High Density (Dis)Illusions: Examining the Market Actor Perspectives in Large Scale Mixed-use Urban Development in the Post Crisis Era

2021 ◽  
Author(s):  
Mariam Hussain
Keyword(s):  
Urban Development ◽  
Large Scale ◽  
High Density ◽  
Mixed Use

Large‐scale high‐density culture of hepatocytes in a liver microsystem with mimicked sinusoid blood flow

2018 ◽  
Vol 12 (12) ◽  
pp. 2266-2276
Author(s):  
Jing Liu ◽  
Chengpan Li ◽  
Shaohui Cheng ◽  
Shengnan Ya ◽  
Dayong Gao ◽  
...  
Keyword(s):  
Blood Flow ◽  
Large Scale ◽  
High Density ◽  
High Density Culture ◽  
Culture Of Hepatocytes

Jane Jacobs

2018 ◽  
Vol 1 (2) ◽  
pp. 156-169
Author(s):  
Paul Kidder ◽  
Keyword(s):  
New York ◽  
New York City ◽  
Urban Development ◽  
York City ◽  
Large Scale ◽  
Population Densities ◽  
Jane Jacobs ◽  
The People ◽  
Architectural Preservation ◽  
American Cities

Jane Jacobs’s classic 1961 book, The Death and Life of Great American Cities, famously indicted a vision of urban development based on large scale projects, low population densities, and automobile-centered transportation infrastructure by showing that small plans, mixed uses, architectural preservation, and district autonomy contributed better to urban vitality and thus the appeal of cities. Implicit in her thinking is something that could be called “the urban good,” and recognizable within her vision of the good is the principle of subsidiarity—the idea that governance is best when it is closest to the people it serves and the needs it addresses—a principle found in Catholic papal encyclicals and related documents. Jacobs’s work illustrates and illuminates the principle of subsidiarity, not merely through her writings on cities, but also through her activism in New York City, which was influential in altering the direction of that city’s subsequent planning and development.

scholarly journals Large-Scale and Refined Green Space Identification-Based Sustainable Urban Renewal Mode Assessment

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Rong Guo ◽  
Xiaoya Song ◽  
Peiran Li ◽  
Guangming Wu ◽  
Zhiling Guo
Keyword(s):  
Urban Planning ◽  
Urban Development ◽  
Large Scale ◽  
Green Space ◽  
Sustainable Urban Development ◽  
Environmental Index ◽  
Wide Range ◽  
Transportation Accessibility ◽  
Urban Function ◽  
Green Model

Urban sustainable renewal has received extensive attention in a wide range of fields, including urban planning, urban management, energy management, and transportation. Given that environmental resource conservation is critical to urban sustainability renewal, this study highlighted the imbalance among green space, urban development, and transportation accessibility. Here, a novel node-place-green model is presented to measure sustainable urban development; meanwhile, deep learning is utilized to identify and extract the green space to measure the environmental index. Based on the generated node, place, and green value, urban developing status could be classified into nine modes for further analysis of transportation, urban function, and ecological construction. The experimental results of Harbin reveal the feasibility of the proposed method in providing specific guidelines for urban planning and policies on sustainable development.

scholarly journals YAP Promotes Cell Proliferation and Stemness Maintenance of Porcine Muscle Stem Cells under High-Density Condition

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3069
Author(s):  
Zheng Liu ◽  
Ling Lin ◽  
Haozhe Zhu ◽  
Zhongyuan Wu ◽  
Xi Ding ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Large Scale ◽  
High Density ◽  
Meat Production ◽  
Density Condition ◽  
High Density Culture ◽  
Differentiation Potential ◽  
Muscle Stem Cells ◽  
Cultured Meat

Muscle stem cells (MuSCs) isolated ex vivo are essential original cells to produce cultured meat. Currently, one of the main obstacles for cultured meat production derives from the limited capacity of large-scale amplification of MuSCs, especially under high-density culture condition. Here, we show that at higher cell densities, proliferation and differentiation capacities of porcine MuSCs are impaired. We investigate the roles of Hippo-YAP signaling, which is important regulators in response to cell contact inhibition. Interestingly, abundant but not functional YAP proteins are accumulated in MuSCs seeded at high density. When treated with lysophosphatidic acid (LPA), the activator of YAP, porcine MuSCs exhibit increased proliferation and elevated differentiation potential compared with control cells. Moreover, constitutively active YAP with deactivated phosphorylation sites, but not intact YAP, promotes cell proliferation and stemness maintenance of MuSCs. Together, we reveal a potential molecular target that enables massive MuSCs expansion for large-scale cultured meat production under high-density condition.

scholarly journals Enhancing Form-Based Code: A parametric approach to urban volumetric morphology in high density cities

2021 ◽  
Author(s):  
◽  
Yingyi Zhang
Keyword(s):  
Hong Kong ◽  
Large Scale ◽  
Positive Impact ◽  
High Density ◽  
Original Form ◽  
Human Society ◽  
Parametric Modelling ◽  
Physical Form ◽  
Urban Regulation ◽  
Modelling System

<p>Parametric tools have been broadly implemented in Architecture, Engineering and Construction (AEC) industry. Recently, an increasing volume of research finds that parametric tools also have the capability to facilitate large-scale planning and urban design. Much of this research, however, focuses on parametric representation or environment simulation. There is insufficient research about using parametric tools to enhance urban regulation. Parametric tools can provide smart design procedures by integrating strategies, solutions and expressions in one system. They may allow alternative approaches to urban regulation that conventional tools do not process.  This research aims to create a parametric modelling system to aid urban regulation. The system offers a visualised coding interface to manipulate parameters and achieve interactive performance feedback at the early stage of urban regulation. Form-Based Code uses the modelling system in this research. It generates a specific morphology by controlling physical form with less focus on land use. With the rise of New Urbanism, Form-Based Code has been used in various American regulation projects. This research extends the application of Form-Based Code, adopting it for urban-peripheral environments outside of the USA. High-density cities where provide the volumetric morphology context is important for this work. Tsim Sha Tsui area of Hong Kong works as an experimental site.  The feasibility of parametric urban regulation is examined by developing a parametric modelling system for Form-Based Code in Hong Kong. Understanding the site’s form characteristics, the transect matrix of Form-Based Code is expanded by incorporating multi-layered zone types and regulating plans. Embedding the zones into parametric modelling software Rhinoceros 3D and Grasshopper 3D, a regenerative prototype works to create real-time scenarios responding to parameters, rules and geometry constraints. The results of parametric urban regulation are evaluated by both Form-Based Code standards and local urban regulation standards to assess its feasibility in context.  This research demonstrates that the parametric modelling system for Form-Based Code has both technological and implemental potential to work as an alternative approach to urban regulation, especially in complex developments. Form complexity is a reflection of sophisticated human-society systems and the sequential evolution of a dynamic morphology. Form-Based Code is enhanced by the parametric modelling system to describe and regulate form complexity in a logical manner. Additionally, although parametric Form-Based Code processing is based on the original Form-Based Code, it is not limited to that. Describing urban regulation with visualised models bridges specialists and the public in community demonstrations and code assembling. The parametric modelling system has a positive impact on resolving challenges, predicting outcomes, and applying urban regulation innovation to the volumetric morphology of high-density cities in Asia.</p>

CO2 in large-scale and high-density CHO cell perfusion culture

1996 ◽  
Vol 22 (1-3) ◽  
pp. 65-78 ◽  
Author(s):  
David R. Gray ◽  
Su Chen ◽  
William Howarth ◽  
Duane Inlow ◽  
Brian L. Maiorella
Keyword(s):  
Large Scale ◽  
Perfusion Culture ◽  
High Density ◽  
Cho Cell

URBAN PLANNING WITH THE GOALS OF SUSTAINABLE DEVELOPMENT

2020 ◽  
Vol 5 (11) ◽  
pp. 56-62
Author(s):  
Elvira Gromilina ◽  
Keyword(s):  
Land Use ◽  
Sustainable Development ◽  
Urban Planning ◽  
Urban Development ◽  
Social Economic ◽  
Social Needs ◽  
Sustainable Urban Development ◽  
Theoretical Approaches ◽  
Mixed Use ◽  
Environmental Goals

The problem of urban planning in the context of globalization and the intensification of urban growth is considered in the context of sustainable development. Under UN-Habitat regulations, urban development must be in line with five principles: compactness, high density, mixed use, variety, limited land-use specialization. Compact urban development is a model for sustainable urban development, based on the synergy of three main dimensions: social, economic and environmental. In contrast to the approach to territorial zoning, the compact city model pays attention not only to the development of mixed land use, but also to social needs in places of employment, leisure, recreation, as well as the need for economic resources. In order to identify strategies for designing a sustainable architectural and planning structure, theoretical approaches to the practice of urban planning are investigated. Implementation of the provisions of UN-Habitat is aimed at reducing energy consumption and harmful emissions, preserving biodiversity, reducing the cost of infrastructure and increasing labor productivity, which helps to achieve a balance of social, economic and environmental goals of sustainable development.

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