Stem Cells in Cardiac Repair – Recent Developments and Future Directions

2012 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Robert J Henning ◽  
Keyword(s):  
Stem Cells ◽  
Heart Disease ◽  
Cause Of Death ◽  
Embryonic Stem ◽  
World Health ◽  
Human Umbilical Cord ◽  
Major Advance ◽  
Future Directions ◽  
The World ◽  
Recent Developments

Myocardial infarction (MI) is the leading cause of death among people in the industrialised world and will, according to the World Health Organization (WHO), become the leading cause of death in the world in 2020. For the treatment of patients with MIs and ischaemic cardiomyopathies, remarkable medical advances have been made during the second half of the 20th Century that have increased patient survival. As a consequence, patients with heart disease are living longer and the incidence of congestive heart failure in patients is significantly increasing. New treatments for patients with acute MI and ischaemic cardiomyopathies are needed. In this regard, the next major advance in the treatment of patients with cardiac disease promises to be stem cells and stem cell products. Currently, basic research scientists and clinicians worldwide are investigating human embryonic stem cells, skeletal stem cells (myoblasts), adult bone marrow stem cells, cardiac stem cells and human umbilical cord stem cells for the treatment of patients with MIs and ischaemic cardiomyopathies. This review highlights the recent developments and the future directions of each of these stem cells in the treatment of patients with heart disease.

Web-Based Machine Learning Application for Heart Disease Prediction

2022 ◽  
pp. 383-393
Author(s):  
Lokesh M. Giripunje ◽  
Tejas Prashant Sonar ◽  
Rohit Shivaji Mali ◽  
Jayant C. Modhave ◽  
Mahesh B. Gaikwad
Keyword(s):  
Machine Learning ◽  
Heart Disease ◽  
Random Forest ◽  
Web Application ◽  
Machine Learning Algorithms ◽  
World Health ◽  
Web Based ◽  
The World ◽  
Comprehensive Survey ◽  
Health Organization

Risk because of heart disease is increasing throughout the world. According to the World Health Organization report, the number of deaths because of heart disease is drastically increasing as compared to other diseases. Multiple factors are responsible for causing heart-related issues. Many approaches were suggested for prediction of heart disease, but none of them were satisfactory in clinical terms. Heart disease therapies and operations available are so costly, and following treatment, heart disease is also costly. This chapter provides a comprehensive survey of existing machine learning algorithms and presents comparison in terms of accuracy, and the authors have found that the random forest classifier is the most accurate model; hence, they are using random forest for further processes. Deployment of machine learning model using web application was done with the help of flask, HTML, GitHub, and Heroku servers. Webpages take input attributes from the users and gives the output regarding the patient heart condition with accuracy of having coronary heart disease in the next 10 years.

Use of Embryonic Stem Cells to Treat Heart Disease

2004 ◽  
pp. 713-722
Author(s):  
Joshua D. Dowell ◽  
Robert Zweigerdt ◽  
Michael Rubart ◽  
Loren J. Field
Keyword(s):  
Stem Cells ◽  
Heart Disease ◽  
Embryonic Stem Cells ◽  
Embryonic Stem

Combinatorial Utilization of Murine Embryonic Stem Cells andIn VivoModels to Study Human Congenital Heart Disease

2018 ◽  
pp. e75
Author(s):  
Abeer Zakariyah ◽  
Rashida Rajgara ◽  
Michael Shelton ◽  
Alexandre Blais ◽  
Ilona S. Skerjanc ◽  
...  
Keyword(s):  
Stem Cells ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Embryonic Stem Cells ◽  
Congenital Heart ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells

scholarly journals Epidemiology of Pediatric Septic Shock

2018 ◽  
Vol 08 (01) ◽  
pp. 003-010 ◽  
Author(s):  
Flávia Machado ◽  
Daniela de Souza
Keyword(s):  
Septic Shock ◽  
Developing Countries ◽  
Severe Sepsis ◽  
Cause Of Death ◽  
Public Health Problem ◽  
Developed Countries ◽  
Global Perspective ◽  
World Health ◽  
Disease Definition ◽  
The World

AbstractSepsis, or dysregulated host response to infection, is considered a worldwide public health problem. It is a major childhood disease both in terms of frequency and severity, and severe sepsis is still considered the main cause of death from infection in childhood. This review provides an overview of the epidemiology of pediatric septic shock. The prevalence of severe sepsis and septic shock among hospitalized children ranges from 1 to 26%. Mortality is high, ranging from 5% in developed countries to up to 35% in developing countries. However, 10 years after the publication of pediatric sepsis definitions, a global perspective on the burden of this disease in childhood is still missing. Major obstacles to a better knowledge of sepsis epidemiology in children are the absence of an adequate disease definition and not having sepsis as a cause of death in the World Health Organization Global Burden of Disease Report, which is one of the most important sources of information for health policies decision-making in the world. Several studies performed in both developed and developing countries have shown that mortality from septic shock is high and is associated with delayed diagnosis, late treatment, and nonadherence to the treatment guidelines. Reducing mortality from sepsis in childhood is a worldwide challenge, especially in developing countries, where the highest number of cases and deaths are recorded and where financial resources are scarce. Many specialists consider that prevention, education, and organization are key to achieve a reduction in the burden of sepsis.

Use of Embryonic Stem Cells to Treat Heart Disease

2013 ◽  
pp. 415-425
Author(s):  
Joshua D. Dowell ◽  
Robert Zweigerdt ◽  
Michael Rubart ◽  
Loren J. Field
Keyword(s):  
Stem Cells ◽  
Heart Disease ◽  
Embryonic Stem Cells ◽  
Embryonic Stem

Diagnosis and assessment of stroke

2016 ◽  
Author(s):  
Candice Delcourt ◽  
Craig Anderson
Keyword(s):  
Heart Disease ◽  
Ischaemic Stroke ◽  
Ischaemic Heart Disease ◽  
Cause Of Death ◽  
Physical Disability ◽  
Early Phase ◽  
Haemorrhagic Stroke ◽  
Common Cause ◽  
The World ◽  
The Impact

Approximately 20 million strokes occur in the world each year and over one-quarter of these are fatal. This makes stroke the second most common cause of death, after ischaemic heart disease, and strokes are responsible for 6 million deaths (almost 10% of all deaths) annually. Stroke has major consequences in terms of residual physical disability, depression, dementia, epilepsy, and carer burden. Moreover, around 20% of survivors experience a further stroke or serious vascular event within a few years of the index event. Ischaemic stroke contributes the greatest share of the impact of stroke, with a rate of approximately 1 in 1000 person-years and accounting for between 60% (in Asia) and 90% (in Western ‘white’ populations) of all strokes around the world. Diagnosis and assessment are essentially clinical and confirmed by CT or MRI scanning. Prognostication is difficult in the early phase of haemorrhagic stroke and in ischaemic stroke is affected by the availability and timely use of treatments to recanalize the occluded vessel.

scholarly journals Global trends in clinical trials involving pluripotent stem cells: a systematic multi-database analysis

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Julia Deinsberger ◽  
David Reisinger ◽  
Benedikt Weber
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Pluripotent Stem Cells ◽  
Search Algorithm ◽  
Embryonic Stem ◽  
Induced Pluripotent Stem Cell ◽  
World Health ◽  
Clinical Use ◽  
Scientific Publications ◽  
Induced Pluripotent

Abstract Pluripotent stem cells (PSCs) hold great potential for novel therapeutic approaches to regenerate or replace functionally impaired tissues. Since the introduction of the induced pluripotent stem cell technology in 2006, the number of scientific publications on this topic has constantly been increasing. However, so far no therapy based on PSCs has found its way into routine clinical use. In this study, we examined research trends related to clinical trials involving PSCs based on data obtained from ClinicalTrials.gov, the ICTRP database from the World Health Organization, as well as from a search of all individual databases that are included in the ICTRP using a multistep search algorithm. Following a stringent inclusion/exclusion procedure 131 studies remained that could be classified as clinical trials involving PSCs. The magnitude of these studies (77.1%) was observational, which implies that no cells were transplanted into patients, and only a minority of studies (22.9%) were of an interventional study type. The number of clinical trials involving induced pluripotent stem cells (iPSCs, 74.8%) was substantially higher than the one involving embryonic stem cells (ESCs, 25.2%). However, the picture changes completely when focusing on interventional studies, where in the majority (73.3%) of cases ESCs were used. Interestingly, also the study duration was significantly shorter for interventional versus observational trials (p = 0.002). When focusing on the geographical study regions, it became obvious that the greatest part of all observational trials was performed in the USA (41.6%) and in France (16.8%), while the magnitude of interventional studies was performed in Asian countries (China 36.7%, Japan 13.3%, South Korea 10.0%) and in the field of ophthalmology. In summary, these results indicate that only a limited number of trials were focusing on the actual transplantation of PSCs into patients in a rather narrow field of diagnoses. The future will tell us, if the iPSC technology will ultimately overcome the current challenges and will finally make its way into routine clinical use.

Human Umbilical Cord Mesenchymal Stem Cells Support Nontumorigenic Expansion of Human Embryonic Stem Cells

2012 ◽  
Vol 21 (7) ◽  
pp. 1515-1527 ◽  
Author(s):  
Dah-Ching Ding ◽  
Woei-Cherng Shyu ◽  
Shinn-Zong Lin ◽  
Hwan-Wun Liu ◽  
Shih-Hwa Chiou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Embryonic Stem Cells ◽  
Umbilical Cord ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Human Umbilical Cord
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