scholarly journals Comparative Study Of The Effect Of Topical Corticosteroid With Non-Steroidal Anti Inflammatory Agents On Post-Operative Inflammation And Corneal Astigmatism After Cataract Surgery.

2019 ◽  
Vol 2 (02) ◽  
pp. 95-99
Author(s):  
Dr. Neeta Pal ◽  
Dr. Thanikachalam Subramanian ◽  
Dr. A. John Bosco ◽  
Dr. Vijay Chawda
Keyword(s):  
Comparative Study ◽  
Topical Corticosteroid ◽  
Cataract Surgery ◽  
Corneal Astigmatism ◽  
Posterior Chamber ◽  
Eye Drops ◽  
Ocular Pain ◽  
Postoperative Control ◽  
Significant Difference ◽  
Anti Inflammatory

Purpose:To compare the effects of topical corticosteroid with non-steroidal anti-inflammatory agents on postoperative control of inflammation, pain and corneal astigmatism. Setting: Indira Gandhi Government General Hospital & Postgraduate Institute, Puducherry. Methods:A prospective comparative study in two hundred patients with visually significant cataract, undergoing manual small incision cataract surgery with implantation of posterior chamber intraocular lens were randomly assigned into four groups with minimum 50 patients in each.  All cases of uncomplicated cataract surgery were assigned to following groups to receive one of the following topical anti-inflammatory agents as postoperative medications: Group A- 1% predinsolone acetate, Group B -0.5% ketorolac tromethamine, Group C 0.09% Bromfenac eye drops, Group D 0.1% Nepafenac eye drops. All patients were examined on 1 day (baseline), 3th day, 5th day, 7th day, 14th day and 1month after surgery for assessment of ocular pain, anterior chamber cells and flare and corneal astigmatism. Results:The cells and flare were least in bromfenac group on the 3rd postoperative day.Nepafenac is effective in inflammation control from 5th postoperative day. There was a significant association of use of drug and severity of ocular pain upto 1stpostoperative week. There was statistically significant difference between NSAIDs and steroid on postoperative astigmatism (P <0.001). Conclusions:Bromfenac is effective as an anti-inflammatory agent in the immediate postoperative period. All the NSAIDs are found to be as effective as steroid after 1 week onwards. The NSAIDs showed reduced astigmatism changes and stabilizes astigmatism much quicker than steroids.

Astigmatism in Straight and Frown Incision in Small Incision Cataract Surgery: A Comparative Study

2017 ◽  
Vol 2 (3) ◽  
pp. 111-116
Author(s):  
Sanjay Gupta ◽  
M Srinivasan ◽  
Shweta Tripathi
Keyword(s):  
Comparative Study ◽  
Cataract Surgery ◽  
Posterior Chamber ◽  
Age Group ◽  
Small Incision Cataract Surgery ◽  
Small Incision ◽  
Incision Size ◽  
Postoperative Astigmatism ◽  
Department Of Ophthalmology ◽  
Significant Difference

ABSTRACT Introduction Blindness due to cataract presents an enormous problem especially in developing countries like India, not only in terms of human morbidity but also in terms of economic loss and social burden. The cataract surgeon of today is challenged to control the sphere as well as the cylinder of the refraction after surgery. Small incision cataract surgery (SICS) is now the method of choice in many parts of the world. This present study has been carried out with the aim to compare the postoperative corneal astigmatism between the two groups of patients undergoing SICS with posterior chamber intraocular lens (PCIOL) implantation with two difference types of incisions, i.e., frown and straight. Material and methods A prospective study was carried out in 60 patients enrolled from the Department of Ophthalmology of Pondicherry Institute of Medical Sciences who underwent SICS with superiorly placed straight and frown incision with PCIOL (each group consisting of 30 patients) during the period from May 2005 to October 2006. Results In this study, 60 patients having senile cataract in the age group of 50 to 75 years were studied. Out of these, the majority were in the age group of 60 to 64 (28.33%) years and only 26.66% were more than 70 years. The male:female ratio was 1:1. In our study, we found that frown incision had significantly better (p < 0.001) mean net astigmatism as compared with the straight incision. Conclusion We conclude that small incision size and absence of suture are the most important factors that contribute to less astigmatism and faster stabilization of SICS, where phacoemulsification cannot be performed. The duration for stabilization of postoperative astigmatism in straight incision group is 6 weeks, whereas it is 3 weeks in frown incision. Frown superior incision has got added advantage of early wound stabilization than straight incision, allowing the patient to resume their daily activities at an early stage. Superior incision group (both frown and straight) had increased amount of with-the-rule (WTR) astigmatism which later shifted to against-the-rule. There was a significant difference in net astigmatism between frown and straight. Postoperative astigmatism also depends on preoperative astigmatism. Patients with preoperative WTR benefited from superior incision cataract surgery. How to cite this article Tripathi S, Srinivasan M, Gupta S. Astigmatism in Straight and Frown Incision in Small Incision Cataract Surgery: A Comparative Study. Int J Adv Integ Med Sci 2017;2(3):111-116.

scholarly journals Topical bromfenac versus prednisolone: post cataract surgery safety and efficacy

2020 ◽  
Vol 7 (4) ◽  
pp. 1375
Author(s):  
Harish R. Trivedi ◽  
Harsha Maheshwari
Keyword(s):  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Macular Oedema ◽  
Cystoid Macular Oedema ◽  
Posterior Chamber ◽  
Prednisolone Acetate ◽  
Eye Drops ◽  
Small Incision Cataract Surgery ◽  
Postoperative Inflammation ◽  
Anti Inflammatory

Background: Cataract surgery can result in postoperative inflammation which increases the risk of complications like increased intraocular pressure (IOP), uveitis and cystoid macular oedema. We aim to evaluate the effectiveness of topical non-steroidal anti-inflammatory drug bromfenac and topical prednisolone in controlling intraocular inflammation after uncomplicated cataract surgery and compare intraocular pressure (IOP) differences, degrees of anterior chamber inflammation and macular oedema between two different treatments.Methods: 100 patients undergoing manual small incision cataract surgery with PMMA posterior chamber intraocular lens implantation were randomly assigned to receive either Bromfenac (0.09%) eye drops or prednisolone acetate (1%) eye suspension as their postoperative anti-inflammatory medication with 50 cases in each group. The patients were examined at the day 1, day 7, day 15, and day 30 after surgery. Postoperative inflammation was evaluated subjectively by intraocular pressure, slit-lamp assessment of signs of inflammation in the form of aqueous cells and flare and optical coherence tomography to rule out post-operative macular oedema.Results: Both the drugs are equally effective in controlling post-operative inflammation and post-operative cystoid macular oedema.Conclusions: Bromfenac (0.09%) is an effective drug in controlling ocular inflammation after un-complicated cataract surgery having effect similar to topical Prednisolone acetate (1%) with minimal side effects and less frequent dosing.

scholarly journals Comparative study between conventional extra capsular cataract extraction versus manual small incision cataract surgery

2017 ◽  
Vol 5 (3) ◽  
pp. 996 ◽  
Author(s):  
Gannaram Laxmiprasad ◽  
Chhaya Shori ◽  
Rakesh Shori ◽  
Ashalatha Alli
Keyword(s):  
Cataract Surgery ◽  
Tertiary Care ◽  
Posterior Chamber ◽  
Small Incision Cataract Surgery ◽  
Visual Rehabilitation ◽  
Surgically Induced Astigmatism ◽  
Small Incision ◽  
Significant Difference ◽  
Induced Astigmatism ◽  
Surgically Induced

Background: Recent reports indicate that both manual small incision cataract surgery and extra capsular cataract excision surgery with posterior chamber intraocular lens implantation are safe and effective for treatment of cataract surgery, however, manual small incision cataract surgery gives better uncorrected vision. Objectives of the study were to compare intraoperative and postoperative complications, to compare induced astigmatism and to compare the visual rehabilitation.Methods: This is a prospective study of 100 consecutive patients assigned to undergo conventional extra capsular cataract excision surgery (50 cases) and manual small incision cataract surgery (50 cases). Study was done for a period of two years at a tertiary care referral hospital. Institutional Ethics Committee permission was taken. Also the informed consent was obtained from each patient.Results: In conventional ECCE, the most common surgically induced astigmatism was WTR in 73.4% of cases with mean of 2.79 D±1.3 on first day. 70% of cases with mean 2.1 D±1.28 and 64% of cases with mean of 1.86 D±1.14 at six weeks. ATR was common in MSICS group, 83.67% of cases with mean of 1.5 D±0.72 on first day, 86% of cases with mean of 1.03 D±0.6 at one week and 88% of cases with mean of 1.27 D±0.81 at six weeks. The induced astigmatism was less in MSICS group compared to ECCE group at first day but after six weeks there was no much significant difference found. Early visual recovery was better in MSICS groupConclusions: MSICS has definitive advantages over conventional ECCE in terms of early visual rehabilitation, minimal surgically induced astigmatism; no suture related complications and reduced surgical time.

scholarly journals Comparison of anti-inflammatory effects of eye drops formulations after uncomplicated cataract surgery

2020 ◽  
Vol 12 ◽  
pp. 251584142092430
Author(s):  
Carlo Cagini ◽  
Adriana Pellegrino ◽  
Alessia Iannone ◽  
Alessio Cerquaglia ◽  
Antonella Modugno ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Aqueous Humour ◽  
Corneal Thickness ◽  
Macular Thickness ◽  
Eye Drops ◽  
Significant Difference ◽  
Group A ◽  
Group B

Aim: The aim of this study is to compare the efficacy of different dexamethasone eye drops formulations in controlling postoperative inflammation. Methods: Cataract surgery was carried out in 72 patients (35 males) divided into two groups: group A (36 patients, mean age = 78.0 ± 5.6) received four times daily for 2 weeks a suspension containing tobramycin 0.3% mg/ml + dexamethasone 0.1% mg/ml, and group B (36 patients, mean age = 76.2 ± 6.8) a solution containing tobramycin 0.3% mg/ml + dexamethasone 0.1% mg/ml. Both groups received ofloxacin 0.5% four times daily for 7 days, and nepafenac 0.1% three times daily for 3 weeks. Best-corrected visual acuity, intraocular pressure, corneal thickness, endothelial cells count, aqueous flare and macular thickness were evaluated preoperatively and at 1 day, 15 days, 1 and 2 months. Results: In group A, intraocular pressure, corneal thickness and aqueous humour flare values preoperatively and at the end of follow-up were 14.3 ± 1.8 and 13.2 ± 1.8 mmHg, 546.4 ± 34.6 and 539.6 ± 36.1 µm, 11.84 ± 4.44 and 13.52 ± 5.54 ph/ms, respectively, with no statistically significant difference. In group B, intraocular pressure, corneal thickness and aqueous humour flare values preoperatively and at the end of follow-up were 14.3 ± 1.5 and 13.1 ± 1.7 mmHg, 552.9 ± 37.4 and 548.1 ± 39.3 µm, 11.45 ± 4.06 and 13.73 ± 4.99 ph/ms, respectively, with no statistically significant difference. No difference was detected in the macular thickness values in the parafoveal area preoperatively and at 2 months follow-up in group A (332.18 ± 16.19 and 337.71 ± 16.33 µm) and group B (329.11 ± 18.28 and 334.37 ± 20.86 µm), respectively. Conclusion: The two different formulations of dexamethasone eye drops reached the same anti-inflammatory effects.

scholarly journals Non-steroidal anti-inflammatory drugs in the post-operative treatment of ophthalmic patients

2015 ◽  
Vol 8 (3) ◽  
pp. 45-48
Author(s):  
Sergey Yurievich Astakhov ◽  
Medeya Vakhtangovna Gobedzhishvili
Keyword(s):  
Cataract Surgery ◽  
Operative Treatment ◽  
Cataract Extraction ◽  
Eye Drops ◽  
Treatment Results ◽  
Before And After ◽  
Inflammatory Processes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Purpose: to analyze the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) after cataract extraction. To determine the NSAID’s role in post-operative inflammatory processes treatment. Results: the rationale of NSAIDs use before and after cataract surgery was validated. The NSAIDs efficacy in terms of post-op inflammation reduction was confirmed. Among NSAIDs benefits, the convenient and easy-to-use instillation regimen of Bromfenac 0.09% eye drops solution was highlighted.

scholarly journals CATARACT SURGERY;

2017 ◽  
Vol 24 (12) ◽  
pp. 1812-1817
Author(s):  
Zulfiqar Ahmed Memon ◽  
Omar Zafar ◽  
Arsalan Farooq ◽  
Shabnam Memon ◽  
Najam ul Hassan ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Air Force ◽  
Prednisolone Acetate ◽  
Eye Drops ◽  
Single Drop ◽  
Treatment Results ◽  
Chi Square ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Chi Square Test

Objectives: To determine the efficacy of topical nepafenac 0.1% eye dropsas compared toprednisolone acetate 1% eye drops in the management of postoperativeinflammation after cataract surgery. Study Design: Randomized controlled clinical study.Place and Duration of study: Pakistan air force hospital Rafiqui from Oct 2016 to Feb 2017.Patients and methods: Two hundred and forty eight eyes were randomly divided in two equalgroups. Patients received nepafenac 0.1% or prednisolone acetate 1% as single drop 8 hourlybeginning 1 day preoperatively, continued till 2 weeks post-operatively. Efficacy of the drugwill be considered if there is no anterior chamber reaction along with no aqueous flare after 2weeks of treatment. Results: 85.5% of cases resolved with topical nepafenac 0.1%as comparedto 88.7% that were cured with prednisolone acetate 1%. Pearson chi square test indicates thatthere is no statistical significant difference (p= 0.449) between the efficacy of two modes oftreatment. Conclusion: Nepafenac 0.1% eye drops are as effective as prednisolone acetate 1%in the prevention of postoperative inflammation with cataract surgery.

scholarly journals Comparison of Astigmatism Correction in Cataract Surgery Between Simultaneous Femtosecond Laser-Assisted Intrastromal Arcuate Keratotomy and Toric Intraocular Lens Implantation

2020 ◽  
Author(s):  
Hye Ji Kwon ◽  
Hun Lee ◽  
Jin Ah Lee ◽  
Jae Yong Kim ◽  
Hungwon Tchah
Keyword(s):  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Intraocular Lens ◽  
Tertiary Care ◽  
Corneal Astigmatism ◽  
Toric Intraocular Lens ◽  
Toric Iol ◽  
Iol Implantation ◽  
Tertiary Care Medical Center ◽  
Significant Difference

Abstract Objectives To compare the efficacy of astigmatic correction between simultaneous femtosecond laser-assisted intrastromal arcuate keratotomy (AK) combined with femtosecond laser-assisted cataract surgery (FLACS) and toric intraocular lens (IOL) implantation during cataract surgery in moderate astigmatism. Design: Retrospective observational study, tertiary care medical center Methods We retrospectively reviewed medical records of patients who underwent astigmatic correction via femtosecond laser-assisted intrastromal AK (AK group; 27 eyes of 27 patients) with FLACS or toric IOL implantation (toric IOL group; 21 eyes of 21 patients). All patients had senile cataracts with corneal astigmatism ranging from + 1.00 to + 2.00 diopters (D) before cataract surgery. We measured visual acuity, intraocular pressure, automated keratometry, manifest refraction and topography preoperatively and at 1-day, 1-month, 3-month, and 6-month postoperatively. Results Refractive astigmatism was significantly decreased in both groups. The mean preoperative and 6-month postoperative refractive astigmatism were 1.85 ± 1.07 and 0.99 ± 0.51 D, respectively, in the AK group (P = 0.028), and 1.84 ± 0.81 and 0.68 ± 0.21 D, respectively, in the toric IOL group (P < 0.001). There was no significant difference in refractive astigmatism between the two groups at 6-month postoperatively (0.99 ± 0.51 vs 0.68 ± 0.21 D, P = 0.057). At 6-month postoperatively, parameters for vector analysis of refractive astigmatism showed no statistical difference between the two groups. Corneal astigmatism was significantly decreased in the AK group. There was significant difference in corneal astigmatism from topography and automated keratometer between the two groups at 6-month postoperatively (0.94 ± 0.40 vs 1.53 ± 0.46 D, P = 0.018 for topography and 0.98 ± 0.69 vs 1.37 ± 0.41 D, P = 0.032 for automated keratometer). Conclusions Femtosecond laser-assisted intrastromal AK in FLACS could be an effective procedure for reducing astigmatism as well as toric IOL implantation in cataract surgery.

scholarly journals Effects of Topical Gabapentin on Ocular Pain and Tear Secretion

2021 ◽  
Vol 12 ◽  
Author(s):  
Maurizio Cammalleri ◽  
Rosario Amato ◽  
Melania Olivieri ◽  
Salvatore Pezzino ◽  
Paola Bagnoli ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Ocular Surface ◽  
Rabbit Model ◽  
Corneal Epithelial Cell ◽  
Epithelial Cell Line ◽  
Eye Drops ◽  
Aquaporin 5 ◽  
Ocular Pain ◽  
Anesthetic Drugs ◽  
Anti Inflammatory

Neuropathic ocular pain is a frequent occurrence in medium to severe dry eye disease (DED). Only palliative treatments, such as lubricants and anti-inflammatory drugs, are available to alleviate patients’ discomfort. Anesthetic drugs are not indicated, because they may interfere with the neural feedback between the cornea and the lacrimal gland, impairing tear production and lacrimation. Gabapentin (GBT) is a structural analog of gamma-amino butyric acid that has been used by systemic administration to provide pain relief in glaucomatous patients. We have already shown in a rabbit model system that its topic administration as eye drops has anti-inflammatory properties. We now present data on rabbits’ eyes showing that indeed GBT given topically as eye drops has analgesic but not anesthetic effects. Therefore, opposite to an anesthetic drug such as oxybuprocaine, GBT does not decrease lacrimation, but–unexpectedly–even stimulates it, apparently through the upregulation of acetylcholine and norepinephrine, and by induction of aquaporin 5 (AQP5) expression in the lacrimal gland. Moreover, data obtained in vitro on a primary human corneal epithelial cell line also show direct induction of AQP5 by GBT. This suggests that corneal cells might also contribute to the lacrimal stimulation promoted by GBT and participate with lacrimal glands in the restoration of the tear film, thus reducing friction on the ocular surface, which is a known trigger of ocular pain. In conclusion, GBT is endowed with analgesic, anti-inflammatory and secretagogue properties, all useful to treat neuropathic pain of the ocular surface, especially in case of DED.

Current Use of Non-steroidal Anti-inflammatory Drugs in the Treatment of Ocular Inflammation Related to Cataract Surgery

2012 ◽  
Vol 06 (03) ◽  
pp. 173 ◽  
Author(s):  
Eric Donnenfeld ◽  
Keyword(s):  
Cataract Surgery ◽  
Ocular Inflammation ◽  
Cystoid Macular Oedema ◽  
Effective Management ◽  
Ocular Pain ◽  
Reduction Of Pain ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Systemic Responses ◽  
Topical Nsaids

Ocular inflammation and pain are a common consequence of cataract surgery, and if left untreated, may lead to extensive ocular damage, resulting in impaired vision as well as decreased satisfaction with the procedure. Effective management of ophthalmic inflammation after surgery is therefore vital. Topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) have become a mainstay of management of ocular pain and inflammation as a result of their anti-inflammatory activity, analgesic property and established safety record. Numerous studies have demonstrated the efficacy of topical NSAIDs in post-operative prevention of ocular inflammation, inhibition of intra-operative miosis, reduction of pain associated with cataract surgery and pre-operative use to prevent cystoid macular oedema. Studies have also indicated that NSAIDs and steroids act synergistically when administered together, and that a combination of steroid and NSAID therapy is recommended to achieve successful outcomes. With appropriate administration, NSAIDs are safe and effective therapeutic agents, which rarely result in serious local and systemic responses.

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