Natural History of Primary Autoimmune Neutropenia in Infancy

PEDIATRICS ◽  
1987 ◽  
Vol 79 (5) ◽  
pp. 728-733
Author(s):  
Lars T. Conway ◽  
Mary E. Clay ◽  
William E. Kline ◽  
Norma K. C. Ramsay ◽  
William Krivit ◽  
...  
Keyword(s):  
Natural History ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Antibiotic Therapy ◽  
Upper Respiratory Tract ◽  
Autoimmune Neutropenia ◽  
Laboratory Findings ◽  
History Of ◽  
Upper Respiratory

Five patients with primary autoimmune neutropenia were evaluated during their first 2 years of life. Their illness resolved spontaneously after 6 to 41 months (median 13 months), and the patients were subsequently followed for 13 to 73 months (median 28 months). None required immunosuppressive therapy to induce remission, and routine antibiotic therapy adequately controlled all infectious episodes. An increased rate of infection, particularly otitis media and upper respiratory tract infection, occurred during the neutropenic period. No other noninfectious illnesses, particularly no other autoimmune diseases, were reported in any of these patients at any time. In each case, resolution of neutropenia paralleled the disappearance of neutrophil autoantibodies which were specific for the NA1 antigen. This report describes the clinical and laboratory findings and the long-term history of primary autoimmune neutropenia in these five patients.

scholarly journals Guillian Barre syndrome epidemiology presentation and outcome

2021 ◽  
Vol 23 (11) ◽  
pp. 263-272
Author(s):  
Dr.Raed jabbar Hussain ◽  
◽  
Dr. Rahan Assim Mohammed Al-Qazzaz ◽  
Kahtan Adnan Abdullah ◽  
◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Cranial Nerves ◽  
Upper Respiratory Tract Infection ◽  
Upper Respiratory Tract ◽  
Mechanical Ventilators ◽  
Study Results ◽  
History Of ◽  
Upper Respiratory

Background Guillain Barre syndrome (GBS) is most common cause of acute flaccid paralysis, affect peripheral nerves with distinctive features clinical, pathological and prognosis. Patient and methods this study is prospective of 60 patients admitted at al-kadymia teaching hospital from first January 2004 to end April 2009. Age includes 1 to ≤11 years. Diagnosis was by clinical examination and confirmed by CSF tests and nerve conduction velocity study. Results It was found that 32 patients were male and 28 were female. Cranial nerves involved in 30% of patients. Sensory symptoms found in 16%. CSF changes was seen in 85.5% patients. Antecedent events were found in 27 patients out of 60, 14 had history of upper respiratory tract infection 45%, 7 had gastroenteritis 11%, 6 patients had history of fever 3 weeks earlier 10% and 15 patients had complicated by respiratory failure managed by mechanical ventilators, During this study 4 patients had been died. Conclusions: Current study conclude about 45% of patients had history antecedent events in as upper respiratory tract infection , gastroenteritis and fever, so cerebrospinal fluid CSF cell in the majority of cases within normal range and mostly lymphocytes, Cranial nerves were affected in most patients without serious sequels so Steroid was not given to most of patients in our study without any significant effect on the course of disease , Hospitalization was range from 2 week to 4 week, Recovery was range from 4 to 12 week and Death rate was 6% .

scholarly journals Congenital Neutropenia in Children: Evaluation of Infectious Complications, Treatment Results and Long-Term Outcome

2021 ◽  
Author(s):  
Işık Odaman Al ◽  
Yeşim Oymak ◽  
Tuba Hİlkay Karapınar ◽  
Melek Erdem ◽  
Salih Gözmen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Infectious Complications ◽  
Upper Respiratory Tract ◽  
Congenital Neutropenia ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Upper Respiratory

Objective: Infections are an important cause of morbidity and mortality for patients with congenital neutropenia. In the present study, we report on the incidence, type, localization of documented infections, as well as the clinical features and long-term outcome in patients with congenital neutropenia in our clinic. Method: We performed a retrospective chart review of children with neutropenia seen at our hospital from 2000-2018. The data of 15 patients with congenital neutropenia were included in this study. Clinical and laboratory data were analyzed retrospectively using patients’ files and an electronic data system. Results: The median age at diagnosis was 34 months (range, four months- 150 months) and the median follow-up time was 48 months (range, 13-179 months). The leading causes of hospital admission before the establishment of the diagnosis were upper respiratory tract infection in six, pneumonia in four, gingival stomatitis in three and soft tissue infection in two patients. We reached the documented 74 hospitalization episodes and the most common reasons for hospitalization were pneumonia (35%), fever (21%), stomatitis (16%), cutaneous and deep soft tissue infections (12%). Conclusion: The management of infectious complications in children with congenital neutropenia is crucial. Early diagnosis is essential to prevent infections and permanent organ damage. Congenital neutropenia should be suspected in patients with a history of frequent upper respiratory tract infection, and necessary investigations should be performed accordingly. However, it should be kept in mind that the clinical findings of the patients may vary despite having the same mutation.

scholarly journals Subacute Thyroiditis Following COVID-19 Vaccination

2021 ◽  
Author(s):  
pardis soltanpoor ◽  
Ghazal Norouzi
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Thyroid Disease ◽  
Subacute Thyroiditis ◽  
Upper Respiratory Tract ◽  
Healthy Patient ◽  
Viral Origin ◽  
History Of ◽  
Upper Respiratory

Subacute thyroiditis (SAT) is an inflammatory thyroid disease of post-viral origin; linked with many viruses such as SARS-COVID-2. The objective of this work is to report a case of SAT associated with COVID-19 vaccination, in a healthy patient with no history of previous COVID-19 or upper respiratory tract infection.

scholarly journals Septal rhinoscleroma

2010 ◽  
Vol 43 (02) ◽  
pp. 219-221
Author(s):  
Mohamed A. Shoeib
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Nasal Cavity ◽  
Past History ◽  
Inferior Turbinate ◽  
Upper Respiratory Tract ◽  
History Of ◽  
Upper Respiratory ◽  
The Right ◽  
Tip Rhinoplasty

ABSTRACTRhinoscleroma is a chronic granulomatous condition of the nose and other structures of the upper respiratory tract. Infection by the bacterium Klebsiella rhinoscleromatis is said to be the cause. A female patient aged 45 years, presented with a past history of trauma to the nose and swelling on her nose since last 1 year. There was nasal asymmetry and internal nasal examination showed a septal swelling protruding to the right nasal cavity with hypertrophied nasal mucosa and inferior turbinate. Open tip rhinoplasty approach was used to excise the mass, which examined pathologically revealing a rhinoscleroma, fibrotic infiltrative stage.

scholarly journals Determinant of Pneumonia Among Children Aged 2-59 Months in Public Health Facilities in Worabe Town, Southern Ethiopia: Facility-Based Case Control Study

2021 ◽  
Author(s):  
Roza kumdin Seramo ◽  
Shikur Mohammed Awol ◽  
Yasin Awol Wabe ◽  
Musa Mohammed Ali
Keyword(s):  
Public Health ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Case Control Study ◽  
Case Control ◽  
Upper Respiratory Tract ◽  
History Of ◽  
Upper Respiratory ◽  
Control Study

Abstract Introduction: Childhood pneumonia remains a major health problem in developing countries, including Ethiopia with significant morbidity and mortality. The determinants of pneumonia in children under –five years of age children are numerous and vary widely vary across the regions of the world. Taking the significance of the problem and variability of risk factors, a study is needed to identify the potential determinants of pneumonia in children under-five children years of age. Methods A facility-based unmatched case-control study was conducted among 435 children (145 cases and 290 controls) aged 2-59 months at public health facilities in Worabe town from December 28, 2016 to January 30, 2017. Data were collected with a pretested interviewer-administered questionnaire, and entered into Epi info and transferred to SPSS version 22 for analysis. Univariate and multivariable logistic regression was employed with a 95% CI, and a p- value of < 0.05 was used as a determinant of pneumonia. Results Among the factors assessed in this study, stunting [AOR=3.6, 95% CI: 1.9-6.9], carrying the child on the back during cooking [AOR= 2.0, 95% CI: 1.2-3.2], absence of chimney in the cooking room [AOR= 2.2, 95% CI: 1.3-3.7], having a history of asthma [AOR= 5.0, 95% CI: 2-12], and a previous upper respiratory tract infection [AOR= 3.7, 95% CI:2.3-6.1] were found to be determinants of pneumonia. Conclusions Children with stunting, a previous history of asthma, acute upper respiratory tract infection and carrying the child on back during cooking were at higher risk of pneumonia. Therefore, all health institutions should promote early treatment and provision of health education about the health risk of child exposure to biomass fuel smoke and early health-seeking for childhood illnesses.

scholarly journals Coinfection withClostridium piliformeandFelid herpesvirus 1in a kitten

2015 ◽  
Vol 27 (4) ◽  
pp. 547-551 ◽  
Author(s):  
Rachel T. Neto ◽  
Francisco A. Uzal ◽  
Emir Hodzic ◽  
Michele Persiani ◽  
Shazia Jolissaint ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Clinical Findings ◽  
Upper Respiratory Tract ◽  
Filamentous Bacteria ◽  
The Third ◽  
History Of ◽  
Clostridium Piliforme ◽  
Upper Respiratory ◽  
Herpesvirus 1

A 1-month-old Domestic Shorthair kitten was submitted for autopsy, with a history of upper respiratory tract infection and diarrhea. This was the third kitten from the same litter that had died with similar clinical findings within a period of 1 month. Severe conjunctivitis, rhinitis, tracheitis, and bronchointerstitial pneumonia were present, together with lymphohistiocytic colitis. Respiratory lesions were caused by infection with Felid herpesvirus 1. Colonic lesions were associated with the presence of long filamentous bacteria, identified as Clostridium piliforme, in the cytoplasm of epithelial cells. Our report describes a case of concurrent C. piliforme infection (Tyzzer’s disease) and feline rhinotracheitis in a kitten.

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