CONGENITAL HYPOPLASIA OF THE ADRENAL GLANDS

PEDIATRICS ◽  
1965 ◽  
Vol 35 (1) ◽  
pp. 70-75
Author(s):  
Anadil Roselli ◽  
Luiz Torres Barbosa

The cases of two sisters with extreme bilateral adrenal hypoplasia, verified at necropsy, have been presented. Two other siblings died in infancy with symptoms which make it very likely that they also had adrenal hypoplasia. A review of the medical literature revealed 23 cases in which necropsy had been performed. These included 15 males and 8 females as well as one set of twins and 3 siblings. Although the incidence of reported cases of adrenal hypoplasia is low, the authors suggest that many cases may have been missed in the past. The clinical picture and possible etiology of this condition have been discussed.

1967 ◽  
Vol 56 (6) ◽  
pp. 665-670 ◽  
Author(s):  
GJERMUND FLUGE ◽  
PETER JOHAN MOE
Keyword(s):  

Author(s):  
Awad A. Shehata ◽  
Dörte Lüschow ◽  
Hafez M. Hafez

Marek's disease (MD), caused by a highly contagious and oncogenic herpesvirus, causes immunosuppression and tumors in chickens. Although several reports on the occurring lymphomas (MD-like conditions) in turkeys have been published, less attention has been paid to the disease in this species. Recently, Marek's disease virus (MDV) has been demonstrated in lymphomatous tumors in commercial turkeys in several countries. The present review aimed to describe the past and recent situation of MD in turkeys, including clinical picture and methods used for diagnosis. Additionally, three hypotheses that might explain the emergence of MDV in turkeys, including virus evolution and evolution of MDV variants, modern hybrid turkeys, and raising of turkeys close to chickens, were discussed. The pathogenesis of MDV infection in turkeys remains unclear, and further investigations are necessary. Although herpesvirus of turkey (HVT) vaccine didn't protect turkeys against challenge with a virulent MDV, Rispens strain is effective, highlighting the need for further assessment of the effectiveness of MDV vaccines in turkeys.


1985 ◽  
Vol 99 (10) ◽  
pp. 953-966 ◽  
Author(s):  
N. Black

SummaryOver the past one hundred years medical views on the cause of glue ear have frequently changed. The medical literature was reviewed to see if these changes reflected advances in the level of scientific support for different causes. This revealed that only a few of the many proposed causes command any scientific support. An explanation for the changing pattern of views on the aetiology of glue ear was therefore sought by considering secular changes in medical knowledge and belief in general. This suggested that the views held on the cause of glue ear at any given time are influenced and largely determined by the prevailing knowledge and beliefs of medicine as a whole. This phenomenon is not peculiar to glue ear—though conditions about which there is considerable uncertainty are probably more susceptible to such influences.


1999 ◽  
Vol 33 (4) ◽  
pp. 594-597 ◽  
Author(s):  
Mani Rajagopalan ◽  
John Little

Objective: We report a patient who developed discontinuation symptoms following nefazodone cessation. Clinical picture: The patient experienced nausea, vomiting, diarrhoea, ataxia, insomnia, marked agitation, headache and flu-like symptoms. Treatment: She was reluctant to recommence nefazodone and was symptomati-cally treated with oxazepam. Outcome: The patient recovered completely in 10 days. Conclusions: Nefazodone discontinuation can result in withdrawal symptoms and therefore needs to be tapered gradually. Those who have experienced discontinuation symptoms with other antidepressants in the past may be at increased risk.


Rare Tumors ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 153-154 ◽  
Author(s):  
Cristian Lolli ◽  
Maria Abbondanza Pantaleo ◽  
Margherita Nannini ◽  
Maristella Saponara ◽  
Maria Caterina Pallotti ◽  
...  

Gastrointestinal stromal tumors (GISTs) are known to be poorly responsive to conventional chemotherapy and historically considered resistant to radiotherapy. In the past the mainstay of GIST treatment was surgery, but the introduction of tyrosine kinase inhibitors (TKIs) imatinib and sunitinib marked the beginning of a new era in the treatment of GIST patients. To date, radiotherapy for GIST has not been administered in clinical practice except for limited palliative settings and there are no clear data on the administration of radiotherapy, alone or in combination with TKIs, with a purely cytoreductive intent. We describe the clinical case of a 48-year-old woman with metastatic GIST treated with external radiotherapy in a critical supraclavicular tumor localization progressively increasing in size with several symptoms and not responsive to systemic TKI therapies. We obtained an initial shrinkage of the mass and subsequent stabilization with an immediate and clear clinical benefit. Although the historical medical literature considered GISTs resistant to radiation therapy, our clinical case suggests this treatment may be appropriate in selected patients.


2021 ◽  
Vol 27 (2) ◽  
pp. 78-83
Author(s):  
Denislav Biserov ◽  
Mariana Konteva ◽  
Ivaneta Yoncheva ◽  
Svetoslav Gogov

Radiation therapy is the main treatment for a large number of neoplastic diseases. Improved survival in this group of patients led to the emergence of a new nosological unit – radiation-induced damage to neighbouring organs and systems. Data accumulated in recent decades has proven conclusively that chest radiotherapy could result in heart damage. Cardiovascular diseases are the leading cause of death in oncological patients in remission. The onset of radiation-induced heart disease (RIHD) can be early with clinical picture of acute myocarditis and late with manifestations of constrictive pericarditis, restrictive cardiomyopathy, coronary artery disease, valvular involvement, heart failure and conduction pathology. Clinical symptoms may manifest years after exposure to radiation. Our team performed a mini-review on the topic, after which we shared our own experience in 10 patients who underwent radiation therapy in the past and were admitted to the Clinic of Cardiology of University Multyprofile Hospital for Active Treatment „Deva Mariya“ with a clinical picture of ACS.


2019 ◽  
Vol 10 ◽  
pp. 166 ◽  
Author(s):  
Georges Sinclair ◽  
Yahya Al-saffar ◽  
Philippa Johnstone ◽  
Mustafa Aziz Hatiboglu ◽  
Alia Shamikh

Background: Cases of gliomas coexisting with multiple sclerosis (MS) have been described over the past few decades. However, due to the complex clinical and radiological traits inherent to both entities, this concurrent phenomenon remains difficult to diagnose. Much has been debated about whether this coexistence is incidental or mirrors a poorly understood neoplastic phenomenon engaging glial cells in the regions of demyelination. Case Description: We present the case of a 41-year-old patient diagnosed with a left-sided frontal contrast enhancing lesion initially assessed as a tumefactive MS. Despite systemic treatment, the patient gradually developed signs of mass effect, which led to decompressive surgery. The initial microscopic evaluation demonstrated the presence of MS and oligodendroglioma; the postoperative evolution proved complex due to a series of MS-relapses and tumor recurrence. An ulterior revaluation of the samples for the purpose of this report showed an MS-concurrent anaplastic astrocytoma. We describe all relevant clinical aspects of this case and review the medical literature for possible causal mechanisms. Conclusion: Although cases of concurrent glioma and MS remain rare, we present a case illustrating this phenomenon and explore a number of theories behind a potential causal relationship.


Author(s):  
Susan North

Sweet and Clean? Bodies and Clothes in Early Modern England challenges the widely held beliefs on bathing and cleanliness in the past. For over 30 years, the work of the French historian, George Vigarello, has been hugely influential on early modern European social history, describing an aversion to water and bathing, and the use of linen underwear as the sole cleaning agent for the body. However, these concepts do not apply to early modern England. Sweet and Clean? analyses etiquette and medical literature revealing repeated recommendations to wash or bathe in order to clean the skin. Clean linen was essential for propriety but advice from medical experts was contradictory. Many doctors were convinced that it prevented the spread of contagious diseases, but others recommended flannel for undergarments, and a few thought changing a fever patient’s linens was dangerous. The methodology of material culture helps determine if and how this advice was practised. Evidence from inventories, household accounts and manuals, and surviving linen garments tracks underwear through its life-cycle of production, making, wearing, laundering, and final recycling. Although the material culture of washing bodies is much sparser, other sources, such as the Old Bailey records, paint a more accurate picture of cleanliness in early modern England than has been previously described. The contrasting analyses of linen and bodies reveal what histories material culture best serves. Finally, what of the diseases—plague, smallpox, and typhus—that cleanliness of body and clothes were thought to prevent? Did following early modern medical advice protect people from these illnesses?


1936 ◽  
Vol 32 (8) ◽  
pp. 917-923
Author(s):  
M. Z. Rothenfeld

X-rays, creating favorable conditions for optimal determination of air in the pleural cavity, greatly facilitated the diagnosis of spontaneous pneumothorax and enriched our experience in this matter. "Over the past few years, there has been a rich literature on spontaneous pneumothorax. Numerous cases of spontaneous pneumothorax with the most unexpected etiology and the most diverse clinical picture have been published, which gave an impetus to revise our previous attitudes on the issue of spontaneous pneumothorax and, first of all, its pathogenesis.


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