What changes does pregnancy bring to the lipid parameters of diabetic patients?

2018 ◽  
Author(s):  
Chaima Jemai ◽  
Amor Nadia Ben ◽  
Nadia Khessairi ◽  
Bourguiba Rim ◽  
Aroua Temessek ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Lipid Parameters

Adjuvant Supplementation with L-Carnitine in Diabetic Population and its effects on Lipid Parameters

2021 ◽  
Vol 15 (8) ◽  
pp. 2017-2019
Author(s):  
Rao Salman Aziz ◽  
Usman Saeed ◽  
Nasim Aslam Ghumman ◽  
Muhammad Arshad ◽  
Asif Sohail ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Triglyceride Level ◽  
Clinical Care ◽  
Diabetic Patients ◽  
Healthy Population ◽  
Patients With Diabetes ◽  
Diabetic Population ◽  
Large Discount ◽  
The Impact ◽  
Lipid Parameters

Background: Diabetes is a complicated disease requires continuous clinical care, to govern blood sugar. Aim: To decides the impact of management of L carentin to diabetics at the lipid profile. Methods: This study turned into performed on 120 diabetic Patients had been decided on from endocrinology and diabetes, inside decided on standards. The Patients distributed into three Strata (1st Strata of healthy population and two Strata of patients with diabetes who were on metformin and glibenclamide, one Strata took a L carnitine in a dose of 1000 mg TDS and a Strata dealing with a placebo for a period of ninety days). Results: It is observed those who are on Lcarnitine, confirmed a large discount (p <0.05) with inside the triglyceride level, at the same time as no large adjustments had been located withinside the level of cholesterol and HDL and LDL. Conclusion: These study outcomes that management of L carentin improved profile of lipid in type-2diabetic Patients. Keyword: Dyslipidemia, Diabetes mellitus (DM), l-carnitine (LC).

scholarly journals Lipid profile among controlled and uncontrolled type-2 diabetic patients in a rural tertiary care center: a comparative study

2020 ◽  
Vol 9 (4) ◽  
pp. 562
Author(s):  
Manu Gangadhar ◽  
Narasimhamurthy K. Muthahanumaiah
Keyword(s):  
Blood Glucose ◽  
Total Cholesterol ◽  
Care Center ◽  
Tertiary Care ◽  
Lipid Profiles ◽  
Diabetic Patients ◽  
Major Health Problem ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lipid Parameters

Background: Diabetes mellitus is one of the major health problem and endemic with rapidly increasing prevalence in both developed and developing countries. It has strong association with dyslipidaemias in relation to glycaemic control and duration of the disease. Dyslipidaemias make diabetic patients more susceptible to coronary artery disease (CAD) which is the major cause of increased mortality and morbidity. Objectives were to estimate the blood glucose levels and lipid profiles among diabetics and to compare the lipid profiles among controlled and uncontrolled diabetic subjects.Methods: A cross sectional study was done including 100 diabetic subjects aged between 40 to 60 years of either sex. Patients were classified into 2 groups with 50 subjects in each group as per their glycemic index. Group 1 was controlled diabetic patients (HbA1c≤7.5%) and Group 2 was uncontrolled diabetic patients (HbA1c>7.5%). Venous blood samples were collected from the subjects. The serum was used for analyzing FBS, PPBS, HbA1c and lipid profiles.Results: FBS, PPBS, HbA1c, total cholesterol, triglycerides and LDL were more in females than male patients but the mean values were not significant statistically except FBS and total cholesterol. All the lipid parameters were elevated among uncontrolled diabetic patients compared to controlled diabetic patients which was statistically significant.Conclusions: Present study concluded that the blood glucose levels and lipid parameters were elevated among uncontrolled diabetics compared to controlled diabetics strongly depicting the co-relation between the glycemic levels and lipid abnormalities. Patients should be educated to monitor regularly and control blood glucose and lipid levels.

5198HbA1C correlates subclinical atherosclerosis in non-diabetes

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
W.-T Wang ◽  
P.-F Hsu ◽  
Y.-J Wang ◽  
Y.-Z Ding ◽  
T.-L Liou ◽  
...  
Keyword(s):  
High Risk ◽  
Coronary Atherosclerosis ◽  
Subclinical Atherosclerosis ◽  
Low Density Lipoprotein ◽  
Smoking Habit ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Lipid Parameters

Abstract Objective We investigated the association of lipid parameters and coronary atherosclerosis related to normal blood sugar (BS) and impaired fasting glucose (IFG), and factors contributing to coronary atherosclerosis. Methods We analyzed 1209 non-diabetic subjects who underwent coronary computed tomography angiography (CCTA). Atherosclerotic plaque pattern severity and patterns were evaluated based on serum glucose values. The association between low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) and plaque patterns in non-diabetic subjects were also analyzed. Results Non-diabetic subjects (age: 58.6±9.7 years; 861 male) were enrolled. Higher glucose levels were correlated with a higher prevalence of mixed plaque, significant (>50% stenosis) high-risk plaque, and calcified plaque in non-diabetic patients. Although serum LDL-C levels were mostly controlled by statin use, atherosclerotic plaques progressed, with increasing A1c values. Multivariate logistic regression analysis showed that age, male gender and A1C were independently associated with the presence of significant mixed plaques after considering BMI, blood pressure, renal function, lipid parameters, uric acid, and smoking habit. Conclusions Although decreasing HDL-C and increasing TG correlated with the presence and severity of coronary atherosclerosis, increasing A1c is independently associated with the presence of high-risk plaque in non-diabetes even if LDL-C is controlled by statin therapy.

Effects of date seeds administration on anxiety and depressive symptoms in streptozotocin-induced diabetic rats: biochemical and behavioral evidences

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Samir Bikri ◽  
Youssef Aboussaleh ◽  
Assia Berrani ◽  
Ismail Louragli ◽  
Affaf Hafid ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Depressive Symptoms ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Behavioral Changes ◽  
Oxidative Stress Marker ◽  
Diabetic Patients ◽  
Chronic Hyperglycemia ◽  
Kidney Liver ◽  
Lipid Parameters

Abstract Objectives Several epidemiological data indicate that chronic hyperglycemia is associated with behavioral changes such as anxiety and depressive symptoms. Date seeds, one of the most potent products with potential antioxidant activities and possess many benefits against hyperglycemia and its complication. The aim of the current study was to explore the potential effect of date seeds extract on biochemical and behavioral changes (anxiety and depression) in streptozotocin (STZ)-diabetic rats. Methods Rats were divided into four groups as follows: normal control, diabetic control, diabetic treated with the lyophilized aqueous extract of the date seed (2,000 mg/kg) (LAE-DS) and diabetics treated with insulin (4 UI/day). Experimental diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). After 24 days treatment period, anxiety and depressive behaviors were evaluated using four behavioral tests. After sacrifice, blood samples were collected to evaluate lipid parameters. In addition, rat organs (kidney, liver and brain) were dissected out in order to estimate lipid peroxidation levels as oxidative stress marker. Results Oral administration of the lyophilized aqueous extract of date seeds and insulin injection for 30 days significantly decreased blood glucose levels in STZ-diabetic rats and protected them against undesirable changes in lipid parameters, including cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and atherosclerosis index. Compared to untreated diabetic rat, a significant decrease in lipid peroxidation levels in kidney, liver and brain (Hippocampus and prefrontal cortex) were observed after treatment with insulin or LAE-DS in diabetic rats. Furthermore, insulin and LAE-DS administration prevented anxiety-related behaviors in STZ-diabetic rats. Conclusions Therefore, it would be possible to combine this extract with insulin and use it as an antioxidant supplement for type 1 diabetic patients.

scholarly journals Effects of Dapagliflozin on Serum and Urinary Uric Acid Levels in Type 2 Diabetic Patients: a Prospective Pilot Trial

2020 ◽  
Author(s):  
Tao Yuan ◽  
Shixuan Liu ◽  
Yingyue Dong ◽  
Yong Fu ◽  
Yan Tang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Pilot Trial ◽  
Diabetic Patients ◽  
Cell Secretion ◽  
Β Cell ◽  
Type 2 Diabetic Patients ◽  
Glucose Levels ◽  
Lipid Parameters ◽  
Type 2 Diabetic

Abstract Background We aimed to evaluate the effects of dapagliflozin short-term therapy on serum uric acid (SUA) and urinary uric acid (UUA) levels in type 2 diabetic patients. Methods In this prospective pilot trial, 8 patients with type 2 diabetes mellitus were assigned to the treatment group with dapagliflozin 10 mg once daily for one week, and 7 subjects with normal glucose tolerance were recruited in the control group. Data of anthropometric measurements, SUA, 24-hour UUA, the fractional excretion of UA (FEUA), serum lipid parameters and 3-hour oral glucose tolerance test (OGTT) were collected in both treatment and control groups, also repeated after treatment. Area under curve of glucose (AUCGlu) was calculated to reflect the general glucose levels, insulin resistance and islet β-cell secretion function were reflected by indices calculated according to the data obtained from OGTT. Results The weight and serum lipid parameters showed no differences before and after dapagliflozin treatment for one week. We found SUA levels reduced from 347.75 ± 7.75 µmol/L before treatment to 273.25 ± 43.18 µmol/L after treatment with a significant difference (p = 0.001), accompanying with a significant increase in FEUA from 0.009 to 0.029 (p = 0.035), and there was a linear correlation between SUA and FEUA levels. The glucose control, insulin sensitivity and islet β-cell secretion function were improved to a certain extent. We also found the decrease in glucose levels were positively correlated with the improvement of islet β-cell secretion function. Conclusions Dapagliflozin can present the effect on reducing SUA by increasing UA excretion within one-week treatment, a certain degree of improvement in glucose levels and islet β-cell function were observed. Trial registration: ClinicalTrials.gov identifier, NCT04014192. Registered 12 July 2019, https://www.clinicaltrials.gov/ct2/show/NCT04014192?term=NCT04014192&draw=2&rank=1. Yes.

scholarly journals Correlation of C-Peptide and HbA1c in Type II Diabetes Mellitus

2021 ◽  
Vol 8 (6) ◽  
pp. 297-303
Author(s):  
V. Aruna
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Poor Glycemic Control ◽  
Diabetic Patients ◽  
C Peptide ◽  
Lipid Parameters

Type 2 Diabetes Mellitus (Non Insulin Dependent Diabetes Mellitus -NIDDM) is a chronic metabolic disorder most prevalent in India with microvascular complications. Several studies were underway to identify biomarkers to detect complications associated with increasing duration of disease. The present study was done to understand the role of Connecting peptide (C-peptide) in pathogenesis of microvascular changes and it’s correlation to dyslipidemia of T2DM. The study was done at Government General Hospital, Guntur. In this study 61 known T2 DM patients and 51 age sex matched controls were selected. Their fasting blood samples were analysed for FBS, HbA1C, Urea, Creatinine, Total Cholesterol, High Density Lipoprotein Cholesterol and C-peptide. Dyslipidemia was not observed in Diabetic patients compared to controls (TC, HDLC & NonHDL p = 0.363, 0.294 & 0.336 respectively). HbA1C and C-peptide showed significant correlation between cases and controls (P = <0.00001). C-peptide showed significant correlation with lipid parameters & lipid ratios in individuals with poor glycemic control identified by HbA1c value of >9%. (ANOVA p = <0.0001) Pearson’s correlation showed negative relation of HbA1c and C-peptide with lipid parameters TC, HDLC & Non HDLC (r = 0.378, 0.732, 0.313 and 0.81, 0.91 & 0.843 consecutively). C-peptide showed significant variation with Non HDL / HDL ratio & Non HDL / TC ratio (p = <0.002 & <0.00007) in diabetic patients with poor glycemic control identified by HbA1c of > 9%. We conclude that C-peptide would be a good marker to assess degree of function of pancreas and predictor of atherogenic complication in longstanding NIDDM. Keywords: Type 2 Diabetes Mellitus, C-peptide, HbA1c, Atherogenesis.

scholarly journals The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Herlanny Santana Bezerra ◽  
Caroline Severo de Assis ◽  
Mayara Karla dos Santos Nunes ◽  
Isabella Wanderley de Queiroga Evangelista ◽  
João Modesto Filho ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Promoter Hypermethylation ◽  
Diabetic Patients ◽  
A1298c Polymorphism ◽  
Lipid Parameters
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