The role of plasma metanephrines and plasma catecholamines in the biochemical testing for Pheochromocytoma

2018 ◽  
Author(s):  
Kirsty Spence ◽  
Steven Hunter ◽  
Campbell Brown ◽  
Paul Thompson ◽  
Karen Mullan ◽  
...  
Keyword(s):  
Plasma Catecholamines ◽  
Biochemical Testing ◽  
Plasma Metanephrines

Catecholamine-fuel interrelationships during exercise in fasting men

1980 ◽  
Vol 48 (1) ◽  
pp. 109-113 ◽  
Author(s):  
J. M. Pequignot ◽  
L. Peyrin ◽  
G. Peres
Keyword(s):  
Maximal Oxygen Consumption ◽  
Plasma Catecholamines ◽  
Plasma Free Fatty Acid ◽  
Work Load ◽  
Bicycle Ergometer ◽  
Plasma Norepinephrine ◽  
Plasma Catecholamine ◽  
Adrenergic Response ◽  
Response To Exercise

Adrenergic response to exercise and the relationships between plasma catecholamines and blood energetic substrates were studied in sedentary men after 15 h of fasting. Subjects pedaled a bicycle ergometer until exhaustion at a work load approximating 80% maximal oxygen consumption. Working ability was diminished by the fast (P less than 0.025). Resting plasma norepinephrine level was increased by fasting. During exercise plasma epinephrine (E) and norepinephrine (NE) concentrations were more elevated in fasting subjects than in fed subjects. Plasma catecholamine (CA) levels in fasting men correlated with blood glucose, blood lactate, and plasma glycerol concentrations. There was no significative correlation between CA and plasma free fatty acid (FFA) levels. The increased adrenergic activity in fasting subjects correlated with reduced endurance time. This study emphasizes the role of CA release, probably combined with other hormonal factors, in the mobilization of energy substrates during submaximal exercise.

Chronic intravenous administration of V1 arginine vasopressin agonist results in sustained hypertension

1994 ◽  
Vol 267 (2) ◽  
pp. H751-H756 ◽  
Author(s):  
A. W. Cowley ◽  
E. Szczepanska-Sadowska ◽  
K. Stepniakowski ◽  
D. Mattson
Keyword(s):  
Body Weight ◽  
Arginine Vasopressin ◽  
Plasma Catecholamines ◽  
Plasma Osmolality ◽  
Sprague Dawley ◽  
Prolonged Administration ◽  
Chronic Stimulation ◽  
Sustained Hypertension ◽  
Sprague Dawley Rats

Despite the well-recognized vasoconstrictor and fluid-retaining actions of vasopressin, prolonged administration of arginine vasopressin (AVP) to normal animals or humans fails to produce sustained hypertension. The present study was performed to elucidate the role of the V1 receptor in determining the ability of AVP to produce sustained hypertension. Conscious Sprague-Dawley rats with implanted catheters were infused with the selective V1 agonist, [Phe2,Ile3,Orn8]vasopressin (2 ng.kg-1.min-1), for 14 days in amounts that were acutely nonpressor. Blood pressure (MAP), heart rate (HR), body weight, and water intake (WI) were determined daily. Plasma AVP, plasma catecholamines norepinephrine and epinephrine, plasma osmolality, and electrolyte concentration were determined before and on days 1 and 7 of infusion. MAP increased significantly by 10.4 +/- 4.5 mmHg on day 1 and rose to 22 +/- 5 mmHg above control by day 14 (transient decrease on days 6-9) and then fell to control levels after the infusion was stopped. HR did not change significantly. Plasma AVP immunoreactivity increased from 2.5 +/- 0.3 to 10.9 +/- 2.1 pg/ml, whereas norepinephrine tended to fall only on day 1, with epinephrine only slightly elevated on day 7. No evidence of fluid retention was found, and rats lost sodium only on the first day of V1 agonist infusion. Body weight increased throughout the study but was unrelated to the changes of MAP. We conclude that chronic stimulation of V1 receptors results in sustained hypertension in rats.

scholarly journals THE ROLE OF NUTRITION IN A CHILD’S PHYSICAL, MENTAL AND EMOTIONAL DEVELOPMENT

2018 ◽  
Vol 28 (4) ◽  
pp. 1209-1212
Author(s):  
Mitko Kocev ◽  
Julijana Sazdova ◽  
Dejan Antonievski
Keyword(s):  
Food Intake ◽  
Dietary Intake ◽  
Food Analysis ◽  
Emotional Development ◽  
Child Nutrition ◽  
Intervention Strategies ◽  
Main Role ◽  
Adequate Nutrition ◽  
Biochemical Testing

The adequate nutrition in childhood has the main role in the physical, mental and emotional development of the child. Herein, the children are considered a prioritized part of the population that can be influenced by different intervention strategies (Deghan et al. 2005). It is of utmost importance to obtain the suitable nutrition to every child, and this is the main reason that causes most of the research on child nutrition to be conducted in the kindergartens. The analysis on the food intake and the type of food in the kindergarten can help us analyse the overall health of the children. Usually, in the process of food analysis we use various components such as the following: dietary intake, anthropometric measurements and biochemical testing. We have identified a few researches that have used the above mentioned components for assessment of the child’s nutrition that we mention in our paper as well.

Hormonal changes and enforced diving in the harbor seal Phoca vitulina. II. Plasma catecholamines

1982 ◽  
Vol 242 (5) ◽  
pp. R528-R532 ◽  
Author(s):  
A. J. Hance ◽  
E. D. Robin ◽  
J. B. Halter ◽  
N. Lewiston ◽  
D. A. Robin ◽  
...  
Keyword(s):  
Recovery Period ◽  
Control Period ◽  
Plasma Catecholamines ◽  
Harbor Seal ◽  
Phoca Vitulina ◽  
Harbor Seals ◽  
Hormonal Changes ◽  
Inotropic Effects ◽  
Arterial Constriction

Plasma epinephrine and norepinephrine concentrations were measured in five harbor seals, Phoca vitulina, during a control period, during a 6-min dive, and during a 30-min postdiving recovery period. Measurements were performed with and without prior glucose administration. Control epinephrine concentrations [189 +/- 118 (SD) pg/ml] and norepinephrine concentrations (340 +/- 191 pg/ml) were similar to resting values in humans. During diving there are dramatic increases in both epinephrine and norepinephrine concentrations, which returned to control values by 30 min of the postdiving recovery period. A similar pattern was found after glucose infusion. The increased catecholamines were not the primary mechanism responsible for arterial constriction during the dive. Persistent diving bradycardia suggests obliteration of the chronotropic effects of catecholamines during the dive. An unchanged stroke volume suggests obliteration of the inotropic effects of catecholamines during the dive. Catecholamines do not appear to be involved in postdiving hyperglycemia and hyperglucogenemia. Neither the regulatory role of increased catecholamines nor the physiological function of increased catecholamines was apparent from the studies. However, dramatic increases in plasma catecholamines during diving appear to be an important component of the hormonal response to prolonged diving in aquatic mammals.

A case of watery diarrhoea syndrome due to an adrenal phaeochromocytoma secreting vasoactive intestinal polypeptide with coincidental autoimmune thyroid disease

1987 ◽  
Vol 114 (3) ◽  
pp. 340-344 ◽  
Author(s):  
B. M. Fisher ◽  
G. J. A. MacPhee ◽  
D. L. Davies ◽  
S. G. McPherson ◽  
I. L. Brown ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Psychiatric Symptoms ◽  
Plasma Catecholamines ◽  
Ct Scanning ◽  
Watery Diarrhoea ◽  
Autoimmune Thyroid ◽  
Biochemical Testing ◽  
Well Differentiated

Abstract. A 40 year old woman presented with a 10 year history of watery diarrhoea and an acute quadriparesis. On clinical examination there was severe muscle weakness and a nodule was palpable in the thyroid gland. Biochemical testing revealed a hypokalaemia at 1.6 mmol/l. Plasma levels of VIP were raised at 202 pmol/l. CT scanning demonstrated a mass in the area of the left adrenal gland, and isotope scanning of the thyroid gland showed a 'cold' nodule. The plasma catecholamines and calcitonin were elevated. The patient also presented with psychiatric symptoms, and the relevance of these to her condition has been discussed. At operation a left adrenal tumour was removed. Post-operatively the patient's symptoms disappeared and the plasma hormone levels returned to normal values. Histological examination of the tumour revealed a well differentiated phaeochromocytoma which contained VIP and calcitonin. The thyroid nodule was excised and showed histological features of autoimmune thyroid disease. It is suggested that in all cases of the WDHA syndrome where the tumour is in an extra-pancreatic site patients should be screened for phaeochromocytoma.

Effect of clonidine on the thermic effect of feeding in humans

1988 ◽  
Vol 254 (1) ◽  
pp. R90-R94 ◽  
Author(s):  
R. S. Schwartz ◽  
L. F. Jaeger ◽  
R. C. Veith
Keyword(s):  
Plasma Catecholamines ◽  
Base Line ◽  
Line Energy ◽  
Liquid Meal ◽  
Skin Patch ◽  
Appearance Rate ◽  
Thyroid Metabolism ◽  
Effect Of Feeding ◽  
Thermic Effect

Previous studies in humans attempting to assess the role of the sympathetic nervous system (SNS) in the thermic effect of feeding (TEF) have investigated the effect of oral or intravenous propranolol on TEF. This approach is potentially limited, however, because of the direct effects of propranolol on catecholamine and thyroid metabolism. In the present study we chose instead to evaluate the effect of clonidine, a centrally acting alpha 2-adrenergic receptor agonist that inhibits SNS outflow, on TEF and SNS activity as reflected by both plasma catecholamines and norepinephrine (NE) kinetics. The TEF and SNS response to an 800-kcal high-carbohydrate liquid meal (85% carbohydrate, 15% protein) was studied in eight healthy male subjects (27 +/- 6 yr) on two separate occasions with the subjects wearing either a clonidine or placebo skin patch for 48 h prior to study. Clonidine significantly suppressed base-line plasma NE concentration (-46%, P less than 0.01) and NE appearance rate (-47%, P = 0.01) compared with placebo, whereas there was no significant effect on epinephrine concentrations, NE clearance rate, or base-line energy expenditure. The expected increments in plasma NE and NE appearance after a meal were also reduced by 54% (P less than 0.05) and 70% (P less than 0.01) of placebo values, respectively, after clonidine. Associated with this reduced SNS response to the meal was a blunting of the expected TEF by 33% (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Haemodynamic Effects of Eating: The Role of Meal Composition

1996 ◽  
Vol 90 (4) ◽  
pp. 269-276 ◽  
Author(s):  
U. Høst ◽  
H. Kelbaek ◽  
H. Rasmusen ◽  
M. Court-Payen ◽  
N. Juel Christensen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Portal Vein ◽  
Forearm Blood Flow ◽  
Plasma Catecholamines ◽  
Left Ventricular ◽  
Gastric Distension ◽  
Left Ventricular Volumes ◽  
Portal Vein Flow

1. The purpose of this study was to investigate the effect of fractional meal stimulation on postprandial haemodynamic changes, the possible correlation between these changes and the potential mediating role of circulating catecholamines and insulin. 2. Healthy young subjects were studied before and after ingestion of isocaloric, isovolumetric high-protein, carbohydrate or fat meals (80–85% of total energy), 60 kJ per kg of body weight. Multigated radionuclide cardiography with autologous 99mTc-labelled erythrocytes was performed for assessment of cardiac output, venous occlusion plethysmography to obtain forearm blood flow and Doppler-ultrasonography for portal vein flow. Plasma levels of catecholamines and insulin were determined by radioimmunoassay. 3. Cardiac output increased considerably after each meal, including the control meal (water) with only minor differences in extent and timing. Left ventricular volumes increased after food intake, most pronounced after carbohydrate and protein. Forearm blood flow increased only after carbohydrate and protein. Portal vein flow increased after all meals, especially after fat, but also after the control meal. There was a significant correlation between the increment in cardiac output and changes in forearm and portal vein flow, but no correlation between either haemodynamic response and plasma catecholamines or insulin. 4. Postprandial cardiovascular changes are not substantially different after various isocaloric and isovolumic meal compositions. Gastric distension seems to play a role in the increase in cardiac output, accomplished by ventricular dilatation. These changes seem to some extent to be linked to changes in muscle and splanchnic flow.

Role of Plasma Catecholamines, Autonomic, and Left Ventricular Function in Normotensive and Hypotension Prone Dialysis Patients

ASAIO Journal ◽  
1993 ◽  
Vol 39 (4) ◽  
pp. 946-953 ◽  
Author(s):  
Yuh-Feng Lin ◽  
Jia-Yi Wang ◽  
Andrew Y-C Shum ◽  
Hann-Kuang Jiang ◽  
Ween-Yuang Lai ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Plasma Catecholamines ◽  
Left Ventricular ◽  
Dialysis Patients

Sympathoadrenal activation in sinoaortic-denervated rats following endotoxin

1991 ◽  
Vol 260 (4) ◽  
pp. R739-R746 ◽  
Author(s):  
Z. Z. Zhou ◽  
R. D. Wurster ◽  
M. Qi ◽  
S. B. Jones
Keyword(s):  
Sham Group ◽  
Plasma Catecholamines ◽  
Plasma Norepinephrine ◽  
Sham Operation ◽  
Plasma Catecholamine ◽  
Induced Hypotension ◽  
The Third ◽  
Sympathoadrenal Activation ◽  
Alpha Chloralose

We evaluated the role of the baroreceptor reflex in mediating the sympathoadrenal activation during endotoxicosis, using acutely as well as chronically denervated rats. Three groups of experiments were conducted. In the first experiment, hemodynamic and plasma catecholamine responses following endotoxin (5 mg/kg iv) were measured in alpha-chloralose-anesthetized rats with acute sinoaortic baroreceptor denervation (SAD) or sham operation. In the second experiment, chronically sinoaortic-denervated rats and sham controls were used and experiments were conducted as in acute preparations. In the third experiment hydralazine (1 mg/kg iv) was given to chronically denervated rats and sham controls to evaluate the singular contribution of hypotension-evoked baroreflex disinhibition in the absence of endotoxin. In both acute and chronic preparations, endotoxin induced marked elevation of plasma norepinephrine and epinephrine in the presence as well as the absence of arterial baroreceptors (P greater than 0.05). Plasma catecholamines were significantly increased by hydralazine-induced hypotension in the sham group, but this elevation was far less than that induced by endotoxin. Hypotension alone did not significantly increase plasma catecholamines in SAD rats. These results suggest that the baroreflex is not the major factor in mediating sympathoadrenal activation during endotoxicosis and that non-baroreflex mechanisms may be involved in stimulating such activation.

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