Fish intake during pregnancy and the risk of child asthma and allergic rhinitis – longitudinal evidence from the Danish National Birth Cohort

Maternal fish intake during pregnancy may influence the risk of child asthma and allergic rhinitis, yet evidence is conflicting on its association with these outcomes. We examined the associations of maternal fish intake during pregnancy with child asthma and allergic rhinitis. Mothers in the Danish National Birth Cohort (n 28 936) reported their fish intake at 12 and 30 weeks of gestation. Using multivariate logistic regression, we examined the associations of fish intake with child wheeze, asthma and rhinitis assessed at several time points: ever wheeze, recurrent wheeze (>3 episodes), ever asthma and allergic rhinitis, and current asthma, assessed at 18 months (n approximately 22 000) and 7 years (n approximately 17 000) using self-report and registry data on hospitalisations and prescribed medications. Compared with consistently high fish intake during pregnancy (fish as a sandwich or hot meal ≥ 2–3 times/week), never eating fish was associated with a higher risk of child asthma diagnosis at 18 months (OR 1·30, 95 % CI 1·05, 1·63, P= 0·02), and ever asthma by hospitalisation (OR 1·46, 95 % CI 0·99, 2·13, P= 0·05) and medication prescription (OR 1·37, 95 % CI 1·10, 1·71, P= 0·01). A dose–response was present for asthma at 18 months only (P for trend = 0·001). We found no associations with wheeze or recurrent wheeze at 18 months or with allergic rhinitis. The results suggest that high (v. no) maternal fish intake during pregnancy is protective against both early and ever asthma in 7-year-old children.

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Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort

British Journal Of Nutrition ◽

10.1017/s0007114513003395 ◽

2013 ◽

Vol 111 (6) ◽

pp. 1096-1108 ◽

Cited By ~ 37

Author(s):

Ekaterina Maslova ◽

Susanne Hansen ◽

Marin Strøm ◽

Thorhallur I. Halldorsson ◽

Sjurdur F. Olsen

Keyword(s):

Allergic Rhinitis ◽

Vitamin A ◽

Birth Cohort ◽

Allergic Disease ◽

Vitamin K ◽

Current Asthma ◽

Maternal Vitamin ◽

Danish National Birth Cohort ◽

Child Asthma ◽

Fat Soluble Vitamins

Fat-soluble vitamins A, E and K have been shown to play roles in immunity and inflammation, but studies on child allergic disease have been few and inconsistent. The aim of the present study was to examine the relationship between maternal intake of vitamins A, E and K in mid-pregnancy and child asthma and allergic rhinitis. We used data on 44 594 mother–child pairs from the Danish National Birth Cohort. Maternal intake of fat-soluble vitamins was calculated based on the information from a validated FFQ completed in mid-pregnancy. At 18 months, interviews with the mothers were conducted to evaluate doctor-diagnosed child asthma. At age 7 years, we assessed child asthma and allergic rhinitis using questions from the International Study of Asthma and Allergies in Childhood questionnaire and by national registries on hospital contacts and medication use. Current asthma was defined as asthma diagnosis and wheeze in the past 12 months by maternal report. We calculated multivariable risk ratios and 95 % CI by comparing the highestv. lowest quintile (Q) of maternal vitamin A, E and K intake in relation to child allergic disease outcomes. Maternal total vitamin K intake was directly associated with ever admitted asthma (Q5v. Q1: 1·23, 95 % CI 1·01, 1·50) and current asthma at 7 years (Q5v. Q1: 1·30, 95 % CI 0·99, 1·70). Weak inverse associations were present for maternal vitamin A and E intake during pregnancy with child allergic rhinitis. Maternal vitamin K intake during pregnancy may increase the risk of child asthma, and should be explored further on a mechanistic level. Conversely, maternal vitamin A and E intake may protect against child allergic rhinitis.

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Maternal thyroid disease in the Danish National Birth Cohort: prevalence and risk factors

Acta Endocrinologica ◽

10.1530/eje-15-0816 ◽

2016 ◽

Vol 174 (2) ◽

pp. 203-212 ◽

Cited By ~ 14

Author(s):

Stine Linding Andersen ◽

Jørn Olsen ◽

Peter Laurberg

Keyword(s):

Risk Factors ◽

Thyroid Cancer ◽

Birth Cohort ◽

Thyroid Disease ◽

Reproductive Age ◽

Self Report ◽

Antithyroid Drugs ◽

Danish National Birth Cohort ◽

Benign Goiter ◽

Maternal Thyroid

ObjectiveThyroid disorders are common in women of reproductive age, but the exact burden of disease before, during and after a pregnancy is not clear. We describe the prevalence of thyroid disease in women enrolled in the Danish National Birth Cohort (DNBC) and investigate some of its risk factors.DesignPopulation-based study within the DNBC, which included 101 032 pregnancies (1997–2003).MethodsWe studied women enrolled in the DNBC who gave birth to a live-born child. Information on maternal thyroid disease (hyperthyroidism, hypothyroidism, benign goiter/nodules, thyroid cancer, and other) before, during and up to 5 years after the woman's first pregnancy in the cohort was obtained from self-report (telephone interview in median gestational week 17) and from nationwide registers on hospital diagnosis of thyroid disease/thyroid surgery (from 1977) and prescriptions of thyroid drugs (from 1995).ResultsOf the 77 445 women studied, 3018 (3.9%) were identified with an onset of thyroid disease before (2.0%), during (0.1%) or in the 5-year period after the pregnancy (1.8%). During the pregnancy, 153 (0.2%) women received antithyroid drugs and 365 (0.5%) received thyroid hormone for hypothyroidism (83 after previous hyperthyroidism, 42 after previous surgery for benign goiter/nodules or thyroid cancer). Significant risk factors for maternal thyroid disease were age, parity, origin, iodine intake, smoking, alcohol, and BMI.ConclusionsAround 4% of Danish pregnant women had either a history of thyroid disease or thyroid disease during pregnancy or were diagnosed with thyroid disease for the first-time in the years following a pregnancy. The spectrum of thyroid disease was influenced by demographic and environmental factors.

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Associations of maternal fish intake during pregnancy and breastfeeding duration with attainment of developmental milestones in early childhood: a study from the Danish National Birth Cohort

American Journal of Clinical Nutrition ◽

10.1093/ajcn/88.3.789 ◽

2008 ◽

Vol 88 (3) ◽

pp. 789-796 ◽

Cited By ~ 111

Author(s):

Emily Oken ◽

Marie Louise Østerdal ◽

Matthew W Gillman ◽

Vibeke K Knudsen ◽

Thorhallur I Halldorsson ◽

...

Keyword(s):

Early Childhood ◽

Birth Cohort ◽

Fish Intake ◽

Breastfeeding Duration ◽

Developmental Milestones ◽

Danish National Birth Cohort

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Prepregnancy Obesity and Fetal Death: A Study Within the Danish National Birth Cohort

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70049-3 ◽

2007 ◽

Vol 2007 ◽

pp. 64-65

Author(s):

P.P. van den Berg

Keyword(s):

Birth Cohort ◽

Fetal Death ◽

Danish National Birth Cohort ◽

Prepregnancy Obesity

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Trajectories of maternal depressive symptoms and offspring’s risk behavior in early adolescence: data from the 2004 Pelotas birth cohort study

BMC Psychiatry ◽

10.1186/s12888-020-03026-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ana Beatriz Bozzini ◽

Jessica Mayumi Maruyama ◽

Tiago N. Munhoz ◽

Aluísio J. D. Barros ◽

Fernando C. Barros ◽

...

Keyword(s):

Cohort Study ◽

Depressive Symptoms ◽

Alcohol Use ◽

Maternal Depression ◽

Risk Behavior ◽

Birth Cohort ◽

Depression Scale ◽

Self Report ◽

Birth Cohort Study ◽

Maternal Depressive Symptoms

Abstract Background This longitudinal study explored the relationship between trajectories of maternal depressive symptoms and offspring’s risk behavior in adolescence contributing to an extremely scarce literature about the impacts of maternal depression trajectories on offspring risk behaviors. Methods We included 3437 11-year-old adolescents from the 2004 Pelotas Birth Cohort Study. Trajectories of maternal depressive symptoms were constructed using Edinburgh Postnatal Depression Scale (EDPS) from age 3 months to 11 years. We identified five trajectories of maternal depressive symptoms: “low” “moderate low”, “increasing”, “decreasing”, and “chronic high”. The following adolescent outcomes were identified via self-report questionnaire and analyzed as binary outcome –yes/no: involvement in fights and alcohol use at age 11. We used logistic regression models to examine the effects of trajectories of maternal depressive symptoms on offspring’s risk behavior adjusting for potential confounding variable. Results Alcohol use and/or abuse as well as involvement in fights during adolescence, were not significantly associated with any specific trajectory of maternal depressive symptoms neither in the crude nor in the adjusted analyses. Conclusion Alcohol use and involvement in fights at age 11 were not associated with any specific trajectory of maternal depression.

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Fecundity and twinning. A study within the Danish National Birth Cohort

Human Reproduction ◽

10.1093/humrep/deh437 ◽

2004 ◽

Vol 19 (10) ◽

pp. 2222-2226 ◽

Cited By ~ 15

Author(s):

Olga Basso ◽

Kaare Christensen ◽

Jørn Olsen

Keyword(s):

Birth Cohort ◽

Danish National Birth Cohort

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Incidence of Otitis Media in a Contemporary Danish National Birth Cohort

PLoS ONE ◽

10.1371/journal.pone.0111732 ◽

2014 ◽

Vol 9 (12) ◽

pp. e111732 ◽

Cited By ~ 38

Author(s):

Tanja Todberg ◽

Anders Koch ◽

Mikael Andersson ◽

Sjurdur F. Olsen ◽

Jørgen Lous ◽

...

Keyword(s):

Birth Cohort ◽

Otitis Media ◽

Danish National Birth Cohort

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Being born small-for-gestational-age is associated with an unfavourable dietary intake in Danish adolescent girls: findings from the Danish National Birth Cohort

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174418000910 ◽

2018 ◽

Vol 10 (4) ◽

pp. 488-496

Author(s):

F. B. Kampmann ◽

L. G. Grunnet ◽

T. I. Halldorsson ◽

A. A. Bjerregaard ◽

C. Granstrøm ◽

...

Keyword(s):

Food Intake ◽

Dietary Intake ◽

Birth Cohort ◽

Gestational Age ◽

Small For Gestational Age ◽

Dietary Fibre ◽

Occupational Status ◽

Food Preferences ◽

Danish National Birth Cohort ◽

Increased Risk

AbstractIndividuals born small have an increased risk for developing type 2 diabetes. Altered food preferences in these subjects seem to play a role; however, limited evidence is available on the association between being born small-for-gestational-age (SGA) at term and food intake in adolescence. Alterations in leptin, ghrelin and dopamine levels are suggested mechanisms linking SGA with later food intake. From a large prospective Danish National Birth Cohort, we compared dietary intake of adolescents being born SGA with normal-for-gestational-age (NGA) adolescents. Intake of foods and nutrients was assessed by a validated food frequency questionnaire in a subsample of 15,607 14-year-old individuals born at term. SGA was defined by birth weight (BW) <10th percentile (n = 1470) and NGA as BW between 10 and 90th percentile (n = 14,137) according to sex and gestational age-specific BW standard curves. Girls born SGA had a 7% (95% CI: 3–12%, P = 0.002) higher intake of added sugar and a 2–8% lower intake of dietary fibre, vegetables, polyunsaturated fatty acids, and total n−6, compared with NGA girls (P < 0.05). Adjusting for parental socio-occupational status, maternal smoking and diet in pregnancy did not substantially change the differences in dietary intake, except from dietary fibre, which were no longer statistically significant. No significant differences in dietary intake between SGA and NGA boys were found. In summary, girls born SGA had an unfavourable dietary intake compared with NGA girls. These differences persisted after controlling for potential confounders, thus supporting a fetal programming effect on dietary intake in girls born SGA at term. However, residual confounding by other factors operating early in childhood cannot be excluded.

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