scholarly journals Hypertension and Stroke: Update on Treatment

2019 ◽  
Vol 14 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Mauricio Wajngarten ◽  
Gisele Sampaio Silva
Keyword(s):  
Blood Pressure ◽  
Haemorrhagic Stroke ◽  
Hypertensive Encephalopathy ◽  
First Episode ◽  
Pressure Management ◽  
Stroke Patients ◽  
Common Cause ◽  
Therapeutic Goals ◽  
Hypertensive Urgencies ◽  
Definition Of

Stroke is the second most common cause of mortality worldwide and the third most common cause of disability. Hypertension is the most prevalent risk factor for stroke. Stroke causes and haemodynamic consequences are heterogeneous which makes the management of blood pressure in stroke patients complex requiring an accurate diagnosis and precise definition of therapeutic goals. In this article, the authors provide an updated review on the management of arterial hypertension to prevent the first episode and the recurrence. They also present a discussion on blood pressure management in hypertensive urgencies and emergencies, especially in the acute phase of hypertensive encephalopathy, ischaemic stroke and haemorrhagic stroke.

scholarly journals Review of major trials of acute blood pressure management in stroke

2021 ◽  
pp. 0271678X2110043
Author(s):  
Thompson G Robinson ◽  
Jatinder S Minhas ◽  
Joseph Miller
Keyword(s):  
Blood Pressure ◽  
Clinical Trials ◽  
Acute Stroke ◽  
Trial Design ◽  
Haemorrhagic Stroke ◽  
Pressure Management ◽  
Blood Pressure Management ◽  
Multiple Trials ◽  
Hypertensive Crises ◽  
Improve Patient

Over the last two decades, there have been a number of major landmark clinical trials, classified as “major” as they sought to address clear clinical practice driven questions, in a pragmatic yet robust trial design, using a large powered sample size (n > 1000), in order to help improve patient outcome through informing guidelines. A commonality across all stroke sub-types included in these trials is the tendency to acute hypertensive crises within the acute stroke period. This phenomenon is associated with greater stroke complications and worsened overall prognosis. Multiple trials have attempted to address the issue of acute blood pressure management during the acute stroke period, with consideration for timing, magnitude of lowering, agent and relationship to other interventions. This review will consider the major clinical trials performed in ischaemic and haemorrhagic stroke that test the hypothesis that acute BP reduction improves clinical outcomes.

Quantum binding energy features of the drug olmesartan bounded to angiotensin type-1 receptor in the therapeutics of stroke

2021 ◽  
Author(s):  
Stephany Campanelli Esmaile ◽  
Daniel Melo de Oliveira Campos ◽  
Maria Karolaynne da Silva ◽  
Katyanna Sales Bezerra ◽  
J. X. Lima Neto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Binding Energy ◽  
Pressure Management ◽  
Common Cause ◽  
The Third ◽  
Blood Pressure Management ◽  
Angiotensin Type

Stroke is the second most common cause of mortality worldwide and the third most common cause of disability. Stroke causes and hemodynamic consequences are heterogeneous, making blood pressure management in...

scholarly journals Hubungan Tekanan Darah dengan Volume Pendarahan Intraserebral pada Pasien Stroke Hemoragik di Ruang Rawat Inap Saraf Rumkital Dr Ramelan Surabaya

2019 ◽  
Vol 16 (2) ◽  
pp. 135
Author(s):  
KENNY YULIAN ◽  
OLIVIA MAHARDANI ADAM ◽  
LESTARI DEWI
Keyword(s):  
Blood Pressure ◽  
Ct Scan ◽  
Intracerebral Haemorrhage ◽  
Hemorrhagic Stroke ◽  
Haemorrhagic Stroke ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Stroke Patients ◽  
Cross Sectional ◽  
The Brain

<p><strong>ABSTRACT</strong></p><p><strong>Background.</strong> Hemorrhagic stroke is a spontaneous bleeding in the brain that is usually life threatening. The most common risk factor of hemorrhagic stroke is hypertension. Hypertension can cause change in the structure of the artery wall which can cause the blood vessels near the brain to rupture easily. <strong>Purpose.</strong> To analyze the correlation between blood pressure and intracerebral haemorrhage volume in hemorrhagic stroke patients in Dr. Ramelan Navy Hospital neurologic ward.  <strong>Method.</strong> This research is using a cross sectional study design. This study is done using primary data collection, using the head CT Scan result to measure the patient’s intracerebral hemorrhage volume and patient’s ER admission data for the blood pressure. <strong>Results.</strong> The study is performed to 26 haemorrhagic stroke patients who fits the inclusion and exclusion criteria. Correlation test shows no correlation between blood pressure and intracerebral haemorrhage volume in haemorrhagic stroke patients in Dr. Ramelan Navy Hospital neurologic ward, with significance (p) value of 0.888 &gt; α (0.05). <strong>Conclusion.</strong> There is no correlation between blood pressure and intracerebral haemorrhage volume in haemorrhagic stroke patients in Dr. Ramelan Navy Hospital neurologic ward.</p><p><strong>Keywords: </strong>Blood Pressure, Intracerebral Haemorrhage Volume, Haemorrhagic Stroke</p><p> </p><p>ABSTRAK</p><p><strong>Latar belakang. </strong>Stroke hemoragik adalah pendarahan otak spontan yang seringkali mengancam jiwa. Faktor resiko utama terjadinya stroke hemoragik adalah adanya hipertensi. Hipertensi dapat menyebabkan perubahan struktur dinding arteri sehingga pembuluh darah didekat otak mudah ruptur. <strong>Tujuan penelitian.</strong> Mengetahui hubungan antara tekanan darah dengan volume pendarahan intraserebral pada pasien stroke hemoragik di ruang rawat inap saraf RUMKITAL Dr. Ramelan Surabaya. <strong>Metode penelitian.</strong> Penelitian ini adalah penelitian dengan desain cross sectional study. Penelitian ini dilakukan dengan perolehan data primer, yaitu berupa hasil CT scan kepala untuk mengetahui volume pendarahan intraserebral pasien dan data pasien saat masuk IGD untuk tekanan darah pasien. <strong>Hasil.</strong> Penelitian dilakukan pada 26 pasien stroke hemoragik yang masuk kriteria inklusi dan eksklusi. Hasil uji korelasi menunjukkan tidak ada hubungan antara tekanan darah dengan volume pendarahan intraserebral pada pasien stroke hemoragik di ruang rawat inap saraf RUMKITAL Dr. Ramelan Surabaya, dengan nilai signifikansi (p) = 0.888 &gt; α (0.05). <strong>Kesimpulan.</strong> Tidak ada hubungan antara tekanan darah dengan volume pendarahan intraserebral pada pasien stroke hemoragik di ruang rawat inap saraf RUMKITAL Dr. Ramelan Surabaya.</p><strong>Kata Kunci : </strong>Tekanan Darah, Volume Pendarahan Intraserebral, Stroke Hemoragik

scholarly journals Blood pressure management in stroke patients

2020 ◽  
Vol 13 (2) ◽  
pp. 69-79
Author(s):  
Seung Min Kim ◽  
Ho Geol Woo ◽  
Yeon Jeong Kim ◽  
Bum Joon Kim
Keyword(s):  
Blood Pressure ◽  
Pressure Management ◽  
Stroke Patients ◽  
Blood Pressure Management

scholarly journals Predictors of In-Hospital Mortality in Stroke Patients

2022 ◽  
Author(s):  
Vindya Shalini Ranasinghe ◽  
Manoji Pathirage ◽  
Indika Bandara Gawarammana
Keyword(s):  
Blood Pressure ◽  
Hospital Mortality ◽  
Demographic Data ◽  
Clinical Signs ◽  
Multivariate Logistic Regression Analysis ◽  
Haemorrhagic Stroke ◽  
Receiver Operating Curve ◽  
Stroke Patients ◽  
Tertiary Referral Center ◽  
Gcs Score

Abstract Background: In-hospital mortality is a good indicator to assess the efficacy of stroke care. Identifying the predictors of in-hospital mortality is important to advance the stroke outcome and plan the future strategies of stroke management. Methods: This was a prospective observational study conducted at a tertiary referral center in Sri Lanka to identify the possible predictors of in-hospital mortality. The study included 246 confirmed stroke patients. The diagnosis of stroke was established on the clinical history, examination and neuroimaging. The differentiation of stroke in to haemorrhagic type and ischaemic type was based on the results of computed tomography. In all patients, demographic data, comorbidities, clinical signs (pulse rate, respiratory rate, systolic blood pressure, diastolic blood pressure, on admission Glasgow Coma Scale (GCS) score) and imaging findings were recorded. Serum electrolyte test was performed in all stroke patients and hyponatremia was defined as serum Na+ less than 131mmol/l. All patients were followed up throughout their hospital course and the in-hospital mortality was recorded. In hospital mortality was defined as the deaths which occurred due to stroke after 24 hours of hospital admission. Results: The incidence of in-hospital mortality was 11.7% (95% confidence interval 8-16.4). The mean day of in-hospital deaths to occur was 5.9 days (SD±3.8 Min 2 Max 20). According to multivariate logistic regression analysis on admission GCS score (Odds Ratio (OR)-0.71) and haemorrhagic stroke type (OR-5.12) predict the in-hospital mortality. The area under the curve of receiver operating curve drawn for the on admission GCS score was 0.78 with a sensitivity of 96.31% and specificity of 41.38% for a patient presented with the GCS score of <10. Conclusion: On admission GCS and haemorrhagic stroke are independent predictors of in-hospital mortality. Patients with on admission GCS <10 have a moderate predictive ability in predicting the in-hospital mortality. Thus, a special attention should be given to the patients with low GCS score and haemorrhagic strokes for reducing rates of in-hospital mortality.

scholarly journals Blood pressure and the brain: the neurology of hypertension

2019 ◽  
Vol 20 (2) ◽  
pp. 100-108 ◽  
Author(s):  
Dearbhla M Kelly ◽  
Peter M Rothwell
Keyword(s):  
Blood Pressure ◽  
Small Vessel Disease ◽  
Signs And Symptoms ◽  
Haemorrhagic Stroke ◽  
Organ Damage ◽  
Hypertensive Encephalopathy ◽  
Brain Health ◽  
Neurological Presentation ◽  
Alzheimer’S Pathology ◽  
The Brain

Hypertension affects more than one in four adults. The brain is an early target of hypertension-induced organ damage, and may manifest as stroke, subclinical cerebrovascular abnormalities and dementia. Hypertension-related small vessel disease can cause vascular dementia and can potentiate Alzheimer’s pathology, lowering the threshold at which signs and symptoms manifest. Many hypertensive emergencies may also have a neurological presentation, such as hypertensive encephalopathy, haemorrhagic stroke or pre-eclampsia. Here we highlight the importance of blood pressure in maintaining brain health and the brain’s role in controlling blood pressure.

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