Relationship Between Bilirubin and Hearing Loss

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 929-930
Author(s):  
LINDA S. DE VRIES
Keyword(s):  
Hearing Loss ◽  
High Risk ◽  
Sensorineural Deafness ◽  
Hyaline Membrane Disease ◽  
Unusual Event ◽  
Hyaline Membrane

In Reply.— We were most interested in Gallaher and Maisels' comments on our paper. Although they mention that sensorineural deafness is an unusual event in their experience, they do not provide us with an incidence and also do not mention their method for testing hearing. Most of our infants, were classified as high risk because they required ventilation for hyaline membrane disease. The ten deaf infants who were high risk and their ten matched controls were all ventilated.

Relationship Between Bilirubin and Hearing Loss

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 929-929
Author(s):  
KEITH J. GALLAHER ◽  
M. JEFFREY MAISELS
Keyword(s):  
Hearing Loss ◽  
Birth Weight ◽  
High Risk ◽  
Low Birth Weight ◽  
Serum Bilirubin ◽  
Sensorineural Deafness ◽  
Potential Influence ◽  
Low Birth Weight Infants ◽  
Lower Serum ◽  
Similar Association

To the Editor.— De Vries et al1 describe an interesting association between serum bilirubin levels > 14 mg/dL and sensorineural deafness in low birth weight infants. A similar association (in infants who were exposed to lower serum bilirubin levels) was reported by Bergman et al.2 These results are important because of their potential influence on how we treat these infants, yet they raise certain questions. The authors classified infants as "high risk" or "low risk" based on the presence of certain "adverse factors," but they do not tell us about the distribution of these factors in the study patients.

A Community Based High Risk Register for Hearing Loss

1982 ◽  
Vol 47 (4) ◽  
pp. 373-375 ◽  
Author(s):  
James L. Fitch ◽  
Thomas F. Williams ◽  
Josephine E. Etienne
Keyword(s):  
Hearing Loss ◽  
System Identification ◽  
High Risk ◽  
Language Learning ◽  
Education Program ◽  
Communication System ◽  
Auditory Signal ◽  
Early Age ◽  
Community Based ◽  
Children With Hearing Loss

The critical need to identify children with hearing loss and provide treatment at the earliest possible age has become increasingly apparent in recent years (Northern & Downs, 1978). Reduction of the auditory signal during the critical language-learning period can severely limit the child's potential for developing a complete, effective communication system. Identification and treatment of children having handicapping conditions at an early age has gained impetus through the Handicapped Children's Early Education Program (HCEEP) projects funded by the Bureau of Education for the Handicapped (BEH).

A Community Based High Risk Register for Hearing Loss

1983 ◽  
Vol 48 (1) ◽  
pp. 110-110
Keyword(s):  
Hearing Loss ◽  
High Risk ◽  
Community Based

For the November 1982 JSHD article, "A Community Based High Risk Register for Hearing Loss," the author would like to acknowledge three additional individuals who made valuable contributions to the study. They are Marie Carrier, Gene Lyon, and Bobbie Robertson.

scholarly journals IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1686
Author(s):  
Adelaida M. Celaya ◽  
Lourdes Rodríguez-de la Rosa ◽  
Jose M. Bermúdez-Muñoz ◽  
José M. Zubeldia ◽  
Carlos Romá-Mateo ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inflammatory Cytokines ◽  
Noise Exposure ◽  
Sensorineural Deafness ◽  
Serum Levels ◽  
Genetic Syndromes ◽  
Expression Ratio ◽  
Postnatal Maturation ◽  
Age Related ◽  
Underlying Mechanisms

Insulin-like growth factor 1 (IGF-1) deficiency is an ultrarare syndromic human sensorineural deafness. Accordingly, IGF-1 is essential for the postnatal maturation of the cochlea and the correct wiring of hearing in mice. Less severe decreases in human IGF-1 levels have been associated with other hearing loss rare genetic syndromes, as well as with age-related hearing loss (ARHL). However, the underlying mechanisms linking IGF-1 haploinsufficiency with auditory pathology and ARHL have not been studied. Igf1-heterozygous mice express less Igf1 transcription and have 40% lower IGF-1 serum levels than wild-type mice. Along with ageing, IGF-1 levels decreased concomitantly with the increased expression of inflammatory cytokines, Tgfb1 and Il1b, but there was no associated hearing loss. However, noise exposure of these mice caused increased injury to sensory hair cells and irreversible hearing loss. Concomitantly, there was a significant alteration in the expression ratio of pro- and anti-inflammatory cytokines in Igf1+/− mice. Unbalanced inflammation led to the activation of the stress kinase JNK and the failure to activate AKT. Our data show that IGF-1 haploinsufficiency causes a chronic subclinical proinflammatory age-associated state and, consequently, greater susceptibility to stressors. This work provides the molecular bases to further understand hearing disorders linked to IGF-1 deficiency.

scholarly journals Reliability and effectiveness of screening for hearing loss in high risk neonates.

BMJ ◽  
1992 ◽  
Vol 304 (6830) ◽  
pp. 806-809 ◽  
Author(s):  
R. J. McClelland ◽  
D. R. Watson ◽  
V. Lawless ◽  
H. G. Houston ◽  
D. Adams
Keyword(s):  
Hearing Loss ◽  
High Risk

scholarly journals Relationship Between Incidence of Hyaline Membrane Disease and Maternal Hypertension During Pregnancy

2017 ◽  
Vol 38 (3-4) ◽  
pp. 47
Author(s):  
Lasmida Nazir Nuriman ◽  
Dadang Sjarif Hidajat
Keyword(s):  
Distress Syndrome ◽  
Hyaline Membrane Disease ◽  
Cross Sectional Study ◽  
Type I ◽  
Cross Sectional ◽  
Hypertension In Pregnancy ◽  
Hyaline Membrane ◽  
Neonatal Respiratory Distress ◽  
Maternal Hypertension ◽  
The Relationship

There have been controversies over the eiTect of hypertension in pregnancy on the incidence of type I neonatal respiratory distress syndrome or hyaline membrane disease (HMD). We investigated the relationship between the incidence of HMD and maternal hypertension during pregnancy in 91 infants at 34 weeks gestation or less. This retrospective cross sectional study included all live born babies between May 1, 1994 and April 30, 1995 at Dr. Hasan Sadikin General Hospital, Bandung. Maternal hypertension during pregnancy was diagnosed in 38 mothers of91 infants studied. The incidence of HMD (5%) in the maternal hypertension during pregnancy group was significantly lower than the 62% in the normotensive group (p<0.01). There was a negative correlation between the occurence of HMD and hypertension during pregnancy. We conclude that the risk of developing HMD in infants born to hypertensive mothers is significantly lower than those born to normotensive mothers.

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