scholarly journals Dietary factors modify post-menopausal breast cancer risk: a case-control study from Turkish Cypriot population

2017 ◽  
Vol 4 (03) ◽  
pp. 1171 ◽  
Author(s):  
Ruqiya Pervaiz ◽  
Faisal Faisal ◽  
Nedime Serakinci
Keyword(s):  
Breast Cancer ◽  
Water Intake ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Factors ◽  
Coffee Intake ◽  
Informed Consent Form ◽  
Increased Risk ◽  
Turkish Cypriot ◽  
Control Study

Background: Being potentially modifiable risk factor of breast malignancy, the role of diet in the development of breast cancer (BC) is of great concern. As up to 40 % of cancers can be prevented through dietary strategies; therefore, this case-control study is conducted with the aim to investigate the effects of frequently used dietary factors and postmenopausal BC risk in Turkish Cypriot population. Material and method: Total 786 postmenopausal women including 401 histologically confirmed BC cases and 385 control, recruited from two hospitals i.e. Near East Hospital and Doctor Burhan Nalbantoglu State Hospital Nicosia, Turkish Republic of Northern Cyprus, between the month of July to December 2016. A standardized interview procedure is used and the information is collected using a structured questionnaire from participants after giving informed consent form. For data analysis, SPSS version 20 software is used. Age-adjusted odds ratios (OD) and 95% confidence interval (CI) were calculated by logistic regression before and after adjusting for potential confounding effects of other factors. Results: The multivariable adjusted model confirmed a 3-fold increased BC risk with daily oil use of ≥ 40 mL (OR = 3.22, 95%CI 2.01-5.17, p<0.001). And 4.1-fold increased risk was associated with 4 to 6 daily servings of sugar intake (OR = 4.19, 95%CI 1.79-9.80, p = 0.001), this risk increased to 7.5-folds (OR = 7.5, 95%CI 3.25-17.32, p<0.001) when the consumption of sugar was increased to > 6 servings per day. Daily 1 to 2-liter water intake was associated with 64% decreased BC risk (OR = 0.36, 95%CI 0.20-0.63, p = 0.001). While, no significant association were observed between consumption of full-fat dairy products (FFDP), olive oil, coffee intake and BC risk. Interestingly, daily 3 or more cups of tea intake were associated with 54% decreased risk of BC (OR = 0.46, 95% CI 0.22-0.98, p = 0.043). Conclusion: The study suggests that the risk of BC can be reduced by limiting the consumption of oil and sugar and increasing daily water intake more than a liter.  

Tamoxifen use correlates with increased risk of hip fractures in older women with breast cancer: A case-control study in Taiwan

2018 ◽  
Vol 19 (1) ◽  
pp. 56-60 ◽  
Author(s):  
Shih-Chang Hung ◽  
Kuan-Fu Liao ◽  
Hung-Chang Hung ◽  
Cheng-Li Lin ◽  
Po-Chang Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Hip Fractures ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Control Study

scholarly journals Association of a Novel KIF26B Gene Polymorphism with Susceptibility to Schizophrenia and Breast Cancer: A Case-Control Study

2021 ◽  
Author(s):  
Saman SARGAZI ◽  
Milad HEIDARI NIA ◽  
Shekoufeh MIRINEJAD ◽  
Mahdiyeh MOUDI ◽  
Mahdiyeh JAFARI SHAHROUDI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
De Novo ◽  
Case Control ◽  
Amplification Refractory Mutation System ◽  
Salting Out ◽  
Current Case ◽  
Increased Risk ◽  
Mutation System ◽  
Control Study

Background: KIF26B gene is found to play essential roles in regulating different aspects of cell proliferation and development of the nervous system. We aimed to determine if rs12407427 T/C polymorphism could affect susceptibility to schizophrenia (SZN) and breast cancer (BC), the two genetically correlated diseases. Methods: The current case-control study was performed from Aug 2018 to Dec 2018. Briefly, 159 female pathologically confirmed BC cases referring to Alzahra Hospital, Isfahan, Iran, and 102 psychologically confirmed SZN patients (60 males and 42 females) admitted to Baharan Hospital, Zahedan, Iran, were enrolled. Using the salting-out method, genomic DNA was extracted, and variants were genotyped using allele-specific amplification refractory mutation system polymerase chain reaction (ARMS-PCR) method. Results: The results revealed a significant association between the KIF26B rs12407427 codominant CT (P=0.001), CC (P=0.0001), dominant CT+CC, and recessive CC (P=0.001) genotypes with the risk of developing SZN. Significant correlations were also found regarding rs12407427 and BC susceptibility in different inheritance models, including over-dominant CT (P=0.026), dominant CT+CC (P=0.001), recessive CC (P=0.009), and codominant CT and CC (P=0.001) genotypes. The over-presence of the C allele was also correlated with an increased risk for SZN (P=0.0001) and BC (P=0.0001). Finally, computational analysis predicted that T/C variation in this polymorphism could change the binding sites in proteins involved in splicing. Conclusion: rs12407427 T/C as a de novo KIF26B variant might be a novel genetic biomarker for SZN and/or BC susceptibility in a sample of the Iranian population.

scholarly journals Lifetime alcohol consumption and breast cancer: a case–control study in Finland

2000 ◽  
Vol 3 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Satu Männistö ◽  
Mikko Virtanen ◽  
Vesa Kataja ◽  
Matti Uusitupa ◽  
Pirjo Pietinen
Keyword(s):  
Breast Cancer ◽  
Alcohol Consumption ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Premenopausal Women ◽  
Case Control ◽  
Total Lifetime ◽  
Increased Risk ◽  
Control Study ◽  
Current Alcohol

AbstractObjectiveTo study the association between lifetime alcohol consumption and the risk of breast cancer.Design and settingA case–control study carried out in eastern Finland. Information about alcohol consumption was obtained by two methods: a self-administered food frequency questionnaire (FFQ) including alcohol consumption during the previous 12 months, and a lifetime alcohol consumption questionnaire (AQ) which was administered by the study nurse.SubjectsThe study consisted of 301 breast cancer cases (25–75 years old) and 443 population controls.ResultsThe subjects reported higher current alcohol consumption in the AQ compared to the FFQ. According to the AQ, premenopausal cases consumed on average 28 g and controls 24 g alcohol week−1; in postmenopausal women the values were 15 and 14 g, respectively. About 30% of premenopausal and 60% of postmenopausal women were classified as non-drinkers. The correlation for current alcohol consumption between the FFQ and the AQ was 0.80 in premenopausal women but only 0.40 in postmenopausal women. Current alcohol consumption seemed to influence the reporting of total lifetime alcohol consumption. Current alcohol consumption was not associated with the risk of breast cancer either in premenopausal or postmenopausal women; neither were associations found between alcohol consumption at age of first use, use before the age of 30, or total lifetime alcohol consumption and the risk of breast cancer.ConclusionsOn average, one to three drinks per week did not increase the risk of breast cancer in this study. Consumption levels were, however, too low to exclude increased risk with high regular consumption. Further research is necessary on lifetime alcohol consumption.

scholarly journals Relation of Gallbladder Cancer, Gallbladder Stones and Breast Cancer with Polluted Rivers – A Case Control Study in the Indo-Gangetic Plains

2021 ◽  
Vol 8 (12) ◽  
pp. 657-661
Author(s):  
Amit Sreen ◽  
Harinder Pal Singh ◽  
Vivek Guleria ◽  
Niket Verma
Keyword(s):  
Breast Cancer ◽  
Gallbladder Cancer ◽  
Case Control Study ◽  
Uttar Pradesh ◽  
Case Control ◽  
Dietary Factors ◽  
Gangetic Plains ◽  
Study Results ◽  
Polluted Rivers ◽  
Control Study

BACKGROUND Gallbladder cancer and breast cancer are two common malignancies seen along the Ganges River and the Indo-Gangetic plains of northern India, especially in the states of Uttar Pradesh and Bihar. Some of the postulated aetiologies include cholelithiasis (gallstones), typhoid carrier state, dietary factors, genetic predisposition and chemical carcinogens. Studies have also linked gallbladder cancer and breast cancer to carcinogens in polluted rivers. We undertook this study to investigate as to whether these conditions and gallstones were more prevalent in populations living close to polluted rivers. We also wanted to investigate as to whether there is any association between gallbladder cancer, gallstones and breast cancer with river pollution. METHODS This was a case-control study carried out in the Department of Oncology of a tertiary level defence hospital between 2018 and 2020. Patients who were diagnosed as having gallbladder cancer, gallstones or breast cancer in this tertiary institute, and were permanent residents of Uttar Pradesh or Bihar were included in the study. RESULTS In this study, we found that patients with gallbladder cancer, gallstones and breast cancer had their home closer to the river at a distance of around 53.9, 54 and 39.1 Kms. respectively compared to controls whose homes were at a distance of 76.7 Kms. CONCLUSIONS This study suggests that proximity to polluted rivers is one more factor in the aetiology of aforementioned diseases. Governmental agencies must consider monitoring and controlling the release of pollutants from the industries into the local nearby rivers. KEYWORDS Gallbladder Neoplasms, Drinking Water, Gallstones, Public Health

scholarly journals Circulating Carnitine Levels and Breast Cancer: A Matched Case-Control Study

2021 ◽  
Author(s):  
Jiayi Zhang ◽  
Gang Wu ◽  
Hailong Zhu ◽  
Fengyuan Yang ◽  
Shuman Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Epidemiologic Studies ◽  
Female Breast Cancer ◽  
False Discovery Rates ◽  
Increased Risk ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background: The existing epidemiologic studies on the association between carnitine and breast cancer development are scarce. This study examined the association between circulating carnitine levels and breast cancer in females.Methods: This 1:1 age-matched case-control study identified 991 female breast cancer cases and 991 female controls without breast cancer. All cases and controls were confirmed with a pathological test. We measured 16 types of whole blood carnitine levels, such as free carnitine (C0) and octadecanoylcarnitine (C18), using targeted metabolomic technology. Results: The average age for cases and controls were 50.0 years (SD: 8.7 years) and 49.5 years (SD: 8.7 years), respectively. After adjusting for covariates, each SD increase in malonylcarnitine (C3DC; OR 0.91; 95% CI 0.83-1.00), decenoylcarnitine (C10:1; OR 0.87; 95% CI 0.79-0.96) and decadienoylcarnitine (C10:2; OR 0.90; 95% CI 0.82-0.99) level was associated with decreased odds of breast cancer. However, higher butyrylcarnitine (C4) levels were associated with increased risk of breast cancer (OR 1.12; 95% CI 1.02-1.23). We observed no relationship between other carnitines with breast cancer. The false discovery rates for C3DC, C4, C10:1 and C10:2 were 0.172, 0.120, 0.064 and 0.139, respectively. Conclusions: Higher levels of C3DC, C10:1, and C10:2 were protective factors for breast cancer, whereas increased C4 levels were a risk factor for breast cancer.

Comparing and assessing the reported penetrance of cancer susceptibility genes for breast cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 1520-1520
Author(s):  
Kanhua Yin ◽  
Danielle Braun ◽  
Ankur Tiwari ◽  
Jin Wang ◽  
Preeti Singh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
General Population ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Case Control ◽  
Cancer Risks ◽  
Cancer Susceptibility Genes ◽  
Increased Risk ◽  
Control Study

1520 Background: It is critical for oncologists to be aware of unbiased and interpretable cancer risks (i.e., penetrance) in carriers with germline pathogenic variants in cancer susceptibility genes. However, relevant literature is large and varies significantly in study design, patient ascertainment, and types of risk estimates reported. This heterogeneity can cause inconsistent conclusions between studies and create barriers for clinicians to understand and apply them in practice. To further understand the current literature, we assessed penetrance studies associated with non-BRCA breast cancer susceptibility genes based on study design and ascertainment adjustment. Methods: We used a validated natural language processing-based abstract classifier to identify all penetrance studies regarding eleven genes: ATM, BARD1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RECQL, STK11, and TP53. Relevant studies were then manually annotated as “with ascertainment adjustment” if a study was based on: (1) a general population; (2) a pedigree analysis or a family-based study with appropriate ascertainment adjustment; or (3) a hospital-based study or a panel testing analysis with well-matched cases and controls. Results: A total of 49 penetrance studies were identified, with a median of nine studies for each gene (range: 4-16). The case-control study was the dominant study type, accounting for over 80% in five genes, 50% in two genes, and 18% to 43% in the other four genes. The proportion of studies with ascertainment adjustment was generally low (mean: 33%) and varied widely between different genes (7% to 80%). Contradictory breast cancer risks (no increased risk vs. significantly increased risk) were found in eight genes (73%) (Table). The most common ascertainment bias identified was a case-control study with cases (patients) who had a strong family history but using general population controls. Conclusions: Ascertainment bias is common in penetrance studies, but few studies adjust for it appropriately. Clinicians should be aware of this issue, and new methods are warranted to select unbiased risk estimates, synthesize them, and provide the accurate general-population penetrance. [Table: see text]

scholarly journals A higher Dietary Inflammatory Index score is associated with a higher risk of breast cancer among Chinese women: a case–control study

2017 ◽  
Vol 117 (10) ◽  
pp. 1358-1367 ◽  
Author(s):  
Wu-Qing Huang ◽  
Xiong-Fei Mo ◽  
Yan-Bin Ye ◽  
Nitin Shivappa ◽  
Fang-Yu Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Chinese Women ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Increased Risk ◽  
Control Study

AbstractPrevious studies have investigated the association between dietary inflammatory potential and the development of cancer. For breast cancer the results have been equivocal. The present study aimed to investigate whether higher Dietary Inflammatory IndexTM (DII) scores were associated with increased risk of breast cancer among Chinese women. A total of 867 cases and 824 controls were recruited into the present case–control study from September 2011 to February 2016. DII scores were computed based on baseline dietary intake assessed by a validated 81-item FFQ. The OR and 95 % CI were assessed by multivariable logistic regression after adjusting for various potential confounders. DII scores in this study ranged from −5·87 (most anti-inflammatory score) to +5·71 (most proinflammatory score). A higher DII score was associated with a higher breast cancer risk (adjusted ORquartile 4 v. 1 2·28; 95 % CI 1·71, 3·03; adjusted ORcontinuous 1·40; 95 %CI 1·25, 1·39). In stratified analyses, positive associations also were observed except for underweight women or women with either oestrogen receptor+ or progesterone receptor+ status (but not both). Results from this study indicated that higher DII scores, corresponding to more proinflammatory diets, were positively associated with breast cancer risk among Chinese women.

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