scholarly journals Lesão anal por papilomavírus humano em mulher vivendo com HIV/aids

2017 ◽  
Vol 27 (3) ◽  
pp. 27017
Author(s):  
Vanessa Laís Diefenthäler ◽  
Mariele Do Amaral Schneider Cardoso ◽  
Janice De Fátima Pavan Zanella ◽  
Paulo Ricardo Moreira ◽  
Janaina Coser
Keyword(s):  
Human Papillomavirus ◽  
Histopathological Examination ◽  
Care Center ◽  
Hpv Infection ◽  
Severe Dysplasia ◽  
Hiv Viral Load ◽  
Anal Lesion ◽  
Anal Bleeding ◽  
Living With Hiv ◽  
Hiv Aids

*** Anal lesion caused by human papillomavirus in a woman living with HIV/AIDS ***AIMS: To describe a case of anal lesion caused by human papillomavirus (HPV) infection in a woman living with HIV/AIDS.CASE DESCRIPTION: A 35-year-old woman, diagnosed with HIV five years ago, reported pruritus ani, anal bleeding, painful defecation, and presence of small warts in the perianal region. The patient was seen at a specialized care center and was subjected to clinical examination with visual inspection, which revealed perianal condyloma. Histopathological examination confirmed the presence of moderate to severe dysplasia associated with HPV-compatible changes. The anal lesion was excised. At the onset of the symptoms, the patient was not on antiretroviral therapy and her HIV viral load was at its highest (2,951 copies/mL) compared with her previous laboratory tests. She had gone through emotional stress and presented with recurrent genital herpes simplex virus infections. These factors may have predisposed her to the development of anal condyloma.CONCLUSIONS: Since HIV infection may alter the history of HPV infection, it is important that screening strategies include cytological analysis of both the cervix and the anal region.

scholarly journals 926. Antibody Response to HPV Vaccination in Pediatric and Adolescent People Living with HIV (PLWH)

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S496-S497
Author(s):  
Roukaya Al Hammoud ◽  
Elizabeth R Unger ◽  
Gitika Panicker ◽  
Gabriela P Del Bianco ◽  
Gloria Heresi ◽  
...  
Keyword(s):  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Hpv Infection ◽  
Pediatric Hiv ◽  
People Living With Hiv ◽  
Hiv Viral Load ◽  
Exact Test ◽  
Peak Titer ◽  
Hpv Types ◽  
Living With Hiv

Abstract Background Immune dysfunction related to HIV infection is associated with an inability to clear HPV infection and may compromise the immunogenicity of quadrivalent HPV vaccine Gardasil® (4v HPV). Methods Between 2005 and 2017, males and females 7 to 20 years old age, were offered 3-dose 4v HPV vaccine. Plasma IgG titers to HPV 6 (H6), 11 (H11), 16 (H16) and 18 (H18) were measured using multiplex VLP-based ELISA. For the 36 patients, median interval from 1st dose to 2nd and 3rd doses were 73 and 216 days. Plasma sample 1 was collected at median of 91 days after dose 1, sample 2, 169 and sample 3, 740 after respective vaccine doses. A 4th sample was available for 26 patients, median 2327 days after dose 1. Rank-sum test, Χ 2 or Fisher’s Exact Test were employed. Results Before vaccination, 10 (28%) were seropositive to 1 or more HPV types. The baseline seropositives were older than seronegatives (16 years vs 11; p=0.007). After dose 3 all participants had an Ab response to at least 1 HPV type and 32 (89%) were seropositive for 4 HPV types. Seroconversions were H18, 87%; H16 97%; H11, 100%; H6, 97%. Seroconversions after 1 dose of 4v HPV among the baseline seronegatives were 61%, 90%, 86% and 86%, respectively and 22 became seropositive for all 4 types. The 4 baseline seronegative PLWH with partial seroconversion had higher median HIV viral load (VL) compared to baseline seronegative group with full seroconversion (12,920 vs 101 copies/ml; p = 0.052), but had comparable CD4 counts. The rate of post vaccination seropositivity and baseline to peak titer response for each HPV type was not significantly different for baseline sero-groups. Among baseline seronegative, all 19 sampled distant from vaccination remained seropositive to at least 1 HPV type (84% to 3 or more types) and 6 (32%) became seronegative (sero-reversion). Those showing sero-reversion had higher VL compared to the 14 who remained seropositive (9100 vs 48; p =0.015). Time from last dose of 4v HPV to sample 4, CD4%, age, gender, and race/ethnicity were similar between the groups. Bar Graphs representing Ab response to the 4 HPV types following each dose of 4v HPV vaccine Conclusion In the complex environment of a pediatric HIV specialty clinic, most PLWH mounted Ab responses to 4v HPV that were durable. H18 was least immunogenic. Patients with higher HIV VL were less likely to seroconvert for all types and were more likely to sero-revert. Disclosures All Authors: No reported disclosures

scholarly journals High-risk human papillomavirus and cervical lesions among women living with HIV/AIDS in Brazilian Amazon, Brazil

2015 ◽  
Vol 19 (6) ◽  
pp. 557-562 ◽  
Author(s):  
Leila da Silva ◽  
Angélica Miranda ◽  
Rosieny Batalha ◽  
Luiz Ferreira ◽  
Mayara Santos ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Brazilian Amazon ◽  
Cervical Lesions ◽  
Women Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals A study of HIV/AIDS awareness among the ICTC clients in a tertiary care center

2021 ◽  
Vol 8 (2) ◽  
pp. 146-151
Author(s):  
Yashaswini M K ◽  
Archana Rao K ◽  
Sangeetha S
Keyword(s):  
Hiv Transmission ◽  
Care Center ◽  
Tertiary Care ◽  
Well Being ◽  
Unprotected Sex ◽  
The Public ◽  
Aids Awareness ◽  
Proper Training ◽  
Living With Hiv ◽  
Hiv Aids

HIV/AIDS poses a significant and one of the most genuine general well-being challenges. For HIV anticipation in the Indian scenario, the main plausible and financially savvy approach that can be adapted is proper training about HIV/AIDS and its various aspects. The present study was embraced to survey the degree of information and awareness about HIV/AIDS among clients attending ICTC facility in our hospital.A total of 200 clients, of age >18yrs, attending the ICTC for HIV testing were studied over a period of 3 months. A questionnaire was prepared in regards to the methods of transmission, preventive techniques, mentality towards patient living with HIV/ AIDS and the source of HIV/ AIDS. The response of clients to the questionnaire was recorded.Among 200 participants, 97% were aware that unprotected sex is a mode of HIV transmission and 64% were aware that infected blood transfusion, use of unsterile needles and syringes contribute to other modes of HIV transmission. It was also noted that uneducated clients had a false perception that HIV can be transmitted by drinking water from same glass and by mosquito bite and this was statistically significant compared to educated individuals. The main source of acquiring positive information among the clients regarding HIV was observed to be television (32.5%). Stigma among the general public was mostly due to fear of contracting the illness. There is a requirement for more noteworthy endeavours toward making data with respect to HIV/AIDS accessible to all. The level of awareness regarding HIV/AIDS needs to be elevated among the public.

scholarly journals Driving Force of Covid-19 Among People Living With HIV/AIDS in Wuhan, China

2020 ◽  
Author(s):  
Wei Guo ◽  
Fangzhao Ming ◽  
Yu Dong ◽  
Qian Zhang ◽  
Lian Liu ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Count ◽  
Driving Force ◽  
Driving Forces ◽  
People Living With Hiv ◽  
Hiv Diagnosis ◽  
Hiv Viral Load ◽  
Increased Risk ◽  
Living With Hiv ◽  
Hiv Aids

Abstract Background: Even people living with HIV/AIDS (PLWHA) were considered to be at increased risk of SARS-CoV-2 infection, the driving force among this group of individuals is still not clear. Methods: We investigated 1,701 PLWHA through a telephone interview and found 11 COVID-19 patients in four districts of Wuhan, China. The demographic features and major clinical characteristics of these patients were retrieved from the information management systems for COVID-19 patients of four districts’ CDC. Statistical analysis was performed to find out the driving force of COVID-19 among PLWHA.Results: The incidence proportion of COVID-19 in PLWHA is 0.6% (95% CI: 0.2% - 1.0%), which is comparable to the overall population incidence rate in Wuhan city (0.6%). Nine out of the 11 COVID-19/AIDS patients had relatively high CD4+ T lymphocyte count (>200/μl) and undetectable HIV viral load (＜20 copies/ml), and ten of them were on antiretroviral therapy. PLWHA who were old, had low CD4+ T lymphocyte count, infected HIV through homosexual activity, and had been diagnosed for HIV for a long time, were more likely to develop COVID-19.Conclusions: PLWHA has comparable COVID-19 morbidity rates as the general population, and older age, low CD4 count, long length since HIV diagnosis, and treatment-naive were potential driving forces of COVID-19 occurrence among PLWHA. Strategies in preventing SARS-CoV-2 infection among PLWHA with worse immune responses are needed. Article Summary Line: As COVID-19 continues to spread around the world, people living with HIV/AIDS (PLWHA) are also at risk of infection with SARS-CoV-2. We investigated the factors associated with SARS-CoV-2 infection among PLWHA in Wuhan, China.

Prevalence and risk factors for anogenital HPV infection and neoplasia among women living with HIV in China

2021 ◽  
pp. sextrans-2021-055019
Author(s):  
Rufei Duan ◽  
Hongyun Zhang ◽  
Aihui Wu ◽  
Chongxi Li ◽  
Le Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hpv Infection ◽  
Hiv Treatment ◽  
Cd4 Count ◽  
Hiv Viral Load ◽  
Cross Sectional Survey ◽  
Specific Level ◽  
Women Living With Hiv ◽  
Hpv Prevalence ◽  
Living With Hiv

ObjectivesTo explore the prevalence and risk factors of anogenital human papillomavirus (HPV) infection and neoplasia among women living with HIV (WLHIV) in China.MethodsA cross-sectional survey was conducted from 2019 to 2020, 409 WLHIV aged 18 years and older were recruited from an HIV treatment clinic in Yunnan, China. Cervical and anal samples were collected for HPV testing of 15 HPV genotypes and cytological interpretation. Women positive for cervical HPV or cytological abnormalities were recalled for colposcopy examination and biopsy when necessary. Prevalence of anogenital HPV infection and neoplasia were compared by logistic regression.ResultsHPV prevalence was 34.2% (140/409) for cervical and 34.7% (142/409) for anal (high-risk HPV being 30.6% (125/409) and 30.3% (124/409), respectively). The most frequent genotypes were HPV-52, HPV-16 and HPV-58 in the cervix, HPV-52, HPV-53 and HPV-39 in the anus, with strong correlation between cervical and anal positivity, both overall and at a type-specific level. Cervical HPV was most associated with short duration of combination antiretroviral therapies (cART) (≤2 vs >2 years, adjusted OR (aOR)=2.25, 95% CI: 1.22 to 4.12) and high initial HIV viral load (≥1000 vs <1000 copies/mL, aOR=1.98, 95% CI: 1.10 to 3.58). Anal HPV was most associated with low nadir CD4 count (<200 vs ≥200 cells/µL, aOR=1.80, 95% CI: 1.01 to 3.22) and low current CD4 count (<350 vs ≥500 cells/µL, aOR=2.06, 95% CI: 1.00 to 4.36). CIN2+ prevalence was 4.6% and associated with low nadir CD4 count (aOR=4.63, 95% CI: 1.24 to 17.25).ConclusionsCervical and anal HPV were strongly correlated and, together with associated neoplasia, were highly prevalent among WLHIV in China. Early initiation of cART to avoid severe immunodeficiency should decrease anogenital HPV prevalence and related cancer burden among WLHIV. Incorporating anogenital cancer prevention services into HIV/AIDS care is warranted.

Prevalence and genotype distribution of human papillomavirus in women living with HIV/AIDS in an area of Northeast Brazil

2020 ◽  
Vol 92 (12) ◽  
pp. 3279-3287
Author(s):  
Brenda Evelin Barreto Silva ◽  
Victor Santana Santos ◽  
Ingrid Emmily Reis Santos ◽  
Edilaine Dória Araújo ◽  
Melina Vieira Alves ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Northeast Brazil ◽  
Genotype Distribution ◽  
Women Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Prevalence of High-Risk Human Papillomavirus Infections before and after Cervical Lesion Treatment, among Women Living with HIV

2021 ◽  
Vol 10 (14) ◽  
pp. 3133
Author(s):  
Timothée Dub ◽  
Sophie Le Cœur ◽  
Nicole Ngo-Giang-Huong ◽  
Wanmanee Matanasarawut ◽  
Pornnapa Suriyachai ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Pap Smear ◽  
Hpv Infection ◽  
Cervical Lesion ◽  
P Value ◽  
Women Living With Hiv ◽  
Treatment Indication ◽  
Living With Hiv ◽  
Lesion Treatment

Even when receiving combination antiretroviral therapy, women living with HIV are at high risk of human papillomavirus (HPV) infection and/or cervical lesions, including cancer. Using data from the PapilloV prospective cohort, we evaluated the prevalence of high-risk HPV (HR-HPV) infections after cervical lesion treatment and investigated factors associated with their carriage. Women were followed up for three years with annual Pap smear and HPV genotyping. We offered treatment to women presenting either a Pap smear with high-grade squamous intraepithelial lesion or higher, and/or a biopsy showing cervical intraepithelial neoplasia II or III. We compared the prevalence of HR-HPV infection at the time of first treatment indication and at the end of follow-up among women who received treatment and those who did not. Overall, 46 women had treatment indication. HR-HPV prevalence significantly decreased from 67% to 27% (p value = 0.001) in the 30 women who received treatment, while it did not significantly decrease (from 56% to 38%) in the 16 women who did not (p value = 0.257). Due to lack of statistical power, the 40% relative difference in HR-HPV carriage between treated and untreated women was not significant. In women living with HIV, the treatment of a cervical lesion may be beneficial for clearing HR-HPV infections.

scholarly journals Epidemiology of high-risk human papillomavirus and cervical lesions in African women living with HIV/AIDS

AIDS ◽  
2017 ◽  
Vol 31 (2) ◽  
pp. 273-285 ◽  
Author(s):  
Helen A. Kelly ◽  
Bernard Sawadogo ◽  
Admire Chikandiwa ◽  
Michel Segondy ◽  
Clare Gilham ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
African Women ◽  
Cervical Lesions ◽  
Women Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Expression of Sp100 Protein in Human Papillomavirus-Associated Sinonasal Inverted Papilloma

2019 ◽  
Vol 100 (1) ◽  
pp. NP21-NP25
Author(s):  
Fei Wang ◽  
Jingru Zhang ◽  
Hongming Wang ◽  
Wei Li
Keyword(s):  
Human Papillomavirus ◽  
Clinical Features ◽  
Histopathological Examination ◽  
Inferior Turbinate ◽  
Hpv Infection ◽  
Inverted Papilloma ◽  
Hpv Dna ◽  
Sinonasal Inverted Papilloma ◽  
Positive Rate ◽  
Hpv 18

Objective: Sinonasal inverted papilloma (SNIP) is a benign tumor characterized by an aggressive growth, a tendency to recur, and an association with malignancy. However, the precise etiology of SNIP is still unknown. The objective of this study was to identify the expression pattern of speckled protein 100 (Sp100) in the malignant transformation (MT) of SNIP and its correlation with human papillomavirus (HPV)-16 and HPV-18 infections and other clinical features. This would further help in understanding the possible mechanisms for the development of SNIP. Methods: Individual nasal mucosa specimens from 40 patients (25 males and 15 females) and 10 inferior turbinate specimens as controls were included in the present study. The samples were divided into several sections for histopathological examination, HPV DNA detection, and immunohistochemical staining. Results: We observed that as SNIP progressed, the Sp100 protein expression was gradually downregulated, and SP100 localization changed from nucleus to the cytoplasm. Positive rate of HPV infection in the SNIP with MT group was higher than that in the other groups, and Sp100 expression was correlated to HPV infections and SNIP with MT. However, no correlation was observed between Sp100 expression and clinical features, such as age, gender, and smoking. Conclusion: Positive rate of HPV infection is high in the SNIP with MT and has a correlation with Sp100 expression. In addition, the expression of Sp100 is downregulated in SNIP with MT, and Sp100 may play a role in the progression of SNIP.

Sign in / Sign up

Export Citation Format

Share Document