Vitamin D and PTH: data from a cross-sectional study in an equatorial population

Objective: Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study. Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnormal levels of calcium, creatinine, glycemia and albumin were also exclusion criteria. Results: 25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL were equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subjects according to the Institute of Medicine (values <20 ng/mL) and in 59%, in consonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as deficiency) criteria. Individuals were divided according to four age brackets: children, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hyperparathyroidism in ROC curve was 26 ng/mL. Conclusion: Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data.

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Vitamin D Deficiency and Psoriasis: A Cross-Sectional study of Iranian Population in Yazd Province

Iranian journal of diabetes and obesity ◽

10.18502/ijdo.v12i3.4457 ◽

2020 ◽

Author(s):

Mohammad Ebrahimzadeh Ardakani ◽

Mohammad Afkhami-Ardekani ◽

Mohammad Reza Taghizadeh Yazdi ◽

Nasim Namiranian ◽

Farideh Radmehr

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Hypovitaminosis D ◽

Serum Levels ◽

Cross Sectional Study ◽

P Value ◽

Sectional Study ◽

Chi Square ◽

Cross Sectional ◽

Significant Difference

Objective: Psoriasis is an inflammatory disease of the skin and the joints. Psoriatic patients sometimes suffer from vitamin D deficiency and hypocalcemia. The aim of our study was to evaluate the level of calcium and vitamin D in patients with psoriasis. Materials and Methods: In this analytical cross sectional study, 110 cases of psoriasis that were referred to Shohadaye Mehrab clinic during 2015 and 110 non-psoriatic patients enrolled. Serum levels of calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphatase (ALK) and 25- hydroxy vitamin D3 [(25OH) D3] were measured in both groups. Data were analyzed using SPSS software version 19. Chi square test and T-test were used for statistical analysis. Results: Among110 patients with psoriasis 74 (67.3%) were men and 36 (32.75%) were women. There was no significant difference in the serum level of calcium (P-value: 0.563), phosphorus (P-value: 0.381), PTH (P-value: 0.364) and ALK (P-value: 0.639) between two groups. Vitamin D deficiency was found in 64.5% of psoriatic patients and 60% of the controls (P-value= 0.45); However 30.9% of psoriatic and 17.3% of the controls suffered from severe hypovitaminosis D. This difference was statistically significant (Pvalue= 0.014).Conclusion: We found a significant relationship between severe hypovitaminosis D and psoriasis. This finding revealed the need for evaluation of psoriatic patients for the presence of vitamin D deficiency.

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KNOWLEDGE AND PERCEPTIONS OF VITAMIN D DEFICIENCY AMONG THE UNITED ARAB EMIRATES POPULATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i18.33988 ◽

2019 ◽

pp. 183-186 ◽

Cited By ~ 1

Author(s):

OSAMA MOHAMED IBRAHIM ◽

NOOR KIFAH AL-TAMEEMI ◽

DALIA DAWOUD

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Blood Level ◽

United Arab Emirates ◽

Cross Sectional Study ◽

Vitamin D Insufficiency ◽

Abu Dhabi ◽

Sectional Study ◽

Cross Sectional

Objectives: The purpose of this study is to assess the Vitamin D deficiency awareness and perceptions between the United Arab Emirates (UAE) population. Methods: A cross-sectional study was done among the population of two emirates at the UAE: Abu Dhabi and Sharjah. Results: Overall, 434 participants completed the survey. Majority of people were aware of phenomenon of Vitamin D deficiency, but only 21.4% of them knew that sunlight is considered the main source of Vitamin D. Moreover, less than half of participants check their Vitamin D blood level regularly and around 55% of them follow-up with their physicians after completing the treatment. High proportion of participant females spend <1 h outdoors (60%) and use sunscreen daily (55%) that cause higher prevalence of Vitamin D deficiency among females than males (83% vs. 42%). Conclusion: This research gives some insights regarding the UAE population’s awareness and perceptions of Vitamin D insufficiency. Decreased awareness of sunlight exposure as a major source of Vitamin D, in addition to lifestyle, contributed to Vitamin D deficiency problem among the UAE population, in general, and in females, in particular.

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Evaluation of the Relationship Between Vitamin D Levels and Related Serum Markers as Well as Disease Activity in Patients With Rheumatoid Arthritis: A Cross-sectional Study in Western Iran

10.21203/rs.3.rs-125995/v2 ◽

2020 ◽

Author(s):

Nasrin Moghimi ◽

Ali Faridfar ◽

Reza Shahriarirad ◽

Mohsen Nikandish ◽

Amirhossein Salimi ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Levels ◽

Cross Sectional Study ◽

Serum Marker ◽

Sectional Study ◽

Cross Sectional ◽

Vitamin D Levels ◽

The Relationship

Abstract Introduction: Many studies have reported the role of vitamin D in rheumatoid arthritis (RA) which is related to several serum autoantibodies such as RF and Anti CCP. It also has been shown that vitamin D deficiency affect the DAS28 and VAS score inversely. Therefore, we aim to assess the relationship between vitamin D deficiency and RA-related autoantibodies including Anti CCP and RF levels and also evaluate the association between these parameters and the severity of disease.Methods: In this cross-sectional study, RA patients over 16 years of age were enrolled. The severity of diseases was assessed via the DAS28 scoring system. Serum levels of 25(OH) vitamin D were determined by the ELISA method, along with other rheumatoid related laboratory evaluations including Anti CCP, RF and CRPResults: A total of 100 patients with a mean age of 45.27± 14.14 were included and evaluated; of them, 75% were female and 77% lived in the city. Most of the patients (66%) had moderate DAS28 levels; however, no substantial relationship was observed between DAS28 and vitamin D levels. A significant positive relation between serum 25(OH)D level and disease duration, as well as the level of education, was observed. There was also no significant correlation between RA-related autoantibodies and inflammatory serum marker with 25(OH)D.Conclusion: Due to vitamin deficiency in the majority of cases (73%) and the relationship between serum 25(OH)D levels and the duration of disease, it can be concluded that vitamin D levels should be checked in those patients.

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The Effect of Gender and Altitude on Vitamin D Status Among Saudi Population: A Cross Sectional Study

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.20:1-6 ◽

2021 ◽

Vol 20 (1) ◽

pp. 1-6

Author(s):

Saif Aboud M Alqahtani

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Sea Level ◽

Hypovitaminosis D ◽

Cross Sectional Study ◽

Health Concern ◽

Total Serum ◽

Saudi Population ◽

Sectional Study ◽

Cross Sectional

Vitamin D deficiency is a major public health concern worldwide, resulting mainly due to insufficient sunlight exposure. The objective of this study was to assess the prevalence of vitamin D deficiency among the Saudi population living at different altitudes. A cross-sectional study was conducted to compare the level of vitamin D deficiency between 3402 (2110 female and 1292 male) population from Jeddah, 12 m above the sea level and with 3957 population (2202 female and 1755 male) from Asir, 2270 m above sea level. Data were collected from the biochemical investigation for total serum 25-hydroxyvitamin D and the serum calcium. Hypovitaminosis D (insufficiency and deficiency) was prevalent in 84.1% of females (n = 1775) and 81.7% of males (n = 1056) from Jeddah while 77.02% females (n = 1696) and 80% males (n = 1404) from Asir region. A negative correlation between Vitamin D and altitude was observed for gender (R = -0.894, P = 0.261) and age (R = -0.812, P = 0.382); the risk of hypovitaminosis D generally increases with decreasing altitude. The probability of Vitamin D deficiency was higher among female populations and study subjects living at the low altitudes, i.e., from the Jeddah region.

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The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD

Nutrients ◽

10.3390/nu11112583 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2583 ◽

Cited By ~ 2

Author(s):

Maria Chiara Mentella ◽

Franco Scaldaferri ◽

Marco Pizzoferrato ◽

Antonio Gasbarrini ◽

Giacinto Abele Donato Miggiano

Keyword(s):

Vitamin D ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Phase Angle ◽

Alimentary Tract ◽

Hypovitaminosis D ◽

Serum Levels ◽

Cross Sectional Study ◽

Cross Sectional ◽

Inflammatory Bowel

Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. The aim of the study was to investigate the association of disease activity, body mass index (BMI) and phase angle with vitamin D deficiency in patients with IBD. A cross-sectional study was conducted on a cohort of 206 IBD patients (October 2016–September 2018). Of these patients, 32.6% were affected by hypovitaminosis D (CD: 38.6%; UC: 25.6%; p < 0.01). Negative and significant associations (p < 0.01) were found between BMI and vitamin D serum levels both in CD and UC patients. BMI represented a determinant of hypovitaminosis D (Odds Ratio (OR) = 1.12, p < 0.01) only in UC patients; phase angle was associated to hypovitaminosis D in both groups (CD: OR = 0.64, p < 0.05; UC: OR = 0.49, p < 0.01). Results of the present study confirm a higher incidence of hypovitaminosis D in patients with CD than in those with UC, and show that nutritional status plays a crucial role in the incidence of vitamin D deficiency in patients with IBD.

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Vitamin D Provision in Children with Congenital Epidermolysis Bullosa: Cross-Sectional Study

Вопросы современной педиатрии ◽

10.15690/vsp.v20i5.2315 ◽

2021 ◽

Vol 20 (5) ◽

pp. 407-412

Author(s):

Irina Yu. Pronina ◽

Nikolay N. Murashkin ◽

Svetlana G. Makarova ◽

Elena L. Semikina ◽

Dmitry S. Yasakov ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Epidermolysis Bullosa ◽

Multivariate Regression ◽

Multivariate Regression Analysis ◽

Cross Sectional Study ◽

Vitamin D Insufficiency ◽

Small Samples ◽

Sectional Study ◽

Cross Sectional

Background. Children with congenital epidermolysis bullosa (CEB) can have vitamin D deficiency due to its malabsorption in intestine and reduced synthesis in skin as these patients have restrictions on staying in the sun. However, the prevalence of vitamin D insufficiency/deficiency among patients with CEB remains not fully studied due to the small samples' sizes in previously studies. Objective. Our aim was to study vitamin D provision in children with CEB. Methods. The study included children aged from 3 to 18 years old with simplex and dystrophic types of CEB hospitalized in our department. The serum level of 25(OH)D was determined via chemiluminescence immunoassay. Vitamin D deficiency was established at 25(OH)D concentration of 20-30 ng/ml, deficiency — < 10-20 ng/ml, deep deficiency — < 10 ng/ml. Results. The study included 129 children with CEB (62 (48%) males, median age 6 (3; 10) years). 101 patients had dystrophic type of disease, 28 — simplex. The median 25(OH)D serum concentration in children with CEB was 21.7 (13.0; 36.6) ng/ml. Vitamin D insufficiency was revealed in 36 (28%) patients, deficiency — in 38 (29%), deep deficiency — in 16 (12%). Independent predictors of 25(OH)D concentration were the type of CEB (concentration was higher in children with simplex type) and age (negative association), but not the patients' gender and the examination season, according to multivariate regression analysis. Conclusion. The study has shown low level of vitamin D provision in children with CEB, whilst 25(OH)D concentration depended on the type of disease and the age of patients.

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Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain

Disease Markers ◽

10.1155/2019/3549402 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6 ◽

Cited By ~ 8

Author(s):

Manuela Pennisi ◽

Giuseppe Di Bartolo ◽

Giulia Malaguarnera ◽

Rita Bella ◽

Giuseppe Lanza ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Levels ◽

Cross Sectional Study ◽

Ratio Analysis ◽

Vitamin D Status ◽

Sectional Study ◽

Musculoskeletal Health ◽

Cross Sectional ◽

Vitamin D Levels

Introduction. Statin-associated muscle symptoms are common side effects of statin therapy. These symptoms include myopathy, myalgia, and rhabdomyolysis. Vitamin D has been associated with musculoskeletal health; thus, its deficiency may produce detrimental effects in this tissue. Indeed, one symptom of vitamin D deficiency is myalgia, and the normalization of low vitamin D levels can relieve it. Patients and Methods. This cross-sectional study examined 1210 statin-treated patients to assess vitamin D status. These patients were divided into two groups: 287 with statin-associated muscle symptoms (SAMS) and 923 control patients without SAMS. Results. We have found a significant association between deficient and insufficient vitamin D status and statin-associated muscle symptoms (SAMS). Vitamin D deficiency (<30 nmol/L) presents 77% (95% C.I. 71.6% to 81.7%) sensitivity and 63.4% (95% C.I. 60.2% to 66.5%) specificity in diagnosing SAMS. Odds ratio analysis showed that this association is moderate-strong both for deficient and for insufficient status. Conclusion. We found a correlation between vitamin D deficiency and SAMS. Therefore, vitamin D levels may be useful for the diagnosis and management of SAMS.

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Evaluation of the Relationship Between Vitamin D Levels and Related Serum Markers as Well as Disease Activity in Patients With Rheumatoid Arthritis: A Cross-sectional Study in Western Iran

10.21203/rs.3.rs-125995/v1 ◽

2020 ◽

Author(s):

Nasrin Moghimi ◽

Ali Faridfar ◽

Reza Shahriarirad ◽

Mohsen Nikandish ◽

Amirhossein Salimi ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Levels ◽

Cross Sectional Study ◽

Serum Marker ◽

Sectional Study ◽

Cross Sectional ◽

Vitamin D Levels ◽

The Relationship

Abstract Background: Many studies have reported the role of vitamin D in autoimmune disease including rheumatoid arthritis (RA) which is related to several serum autoantibodies such as RF and Anti CCP. It also has been shown that vitamin D deficiency affect the DAS28 and VAS score inversely. Therefore, the aim of this study was to assess the relationship between vitamin D deficiency and RA-related autoantibodies including Anti CCP and RF levels and also evaluate the association between these parameters and the severity of rheumatoid arthritis.Methods: In this cross-sectional study, RA patients over 16 years of age who refer to the clinic and rheumatology ward were enrolled. The severity of diseases was assessed via the DAS28 scoring system. Serum levels of 25(OH) vitamin D were determined by the ELISA method, along with other rheumatoid related laboratory evaluations including Anti CCP, RF and CRPResults: A total of 100 patients with a mean age of 45.27± 14.14 were included and evaluated; of them, 75% were female and 77% lived in the city. Most of the patients (66%) had moderate DAS28 levels; however, no substantial relationship was observed between DAS28 and vitamin D levels. A significant positive relation between serum 25(OH)D level and disease duration, as well as the level of education, was observed. There was also no significant correlation between RA-related autoantibodies (e.g. anti CCP, and RF) and inflammatory serum marker (e.g. CRP) with 25(OH)D.Conclusion: Due to vitamin deficiency in the majority of cases (73%) and the relationship between serum 25(OH)D levels and the duration of disease, it can be concluded that vitamin D levels should be checked in those patients.

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The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective cross-sectional study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v18i2.6501 ◽

2020 ◽

Author(s):

Nazanin Alavi ◽

Mahbod Ebrahimi ◽

Firoozeh Akbari-Asbagh

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Ovarian Reserve ◽

Serum Levels ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Vitamin D Levels ◽

The Impact

Background: Vitamin D deficiency and infertility are two important health problems in Iran. Some studies suggest that vitamin D may influence Anti-Müllerian hormone (AMH) and antral follicle count (AFC) as an ovarian reserve. Objective: The present study aimed to investigate the impact of vitamin D on AMH serum concentrations/AFC. Materials and Methods: three hundred and five infertile women referred to the IVF Unit of Yas hospital, between July and December 2017, were enrolled in this cross-sectional study. The demographic characteristics of the participants, as well as the serum levels of vitamin D, AMH, and ultrasonic examination of AFC were recorded. Results: Finally, 287 infertile women were included in the analysis with a mean age of 29.95 ± 4.73 yr (18-45 yr) and a mean Body mass indexof 25.11 ± 4.41 kg/m2. The median AMH and vitamin D levels were 3.20 and 22.82 ng/ml, respectively. Considering the cut-off level of 20 ng/ml, 58.7% were vitamin D deficient. Regression analysis showed no association between AMH and vitamin D levels (p = 0.161), even after adjusting for baseline variables (p = 0.182). A total of 120 patients had an AFC < 6 and 164 ≥ 6, which was not statistically different between the groups with normal level or deficient vitamin D (p = 0.133). Conclusion: The present cross-sectional study showed no significant association between serum levels of vitamin D and AMH or AFC in infertile women, even after adjusting for baseline variables. Key words: Anti-Müllerian hormone, Infertility, Vitamin D deficiency, Ovarian follicle.

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