scholarly journals Relation of Gallbladder Cancer, Gallbladder Stones and Breast Cancer with Polluted Rivers – A Case Control Study in the Indo-Gangetic Plains

2021 ◽  
Vol 8 (12) ◽  
pp. 657-661
Author(s):  
Amit Sreen ◽  
Harinder Pal Singh ◽  
Vivek Guleria ◽  
Niket Verma
Keyword(s):  
Breast Cancer ◽  
Gallbladder Cancer ◽  
Case Control Study ◽  
Uttar Pradesh ◽  
Case Control ◽  
Dietary Factors ◽  
Gangetic Plains ◽  
Study Results ◽  
Polluted Rivers ◽  
Control Study

BACKGROUND Gallbladder cancer and breast cancer are two common malignancies seen along the Ganges River and the Indo-Gangetic plains of northern India, especially in the states of Uttar Pradesh and Bihar. Some of the postulated aetiologies include cholelithiasis (gallstones), typhoid carrier state, dietary factors, genetic predisposition and chemical carcinogens. Studies have also linked gallbladder cancer and breast cancer to carcinogens in polluted rivers. We undertook this study to investigate as to whether these conditions and gallstones were more prevalent in populations living close to polluted rivers. We also wanted to investigate as to whether there is any association between gallbladder cancer, gallstones and breast cancer with river pollution. METHODS This was a case-control study carried out in the Department of Oncology of a tertiary level defence hospital between 2018 and 2020. Patients who were diagnosed as having gallbladder cancer, gallstones or breast cancer in this tertiary institute, and were permanent residents of Uttar Pradesh or Bihar were included in the study. RESULTS In this study, we found that patients with gallbladder cancer, gallstones and breast cancer had their home closer to the river at a distance of around 53.9, 54 and 39.1 Kms. respectively compared to controls whose homes were at a distance of 76.7 Kms. CONCLUSIONS This study suggests that proximity to polluted rivers is one more factor in the aetiology of aforementioned diseases. Governmental agencies must consider monitoring and controlling the release of pollutants from the industries into the local nearby rivers. KEYWORDS Gallbladder Neoplasms, Drinking Water, Gallstones, Public Health

scholarly journals Correlation of FGFR2 rs2981582 polymorphisms with susceptibility to breast cancer: a case-control study in a Chinese population

2019 ◽  
Vol 47 (10) ◽  
pp. 4753-4763
Author(s):  
Jin Shu ◽  
Xuelian Hui ◽  
Xin Zheng ◽  
Juan Zhao ◽  
Zhaochen Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Estrogen Receptor Status ◽  
Meta Analysis ◽  
Case Control ◽  
Plasma Dna ◽  
Study Results ◽  
Significant Difference ◽  
The Relationship ◽  
Control Study

Objective Breast cancer (BC) is a common malignancy among women worldwide. Fibroblast growth factor receptor 2 (FGFR2) rs2981582 is reported to play a vital role in BC development. However, the relationship between them remains unclear. Methods Ninety-five patients and 140 healthy controls were enrolled in the study. Plasma DNA was genotyped by the MassARRAY method. A meta-analysis was conducted to clarify the effect of FGFR2 polymorphism on BC risk. Results Our case-control study results revealed a significant difference in CC, TC, and TT genotypes between patients and controls. Logistic regression analysis showed that TT and TC genotype and the dominant mode were significantly correlated with BC development [odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.050–2.27; OR = 1.81, 95% CI: 1.24–2.73; OR = 2.15, 95% CI: 1.25–5.31, respectively], even after adjusting for age, body weight, drinking, smoking, and estrogen receptor status. A meta-analysis of 15 studies showed significant differences among the dominant, recessive, heterozygote, and homozygote models between patients and controls. Conclusions Our results showed an association of FGFR2 rs2981582 polymorphism with BC in an Asian population. However, a more comprehensive study of the relationship between the polymorphism and BC is still needed.

scholarly journals Dietary factors modify post-menopausal breast cancer risk: a case-control study from Turkish Cypriot population

2017 ◽  
Vol 4 (03) ◽  
pp. 1171 ◽  
Author(s):  
Ruqiya Pervaiz ◽  
Faisal Faisal ◽  
Nedime Serakinci
Keyword(s):  
Breast Cancer ◽  
Water Intake ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Factors ◽  
Coffee Intake ◽  
Informed Consent Form ◽  
Increased Risk ◽  
Turkish Cypriot ◽  
Control Study

Background: Being potentially modifiable risk factor of breast malignancy, the role of diet in the development of breast cancer (BC) is of great concern. As up to 40 % of cancers can be prevented through dietary strategies; therefore, this case-control study is conducted with the aim to investigate the effects of frequently used dietary factors and postmenopausal BC risk in Turkish Cypriot population. Material and method: Total 786 postmenopausal women including 401 histologically confirmed BC cases and 385 control, recruited from two hospitals i.e. Near East Hospital and Doctor Burhan Nalbantoglu State Hospital Nicosia, Turkish Republic of Northern Cyprus, between the month of July to December 2016. A standardized interview procedure is used and the information is collected using a structured questionnaire from participants after giving informed consent form. For data analysis, SPSS version 20 software is used. Age-adjusted odds ratios (OD) and 95% confidence interval (CI) were calculated by logistic regression before and after adjusting for potential confounding effects of other factors. Results: The multivariable adjusted model confirmed a 3-fold increased BC risk with daily oil use of ≥ 40 mL (OR = 3.22, 95%CI 2.01-5.17, p<0.001). And 4.1-fold increased risk was associated with 4 to 6 daily servings of sugar intake (OR = 4.19, 95%CI 1.79-9.80, p = 0.001), this risk increased to 7.5-folds (OR = 7.5, 95%CI 3.25-17.32, p<0.001) when the consumption of sugar was increased to > 6 servings per day. Daily 1 to 2-liter water intake was associated with 64% decreased BC risk (OR = 0.36, 95%CI 0.20-0.63, p = 0.001). While, no significant association were observed between consumption of full-fat dairy products (FFDP), olive oil, coffee intake and BC risk. Interestingly, daily 3 or more cups of tea intake were associated with 54% decreased risk of BC (OR = 0.46, 95% CI 0.22-0.98, p = 0.043). Conclusion: The study suggests that the risk of BC can be reduced by limiting the consumption of oil and sugar and increasing daily water intake more than a liter.  

scholarly journals A case–control study on seaweed consumption and the risk of breast cancer

2009 ◽  
Vol 103 (9) ◽  
pp. 1345-1353 ◽  
Author(s):  
Yoon Jung Yang ◽  
Seok-Jin Nam ◽  
Gu Kong ◽  
Mi Kyung Kim
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Menopausal Status ◽  
Daily Intake ◽  
Premenopausal Women ◽  
Case Control ◽  
Dietary Factors ◽  
Average Intake ◽  
Control Study

Gim (Porphyra sp.) and miyeok (Undaria pinnatifida) are the seaweeds most consumed by Koreans. We investigated the association between the intake of gim and miyeok and the risk of breast cancer in a case–control study. Cases were 362 women aged 30–65 years old, who were histologically confirmed to have breast cancer. Controls visiting the same hospital were matched to cases according to their age (sd 2 years) and menopausal status. Food intake was estimated by the quantitative FFQ with 121 items, including gim and miyeok. Conditional logistic regression analysis was used to obtain the OR and corresponding 95 % CI. The average intake and consumption frequency of gim in cases were lower than in controls. The daily intake of gim was inversely associated with the risk of breast cancer (5th v. 1st quintile, OR, 0·48; 95 % CI, 0·27, 0·86; P for trend, 0·026) after adjustment for potential confounders. After stratification analysis was performed according to menopausal status, premenopausal women (5th v. 1st quintile, OR, 0·44; 95 % CI, 0·24, 0·80; P for trend, 0·007) and postmenopausal women (5th v. 1st quintile, OR, 0·32; 95 % CI, 0·13, 0·80; P for trend, 0·06) showed similar inverse associations between gim intake and the risk of breast cancer after an adjustment for potential confounders except dietary factors. Miyeok consumption did not have any significant associations with breast cancer. These results suggest that high intake of gim may decrease the risk of breast cancer.

scholarly journals The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Chih-Chiang Hung ◽  
Youngsen Yang ◽  
I-Chen Tsai ◽  
Chiann-yi Hsu ◽  
Chia-Hua Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Liposomal Doxorubicin ◽  
Case Control Study ◽  
Pegylated Liposomal Doxorubicin ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Study Results ◽  
Control Study

Breast cancer is a global issue regarding women’s health, and high incident rates remain in the Taiwanese female population. Chemotherapy, using anthracycline-based chemotherapeutic agents in neoadjuvant settings, has been introduced as a promising new therapeutic option for treatment of invasive breast cancer. Set apart from conventional anthracycline regimens such as epirubicin, pegylated liposomal doxorubicin (Lipo-Dox®, PLD) was introduced for providing a justifiable treatment effect, while offering a favorable toxicity profile for breast cancer patients in a metastatic setting. However, the efficacy of PLD in neoadjuvant settings for breast cancer patients has not yet been sufficiently reported. This study aims to investigate the efficacy of PLD-based neoadjuvant chemotherapy in breast cancer patients using a retrospective matched case-control study. A total of 183 PLD cases and 183 epirubicin-based controls were included after a 1 : 1 ratio case-control matching procedure was held, according to the matching criteria. These criteria included the patient’s preoperative clinical stage, molecular subtype, chemotherapy regimen with taxanes prior to surgery, and histological grade. All data were collected according to an institutional review board approved protocol. The study results reported that the PLD and epirubicin groups both obtained similar outcomes in pathologic complete response (pCR), recurrence, and overall survival rate with no statistically significant differences. Overall, the study results demonstrate that PLD-based neoadjuvant chemotherapy offers a similar effect of treatment with a favorable toxicity profile within the study follow-up duration, when compared with conventional epirubicin-based neoadjuvant chemotherapy.

scholarly journals Exposure to organochlorine pesticides as a predictor to breast cancer: A case-control study among Ethiopian women

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257704
Author(s):  
Seblework Mekonen ◽  
Mohammedgezali Ibrahim ◽  
Higemengist Astatkie ◽  
Aynalem Abreha
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Organochlorine Pesticides ◽  
Case Control Study ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Study Results ◽  
Study Participants ◽  
Control Study

Breast cancer (BC) is becoming one of the most prevalent non-infectious disease in low and middle income countries. The steady rise of BC incidence may be related to the different risk factors. Among many, rampant presence of environmental pollutants might be one of the risk factors. Therefore, the aim of this study is to investigate exposure to organochlorine pesticides as a risk factor to breast cancer. A case-control study design was employed among breast cancer patients and non-breast cancer individuals (controls). Blood samples were collected from 100 study participants (50 cases and 50 controls) followed by serum separation, extraction and cleanup using standard analytical procdures. The findings revealed that ten organochlorine pesticides were detected in the serum of the study participants. From the detected organochlorine pesticides, heptachlor was observed at higher concentration for breast cancer patients (6.90±4.37 μg/L) and controls (9.15±3.84 μg/L). Mean serum level of p,p’-DDE, p,p’-DDT, heptachlor, gamma-chlordane, endosulfan, and dibutyl-chlorendate were significantly higher in the serum of breast cancer patients than the controls. From the studied pesticides, p,p’-DDT and gamma-chlordane are significant predictors for BC, while, others are equivocal. A unit increment of the concentration of p,p’-DDT (AOR; 2.03, 95% CI: 1.041–3.969) increased the odds of developing breast cancer by two, while for gamma-chlordane (AOR;3.12, 95% CI; 1.186–8.203) by three. Our study results suggesting that, organochlorines are a risk factors for breast cancer in Ethiopia. Decreasing exposure to such organochlorines might have a significant public health relevance in reducing non-communicable chronic illnesses. Besides, continues monitoring of persistent organic pollutants using body biomarkers is important for disease prevention and device mitigation measures.

Sign in / Sign up

Export Citation Format

Share Document