scholarly journals Hypothalamic involvement and insufficient sex steroid supplementation are associated with low bone mineral density in women with childhood onset craniopharyngioma

2011 ◽  
Vol 165 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Helene Holmer ◽  
Vera Popovic ◽  
Bertil Ekman ◽  
Cecilia Follin ◽  
Ann Britt Siversson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Calcium Intake ◽  
Hormone Replacement ◽  
Leptin Resistance ◽  
Mineral Density ◽  
Childhood Onset ◽  
The Impact ◽  
Hypothalamic Damage

ContextData on bone mineral density (BMD) are lacking in adults with childhood onset (CO)–craniopharyngioma (CP) with hypothalamic damage from the tumor. In patients with CO GH deficiency, BMD increases during GH treatment.ObjectiveThe aims were to evaluate BMD in adults with CO–CPs on complete hormone replacement, including long-term GH and to evaluate the impact of hypothalamic damage on these measures.Design and participantsBMD (dual-energy X-ray absorptiometry), markers of bone turn over, physical activity and calcium intake were assessed in 39 CO–CP adults (20 women), with a median age of 28 (17–57) years, in comparison with matched population controls.ResultsLate puberty induction was recorded in both genders, but reduced androgen levels in females only. Only CP women had lower BMD (P=0.03) at L2–L4, and reduced Z-scores at femoral neck (P=0.004) and L2–L4 (P=0.004). Both genders had increased serum leptin levels (P=0.001), which significantly correlated negatively with BMD at L2–L4 (P=0.003; r=−0.5) and 45% of CP women had Z-score levels ≤−2.0 s.d. Furthermore, 75% of those with a Z-score ≤−2.0 s.d. had hypothalamic involvement by the tumor. Calcium intake (P=0.008) and physical activity (P=0.007) levels were reduced in CP men only. Levels of ostecalcin and crossLaps were increased in CP men only.ConclusionsDespite continuous GH therapy, low BMD was recorded in CO–CP females. Insufficient estrogen and androgen supplementation during adolescence was the main cause, but hypothalamic involvement with consequent leptin resistance was also strongly associated with low BMD in both genders.

THE IMPACT OF PHYSICAL ACTIVITY DIFFERENCES ON BONE MINERAL DENSITY BETWEEN TWO COLLEGE FEMALE POPULATIONS

2002 ◽  
Vol 34 (5) ◽  
pp. S38
Author(s):  
W R. Barfield ◽  
J F. Otteni ◽  
A M. McBryde ◽  
P J. Nietert ◽  
J S. Carter
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
College Female ◽  
The Impact

Correlates and Determinants of Bone Mineral Density in Prepubertal Girls

2002 ◽  
Vol 14 (4) ◽  
pp. 345-357 ◽  
Author(s):  
Peter N. Wiebe ◽  
Cameron J.R. Blimkie ◽  
Nathalie Farpour-Lambert ◽  
Julie Briody ◽  
Helen Woodhead ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Fat Mass ◽  
Calcium Intake ◽  
Physical Activity Level ◽  
Linear Regression Analysis ◽  
Activity Level ◽  
Dietary Calcium Intake ◽  
Mineral Density

The correlates and determinants of total body (TB), femoral neck (FN), greater trochanter (GT) and leg areal bone mineral density (aBMD), and FN volumetric (vol) BMD were investigated in 42 healthy 6–10-year-old girls. Predictor variables included age, height, weight, lean tissue mass (LTM), fat mass, percent body fat, physical activity level, calcium intake, isokinetic knee flexion and extension strength and endocrine (E2) status. Bone density and body composition were determined by dual energy-x-ray absorptiometry (DEXA), and pubertal status was self-determined. LTM, weight, age, knee extensor strength and fat mass were significantly correlated (Pearson correlation coefficients; 0.36 £ r ‡ 0.62) with TBaBMD. These same variables with the addition of height and knee flexor strength were significantly correlated (0.33 £ r ‡ 0.77) with leg aBMD. Only LTM correlated significantly with FNaBMD and none of the independent variables correlated with FNvolBMD or GTaBMD. Only LTM entered as a significant predictor in multiple linear regression analysis (R2 = 46.7%) for TBaBMD. In conclusion, estradiol status, dietary calcium intake and physical activity level appeared not to be important predictors of BMD in this population, whereas LTM was consistently correlated with most BMD measures and was the single significant determinant of TBaBMD in this study.

Predictors of bone mineral density in a convenience sample of young Caucasian adults living in southern Ontario

2012 ◽  
Vol 37 (4) ◽  
pp. 706-714 ◽  
Author(s):  
Laura E. Chouinard ◽  
Janis Randall Simpson ◽  
Andrea C. Buchholz
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Body Mass ◽  
Bone Mineral ◽  
Bone Health ◽  
Calcium Intake ◽  
Health Concern ◽  
Mineral Density ◽  
Southern Ontario ◽  
Men And Women

Osteoporosis is a major public health concern in Canada and worldwide. Although much is known about bone health in older adults, little is known about bone health in young, healthy Canadian men and women. The objectives of this research were to describe bone mineral density (BMD) of young, healthy adults living in southern Ontario, Canada, and to identify predictors of BMD in this population. Two-hundred and fifty-eight Caucasian men and women aged 18–33 years completed health and physical activity questionnaires along with a calcium and vitamin D specific food frequency questionnaire. Height and mass were measured. BMD of the total hip, femoral neck, spine, and total body was measured using dual energy X-ray absorptiometry. Among men, body mass, weight-bearing physical activity, and calcium intake were significant predictors of BMD. Among women, body mass, calcium intake, and family history of osteoporosis significantly predicted log BMD. The predictors of BMD in young Canadian men and women identified in this study may inform the development of longitudinal studies designed to examine the influence of lifestyle factors on BMD in young adults.

Bone mineral density of a native population of Argentina with low calcium intake and heavy physical activity

Bone ◽  
1996 ◽  
Vol 18 (1) ◽  
pp. S115
Author(s):  
A Spindler ◽  
E Lucero ◽  
A Berman ◽  
S Paz ◽  
E Vega ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Calcium Intake ◽  
Native Population ◽  
Mineral Density ◽  
Low Calcium

scholarly journals Low bone mineral density following gastric bypass is not explained by lifestyle and lack of exercise

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Katharina Stevens ◽  
Hella Hultin ◽  
Per Hellman ◽  
Magnus Sundbom
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Calcium Intake ◽  
Lifestyle Factors ◽  
Mineral Density ◽  
Study Participants

Abstract Background Bariatric surgery, Roux-en-Y gastric bypass (RYGBP) in particular, is associated with weight loss as well as low bone mineral density. Bone mineral density relies upon multiple factors, some of which are lifestyle factors. The aim of this study was to compare lifestyle factors in order to eliminate them as culprits of the suspected difference in BMD in RYGBP operated and controls. Materials and methods Study participants included 71 RYGBP-operated women (42.3 years, BMI 33.1 kg/m2) and 94 controls (32.4 years, BMI 23.9 kg/m2). Each completed a DEXA scan, as well as survey of lifestyle factors (e.g. physical activity in daily life, corticosteroid use, and calcium intake). All study participants were premenopausal Caucasian women living in the same area. Blood samples were taken in RYGBP-patients. Results BMD was significantly lower in RYGBP, femoral neck 0.98 vs. 1.04 g/cm2 compared to controls, despite higher BMI (present and at 20 years of age) and similar physical activity and calcium intake. In a multivariate analysis, increased time since surgery and age were negatively associated with BMD of the femoral neck and total hip in RYGBP patients. Conclusion Despite similar lifestyle, RYGBP was followed by a lower BMD compared to controls. Thus, the reduced BMD in RYGBP cannot be explained, seemingly nor prevented, by lifestyle factors. As the reduction in BMD was associated with time since surgery, strict follow-up is a lifelong necessity after bariatric surgery, and especially important in younger bariatric patients.

scholarly journals Low Bone Mineral Density Following Gastric Bypass Is Not Explained by Lifestyle and Lack of Exercise

2021 ◽  
Author(s):  
Hella Hultin ◽  
Katharina Stevens ◽  
Magnus Sundbom ◽  
Per Hellman
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Calcium Intake ◽  
Lifestyle Factors ◽  
Mineral Density ◽  
Study Participants

Abstract Background: Bariatric surgery, Roux-en-Y gastric bypass (RYGBP) in particular, is associated with weight loss as well as low bone mineral density. Bone mineral density relies upon multiple factors, some of which are lifestyle factors. The aim of this study was to compare lifestyle factors in order to eliminate them as culprits of the suspected difference in BMD in RYGBP operated and controls. Materials and Methods: Study participants included 71 RYGBP-operated women (42.3 yrs, BMI 33.1) and 94 controls (32.4 years, BMI 23.9). Each completed a DEXA scan, as well as survey of lifestyle factors (e.g. physical activity in daily life, corticosteroid use, and calcium intake). All study participants were premenopausal Caucasian women living in the same area. Blood samples were taken in RYGBP-patients.Results: BMD was significantly lower in RYGBP, femoral neck 0.98 vs. 1.04 g/cm2 compared to controls, despite higher BMI (present and at 20 years of age) and similar physical activity and calcium intake. In a multivariate analysis, increased time since surgery and age were negatively associated with BMD of the femoral neck and total hip in RYGBP patients. Conclusion: Despite similar lifestyle, RYGBP was followed by a lower BMD compared to controls. Thus, the reduced BMD in RYGBP cannot be explained, seemingly nor prevented, by lifestyle factors. As the reduction in BMD was associated with time since surgery, strict follow-up is a lifelong necessity after bariatric surgery, and especially important in younger bariatric patients.

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