scholarly journals Walking and postural balance in adults with severe short stature due to isolated GH deficiency

2019 ◽  
Vol 8 (4) ◽  
pp. 416-424 ◽  
Author(s):  
Ananda A Santana-Ribeiro ◽  
Giulliani A Moreira-Brasileiro ◽  
Manuel H Aguiar-Oliveira ◽  
Roberto Salvatori ◽  
Vitor O Carvalho ◽  
...  
Keyword(s):  
Short Stature ◽  
Postural Balance ◽  
Fall Risk ◽  
Gh Deficiency ◽  
Muscle Tone ◽  
Receptor Gene ◽  
Leg Length ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Severe Short Stature

Objectives Walking and postural balance are extremely important to obtain food and to work. Both are critical for quality of life and ability to survive. While walking reflects musculoskeletal and cardiopulmonary systems, postural balance depends on body size, muscle tone, visual, vestibular and nervous systems. Since GH and IGF-I act on all these systems, we decided to study those parameters in a cohort of individuals with severe short stature due to untreated isolated GH deficiency (IGHD) caused by a mutation in the GHRH receptor gene. These IGHD subjects, despite reduction in muscle mass, are very active and have normal longevity. Methods In a cross-sectional study, we assessed walking (by a 6-min walk test), postural balance (by force platform) and fall risk (by the 'Timed Up and Go' test) in 31 IGHD and 40 matched health controls. Results The percentage of the walked distance measured in relation to the predicted one was similar in groups, but higher in IGHD, when corrected by the leg length. Absolute postural balance data showed similar velocity of unipodal support in the two groups, and better values, with open and closed eyes and unipodal support, in IGHD, but these differences became non-significant when corrected for height and lower-limb length. The time in 'Timed Up and Go' test was higher in IGHD cohort, but still below the cut-off value for fall risk. Conclusion IGHD subjects exhibit satisfactory walking and postural balance, without increase in fall risk.

scholarly journals Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene

2008 ◽  
Vol 69 (1) ◽  
pp. 153-158 ◽  
Author(s):  
Carla R. P. Oliveira ◽  
Roberto Salvatori ◽  
Luciana M. A. Nóbrega ◽  
Erick O. M. Carvalho ◽  
Menilson Menezes ◽  
...  
Keyword(s):  
Short Stature ◽  
Gh Deficiency ◽  
Receptor Gene ◽  
Homozygous Mutation ◽  
Abdominal Organs ◽  
Ghrh Receptor ◽  
Severe Short Stature

Presence ofGH1and absence ofGHRHRgene mutations in a large cohort of Argentinian patients with severe short stature and isolated GH deficiency

2013 ◽  
Vol 80 (4) ◽  
pp. 618-620 ◽  
Author(s):  
Matias Juanes ◽  
Roxana Marino ◽  
Marta Ciaccio ◽  
Isabel Di Palma ◽  
Pablo Ramirez ◽  
...  
Keyword(s):  
Short Stature ◽  
Gh Deficiency ◽  
Large Cohort ◽  
Severe Short Stature

scholarly journals Fall risk among older adults residing in Bharatpur, Chitwan, Nepal

2020 ◽  
Vol 10 (3) ◽  
pp. 12-15
Author(s):  
Jogmaya Limbu ◽  
Sunita Poudyal
Keyword(s):  
Older Adults ◽  
Older People ◽  
Fall Risk ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Structured Interview ◽  
Cross Sectional Study ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Risk Of Falls

Background: Falls in older people is a common serious health problem that has profound im­pact on overall health and quality of life of older people. The aim of this study was to assess the fall risk among older adults. Methods: The descriptive cross-sectional study was carried out among older adults residing in Bharatpur, Chitwan. A total of 98 older adults were selected by using simple random sampling technique. The data were collected by using structured interview schedule and fall risk was as­sessed by Timed Up and Go (TUG) test. Data were collected from 23rd June, 2019 to 7th July, 2019. Obtained data were analyzed using descriptive and inferential statistics. Results: The study findings revealed that more than half (60.2%) of the older adults were from the age group of ≤79 years, male (63.3%) and almost half (50%) were illiterate. Nearly all (96.9%) older adults were living with their family however, 50% were undernourished (BMI- <22.9). Ma­jorities (66.3%) were suffering from chronic diseases and had been taking medicine. Majority of older adults reported vision problem (64.3%) and hearing problem (60.2%). However, only 8.2% reported history of fall within last 6-12 months. More than half (59.2%) of the older adults had high risk of fall and found significant association with age (p=0.039) and vision problem (p=0.043). Conclusions: More than half of the older adults are in risk of falls. Therefore, more emphasis should be given in screening the older people for fall risk factors as preventive measures.

scholarly journals The Application of 'Timed Up and Go' Test in Fall Screening of Elderly People in Shanghai: A Cross-Sectional Study

2021 ◽  
Author(s):  
Jian Wang ◽  
Xiuqin Chen ◽  
Xiaoming Sun ◽  
Huifen Ma ◽  
Yan Yu ◽  
...  
Keyword(s):  
Elderly People ◽  
Predictive Value ◽  
Fall Risk ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cluster Sampling ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
And Gender

Background: We aimed to evaluate the predictive value of the 'Timed Up and Go' test (TUGT) for identifying fall risk in community-dwelling elderly. Methods: From Aug 2016 to Feb 2017, cluster sampling was conducted among residents aged over 60 from 15 communities in Songjiang district, Shanghai. Face-to-face questionnaire interviews and TUGT measures were conducted to collect data. Results: 6,014 participants were enrolled, with an average age 72.7±7.0 years. 637 (10.6%) elderly people had a fall experience in the past year. TUGT for the non-fall group, one-fall group and recurrent-fall group was 9.02±4.39, 10.00±5.26 and 10.78±4.51 seconds respectively (P<0.001). ROC analysis showed that the TUGT cut-off point for the elderly was 12.5 seconds and AUC was 0.573 for any-fall group and 0.613 for recurrent-fall group respectively. After adjusting for age and gender, the predictive value was not high for any-fall group (AUC=0.614) and recurrent-fall group (AUC=0.648). The TUGT cut-off point for the elderly aged below 65, 65-74, 75-84 and 85 and above was 13.52s, 12.51s, 12.51s, 12.00s, respectively. After adjustment of the confounding factors, the OR values for the risk of fall for the elderly men and women who completed TUGT longer than the cut-off point was 2.404 and 2.075 times higher than those who completed TUGT shorter than the cut-off point, respectively. Conclusion: TUGT with the cut-off score of 12.5s has limited capability in predicting fall risk in community-dwelling elderly.

scholarly journals Lifetime congenital isolated GH deficiency does not protect from the development of diabetes

2013 ◽  
Vol 2 (2) ◽  
pp. 112-117 ◽  
Author(s):  
Taísa A R Vicente ◽  
Ívina E S Rocha ◽  
Roberto Salvatori ◽  
Carla R P Oliveira ◽  
Rossana M C Pereira ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Cell Function ◽  
Gh Deficiency ◽  
Receptor Gene ◽  
Area Under The Curve ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Insulinogenic Index ◽  
Model Assessment ◽  
Cross Sectional

ObjectivesAdult subjects with untreated, lifetime, isolated GH deficiency (IGHD) due to a homozygous GHRH receptor gene mutation (MUT/MUT) residing in Itabaianinha, Brazil, present with lower BMI, higher prevalence of impaired glucose tolerance (IGT), increased insulin sensitivity (IS), and reduced β-cell function (βCF) when compared with non-BMI-matched homozygous normal controls. However, the prevalence of diabetes mellitus (DM) in this cohort is unknown. Comparing their IS and βCF with BMI-matched individuals heterozygous for the same mutation (MUT/N) may be useful to elucidate the role of the GH–IGF1 axis in IS and βCF. The purposes of this work were to verify the prevalence of IGT and DM in adult MUT/MUT subjects from this kindred and to compare IS and βCF in MUT/MUT and MUT/N.DesignCross-sectional study.MethodsWe studied most (51) of the living IGHD adults of this kindred who are GH naive. The oral glucose tolerance test (OGTT) could be performed in 34 subjects, fasting glucose was measured in 15, while two had a previous diagnosis of DM. The OGTT results of 24 MUT/MUT subjects were compared with those of 25 BMI-matched MUT/N subjects. IS was assessed by homeostatic model assessment of insulin resistance (HOMA–IR), quantitative IS check index, and oral glucose IS index for 2 and 3 h. βCF was assayed by HOMA-β, insulinogenic index, and the area under the curve of insulin:glucose ratio.ResultsThe prevalence of DM and IGT in IGHD was 15.68 and 38.23% respectively. IS was increased and βCF was reduced in MUT/MUT in comparison with MUT/N.ConclusionsLifetime, untreated IGHD increases IS, impairs βCF, and does not provide protection from diabetes.

scholarly journals Relationship between SHARE-FI Frailty Scores and Physical Performance Measures in Older Adult Medicaid Recipients

Geriatrics ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 51 ◽  
Author(s):  
Margaret Danilovich ◽  
Laura Diaz ◽  
Daniel Corcos ◽  
Jody Ciolino
Keyword(s):  
Older Adult ◽  
Physical Performance ◽  
Performance Measures ◽  
Gait Speed ◽  
Fall Risk ◽  
Assessment Tool ◽  
Performance Measure ◽  
Self Report ◽  
Timed Up And Go ◽  
Cross Sectional

The Survey of Health, Ageing and Retirement in Europe-Frailty Instrument (SHARE-FI) is a frailty assessment tool designed for primary care settings comprised of four self-report questions and grip strength measurement, yet it is not known how SHARE-FI scores relate to objective physical performance measures that assess physical functioning, fall risk, and disability. This cross-sectional, observational study examined the association between SHARE-FI scores and a battery of physical performance measures in a sample of older adult, Medicaid waiver recipients (n = 139, mean age = 74.19 ± 8.36 years). We administered the SHARE-FI, Timed Up and Go (TUG), gait speed, and Short Physical Performance Battery (SPPB) in participants’ homes. Among clients, 45% were frail, 35% pre-frail, and 20% non-frail. There were significant differences in all physical performance measure scores with respect to SHARE-FI category. SHARE-FI continuous scores significantly predicted TUG time, all domains of the SPPB, gait speed, and inability to complete the chair rise test. Self-reported walking difficulty and objectively measured gait speed were significantly correlated. The SHARE-FI continuous frailty score predicts scores on a variety of validated physical performance measures. Given the fast administration time, the SHARE-FI could potentially be used to serve as a surrogate for physical performance measures with known association with physical function, fall risk, and disability.

scholarly journals Head Posture and Postural Balance in Community-Dwelling Older Adults Who Use Dentures

Medicina ◽  
2020 ◽  
Vol 56 (10) ◽  
pp. 529
Author(s):  
Youngsook Bae ◽  
Yongnam Park
Keyword(s):  
Older Adults ◽  
Postural Balance ◽  
Postural Sway ◽  
Pearson Correlation ◽  
Community Dwelling ◽  
Neck Muscle ◽  
Timed Up And Go ◽  
Cross Sectional ◽  
Forward Head Posture ◽  
Head Posture

Background and objectives: Tooth loss and consequent denture use and impaired posture and postural balance are more prevalent in older adults than in the young ones. The aim of this cross-sectional study was to identify the association between denture use, head posture, postural balance, and neck muscle strength (NMS). Materials and methods: We included 107 participants (56 in the non-denture use group and 51 in the denture use group) and measured their NMS, forward head posture, and postural balance. Forward head posture was measured using the craniocervical angle (CRA). Postural balance was assessed using a timed up-and-go test (TUG) and postural sway. An independent t-test was used to analyze the differences between the groups; Pearson correlation analysis was used to analyze the correlation of period of denture use, head posture, and postural balance. Results: We found that the denture use group had lower NMS, smaller CRA, longer TUG, and longer postural sway length than the non-denture use group. Duration of denture use was significantly correlated with TUG. Conclusions: Our findings reveal that denture use does not help with NMS, forward head maintain NMS, head posture, and postural balance in older adults.

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