scholarly journals Maternal thyroid disease in the Danish National Birth Cohort: prevalence and risk factors

2016 ◽  
Vol 174 (2) ◽  
pp. 203-212 ◽  
Author(s):  
Stine Linding Andersen ◽  
Jørn Olsen ◽  
Peter Laurberg
Keyword(s):  
Risk Factors ◽  
Thyroid Cancer ◽  
Birth Cohort ◽  
Thyroid Disease ◽  
Reproductive Age ◽  
Self Report ◽  
Antithyroid Drugs ◽  
Danish National Birth Cohort ◽  
Benign Goiter ◽  
Maternal Thyroid

ObjectiveThyroid disorders are common in women of reproductive age, but the exact burden of disease before, during and after a pregnancy is not clear. We describe the prevalence of thyroid disease in women enrolled in the Danish National Birth Cohort (DNBC) and investigate some of its risk factors.DesignPopulation-based study within the DNBC, which included 101 032 pregnancies (1997–2003).MethodsWe studied women enrolled in the DNBC who gave birth to a live-born child. Information on maternal thyroid disease (hyperthyroidism, hypothyroidism, benign goiter/nodules, thyroid cancer, and other) before, during and up to 5 years after the woman's first pregnancy in the cohort was obtained from self-report (telephone interview in median gestational week 17) and from nationwide registers on hospital diagnosis of thyroid disease/thyroid surgery (from 1977) and prescriptions of thyroid drugs (from 1995).ResultsOf the 77 445 women studied, 3018 (3.9%) were identified with an onset of thyroid disease before (2.0%), during (0.1%) or in the 5-year period after the pregnancy (1.8%). During the pregnancy, 153 (0.2%) women received antithyroid drugs and 365 (0.5%) received thyroid hormone for hypothyroidism (83 after previous hyperthyroidism, 42 after previous surgery for benign goiter/nodules or thyroid cancer). Significant risk factors for maternal thyroid disease were age, parity, origin, iodine intake, smoking, alcohol, and BMI.ConclusionsAround 4% of Danish pregnant women had either a history of thyroid disease or thyroid disease during pregnancy or were diagnosed with thyroid disease for the first-time in the years following a pregnancy. The spectrum of thyroid disease was influenced by demographic and environmental factors.

scholarly journals Risk Factors of Early Otitis Media in the Danish National Birth Cohort

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166465 ◽  
Author(s):  
Asbjørn Kørvel-Hanquist ◽  
Anders Koch ◽  
Janni Niclasen ◽  
Jesper Dammeye ◽  
Jørgen Lous ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Cohort ◽  
Otitis Media ◽  
Danish National Birth Cohort

scholarly journals Fish intake during pregnancy and the risk of child asthma and allergic rhinitis – longitudinal evidence from the Danish National Birth Cohort

2013 ◽  
Vol 110 (7) ◽  
pp. 1313-1325 ◽  
Author(s):  
Ekaterina Maslova ◽  
Marin Strøm ◽  
Emily Oken ◽  
Hannia Campos ◽  
Christoph Lange ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Birth Cohort ◽  
Fish Intake ◽  
Self Report ◽  
Multivariate Logistic Regression ◽  
Medication Prescription ◽  
Danish National Birth Cohort ◽  
Child Asthma ◽  
Recurrent Wheeze ◽  
High Fish

Maternal fish intake during pregnancy may influence the risk of child asthma and allergic rhinitis, yet evidence is conflicting on its association with these outcomes. We examined the associations of maternal fish intake during pregnancy with child asthma and allergic rhinitis. Mothers in the Danish National Birth Cohort (n 28 936) reported their fish intake at 12 and 30 weeks of gestation. Using multivariate logistic regression, we examined the associations of fish intake with child wheeze, asthma and rhinitis assessed at several time points: ever wheeze, recurrent wheeze (>3 episodes), ever asthma and allergic rhinitis, and current asthma, assessed at 18 months (n approximately 22 000) and 7 years (n approximately 17 000) using self-report and registry data on hospitalisations and prescribed medications. Compared with consistently high fish intake during pregnancy (fish as a sandwich or hot meal ≥ 2–3 times/week), never eating fish was associated with a higher risk of child asthma diagnosis at 18 months (OR 1·30, 95 % CI 1·05, 1·63, P= 0·02), and ever asthma by hospitalisation (OR 1·46, 95 % CI 0·99, 2·13, P= 0·05) and medication prescription (OR 1·37, 95 % CI 1·10, 1·71, P= 0·01). A dose–response was present for asthma at 18 months only (P for trend = 0·001). We found no associations with wheeze or recurrent wheeze at 18 months or with allergic rhinitis. The results suggest that high (v. no) maternal fish intake during pregnancy is protective against both early and ever asthma in 7-year-old children.

scholarly journals Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort

2019 ◽  
Vol 127 (11) ◽  
pp. 117002 ◽  
Author(s):  
Kosuke Inoue ◽  
Beate Ritz ◽  
Stine Linding Andersen ◽  
Cecilia Høst Ramlau-Hansen ◽  
Birgit Bjerre Høyer ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Birth Cohort ◽  
Early Pregnancy ◽  
Perfluoroalkyl Substances ◽  
Danish National Birth Cohort ◽  
Maternal Thyroid

scholarly journals Correction: Risk Factors of Early Otitis Media in the Danish National Birth Cohort

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0171901
Author(s):  
Asbjørn Kørvel-Hanquist ◽  
Anders Koch ◽  
Janni Niclasen ◽  
Jesper Dammeyer ◽  
Jørgen Lous ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Cohort ◽  
Otitis Media ◽  
Danish National Birth Cohort

Attachment Organization in Suicide Prevention Research

Crisis ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Amanda Venta ◽  
Carla Sharp
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Interpersonal Relationships ◽  
Suicide Ideation ◽  
Suicide Attempts ◽  
Critical Role ◽  
Self Report ◽  
Future Research ◽  
Self Harm

Background: Identifying risk factors for suicide-related thoughts and behaviors (SRTB) is essential among adolescents in whom SRTB remain a leading cause of death. Although many risk factors have already been identified, influential theories now suggest that the domain of interpersonal relationships may play a critical role in the emergence of SRTB. Because attachment has long been seen as the foundation of interpersonal functioning, we suggest that attachment insecurity warrants attention as a risk factor for SRTB. Aims: This study sought to explore relations between attachment organization and suicidal ideation, suicide attempts, and self-harm in an inpatient adolescent sample, controlling for demographic and psychopathological covariates. Method: We recruited 194 adolescents from an inpatient unit and assigned them to one of four attachment groups (secure, preoccupied, dismissing, or disorganized attachment). Interview and self-report measures were used to create four variables reflecting the presence or absence of suicidal ideation in the last year, single lifetime suicide attempt, multiple lifetime suicide attempts, and lifetime self-harm. Results: Chi-square and regression analyses did not reveal significant relations between attachment organization and SRTB, although findings did confirm previously established relations between psychopathology and SRTB, such that internalizing disorder was associated with increased self-harm, suicide ideation, and suicide attempt and externalizing disorder was associated with increased self-harm. Conclusion: The severity of this sample and methodological differences from previous studies may explain the nonsignificant findings. Nonsignificant findings may indicate that the relation between attachment organization and SRTB is moderated by other factors that should be explored in future research.

Trauma-Related Shame, Sexual Assault Severity, Thwarted Belongingness, and Perceived Burdensomeness Among Female Undergraduate Survivors of Sexual Assault

Crisis ◽  
2019 ◽  
Vol 40 (2) ◽  
pp. 134-140 ◽  
Author(s):  
Christopher R. DeCou ◽  
Stephanie P. Kaplan ◽  
Julie Spencer ◽  
Shannon M. Lynch
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Sexual Assault ◽  
Self Report ◽  
Psychosocial Risk ◽  
Thwarted Belongingness ◽  
Female Undergraduate ◽  
Perceived Burdensomeness ◽  
Cross Sectional ◽  
And Behavior

Abstract. Background and Aim: This study evaluated trauma-related shame as a mediator of the association between sexual assault severity and perceived burdensomeness and thwarted belongingness. Method: A total of 164 female undergraduates who reported attempted or completed sexual assault completed self-report measures of sexual assault, trauma-related shame, perceived burdensomeness, and thwarted belongingness. Results: Using path analysis, trauma-related shame mediated the association between sexual assault severity and perceived burdensomeness, and between sexual assault severity and thwarted belongingness. Limitations: The findings of this study are limited by the retrospective, self-report, and cross-sectional nature of these data, and do not allow for causal inference. Conclusion: Trauma-related shame warrants additional investigation as a mechanism that explains the association between sexual assault and psychosocial risk factors for suicidal ideation and behavior.

Graves'-Basedow disease in pregnancy

2015 ◽  
Vol 54 (03) ◽  
pp. 106-111 ◽  
Author(s):  
S. L. Andersen ◽  
P. Laurberg
Keyword(s):  
Side Effects ◽  
Birth Defects ◽  
Thyroid Dysfunction ◽  
National Study ◽  
Antithyroid Drugs ◽  
Upper Limit ◽  
Special Concern ◽  
Maternal Thyroid ◽  
Toxic Reactions ◽  
Serum Tsh

SummaryThyroid hormones are essential development factors and maternal thyroid dysfunction may cause pregnancy complications and diseases in the fetus/child. In the present review we discuss new data on the incidence of Graves'-Basedow disease (GBD) in and around pregnancy, and how hyperthyroidism may affect the risk of spontaneous abortion and stillbirth.A special concern in pregnant women is the potential side effects from the use of antithyroid drugs (ATDs). One type of side effects is the allergic/toxic reactions to the drugs, which seem to be similar in and outside pregnancy, and another is that ATDs tend to over treat the fetus when the mother with GBD is made euthyroid. To avoid fetal hypothyroidism, the lowest possible ATD dose should be used to keep maternal thyroid function at the upper limit of normality with low serum TSH. Birth defects after the use of methimazole (MMI) (or its prodrug carbimazole) have been considered to be very rare, and no risk has previously been associated with the use of propylthiouracil (PTU). However, a recent Danish national study found that 1/30 of children exposed to MMI in early pregnancy had birth defects associated with this, and many defects were severe. PTU exposure was associated with defects in 1/40, and these defects were less severe. Proposals are given on how to reduce the risk of ATD associated birth defects.

Ultrasound risk factors of thyroid cancer

2014 ◽  
Author(s):  
Alicja Muszynska-Oglaza ◽  
Jacek Pypkowski ◽  
Anna Guz ◽  
Marta Mucha-Zielinska ◽  
Roman Junik
Keyword(s):  
Risk Factors ◽  
Thyroid Cancer
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