽  
Sodium Reabsorption ◽  
Upright Posture ◽  
Plasma Atrial Natriuretic Peptide ◽  
Supine Posture ◽  
Atrial Natriuretic

1. The effect of changes of posture on plasma atrial natriuretic peptide concentrations and renal function was studied in normal human volunteers. 2. Plasma atrial natriuretic peptide concentrations increased in the supine posture, reached a maximum value after 30–60 min, remained elevated for 4 h and decreased to baseline values on return to the upright posture. Inflation of antishock trousers, which apply positive pressure to the legs and lower abdomen, attenuated the fall in plasma atrial natriuretic peptide concentration in the upright position. 3. In the supine posture there were increases in urine flow rate, sodium, lithium, fractional sodium and fractional lithium clearances. Fractional distal water and sodium excretion, and total distal water and sodium reabsorption, which were estimated by the lithium clearance technique, also increased. 4. Heart rate and systolic and diastolic blood pressures decreased in the supine and increased on return to the upright posture. Inflation of antishock trousers prevented the increase in heart rate in the upright posture. 5. The contribution of haemodynamic factors to the increase in plasma atrial natriuretic peptide concentrations in the supine position and the relationship between this increase and the associated changes in renal function are discussed. However, the contribution of atrial natriuretic peptide to these changes is uncertain.

Circadian rhythms of atrial natriuretic peptide, renin, aldosterone, cortisol, blood pressure and heart rate in normal and hypertensive subjects

1990 ◽  
Vol 8 (1) ◽  
pp. 85-95 ◽  
Author(s):  
Francesco Portaluppi ◽  
Bruno Bagni ◽  
Ettore degli Uberti ◽  
Loris Montanari ◽  
Rosy Cavallini ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Circadian Rhythms ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Atrial Natriuretic

Abstract 54: Procalcitonin, Copeptin and Midregional Pro-atrial Natriuretic Peptide as Markers of Ischemic Stroke Risk: The Northern Manhattan Study

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Mira Katan ◽  
Yeseon P Moon ◽  
Janet DeRosa ◽  
Myunghee C Paik ◽  
Beat Mueller ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Ischemic Stroke ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Stroke Risk ◽  
Hemodynamic Stress ◽  
Increased Risk ◽  
Ischemic Stroke Risk ◽  
Atrial Natriuretic

Background: Chronic infections and neuroendocrine dysfunction may be risk factors for ischemic stroke. We hypothesized that selected blood biomarkers of infection (procalcitonin, or PCT), hypothalamic-pituitary-axis function (copeptin), and hemodynamic stress (midregional pro-atrial natriuretic peptide, or MRproANP) would be associated with incident ischemic stroke risk in the multi-ethnic, urban Northern Manhattan Study (NOMAS) cohort. Methods: A case-cohort study was performed among initially stroke-free participants from the prospective population-based NOMAS study. The mean follow up was 11 years. Cases were defined as first ischemic stroke (including fatal) with available baseline blood (n=172). We randomly selected controls among those who did not develop an event (n=344). Biomarkers were measured in a blinded batch analysis (Laboratory of the Medical University Clinic, Aarau, Switzerland, using B.R.A.H.M.S assays by Thermo Fisher Scientific). We calculated hazard ratios and 95% confidence intervals (HR, 95% CI) using Cox proportional hazards models, with inverse probability weighting to correct for the case-cohort study design, to estimate the association with risk of stroke after adjusting for demographic, behavioral, and medical risk factors. Results: Mean age of cases was 72 (IQR 65-78); 59% were female. After full adjustment, those with PCT in the top quartile, compared to the lowest quartile, were at increased risk of ischemic stroke (adjusted HR 1.98, 95% CI 1.02-3.83). Those with MRproANP levels in the top quartile, compared to the lowest quartile, were also at increased risk of stroke (adjusted HR 3.45, 95% CI 1.58-7.52), but not those with higher copeptin levels. The distribution of MRproANP differed by stroke etiology. Levels of MRproANP were greater for cardioembolic strokes (CE), and MRproANP levels were predictive of CE (adjusted HR 3.29 per SD, 95% CI 1.89-5.72). Conclusion: Higher levels of procalcitonin, a marker of infection, and MRproANP, a marker for hemodynamic stress, were independently associated with ischemic stroke risk in this multiethnic, urban cohort. MRproANP was specifically associated with cardioembolic stroke risk. Further study is needed to confirm these results.

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