scholarly journals Adrenarche in nonhuman primates: the evidence for it and the need to redefine it

2012 ◽  
Vol 214 (2) ◽  
pp. 121-131 ◽  
Author(s):  
A J Conley ◽  
R M Bernstein ◽  
A D Nguyen
Keyword(s):  
Nonhuman Primates ◽  
Great Apes ◽  
Complex Nature ◽  
Suitable Model ◽  
Adrenal Androgen ◽  
Adrenal Androgens ◽  
Old World ◽  
Developmental Event ◽  
Androgen Secretion ◽  
Definition Of

Adrenarche is most commonly defined as a prepubertal increase in circulating adrenal androgens, dehydroepiandrosterone (DHEA) and its sulfo-conjugate (DHEAS). This event is thought to have evolved in humans and some great apes but not in Old World monkeys, perhaps to promote brain development. Whether adrenarche represents a shared, derived developmental event in humans and our closest relatives, adrenal androgen secretion (and its regulation) is of considerable clinical interest. Specifically, adrenal androgens play a significant role in the pathophysiology of polycystic ovarian disease and breast and prostate cancers. Understanding the development of androgen secretion by the human adrenal cortex and identifying a suitable model for its study are therefore of central importance for clinical and evolutionary concerns. This review will examine the evidence for adrenarche in nonhuman primates (NHP) and suggest that a broader definition of this developmental event is needed, including morphological, biochemical, and endocrine criteria. Using such a definition, evidence from recent studies suggests that adrenarche evolved in Old World primates but spans a relatively brief period early in development compared with humans and some great apes. This emphasizes the need for frequent longitudinal sampling in evaluating developmental changes in adrenal androgen secretion as well as the tenuous nature of existing evidence of adrenarche in some species among the great apes. Central to an understanding of the regulation of adrenal androgen production in humans is the recognition of the complex nature of adrenarche and the need for more carefully conducted comparative studies and a broader definition in order to promote investigation among NHP in particular.

Fiduciary Principles in Investment Advice

2019 ◽  
pp. 144-165
Author(s):  
Arthur B. Laby
Keyword(s):  
Fiduciary Duty ◽  
Duty Of Care ◽  
Complex Nature ◽  
State Law ◽  
Fiduciary Duties ◽  
Legal Obligations ◽  
Standards Of Conduct ◽  
Investment Advisers ◽  
Definition Of ◽  
Investment Advice

This chapter examines the fiduciary principles governing investment advice. Fiduciary principles in investment advice are both straightforward and complex. They are straightforward because most investment advisers are considered fiduciaries and subject to strict fiduciary duties under federal and state law. Their complex nature arises from the fact that many individuals and firms provide investment advice but are not deemed investment advisers and, therefore, are not subject to a fiduciary obligation. This chapter first explains whether and when an advisory relationship gives rise to fiduciary duties by focusing on both federal and state law, as well as the individuals and firms that typically provide investment advice. In particular, it looks at certain persons and entities excluded from the definition of investment adviser and thus not subject to the Investment Advisers Act of 1940, namely broker-dealers, banks, and family offices as well as accountants, lawyers, teachers, and engineers. The chapter also considers fiduciaries under ERISA, the Investment Company Act, and the Commodity Exchange Act before discussing the fiduciary duty of loyalty and how it is expressed and applied in investment advisory relationships; the fiduciary duty of care and how it differs from other standards of conduct, such as a duty of suitability; and other legal obligations imposed on investment advisers and how those obligations relate to an adviser’s fiduciary duty. Finally, the mandatory or default terms with regard to an investment adviser’s fiduciary duties are explored, along with remedies available for breach of fiduciary duty.

scholarly journals Comparison of nonhuman primates identified the suitable model for COVID-19

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Shuaiyao Lu ◽  
Yuan Zhao ◽  
Wenhai Yu ◽  
Yun Yang ◽  
Jiahong Gao ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Suitable Model

Dissociation of cortisol and adrenal androgen secretion in poorly controlled insulin-dependent diabetes mellitus

1992 ◽  
Vol 127 (2) ◽  
pp. 115-117 ◽  
Author(s):  
RM Couch
Keyword(s):  
Diabetes Mellitus ◽  
Good Control ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dehydroepiandrosterone Sulfate ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Poor Control ◽  
Adrenal Androgen ◽  
Insulin Dependent ◽  
Androgen Secretion

In acute illness, cortisol secretion increases whereas that of the adrenal androgens, dehydroepiandrosterone and dehydroepiandrosterone sulfate declines. The present study examined if a similar dissociation of cortisol and adrenal androgen secretion occurs in poorly controlled diabetes mellitus. Serum concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone sulfate obtained at 08.00 were compared in 13 post-pubertal diabetics (mean age 18.0 years) in good control (HbA1C<8.0%) and 10 post-pubertal diabetics (mean age 17.0 years) in poor control (HbA1C> 10.0%). Those in poor control had significantly higher serum cortisol (597±94 nmol/l vs 479±208, p < 0.05), lower dehydroepiandrosterone (13.1±5.5 nmol/l vs 25.3±16.9, p<0.025) and lower dehydroepiandrosterone sulfate (4.5±2.4 μmol/l vs 7.0±3.7, p<0.025). The ratios of dehydroepiandrosterone and dehydroepiandrosterone sulfate to cortisol were also significantly lower in those with poor control. It is concluded that poor control of insulin-dependent diabetes mellitus results in a dissociation of cortisol and adrenal androgen secretion.

scholarly journals ‘A transverse scar on the neck’ – psychosomatic approach in the differential diagnosis and surgical treatment of hyperthyroidism in post-war Finland

2021 ◽  
Vol 65 (2) ◽  
pp. 140-156
Author(s):  
Eve-Riina Hyrkäs
Keyword(s):  
Surgical Treatment ◽  
Psychiatric Patients ◽  
Differential Diagnostics ◽  
Historical Study ◽  
Complex Nature ◽  
Surgical Interventions ◽  
Somatic Illness ◽  
Post War ◽  
Definition Of ◽  
The Mind

AbstractIn the Finnish medical discussion during the middle decades of the twentieth century, the challenging differential diagnostics between hyperthyroidism and various neuroses was perceived to yield a risk of unnecessary surgical interventions of psychiatric patients. In 1963, the Finnish surgeon Erkki Saarenmaa claimed that ‘the most significant mark of a neurotic was a transverse scar on the neck’, a result of an unnecessary thyroid surgery. The utterance was connected to the complex nature of thyroid diseases, which seemed to be to ‘a great extent psychosomatic’. Setting forth from this statement, the article aims to decipher the connection between hyperthyroidism, unnecessary surgical treatment and the psychosomatic approach in Finnish medicine. Utilising a wide variety of published medical research and discussion in specialist journals, the article examines the theoretical debate around troublesome diagnostics of functional complaints. It focuses on the introduction of new medical ideas, namely the concepts of ‘psychosomatics’ and ‘stress’. In the process, the article aims to unveil a definition of psychosomatic illness that places it on a continuum between psychological and somatic illness. That psychosomatic approach creates a space with interpretative potential can be applied to the historiography of psychosomatic phenomena more generally. Further inquiry into the intersections of surgery and psychosomatics would enrich both historiographies. It is also argued that the historical study of psychosomatic syndromes may become skewed, if the term ‘psychosomatic’ is from the outset taken to signify something that is all in the mind.

scholarly journals Towards the determination of capabilities relevant for expert thinking

2006 ◽  
Vol 38 (1) ◽  
pp. 45-59
Author(s):  
Zora Krnjaic
Keyword(s):  
Complex Nature ◽  
Crystallized Intelligence ◽  
Domain Specific ◽  
Abstract Thought ◽  
Key Concepts ◽  
Definition Of ◽  
Systematic Education ◽  
Special Relevance ◽  
Complex Manner

The paper starts from the assumption that expert thinking is a complex manner of thinking of higher order, comprising higher mental functions and complex capabilities based on deep structures and knowledge patterns. It is a domain-determined and specialized thinking developed through systematic education. Particular aspects of ability, selected for this study, primarily concern the relation between abilities and knowledge and the relation between general and specific abilities. Particular emphasis was laid on the key concepts of the theories presented, relevant for the study of the complex nature of expert thinking. Special attention was paid to mediated intelligence and the process of systemogenesis of knowledge, Katel?s definition of crystallized intelligence, Gardener?s work on multiple intelligences in the context of knowledge and experience as well as Sternberg?s two-facet subtheory. The capability for abstract thought and the ability to select what is important as well as the domain of relevant specific capability are assumed to be of special relevance for understanding expert thinking and, as such, they were articulated and examined. Expert thinking-abstract, specialized and domain-specific, seems to be based on general and specific capabilities and their interaction.

scholarly journals Characterization of odours emitted by liquid waste treatment plants (LWTPs)

2016 ◽  
Vol 18 (4) ◽  
pp. 721-727 ◽  
Keyword(s):  
Waste Treatment ◽  
Liquid Waste ◽  
Management Tool ◽  
Complex Nature ◽  
Atmospheric Conditions ◽  
Exposed Population ◽  
Waste Treatment Plants ◽  
Odour Emissions ◽  
Definition Of

<p>Odour emissions from liquid waste treatment plants (LWTPs) generally cause significant effects on the environment in terms of nuisance to exposed population. The particular and complex nature of the mixture of the volatile substances, its variability in time and the strong influence of the atmospheric conditions, are the elements that delayed their regulation and relative management.</p> <p>Limited data are available in the technical and scientific literature, regarding the odour emissions characterization from liquid waste treatment plants. Moreover there isn’t a common strategy from the different European Countries in the regulation of their emissions.</p> <p>Different methods can be used to measure odour emissions from environmental engineering plants, and currently, in Europe, the most used techniques for odour emissions characterization and quantification is the dynamic olfactometry, according to EN 13725:2003.</p> <p>The aim of this study is the characterization of the odour emissions from different liquid waste treatment plants (LWTPs), trough a case study of two large real LWTPs, in order to identify the principal odour sources and to define their related odour emissions.</p> <p>Odour Concentration Index (OCI) is proposed as a useful and simply odour management tool for the identification of the priority actions necessary to identify and control the main odorous sources. Relationship between the measured odour emissions and the types of treated liquid waste (identified in terms of EWC code, COD and NH4<sup>+</sup>) is also discussed.</p> <p>Results show that the influent collection tank is the source with the highest detected odour emissions. OCI results are useful for the definition of a clear priority action for odour control, similar for both investigated plants. Between the characterized types of liquid waste treated by LWTPs the leachate (EWC 190703) show the maximum odour emissions.</p>

scholarly journals Pulmonary granuloma is not always the tuberculosis hallmark: pathological findings of different tuberculosis stages in New and Old World Nonhuman Primates naturally infected with the Mycobacterium tuberculosis Complex

2021 ◽  
Author(s):  
Asheley H. B. Pereira ◽  
Claudia A. A. Lopes ◽  
Thalita A. Pissinatti ◽  
Ana C. A. Pinto ◽  
Daniel R. A. Oliveira ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
New World ◽  
Nonhuman Primates ◽  
World Monkey ◽  
Histological Evaluation ◽  
New World Monkeys ◽  
Old World Monkeys ◽  
Pathological Findings ◽  
Old World ◽  
Pulmonary Granuloma

Abstract Herein we present the pathological findings of different tuberculosis stages in Old and New World monkeys kept under human care in Rio de Janeiro, Brazil and naturally infected with Mycobacterium tuberculosis Complex. Fifteen nonhuman primates from five different colonies were incorporated into the study. There are 60% (9/15) Old World Monkeys and 40% (6/15) New World Monkeys. According to the gross and histopathologic findings, the lesions in nonhuman primates of this study are classified into the chronic-active, extrapulmonary, early-activation or latent-reactivation tuberculosis stage. Among the Old World Monkey, 66.7% (6/9) of nonhuman primates, all rhesus monkeys (Macaca mulatta), showed severe granulomatous pneumonia. In all Old World Monkeys cases, typical granulomas were seen in at least one organ regardless of the stage of the disease. In the New World Monkeys, the typical pulmonary granulomas were seen in 16.7% (1/6) of the cases, just in the latent-reactivation stage in Uta Hick’s Bearded Saki (Chiropotes utahickae). In this study, 66.7% (6/9) of Old World Monkeys (OWM) and 83.3% (5/6) of New World Monkeys (NWM) showed pulmonary changes at the histological evaluation. The tuberculosis diagnosis in the nonhuman primates in this study was based on pathological, immunohistochemical, molecular, and bacteriological culture. Although the typical presentation was observed in some cases, the absence of pulmonary granuloma did not exclude the tuberculosis occurrence in nonhuman primates of the Old and New World. Tuberculosis should be included as a cause of interstitial pneumonia with foamy macrophages infiltration in the New World nonhuman primates. Due to the high sensitivity of immunohistochemistry with Anti-Mycobacterium tuberculosis, we suggest the addition of this technique as a diagnostic tool of tuberculosis in the nonhuman primates even when the typical changes are not seen.

Cortical Orofacial Motor Representation in Old World Monkeys, Great Apes, and Humans

2004 ◽  
Vol 63 (2) ◽  
pp. 82-106 ◽  
Author(s):  
Chet C. Sherwood ◽  
Ralph L. Holloway ◽  
Joseph M. Erwin ◽  
Patrick R. Hof
Keyword(s):  
Great Apes ◽  
Old World Monkeys ◽  
Motor Representation ◽  
Old World

A new species of the genus Odonteus (Coleoptera: Geotrupidae) from northern Pakistan

Zootaxa ◽  
2005 ◽  
Vol 968 (1) ◽  
pp. 1
Author(s):  
GIUSEPPE M. CARPANETO ◽  
ROBERTO MIGNANI
Keyword(s):  
New Species ◽  
North America ◽  
Adult Female ◽  
Adult Male ◽  
Similar Species ◽  
Northern Pakistan ◽  
Relict Species ◽  
Old World ◽  
Definition Of ◽  
A New Species

A remarkable new species, Odonteus gandhara Carpaneto & Mignani, n. sp., is described from northern Pakistan. The holotype (adult male) and the paratype (adult female) are illustrated and compared with O. armiger (Scopoli, 1772) and O. orientalis Mittal, 1998, the only two species of this genus recognized in the Old World. Both O. armiger and O. orientalis have the eye not completely divided by the canthus and have a sensory area on the external side of the last antennomere (this character has never been discussed in the literature until now). These two character states in O. armiger and O. orientalis compel emendations to the definition of the genus. The new species has a great zoogeographical relevance because similar species occur in North America (O. obesus LeConte, 1859 and O. falli Wallis, 1928), and probably represents a relict species endemic to the Himalayan range.

Sign in / Sign up

Export Citation Format

Share Document