New International Classification of Retinopathy of Prematurity

PEDIATRICS ◽  
1984 ◽  
Vol 74 (1) ◽  
pp. 160-161
Author(s):  
ARNALL PATZ
Keyword(s):  
Birth Weight ◽  
Survival Rate ◽  
Low Birth Weight ◽  
Premature Infants ◽  
Retinopathy Of Prematurity ◽  
International Classification ◽  
Low Birth Weight Infants ◽  
Retrolental Fibroplasia ◽  
Epidemic Period

The new international classification of the acute retinopathy of prematurity appearing in this issue1 is a timely and important contribution to the ocular examination and management of the retinopathy in these premature infants. During the epidemic period of the retinopathy of prematurity, generally designated then as retrolental fibroplasia, the survival rate of very small premature infants with birth weight less than 1,000 g was less than 10%. By the 1980s, due to improved neonatal care, that survival rate has increased by fourfold or greater. These low-birth-weight infants, who are at the highest risk of developing the retinopathy of prematurity, are surviving today, but in the early 1950s they would not have lived long enough to develop the disease.

d-Penicillamine and Retinopathy of Prematurity

PEDIATRICS ◽  
1988 ◽  
Vol 82 (6) ◽  
pp. 951-952
Author(s):  
LAJOS LAKATOS
Keyword(s):  
Birth Weight ◽  
Vitamin E ◽  
Low Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Marked Decrease ◽  
Neonatal Period ◽  
Low Birth Weight Infants ◽  
Retrolental Fibroplasia ◽  
Clinical Observations

To the Editor.— The letter to the editor by Johnson et al1 and studies by others regarding vitamin E prophylaxis for retinopathy of prematurity suggest that further research into the prevention of retinopathy of prematurity should not be limited to vitamin E. On the basis of clinical observations we reported that d-penicillamine treatment in the neonatal period was associated with a marked decrease in the incidence of severe retrolental fibroplasia among the very low birth weight infants.2

scholarly journals Survival rate dependent variations in retinopathy of prematurity treatment rates in very low birth weight infants

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jae Hyun Park ◽  
Jong Hee Hwang ◽  
Yun Sil Chang ◽  
Myung Hee Lee ◽  
Won Soon Park
Keyword(s):  
Birth Weight ◽  
Survival Rate ◽  
Low Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Target Range ◽  
Treatment Rate ◽  
Low Birth Weight Infants ◽  
Rate Dependent ◽  
Group I

Abstract As increased oxidative stress causes increased mortality and morbidities like bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) in very low birth weight infants (VLBWIs), the conundrum of improved survival but increased ROP observed with the high oxygen saturation target range of 91–95% is difficult to explain. To determine the survival rate-dependent variation in ROP treatment rate, 6292 surviving eligible VLBWIs registered in the Korean Neonatal Network were arbitrarily grouped according to the survival rate of infants at 23–24 weeks’ gestation as group I (> 70%, n = 1626), group II (40–70%, n = 2984) and group III (< 40%, n = 1682). Despite significantly higher survival and lower BPD rates in group I than in groups II and III, the ROP treatment rate was higher in group I than in groups II and III. However, the adjusted odds ratios for ROP treatment were not significantly different between the study groups, and the ROP treatment rate in the infants at 23–24 weeks’ gestation was 21-fold higher than the infants at ≥ 27 weeks’ gestation. The controversial association between improved survival and reduced BPD reflecting quality improvement of neonatal intensive care but increased ROP treatment rate might be primarily attributed to the improved survival of the most immature infants.

NEW CONCERNS ABOUT THERAPIES FOR RETINOPATHY OF PREMATURITY

PEDIATRICS ◽  
1996 ◽  
Vol 98 (6) ◽  
pp. A30-A30
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Premature Infants ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Patient Characteristics ◽  
Low Birth Weight Infants ◽  
Factors Associated ◽  
Corrected Visual Acuity

Purpose. Cryotherapy for retinopathy of prematurity (ROP) is effective in reducing the incidence of blindness in premature infants. However, macular complications associated with successful treatment have not yet been well studied. Methods. Eighteen very low birth weight (&lt;1251 g) infants (32 eyes) who received cryotherapy for ROP were examined serially for regression of disease and for development of macular abnormalities. Patient characteristics and treatment factors were evaluated to identify risk factors associated with the development of macular abnormalities after successful cryotherapy. Results. Eleven of 32 eyes (34.4%) that had undergone cryotherapy developed significant macular abnormalities, including macular coloboma-like change (six eyes), macular hyperpigmentation (two eyes), irregularly mottled macular hyperpigmentation and hypopigmentation (two eyes), and macular hyperpigmentation and hypopigmentation with subretinal proliferation (one eye). Corrected visual acuity in affected eyes ranged from 0.15 to 0.03 (20/133 to 20/666) compared with 1.0 to 0.2 (20/20 to 20/100) in treated eyes without macular abnormality (P = .0002). No difference in gestational age was noted between infants who did or did not develop macular coloboma-like lesions or pigment abnormalities. Eyes with macular abnormality had more posterior disease (P = .037) and received significantly more cryotherapy than did eyes without macular abnormality (P = .0005). Conclusions. In very low birth weight infants receiving cryotherapy for ROP, development of macular coloboma-like lesions and macular pigment abnormalities were related to greater severity of ROP and a greater amount of cryotherapy. Macular abnormalities were associated with markedly worse visual outcomes than were treated eyes without macular abnormality.

Arterial Catheters, Endothelin, and ROP

PEDIATRICS ◽  
1991 ◽  
Vol 88 (4) ◽  
pp. 874-875
Author(s):  
ITSURO YAMANOUCHI ◽  
IKUKO IGARASHI
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Retinopathy Of Prematurity ◽  
Very Low Birth Weight ◽  
Medical Center ◽  
International Classification ◽  
National Hospital ◽  
Vlbw Infants

To the Editor.— During the 15 years from 1976 to 1990, a total of 615 cases of very low birth weight (VLBW) infants weighing between 500 and 1500 g were treated at the Okayama National Hospital Children's Medical Center. 497 of them survived. There were 121 cases of retinopathy of prematurity (ROP), 15 of which were treated with cryocoagulation. The Table shows the classification of the VLBW cases according to birth weight and International Classification of ROP.

Massive studies, minimal progress

PEDIATRICS ◽  
1977 ◽  
Vol 60 (5) ◽  
pp. 756-756
Author(s):  
J. F. L.
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Peer Group ◽  
Blood Gas ◽  
Low Birth Weight Infants ◽  
Multicenter Studies ◽  
Retrolental Fibroplasia ◽  
University Centers

Large, expensive, multidisciplined, multicenter studies present special problems to journals. The study by Kinsey et al. in this issue (p. 655) is a good example. This study was designed by a distinguished peer group. It was carried out in five university centers by 27 investigators, written up for publication by ten authors, evaluated by statisticians, and was ready for publication nearly nine years after the research was first begun. The goal of the study was a very good one. The authors hoped to define the level of PaO2 and the duration of exposure which could result in retrolental fibroplasia. Nearly 10,000 blood gas studies were carried out on 589 low-birth-weight infants.

Retrolental Fibroplasia and Blood Transfusion in Very Low-Birth-Weight Infants

PEDIATRICS ◽  
1981 ◽  
Vol 68 (6) ◽  
pp. 770-774 ◽  
Author(s):  
Linda M. Sacks ◽  
David B. Schaffer ◽  
Endla K. Anday ◽  
George J. Peckham ◽  
Maria Delivoria-Papadopoulos
Keyword(s):  
Birth Weight ◽  
Blood Transfusion ◽  
Low Birth Weight ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Very Low Birth Weight ◽  
Statistical Significance ◽  
Low Birth Weight Infants ◽  
Retrolental Fibroplasia ◽  
Packed Red Blood Cells

The relative contribution of transfusions of adult blood to the development of retrolental fibroplasia (RLF) in very low-birth-weight infants was examined. Five years of experience with the expanded use of replacement and exchange transfusions in 90 infants with birth weight ≤1,250 gm was reviewed. Twenty percent of the infants developed cicatricial RLF. Exchange transfusion was not related to development of cicatricial RLF. The incidence of RLF in infants receiving ≥130 ml of packed red blood cells per kilogram of birth weight as replacement blood transfusion (RBT) was significantly higher (42.9%) than that in infants receiving 61 to 131 ml of packed red blood cells per kilogram (15.4%) and infants receiving ≤60 ml of packed red blood cells per kilogram (0%), P &lt; .001. The need for RBT, however, was strongly correlated (r = .85, P &lt; .001) with increasing duration of O2 therapy. When O2 therapy was controlled for, the association between RBT and RLF did not achieve statistical significance (P = .07). The association between RBT and RLF remained significant when adjusted for duration of therapy in fractional inspired oxygen (FIO2) &gt;0.4. Further detailed studies of large numbers of susceptible infants are warranted to assess the magnitude of the contribution of transfusions of adult blood to development of RLF.

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