scholarly journals Alexithymia in multiple sclerosis

2021 ◽  
Vol 11 (3) ◽  
pp. 91-95
Author(s):  
Nataliya Starynets, ◽  
GA Starynets
Keyword(s):  
Multiple Sclerosis ◽  
Depression And Anxiety ◽  
State Trait Anxiety Inventory ◽  
Mcdonald Criteria ◽  
Marginal Group ◽  
Hospital Patients ◽  
Group A ◽  
High Degree ◽  
Degrees Of Severity ◽  
Status Level

Background: An independent psychological construct like alexithymia is the least studied in multiple sclerosis (MS). The objective of this study was to determine the level of alexithymia in patients with MS and the degree of influence on it of different social and demographic characteristics of patients, including gender, age, place of residence, marital status, level of education, clinical parameters of the disease, depression and anxiety. Materials and methods: 88 hospital patients with varying degrees of severity and type of MS were examined, according to the McDonald criteria, 2010. The following scales were used to assess the signs of depression, anxiety and alexithymia: the Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory (STAI), the Toronto Alexithymia Scale (TAS-26). Results: The prevalence of alexithymia in patients with MS was 36.36%, while 34.09% represented the "marginal" group. A statistically significant positive correlation between alexithymia and depression and anxiety in patients with MS was established. High levels of alexithymia were detected with a high degree of depression on the BDI scale. None of the above socio-demographic and clinical variables influenced statistically significantly the presence of alexithymia. Conclusion: Alexithymia can be a key psychological factor that impedes the true emotional integration of disease-related changes.

scholarly journals Interleukin 1 Beta Is Associated With Depression in Multiple Sclerosis Patients

2021 ◽  
Author(s):  
Hugo Aguilar-Talamantes ◽  
Azul Islas-Hernandez ◽  
Aleida Rodriguez-Castañeda ◽  
Brenda Bertado-Cortes ◽  
Irma Corlay-Noriega ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Inflammatory Diseases ◽  
Interleukin 1 ◽  
Depression Scale ◽  
Cross Sectional Study ◽  
Depression And Anxiety ◽  
Cross Sectional ◽  
Psychiatric Interview ◽  
Mcdonald Criteria ◽  
Multiple Sclerosis Patients

Abstract Depressive and anxiety symptoms occur more frequently in chronic encephalomyelitis. Inflammatory diseases are highly associated with psychiatric comorbidities, which has been well established in Multiple Sclerosis. However, no biomarkers have been found with the capacity to discern between MS and depression. Thirty-six individuals with a diagnosis of MS according to the revised McDonald criteria, were recruited from an outpatient Neurology and Psychiatry from the medical unit of high specialty in Mexico. We measured the association between BDNF, IL-1β, and TNFα in serum with the presence of depression and anxiety using the semi-structured psychiatric interview, the Beck Depression Inventory (IDB), and Hospital Anxiety and Depression Scale (HADS). This was a cross-sectional study. The Logistic Regression was used for the multivariate analysis adjusted by the Multiple Sclerosis Severity Score (MSSS). With a power of 0.75 in the final model, patients with multiple sclerosis, depression, and anxiety obtained the highest values of IL-1 β in our study.

scholarly journals Interleukin 1 beta is associated with depression in Multiple Sclerosis patients

2020 ◽  
Author(s):  
Hugo Aguilar-Talamantes ◽  
Azul Islas-Hernandez ◽  
Aleida Rodriguez-Castañenda ◽  
Brenda Bertado-Cortés ◽  
Irma Corlay-Noriega ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Inflammatory Diseases ◽  
Interleukin 1 ◽  
Depression Scale ◽  
Cross Sectional Study ◽  
Depression And Anxiety ◽  
Cross Sectional ◽  
Psychiatric Interview ◽  
Mcdonald Criteria ◽  
Multiple Sclerosis Patients

AbstractDepressive and anxiety symptoms occur more frequently in chronic encephalomyelitis. Inflammatory diseases are highly associated with psychiatric comorbidities, which has been well established in Multiple Sclerosis. However, no biomarkers have been found with the capacity to discern between MS and depression. Thirty-six individuals with a diagnosis of MS according to the revised McDonald criteria, were recruited from an outpatient Neurology and Psychiatry from the medical unit of high specialty in Mexico. We measured the association between BDNF, IL-1β, and TNFα in serum with the presence of depression and anxiety using the semi-structured psychiatric interview, the Beck Depression Inventory (IDB), and Hospital Anxiety and Depression Scale (HADS). This was a cross-sectional study. The Logistic Regression was used for the multivariate analysis adjusted by the Multiple Sclerosis Severity Score (MSSS). With a power of 0.75 in the final model, patients with multiple sclerosis, depression, and anxiety obtained the highest values of IL-1 β in our study.

scholarly journals MRI of the Entire Spinal Cord—Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1424
Author(s):  
Esben Nyborg Poulsen ◽  
Anna Olsson ◽  
Stefan Gustavsen ◽  
Annika Reynberg Langkilde ◽  
Annette Bang Oturai ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Brain Mri ◽  
Anatomical Location ◽  
Spinal Cord Lesions ◽  
Chi Square ◽  
Exact Test ◽  
Mcdonald Criteria ◽  
Chi Square Test

Spinal cord lesions are included in the diagnosis of multiple sclerosis (MS), yet spinal cord MRI is not mandatory for diagnosis according to the latest revisions of the McDonald Criteria. We investigated the distribution of spinal cord lesions in MS patients and examined how it influences the fulfillment of the 2017 McDonald Criteria. Seventy-four patients with relapsing-remitting MS were examined with brain and entire spinal cord MRI. Sixty-five patients received contrast. The number and anatomical location of MS lesions were assessed along with the Expanded Disability Status Scale (EDSS). A Chi-square test, Fischer’s exact test, and one-sided McNemar’s test were used to test distributions. MS lesions were distributed throughout the spinal cord. Diagnosis of dissemination in space (DIS) was increased from 58/74 (78.4%) to 67/74 (90.5%) when adding cervical spinal cord MRI to brain MRI alone (p = 0.004). Diagnosis of dissemination in time (DIT) was not significantly increased when adding entire spinal cord MRI to brain MRI alone (p = 0.04). There was no association between the number of spinal cord lesions and the EDSS score (p = 0.71). MS lesions are present throughout the spinal cord, and spinal cord MRI may play an important role in the diagnosis and follow-up of MS patients.

scholarly journals Adverse health behaviours are associated with depression and anxiety in multiple sclerosis: A prospective multisite study

2015 ◽  
Vol 22 (5) ◽  
pp. 685-693 ◽  
Author(s):  
Kyla A. McKay ◽  
Helen Tremlett ◽  
John D. Fisk ◽  
Scott B. Patten ◽  
Kirsten Fiest ◽  
...  
Keyword(s):  
Mental Health ◽  
Multiple Sclerosis ◽  
Alcohol Dependence ◽  
Smoking Status ◽  
Health Behaviours ◽  
Depression And Anxiety ◽  
Adverse Health ◽  
Disability Status ◽  
Relapsing Remitting ◽  
Anxiety Depression

Background: Depression and anxiety are common among people with multiple sclerosis (MS), as are adverse health behaviours, but the associations between these factors are unclear. Objective: To evaluate the associations between cigarette smoking, alcohol use, and depression and anxiety in MS in a cross-Canada prospective study. Methods: From July 2010 to March 2011 we recruited consecutive MS patients from four MS clinics. At three visits over two years, clinical and demographic information was collected, and participants completed questionnaires regarding health behaviours and mental health. Results: Of 949 participants, 75.2% were women, with a mean age of 48.6 years; most had a relapsing−remitting course (72.4%). Alcohol dependence was associated with increased odds of anxiety (OR: 1.84; 95% CI: 1.32–2.58) and depression (OR: 1.53; 95% CI: 1.05–2.23) adjusting for age, sex, Expanded Disability Status Scale (EDSS), and smoking status. Smoking was associated with increased odds of anxiety (OR: 1.29; 95% CI: 1.02–1.63) and depression (OR: 1.37; 95% CI: 1.04–1.78) adjusting for age, sex, EDSS, and alcohol dependence. Alcohol dependence was associated with an increased incidence of depression but not anxiety. Depression was associated with an increased incidence of alcohol dependence. Conclusion: Alcohol dependence and smoking were associated with anxiety and depression. Awareness of the effects of adverse health behaviours on mental health in MS might help target counselling and support for those ‘at risk’.

Effects of depression and anxiety on mortality in a mixed cancer group: a longitudinal approach using standardised diagnostic interviews

2014 ◽  
Vol 24 (6) ◽  
pp. 718-725 ◽  
Author(s):  
Caryn Mei Hsien Chan ◽  
Wan Azman Wan Ahmad ◽  
Mastura MD Yusof ◽  
Gwo-Fuang Ho ◽  
Edward Krupat
Keyword(s):  
Depression And Anxiety ◽  
Cancer Group ◽  
Diagnostic Interviews ◽  
Longitudinal Approach ◽  
Group A

Еarly diagnosis of multiple sclerosis: experience with the use of class G oligoclonal immunoglobulin

2021 ◽  
Vol 26 (3) ◽  
pp. 34-39
Author(s):  
Z. A. Goncharova ◽  
Y. Y. Pogrebnova ◽  
N. M. Yarosh ◽  
S. M.M. Sehweil
Keyword(s):  
Multiple Sclerosis ◽  
Early Diagnosis ◽  
Literature Review ◽  
Demyelinating Disease ◽  
Mcdonald Criteria ◽  
Mri Features ◽  
Oligoclonal Igg ◽  
Relationship Of ◽  
The Relationship

The article presents the literature review and our experience in early diagnosis of multiple sclerosis based on the updated McDonald criteria of 2017. The study included 256 patients with clinic symptoms of probable idiopathic infl ammatory demyelinating disease, including rare and atypical forms of demyelination. As a result of the study the sensitivity and specifi city of the determination of oligoclonal immunoglobulin G in the population of Rostov-on-Don was described for the fi rst time, including dependence of the duration of the disease. The relationship of clinical and MRI features of the fi rst attack of the disease with the probability of determining oligoclonal IgG in the cerebrospinal fl uid is refl ected

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