scholarly journals Endogenous sex hormones in men aged 40-80 years

2003 ◽  
pp. 583-589 ◽  
Author(s):  
M Muller ◽  
I den Tonkelaar ◽  
JH Thijssen ◽  
DE Grobbee ◽  
YT van der Schouw
Keyword(s):  
Physical Activity ◽  
Health Status ◽  
Waist Circumference ◽  
Sex Hormones ◽  
Life Style ◽  
General Health ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
General Health Status

OBJECTIVE: To determine the relationship between aging, life-style factors and health-related factors and endogenous sex hormone levels. DESIGN: Cross-sectional study of 400 independently living men between 40 and 80 Years of age. METHODS: After exclusion of subjects who were not physically or mentally able to visit the study center, 400 men were randomly selected from a population-based sample. Total testosterone (TT), bioavailable testosterone (BT) (i.e. not bound to sex hormone-binding globulin (SHBG)), SHBG, estradiol (E(2)) and dehydroepiandrosterone-sulfate (DHEA-S) were investigated for their relationship with age, body mass index (BMI), waist circumference, smoking, physical activity and general health status. Multivariate models using ANCOVA analyses were used to examine the contribution of life-style factors to sex hormone variability. RESULTS: TT, BT and DHEA-S decreased with age; 0.2, 0.7 and 1.2%/Year respectively. SHBG showed an increase with age of 1.1%/Year. No changes with age were found for E(2). General health status modified the association of TT and SHBG with age (P interaction 0.10 and 0.002 respectively). Increased BMI and waist circumference were associated with decreased TT, BT, SHBG and DHEA-S and increased E(2) (all P<0.01). Current smoking, lower alcohol intake and a higher physical activity score were associated with higher TT and SHBG levels. CONCLUSION: This study showed the important determinants of sex hormones were age, BMI, waist circumference, smoking, general health status and physical activity. Furthermore, it can be concluded that general health status modified the effect between sex hormones and age. For future observational studies it should be taken into account that the above-mentioned determinants may alter the association between sex hormones and diseases and related conditions.

Sleep, Physical Activity, and General Health Status: US Pediatricians and the General US Adult Population

2019 ◽  
Vol 19 (3) ◽  
pp. 269-277
Author(s):  
Elizabeth A. Gottschlich ◽  
Kandyce Larson ◽  
Blake Sisk ◽  
Mary Pat Frintner
Keyword(s):  
Physical Activity ◽  
Health Status ◽  
General Health ◽  
Adult Population ◽  
General Health Status

scholarly journals Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men

2010 ◽  
Vol 162 (4) ◽  
pp. 747-754 ◽  
Author(s):  
Torkel Vikan ◽  
Henrik Schirmer ◽  
Inger Njølstad ◽  
Johan Svartberg
Keyword(s):  
Type 2 Diabetes ◽  
Waist Circumference ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Adjusted Risk ◽  
The Third ◽  
Increased Risk

ObjectiveTo study the impact of endogenous sex hormone levels in community-dwelling men on later risk for type 2 diabetes.DesignPopulation-based prospective cohort study.MethodsFor the analyses, 1454 men who participated in the fourth Tromsø study (1994–1995) were used. Cases of diabetes were retrieved and validated until 31.12.05 following a detailed protocol. The prospective association between sex hormones and diabetes was examined using Cox proportional hazard regression analysis, allowing for multivariate adjustments.ResultsThere was a significantly lowered multi-adjusted risk for later diabetes with higher normal total testosterone levels, both linearly per s.d. increase (hazard ratio (HR) 0.71, confidence interval (CI) 0.54–0.92) and in the higher quartiles of total testosterone than in the lowest quartiles (HR 0.53, CI 0.33–0.84). A reduced multi-adjusted risk for incident diabetes was also found for men with higher sex hormone-binding globulin (SHBG) levels, both linearly per s.d. increase (HR 0.55, CI 0.39–0.79) and when comparing the third (HR 0.38, CI 0.18–0.81) and the fourth quartile (HR 0.37, CI 0.17–0.82) to the lowest quartile. The associations with total testosterone and SHBG were no longer significant after inclusion of waist circumference to the multivariate models. Estradiol (E2) was positively associated with incident diabetes after multivariate adjustments including waist circumference when comparing the second (HR 0.49, CI 0.26–0.93) and the third (HR 0.51, CI 0.27–0.96) quartile to the highest quartile.ConclusionMen with higher E2 levels had an increased risk of later diabetes independent of obesity, while men with lower total testosterone and SHBG had an increased risk of diabetes that appeared to be dependent on obesity.

Physical activity, body composition and general health status of physically active students of the University of the Third Age (U3A)

2016 ◽  
Vol 64 ◽  
pp. 66-74 ◽  
Author(s):  
Izabela Zając-Gawlak ◽  
Dariusz Pośpiech ◽  
Aleksandra Kroemeke ◽  
Małgorzata Mossakowska ◽  
Aleš Gába ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Health Status ◽  
General Health ◽  
General Health Status ◽  
Physically Active ◽  
Third Age ◽  
The Third ◽  
The University

scholarly journals Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank

2021 ◽  
Author(s):  
Eleanor L. Watts ◽  
Aurora Perez-Cornago ◽  
Aiden Doherty ◽  
Naomi E. Allen ◽  
Georgina K. Fensom ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Activity Levels ◽  
Uk Biobank ◽  
Activity Data ◽  
Physical Activity Levels ◽  
Objectively Measured ◽  
Risk Of Cancer

Abstract Purpose Physical activity may reduce the risk of some types of cancer in men. Biological mechanisms may involve changes in hormone concentrations; however, this relationship is not well established. Therefore, we aimed to investigate the associations of physical activity with circulating insulin-like growth factor-I (IGF-I), sex hormone-binding globulin (SHBG, which modifies sex hormone activity), and total and free testosterone concentrations, and the extent these associations might be mediated by body mass index (BMI). Methods Circulating concentrations of these hormones and anthropometric measurements and self-reported physical activity data were available for 117,100 healthy male UK Biobank participants at recruitment. Objectively measured accelerometer physical activity levels were also collected on average 5.7 years after recruitment in 28,000 men. Geometric means of hormone concentrations were estimated using multivariable-adjusted analysis of variance, with and without adjustment for BMI. Results The associations between physical activity and hormones were modest and similar for objectively measured (accelerometer) and self-reported physical activity. Compared to men with the lowest objectively measured physical activity, men with high physical activity levels had 14% and 8% higher concentrations of SHBG and total testosterone, respectively, and these differences were attenuated to 6% and 3% following adjustment for BMI. Conclusion Our results suggest that the associations of physical activity with the hormones investigated are, at most, modest; and following adjustment for BMI, the small associations with SHBG and total testosterone were largely attenuated. Therefore, it is unlikely that changes in these circulating hormones explain the associations of physical activity with risk of cancer either independently or via BMI.

scholarly journals Associations Between Dietary Inflammatory Index and Sex Hormones Among 6- to 19-Year-Old Children and Adolescents in NHANES 2015–2016

2022 ◽  
Vol 12 ◽  
Author(s):  
Yuxia Ma ◽  
Ruiqiang Li ◽  
Wenqiang Zhan ◽  
Xin Huang ◽  
Yutian Zhou ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Sex Hormones ◽  
Linear Regression Analysis ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Female Adolescents ◽  
Total Testosterone ◽  
Dietary Inflammatory Index ◽  
Negatively Associated ◽  
Inflammatory Index

ObjectivesThis study aimed to assess the relationship between dietary inflammatory index (DII) and sex steroids in children (6-11 years old) and adolescents (12-19 years old) in the U.S. National Health and Nutrition Examination Survey, 2015–2016.MethodsParticipants between the ages of 6-19 have 24-hour dietary intake data, serum sex hormones [total testosterone (TT), estradiol (E2)], and sex hormone-binding globulin (SHBG) available data (n = 1382). The free androgen index (FAI) is calculated as TT divided by SHBG and the ratio of TT to E2 (TT/E2). The constructed puberty state is defined as high levels of steroid hormones (TT≥50 ng/dL in men, E2≥20 pg/ml in women) or onset of menarche. Multiple linear regression analysis was stratified by gender-age and gender-pubertal status groups to evaluate the association between DII and sex hormone levels.ResultsAfter adjusting for covariates, the association between consecutive DII and sex hormone indicators by gender and age group. In male adolescents, DII was always negatively associated with TT (P-trend = 0.09), FAI (P-trend = 0.03) and E2 (P-trend = 0.01), and monotonically positively associated with SHBG (P-trend = 0.02).In female adolescents, with the increase of DII, a significant positive correlation with SHBG was observed (β 0.017, 95%CI: 0.009,0.053) (Table 3). Among female adolescents, a significant negative association between DII and TT and a significant positive association between SHBG were observed in this group. Moreover, DII was positively associated with SHBG of prepubertal males and negatively associated with FAI of prepubertal females.ConclusionsDII was associated with decreased levels of certain sex steroid hormones (TT, FAI, and E2) and increased levels of SHBG in adolescents or pubertal individuals, with the associations presenting somewhat sex-dependent pattern. However, there is little evidence that there is a significant association in children or prepubertal children. Further research needs to be carried out to verify our results.

scholarly journals Moderate intensity aerobic exercise effects on the quality of life and general health

2021 ◽  
Author(s):  
Dilara Sak ◽  
Taygun Dayı ◽  
Erkan Günay ◽  
Adile Öniz
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Health Status ◽  
Aerobic Exercise ◽  
General Health ◽  
Life Quality ◽  
Moderate Intensity ◽  
General Health Status ◽  
Competitive Cyclists

Objective: Effects of regular physical activity on the human health is an important factor for the life quality parameters. The present study aimed to determine effects of moderate aerobic exercise on the life quality and human health. Materials and Methods: There were three groups (competitive cyclists, recreational cyclists and control) who voluntarily participated in this study. The cyclists of the National Bicycle Federation who could continue trainings during the Corona virus pandemic (n: 50), cyclists of the amateur clubs (n: 50) and 50 sedentary adults (≥19 years) were enrolled (n:150). World Health Organization Quality of Life Questionnaire Abbreviated Version - WHOQOL-BREF-TR was used to determine participants' life qualities. Results: Competitive cyclists trained for 13.33 (±7.24) hours per week and they had 4798 min/week MET values. Subgroup scores of WHQOL-BREF-TR (physical, psychological, social, environmental, national environment, general life quality and health) were found to be higher in competitive cyclists than others (recreational cyclists and sedentary adults). In addition, the values of competitive and amateur cyclists in the physical health level parameters were higher than the control group. Competitive cyclists had higher scores for psychological, social health and general life quality subgroups than others (p<0.05). Conclusion: The present study showed that if physical activity level increases, general health status and life quality increase. As a result of the study, it was found that moderate-intensity aerobic exercise (2600-4800 MET-min/week energy expenditure) between 7-13 hours a week supports the protection of general health and has positive effects on life quality. There is a need for future research to determine different exercise types, intensity, frequency and their effects on the general health status and life quality.

Abstract P054: Endogenous Sex Hormone Levels and Endothelial Function Among Men and Post-Menopausal Women in the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Lena Mathews ◽  
Vinita Subramanya ◽  
Di Zhao ◽  
Pamela Ouyang ◽  
Dhanajay Vaidya ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Sex Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Cvd Risk ◽  
Men And Women ◽  
Hormone Levels ◽  
Menopausal Women ◽  
Post Menopausal

Background: Sex is a major determinant of cardiovascular disease (CVD). Endogenous sex hormones exert a variety of effects on the vascular endothelium, and changes in sex hormone levels after menopause may play a role in CVD risk in women. We hypothesized that a more androgenic sex hormone profile among post-menopausal women, but not among men, would be associated with reduced blood flow-mediated vasodilation (FMD) of the brachial artery, a marker of worse endothelial function. Methods: We examined 1396 post-menopausal women and 1707 men participating in MESA, who were free of clinical CVD at baseline. Sex hormone levels [total testosterone (T), sex hormone binding globulin (SHBG), estradiol (E2)] were measured at Exam 1 (2000-02); free T and T/E2 ratio were calculated. FMD was measured by high-resolution ultrasound. Using multivariable adjusted Poisson and linear regression methods, we tested the cross-sectional associations of sex hormones (log transformed) with FMD. Results: The mean age of men and women was 61 and 64 years, respectively. Of women, 34% were using hormone therapy (HT). Among women, after adjusting for demographics, CVD risk factors, and HT use, higher SHBG was associated with higher FMD, whereas higher free T was associated with lower FMD (Table, Model 2). In women, when examining the “best FMD response” (top decile vs. bottom 9 deciles), higher E2 was positively associated with a prevalent best response, whereas higher free T was inversely associated. Among men, a higher T/E2 ratio was marginally associated with lower FMD. Conclusion: The association between sex hormones and FMD differs in men and women. Higher E2 and SHBG and lower free T levels were associated with better FMD in post-menopausal women but not in men. Higher T/E2 ratio was associated with lower FMD in men. Further studies are needed to assess longitudinal changes in sex hormone levels and their association with vascular aging. Sex hormone levels may help identify individuals at increased CVD risk who may benefit from other risk reduction strategies.

scholarly journals A longitudinal analysis of mental and general health status of informal carers in Australia

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Itismita Mohanty ◽  
Theo Niyonsenga
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Health Status ◽  
Health Outcomes ◽  
General Health ◽  
Health Behaviours ◽  
General Health Status ◽  
Social Drinking ◽  
Drinking Status ◽  
Informal Carers

Abstract Background The study investigated the self-assessed mental and general health status of informal carers in Australia. It evaluated the influence of carer’s health behaviours, namely physical activity, smoking and drinking status, along with their social connectedness and workforce engagement on their health status. Methods The study used a retrospective longitudinal design using data from the Household Income and Labour Dynamics of Australia survey, waves 5–15 (2005–2015). It included individuals aged 15 years and older from Australian households surveyed over a period of 11 years. The sample consisted of 23,251 individuals. The outcome measures included: mental health, general health and physical functioning domains of the Short Form 36 Questionnaire, a widely used multi-dimensional measure of health-related quality of life. Using fixed effects regression and following individuals over time, the analysis took care of the issue of individuals self-selecting themselves as carers due to some predisposing factors such as age, poor health, socioeconomic status and sedentary behaviour. Results There were statistically significant carer-noncarer status differences in mental (Beta = − 0.587, p = 0.003) and general health (Beta = − 0.670, p = 0.001) outcomes. Aging had a modifying impact on carers’ mental and general health outcomes. Older carers coped better with their caregiving responsibilities than younger ones. Moreover, while physical activities had a positive influence on both mental and general health for non-carers, with more activities generating better health outcomes, it only had a modifying impact on carers’ mental health. Furthermore, the study found that moderate levels of social drinking had beneficial modifying impact on carers’ mental and general health. Conclusion This study added value to the literature on informal carers’ mental and general health in Australia by identifying some of the protective and risk factors. The study found the modifying effects of carers’ age, health behaviours such as physical activity, smoking and drinking status on their health. Finally, the study identified an apparent beneficial link between moderate levels of social drinking and carer health that needs to be further explored with more targeted future research.

scholarly journals Circulating sex hormone levels in relation to male sperm quality

2020 ◽  
Author(s):  
Wei Zhao ◽  
Jun Jing ◽  
Yong Shao ◽  
Rong Zeng ◽  
Cencen Wang ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Sperm Motility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sperm Maturation ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Inverse Association

Abstract Background Although sex hormones play critical roles in spermatogenesis and sperm maturation, it remains inconclusive whether circulating sex hormones can serve as non-invasive biomarkers to improve the assessment of sperm quality. Methods We systematically evaluated the association of various sex hormones in serum with sperm quality among 338 men in subfertile couples. Concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (TT), total estradiol (E2), and sex hormone-binding globulin (SHBG) were detected by chemiluminescent immunoassay. Free testosterone and estradiol were calculated using a validated algorithm. A generalized liner regression model controlling for lifestyle factors was used to evaluate the associations with sperm count, concentration, motility, and morphology.Results After adjusting for age, body mass index, current smoking and alcohol drinking, LH, FSH, and TT levels were all inversely associated with sperm motility (all P for trend < 0.05); however, in mutual adjustment analysis, only LH remained an inverse association with sperm motility after adjusting for FSH and TT levels (P for trend = 0.04). Higher concentrations of LH were also associated with lower sperm progressive motility (P for trend = 0.04). Moreover, LH and FSH levels were both inversely associated with normal sperm morphology (P for trend = 0.04 and 0.02, respectively). Conclusions Increased levels of LH are associated with poor sperm motility and morphology, suggesting that LH may play a central role in sperm maturation. Future studies are warranted to assess potential clinical utility of LH for risk stratification and tailed prevention of male infertility.

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