scholarly journals Features of purulent pododermatitis course in cattle

2018 ◽  
Vol 20 (83) ◽  
pp. 286-289
Author(s):  
N.M. Khomyn ◽  
A.R. Mysak ◽  
S.V. Tsisinska ◽  
V.V. Pritsak
Keyword(s):  
Successful Treatment ◽  
Rapid Recovery ◽  
Microscopic Fungi ◽  
Theoretical Substantiation ◽  
Anti Inflammatory ◽  
Orthopedic Diseases ◽  
Biophysical Indices ◽  
Hygienic Conditions

The article deals with the results of researches of many scientists concerning the pathogenesis of purulent pododermatitis in cattle. A considerable distribution of orthopedic diseases, in particular pododermatitis in highly productive cows, has been established. It is proved that untimely corrective cleansing of the hoof, and as a consequence of deformation, prolonged stall content, unsatisfactory zoo-hygienic conditions, in particular, the high content of ammonia in the air, moisture, nymphs on the floor, the imbalance of ration of feeds, the deficit in ration of nutrients and minerals, the absence of the mition and insolation, leads to a deterioration in the quality of the hoof, which is manifested by changes in biochemical and biophysical indices. This leads to aseptic pododermatitis, and penetration into the area of the sole of the microflora and microscopic fungi contributes to the purulent inflammation of the base of the skin of the hoof soles in the livestock. The theoretical substantiation and practical confirmation of the role of microscopic fungi in the pathogenesis of purulent pododermatitis in cattle, which is to destroy hoof keratin, which is due to the keratolytic properties of fungi. It has been scientifically proven that the identification of keratomycetes in the hoof horn is important in the diagnosis of purulent poddlermatitis in animals and influences the choice of directions for their successful treatment. It was established that the elimination of negative conditions of keeping, feeding, corrective cleansing, provision of animals for motion and insolation in combination with the application for therapeutic purposes of substances that possess not only anti-inflammatory, antimicrobial, but also fungicidal properties contributes to the rapid recovery of orthopedic animals.

scholarly journals A Translational Perspective of Maternal Immune Activation by SARS-CoV-2 on the Potential Prenatal Origin of Neurodevelopmental Disorders: The Role of the Cholinergic Anti-inflammatory Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
José Javier Reyes-Lagos ◽  
Eric Alonso Abarca-Castro ◽  
Juan Carlos Echeverría ◽  
Hugo Mendieta-Zerón ◽  
Alejandra Vargas-Caraveo ◽  
...  
Keyword(s):  
Immune Activation ◽  
Neurodevelopmental Disorders ◽  
Inflammatory Pathway ◽  
Maternal Immune Activation ◽  
Increased Risk ◽  
Anti Inflammatory ◽  
Psychophysiological Data

The emergent Coronavirus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) could produce a maternal immune activation (MIA) via the inflammatory response during gestation that may impair fetal neurodevelopment and lead to postnatal and adulthood mental illness and behavioral dysfunctions. However, so far, limited evidence exists regarding long-term physiological, immunological, and neurodevelopmental modifications produced by the SARS-CoV-2 in the human maternal-fetal binomial and, particularly, in the offspring. Relevant findings derived from epidemiological and preclinical models show that a MIA is indeed linked to an increased risk of neurodevelopmental disorders in the offspring. We hypothesize that a gestational infection triggered by SARS-CoV-2 increases the risks leading to neurodevelopmental disorders of the newborn, which can affect childhood and the long-term quality of life. In particular, disruption of either the maternal or the fetal cholinergic anti-inflammatory pathway (CAP) could cause or exacerbate the severity of COVID-19 in the maternal-fetal binomial. From a translational perspective, in this paper, we discuss the possible manifestation of a MIA by SARS-CoV-2 and the subsequent neurodevelopmental disorders considering the role of the fetal-maternal cytokine cross-talk and the CAP. Specifically, we highlight the urgent need of preclinical studies as well as multicenter and international databanks of maternal-fetal psychophysiological data obtained pre-, during, and post-infection by SARS-CoV-2 from pregnant women and their offspring.

scholarly journals The Level Of Knowledge on the Use Of NSAIDs As Analgesic For Dysmenorrhea Case In Faculty of Health Universitas Muhammadiyah Lamongan

2020 ◽  
Vol 12 (2) ◽  
pp. 287
Author(s):  
Primanitha Ria Utami ◽  
Devi Ristian Octavia ◽  
Selly Septi Fandinata
Keyword(s):  
Sampling Technique ◽  
Or Education ◽  
Pain Reliever ◽  
Level Of Knowledge ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Almost All ◽  
The University

Non-steroidal anti-inflammatory (anti-inflammatory) drugs, or better known as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) or NSAIDs are a group that has analgesic (pain reliever), anti-pyretic (fever) properties. to determine the level of knowledge on the use of NSAIDs as anti-pain in cases of dysmenorrhea in the University of Muhammadiyah Lamongan. The research design used in this research is descriptive, in taking the sample using the total sampling technique. Collecting data by distributing questionnaires with data analysis presented in tabular form. The results of this study indicate that of the 266 respondents, almost all respondents know about knowledge of dysmenorrhea well (83.8%). In the results of this study, there were still respondents who did not know the proper use of NSAIDs as analgesic. So in this case the role of pharmaceutical personnel is needed in providing information or education to people who consume NSAIDs, in order to achieve a quality of life for the community and avoid unwanted therapeutic responses. Keywords : NSAID ; dysmenorrhea ; analgesic 

scholarly journals Brazilian recommendations for the use of nonsteroidal anti-inflammatory drugs in patients with axial spondyloarthritis

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Ricardo da Cruz Lage ◽  
Claudia Diniz Lopes Marques ◽  
Thauana Luiza Oliveira ◽  
Gustavo Gomes Resende ◽  
Charles Lubianca Kohem ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Axial Spondyloarthritis ◽  
Meta Analysis ◽  
Evaluation Methodology ◽  
Assessment Development ◽  
Brazilian Society ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

AbstractSpondyloarthritis (SpA) is a group of chronic inflammatory systemic diseases characterized by axial and/or peripheral joints inflammation, as well as extra-articular manifestations. Over some decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been the basis for the pharmacological treatment of patients with axial spondyloarthritis (axSpA). However, the emergence of the immunobiologic agents brought up the discussion about the role of NSAIDs in the management of these patients. The objective of this guideline is to provide recommendations for the use of NSAIDs for the treatment of axSpA. A panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of randomized clinical trials for 15 predefined questions. The Grading of Recommendations, Assessment, Development and Evaluation methodology to assess the quality of evidence and formulate recommendations were used, and at least 70% agreement of the voting panel was needed. Fourteen recommendations for the use of NSAIDs in the treatment of patients with axSpA were elaborated. The purpose of these recommendations is to support clinicians’ decision making, without taking out his/her autonomy when prescribing for an individual patient.

Advances in the Use of Anti-inflammatory Agents to Manage Chemotherapy-induced Oral and Gastrointestinal Mucositis

2018 ◽  
Vol 24 (14) ◽  
pp. 1518-1532 ◽  
Author(s):  
Vaishnavi J. Mahendran ◽  
Andrea M. Stringer ◽  
Susan J. Semple ◽  
Yunmei Song ◽  
Sanjay Garg
Keyword(s):  
Nuclear Factor Kappa B ◽  
Alimentary Tract ◽  
Therapeutic Interventions ◽  
Treatment And Prevention ◽  
Gastrointestinal Mucositis ◽  
Anti Inflammatory ◽  
Natural Medicines ◽  
Pro Inflammatory Cytokines

Mucositis is a side effect associated with the use of chemotherapy, and has a significant impact on the quality of life. Mucositis, by definition, refers to the inflammation of the mucosa and occurs throughout the alimentary tract from the mouth to anus. Nuclear Factor kappa B (NFκB) encompasses a family of transcription factors, which upregulate pro-inflammatory cytokines. These are recognized as key targets in developing therapeutic interventions for chemotherapy-induced mucositis, and cyclooxygenase (COX)-2 inhibition may also be beneficial in reducing the severity and duration. This review focuses on the pathobiology of chemotherapy-induced oral and gastrointestinal mucositis and recent research examining the role of agents with anti-inflammatory activity in treatment and prevention of the condition. We consider agents in clinical use as well as some others under current investigation including plant-derived and other natural medicines.

Cognitive Health Counseling 40+

2013 ◽  
Vol 21 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Anne Eschen ◽  
Franzisca Zehnder ◽  
Mike Martin
Keyword(s):  
Outcome Variable ◽  
Pilot Phase ◽  
Subjective Memory ◽  
Cognitive Health ◽  
Health Counseling ◽  
Agents Of Change ◽  
Main Outcome Variable ◽  
Further Development

This article introduces Cognitive Health Counseling 40+ (CH.CO40+), an individualized intervention that is conceptually based on the orchestration model of quality-of-life management ( Martin & Kliegel, 2010 ) and aims at improving satisfaction with cognitive health in adults aged 40 years and older. We describe the theoretically deduced characteristics of CH.CO40+, its target group, its multifactorial nature, its individualization, the application of subjective and objective measures, the role of participants as agents of change, and the rationale for choosing participants’ satisfaction with their cognitive health as main outcome variable. A pilot phase with 15 middle-aged and six older adults suggests that CH.CO40+ attracts, and may be particularly suitable for, subjective memory complainers. Implications of the pilot data for the further development of the intervention are discussed.

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