Coronal Craniostenosis: Fetal Head Constraint as One Possible Cause

A retrospective study of 11 instances of idiopathic coronal craniostenosis in otherwise normal children revealed that early lightening, prolonged moderate to severe pelvic discomfort late in pregnancy, and/or an abnormal fetal lie were unusual gestational features indicative of intrauterine constraint for eight of these patients. The impression of unusual constraint in utero was futher implied by finding associated positional foot deformities in four of these latter eight children. We hypothesize that prolonged constraint of the fetal head may limit anteroposterior growth stretch at the coronal suture and thereby predispose toward early sutural fusion.

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Sagittal craniostenosis: Fetal head constraint as one possible cause

The Journal of Pediatrics ◽

10.1016/s0022-3476(79)80728-3 ◽

1979 ◽

Vol 95 (5) ◽

pp. 747-750 ◽

Cited By ~ 93

Author(s):

John M. Graham ◽

Margot deSaxe ◽

David W. Smith

Keyword(s):

Fetal Head ◽

Possible Cause

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Vertebral malformation in the mouse foetus caused by X-radiation of the mother during pregnancy

Development ◽

10.1242/dev.12.4.841 ◽

1964 ◽

Vol 12 (4) ◽

pp. 841-850

Author(s):

Ujihiro Murakami ◽

Yoshiro Kameyama

Keyword(s):

Early Pregnancy ◽

Vertebral Column ◽

Strain Differences ◽

In Utero ◽

Oxygen Deprivation ◽

Experimental Animals ◽

Vertebral Malformation ◽

Pregnant Mice ◽

Maternal Hypoxia ◽

In Pregnancy

Maternal hypoxia in early pregnancy can result in malformations of the vertebrae of mouse foetuses, and there is a tendency for more posterior vertebrae to be affected the later in pregnancy the oxygen deprivation occurs (Murakami & Kameyama, 1963). Ingalls et al. (1957) and Degenhardt (1954, 1959) had earlier obtained similar results. We have also exposed pregnant mice to X-radiation and studied the consequent malformations. The effects on the extremities have already been described (Murakami, Kameyama & Nogami, 1963), and in the present paper we shall describe the effects on the vertebral column. Vertebral malformations in animals irradiated in utero have been described by Job, Leibold & Fitzmaurice (1935), Warkany and Schraffenberger (1947), Russell. (1950, 1954), and Russell & Russell (1954). In order to obtain results comparable with those of our experiments with hypoxia, no less than to detect inter-strain differences, we used mice of the ddN and CF1 strains originally supplied by the Central Laboratories for Experimental Animals, Tokyo (Zikkendobutsu Chuo Kenkyujo).

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Neurodevelopment following exposure to antiseizure medications in utero: a review

Current Neuropharmacology ◽

10.2174/1570159x19666210716111814 ◽

2021 ◽

Vol 19 ◽

Author(s):

Rebecca L Bromley ◽

Matthew Bluett-Duncan

Keyword(s):

Lower Risk ◽

In Utero ◽

Neurodevelopmental Outcomes ◽

Unexposed Control ◽

Long Period ◽

Risks And Benefits ◽

Limited Experience ◽

Potential Impact ◽

Child's Brain ◽

In Pregnancy

: Exposure in the womb to antiseizure medications and their potential impact on the developing child's brain has long been researched. Despite this long period of interest, this review highlights above the well-known risks associated with valproate exposure; more data is required for conclusions regarding all other antiseizure medications. Limited experience with phenytoin and phenobarbital in monotherapy clearly defines the risk to later child postnatal functioning difficult. However, the evidence of an impact is stronger for phenobarbital than for phenytoin. The widely prescribed lamotrigine is limited in its investigation compared to unexposed control children. It has been demonstrated to carry a lower risk than valproate for specific outcomes; whether associated with a more moderate impact on broader aspects of neurodevelopmental functioning is still to be understood. Data for levetiracetam, topiramate, and oxcarbazepine are too limited to conclude most neurodevelopmental outcomes confidently. This slow accumulation of evidence impacts the safest use of medications in pregnancy and makes counseling women regarding the risks and benefits of specific antiseizure drugs difficult. Improved focus, funding, and research methodologies are urgently needed.

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A retrospective study of the health profile of neonates of mothers with anemia in pregnancy and pregnancy induced hypertension in Lagos, Nigeria

Journal of Public Health in Africa ◽

10.4081/jphia.2014.286 ◽

2014 ◽

Vol 5 (2) ◽

Cited By ~ 1

Author(s):

Olusola Funmilayo Sotunde ◽

Silifat Ajoke Sanni ◽

Oluseye Olusegun Onabanjo ◽

Ibiyemi O. Olayiwola ◽

Mure Agbonlahor

Keyword(s):

Retrospective Study ◽

Birth Weight ◽

Sampling Technique ◽

Neonatal Health ◽

Pregnancy Induced Hypertension ◽

Health Profile ◽

Maternal Complications ◽

Induced Hypertension ◽

Anemia In Pregnancy ◽

In Pregnancy

Our study assessed the health profile of neonates in relation to anemia in pregnancy and pregnancy induced hypertension (PIH). This was a retrospective study where a systematic random sampling technique was used to select a total of 1046 case records of pregnant women registered for ante-natal care at Lagos Island Maternity Hospital, Lagos, Nigeria, between 2005 and 2009. Socio-demographic characteristics of the mothers, prevalence of anemia and PIH, and neonatal health profile were obtained from the case records and were analyzed using both descriptive and inferential statistics. Pearson product moment correlation was used to show the relationship (P≤0.05) between maternal complications and neonatal health profile. Majority (68.8%) of the mothers had anemia and 6.7 % had PIH. Majority (97.12%) of the neonates were live births and 2.88% of the neonates were still births, 65.4% of the women with still birth pregnancy outcome had anemia, and 34.6% had PIH. Majority (74%) of the neonates had birth weight within normal range (2.5-4.0 kg) and majority (68%) had normal Apgar score at 5 min of birth (7- 10). A positive correlation existed between the packed cell volume of the mother and the birth weight of the neonates (r=0.740, P≤0.05). A negative correlation existed between the incidence of PIH and the birth weight of the neonates (r=

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Descent of Fetal Head into The Pelvic Inlet in Primigravida: Systematic Review

Sumatera Medical Journal ◽

10.32734/sumej.v4i2.5845 ◽

2021 ◽

Vol 4 (2) ◽

Author(s):

Imanuel Sihotang ◽

Makmur Sitepu ◽

Muhammad Rusda

Keyword(s):

Systematic Review ◽

Antenatal Care ◽

Pelvic Cavity ◽

Fetal Head ◽

Pregnancy And Childbirth ◽

The World ◽

Pelvic Inlet ◽

Review Study ◽

In Pregnancy

Background: Skilled care before, during and after delivery can save the lives of women and newborns. Antenatal care is useful for detecting problems in pregnancy and childbirth, as well as preparing for labor. It is estimated that labor will begin 2-3 weeks after the entry of the fetal head on pelvic inlet. Objective: This study was conducted to determine the prevalence of descending of the fetal head at the pelvic inlet in the primigravida of 34-36 weeks of gestation. Methods: This study uses a systematic review study method with the data used are the results of research that have been circulating in the world. Results: In Weekes and Flynn's (1975) study, the entry of the fetal head into the pelvic cavity and having passed the pelvic inlet with a sample of 422 primigravidas, the prevalence was 34 weeks (2%), 35 weeks (1%). Of the three studies analyzed at 36 weeks' gestation, a prevalence was 4.22%.

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Acute Appendicitis in Pregnancy

Scottish Medical Journal ◽

10.1177/003693308002500108 ◽

1980 ◽

Vol 25 (1) ◽

pp. 36-38 ◽

Cited By ~ 7

Author(s):

R. G. Farquharson

Keyword(s):

Retrospective Study ◽

Acute Appendicitis ◽

Neonatal Mortality ◽

Maternal Morbidity ◽

Causal Factor ◽

Delay In Diagnosis ◽

In Pregnancy

A retrospective study of appendicitis in pregnancy in Aberdeen has been performed. The incidence, symptoms, findings at laparotomy and outcome are described. Delay in diagnosis is stressed as the causal factor in increased maternal morbidity and high neonatal mortality.

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