SYSTEMIC BLOOD FLOW IN INFANTS AND CHILDREN WITH AND WITHOUT HEART DISEASE

PEDIATRICS ◽  
1963 ◽  
Vol 32 (2) ◽  
pp. 186-201
Author(s):  
Glen G. Cayler ◽  
Abraham M. Rudolph ◽  
Alexander S. Nadas
Keyword(s):  
Cardiac Output ◽  
Heart Disease ◽  
Cardiac Index ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Close Correlation ◽  
Significant Difference ◽  
Normal Increase ◽  
Response To Exercise

A technique for measuring cardiac output by the Fick method in small infants during cardiac catheterization is described. Data on resting oxygen consumption, arteriovenous oxygen difference and systemic cardiac output is presented for a group of 126 subjects composed mainly of infants and young children with congenital heart disease. It was found that (a) there was no significant difference in mean resting cardiac index for patients with body surface area under 1.0 square meter regardless of the presence of, or the severity of, heart disease, and (b) patients with heart disease who were larger than 1.0 square meter had significantly lower mean cardiac indices and higher arteriovenous oxygen differences than the control patients. An excellent linear correlation of cardiac output to body surface area was found. There was also a close correlation between index and regression lines for cardiac output leading support to the validity of the cardiac index concept for comparing cardiac outputs in various sized patients. The normal increase in cardiac output during exercise is greater for children than for adults. Forty-seven per cent (8 of 17) children with heart disease showed low cardiac output response to exercise.

scholarly journals Study of thyroid volume by ultrasonography in clinically euthyroid patients

1970 ◽  
Vol 32 (2) ◽  
pp. 36-43 ◽  
Author(s):  
P Kayastha ◽  
S Paudel ◽  
DM Shrestha ◽  
RJ Ghimire ◽  
S Pradhan
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Reference Values ◽  
Body Surface ◽  
Pearson Correlation ◽  
Thyroid Volume ◽  
Specific Reference ◽  
Reference Ranges ◽  
Hilly Region ◽  
Significant Difference

Introduction: The purpose of this study was to establish reference ranges of total thyroid volume among clinically euthyroid Nepalese population using Ultrasonography and correlate this volume with age, sex, individual’s built and geographic location. Methods: This was a prospective cross sectional study involving 485 clinically euthyroid individuals. B - mode Ultrasonography was used to measure the total thyroid volume by combining the volume of both the lobes obtained by using formula for prolate ellipsoid. Age specific reference values for thyroid volume were obtained and Pearson correlation test was used to see the relationship with various factors. Results: Among 485 individuals between 1 to 83 years of age, 221(45.57%) were males and 264(54.43%) were females. Maximum [354 individuals (72.99%)] were from hilly region and minimum [16 individual (3.30%)] were from Himalayan region. Mean thyroid volume was 6.629 ± 2.5025 ml. In general, thyroid volume was found to be more in older individuals than in young age group. There was no significant difference of thyroid volume between males and females. Thyroid volume best correlated with body surface area (r=0.444, p<0.0001). The volume had a positive correlation with weight (r=0.443, p<0.0001), body mass index (r=0.371, p<0.0001) and height (r=0.320, p<0.0001) of the individual. Conclusions: This study estimated the reference range of total thyroid volume for Nepalese population. These ranges are significantly lower than the WHO/ICCIDD thyroid volume references and reference values obtained in various other countries. Total thyroid volume best correlated with Body surface area. Keywords: Body surface area; clinically euthyroid; total thyroid volume; ultrasonography DOI: http://dx.doi.org/10.3126/joim.v32i2.4944 Journal of Institute of Medicine, August, 2010; 32: 36-43

scholarly journals Increased mortality in women: sex differences in burn outcomes

2017 ◽  
Vol 5 ◽  
Author(s):  
Karen Karimi ◽  
Iris Faraklas ◽  
Giavonni Lewis ◽  
Daniel Ha ◽  
Bridget Walker ◽  
...  
Keyword(s):  
Sex Differences ◽  
Body Size ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Thermal Injury ◽  
Inhalation Injury ◽  
Inpatient Mortality ◽  
Burn Centers ◽  
Significant Difference

Abstract Background There is increasing evidence that sex differences may influence responses after thermal injury and affect clinical outcomes. The objective of this study was to evaluate the relationships between sex, thermal injury, body size, and inpatient mortality in burn patients. Methods Medical records of adults with &gt;20% total body surface area (TBSA) burn injury admitted to two American Burn Association (ABA)-verified burn centers between 2008 and 2014 were retrospectively reviewed. Injury details and baseline characteristics, including body size as estimated by body surface area (BSA) and body mass index (BMI) were recorded, along with details of the hospital course. The primary outcome of inpatient mortality was compared between sexes. Results Out of 334 subjects, 60 were women (18%). Median TBSA was 33% (IQR 25–49) in this cohort, with 19% full thickness burns and 30% inhalation injury. Despite no significant difference in age, presence of inhalation injury, TBSA, or depth of burn, women had significantly higher rates of inpatient mortality (45 vs. 29%, P = 0.01). BSA was significantly lower in women vs. men (P &lt; 0.001), but this difference was not more pronounced among non-survivors. There was no difference in BMI between men and women non-survivors. Although not significant (P = 0.28), women succumbed to their injuries sooner than men (day 4 vs. 10 post-injury). Conclusions Women are less likely to survive burn injuries and die sooner than men with similar injuries. Body size does not appear to modulate this effect. Burn centers should be aware of the higher mortality risk in women with large burns.

scholarly journals Usefulness of Cardiac Index to Predict Early and 30-Day Mortality in Non-Cardiac Patients Being Admitted to Intensive Care Units

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Vahan Moradians ◽  
Seyed Ali Javad Moosavi ◽  
Mohammad Niyakan Lahiji ◽  
Maryam Izadi
Keyword(s):  
Cardiac Output ◽  
Intensive Care ◽  
Cardiac Index ◽  
Surface Area ◽  
Intensive Care Units ◽  
Body Surface ◽  
Simplified Acute Physiology Score ◽  
The Body ◽  
Acute Physiology Score ◽  
Cardiac Patients

Introduction: Cardiac index is a hemodynamic parameter defined as the ratio of the cardiac output, i.e., the volume of blood ejected from the left ventricle in 1 min, to the body surface area. This study aimed to assess the cardiac index to predict early and 30-day outcomes of non-cardiac patients being admitted to intensive care units using a non-invasive approach. Materials and Methods: This prospective cohort study included 31 non-cardiac patients who were consecutively admitted to the intensive care units of Rasoul-e-Akram Hospital, Tehran, Iran, in 2016. On admission, the simplified acute physiology score II to predict mortality and the cardiac output (by two-dimensional echocardiography) of each patient were determined. The cardiac index was calculated by dividing the cardiac output by the body surface area. In-hospital mortality and complications were assessed, and the association between simplified acute physiology score II and cardiac index was determined. The patients were followed-up 30 days after discharge by telephone to determine late death, occurrence of myocardial infarction, readmission, or re-hospitalization. Results: The mean cardiac index was significantly lower among the patients who died in intensive care units than in those who survived (2.86 ± 0.63 versus 3.70 ± 0.49, p = 0.006). A significant inverse association was found between Simplified Acute Physiology Score II and cardiac index (r = −0.539, p = 0.002). The length of hospital and intensive care units stay was not associated with Simplified Acute Physiology Score -II or cardiac index. The receiver operating characteristic curve analysis revealed that the cardiac index was effective in predicting in intensive care units mortality (area under curve = 0.857, p = 0.007). The best cut-off value for the cardiac index to predict in intensive care units mortality was 3.35, yielding a sensitivity of 83.3% and a specificity of 80.0%. Conclusion: Measuring the cardiac index during intensive care units admission using a noninvasive approach even in non-cardiac patients can predict in intensive care units mortality with high sensitivity and specificity.

scholarly journals Determining Early Remodeling Patterns in Diabetes and Hypertension Using Cardiac Computed Tomography: The Feasibility of Assessing Early LV Geometric Changes

2020 ◽  
Vol 33 (6) ◽  
pp. 496-504
Author(s):  
Jeroen Walpot ◽  
Joao R Inácio ◽  
Samia Massalha ◽  
Alomgir Hossain ◽  
Gary R Small ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Heart Disease ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Cardiac Computed Tomography ◽  
Structural Heart Disease ◽  
Left Ventricular ◽  
Cardiac Computed Tomography Angiography ◽  
Geometric Changes

Abstract BACKGROUND There is conflicting data on early left ventricle (LV) remodeling in diabetes mellitus (DM) and hypertension (HTN). This study examines the feasibility of cardiac computed tomography angiography (CCTA) to detect early LV geometric changes in patients with DM and HTN. METHODS Consecutive patients (n = 5,992) who underwent prospective electrocardiography (ECG)-triggered (mid-diastolic) CCTA were screened. Patients with known structural heart disease or known LV dysfunction were excluded. Left ventricular mass (LVM), left ventricular mid-diastolic volume (LVMDV), and LV concentricity (LVM/LVMDV) were measured and indexed to body surface area. RESULTS A total of 4,283 patients were analyzed (mean age 57 ± 10.69 years, female 46.7%). DM, HTN, and HTN + DM were present in 4.1%, 35.8% and 10.6% of patients, respectively. Compared to normal patients, HTN and HTN + DM patients had increased LVM indexed to body surface area (LVMi) (56.87 ± 17.24, 59.26 ± 13.62, and 58.56 ± 13.09, respectively; P &lt; 0.05). There was no difference in LVMi between normal subjects and patients with DM (56.39 ± 11.50, P = 0.617). Concentricity indices were higher in patient with HTN (1.0456 ± 0.417; P &lt; 0.001), DM (1.109 ± 0.638; P = 0.004), and HTN + DM (1.083 ± 0.311, P &lt; 0.001) than normal individuals (0.9671 ± 0.361). There was no overlap of the 95% confidence intervals in the composite of concentricity indices and LVMi between the different groups. CONCLUSIONS CCTA measures of LVM and concentricity index may discriminate patients with HTN and DM before overt structural heart disease.

Fallacy of indexing renal and systemic hemodynamic measurements for body surface area

1995 ◽  
Vol 268 (4) ◽  
pp. R978-R988 ◽  
Author(s):  
S. T. Turner ◽  
S. L. Reilly
Keyword(s):  
Cardiac Output ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Indexing Method

Renal plasma flow, glomerular filtration rate, and cardiac output are traditionally indexed for body surface area by expressing these traits as per-surface-area ratios. Indexing is intended to remove interindividual variation attributable to differences in body size. Regression is an alternative method commonly used to adjust other biological traits for the effects of a covariate, such as body surface area. The purpose of this study was to compare the indexing and regression methods of adjusting renal plasma flow, glomerular filtration rate, and cardiac output for interindividual differences in body surface area. We estimated renal plasma flow by the clearance of p-aminohippurate, glomerular filtration rate by clearance of inulin, and cardiac output by thoracic electrical impedance in a sample of 78 unrelated females and 78 unrelated males (ages 20-49.9 yr) from the general population of Rochester, MN. The indexing method created negative dependencies of renal plasma flow and cardiac output on body surface area and failed to eliminate the positive dependency of glomerular filtration rate on body surface area. Moreover, indexing obscured differences in mean renal plasma flow between females and males and created differences in mean cardiac output between the genders. In contrast, the regression method consistently eliminated dependencies of each trait on body surface area and did not lead to inappropriate inferences about mean differences in these traits between females and males. We conclude that the indexing method of adjusting renal plasma flow, glomerular filtration rate, and cardiac output for interindividual differences in body surface area should be abandoned and replaced by use of the regression method.

Determination of body surface area in Indian Hindu children

1961 ◽  
Vol 16 (6) ◽  
pp. 969-970 ◽  
Author(s):  
Sachchidananda Banerjee ◽  
Ashim Kumar Bhattacharya
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Indian Children ◽  
Du Bois ◽  
Significant Difference ◽  
New Equation ◽  
New Formula

Body surface area (BSA) was actually measured in 13 Indian Hindu children, of ages varying between 3 and 12 yr, with tape and surface integrator. In 9 out of 13 children the results obtained were lower than the BSA calculated with the weight-height formula of Du Bois and Du Bois. Based on the actual measurements, a new constant for the weight-height formula was obtained and a new equation: surface area, cm2 = weight 0.425 kg x height 0.725 cm x 70, has been suggested for the BSA of Indian children. A nomogram for reading off surface area in metric units based on the above formula was prepared. A significant difference existed between the BSA calculated with the new formula and that of Du Bois and Du Bois. Submitted on December 30, 1960

scholarly journals The clinical implications of body surface area as a poor proxy for cardiac output

2021 ◽  
Author(s):  
Michiel D. Vriesendorp ◽  
Rolf H.H. Groenwold ◽  
Howard C. Herrmann ◽  
Stuart J. Head ◽  
Rob A.F. De Lind Van Wijngaarden ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Clinical Implications

scholarly journals Dural sac localization using myelography and its application to the lumbosacral epidural in dogs

2021 ◽  
Vol 10 (4) ◽  
pp. 371-376
Author(s):  
Ana Zapata ◽  
Carlos Ros ◽  
Elena Ríos Álvarez ◽  
Myriam Martin ◽  
Alejandra García De Carellán Mateo
Keyword(s):  
Body Weight ◽  
Surface Area ◽  
Body Surface Area ◽  
Epidural Space ◽  
Body Surface ◽  
Epidural Injection ◽  
Dural Sac ◽  
Needle Position ◽  
Significant Difference ◽  
The Relationship

Background: The techniques described for the identification of the lumbosacral (LS) epidural space in dogs do not guarantee the needle position or an accidental subarachnoid puncture, especially in small size dogs.Aim: To determine the relationship between body weight and the location of the dural sac (DS) using myelography in dogs, and to determine the possibility of subarachnoid puncture during LS epidural based on the position of the DS.Methods: Four masked observers evaluated 70 myelographic studies of dogs, annotating the vertebrae where the DS ended, if it was localized before or after the LS space, and if accidental subarachnoid puncture during LS epidural injection was possible (yes/no). Body weight (kg) was categorized into: less than 10 kg, between 10 and 20 kg, and more than 20 kg and was also converted to body surface area (BSA) as a continuous variable.Results: The DS ended at the LS space or caudally in 50% of dogs. There was a statistically significant difference between the position of the DS and the dog’s BSA (p = 0.001). The DS ended caudal to the LS space in 72.7% of dogs weighing <10 kg, in 25% of dogs between 10 and 20 kg and in 15% of dogs in the >20 kg category. The observers considered a possible subarachnoid puncture during LS epidural in 69.7% of patients <10 kg, 16.6% on those between 10 and 20 kg, and in 11.7% of the dogs >20 kg.Conclusion: The DS ended caudal to the LS space in almost 3/4 dogs in the <10 kg category, so accidental subarachnoid puncture during LS epidural is highly possible in this weight range.

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