Therapeutic approaches for pusher syndrome after a stroke: a literature review

Purpose: The main objective of this review is to gather the information available about idiopathic toe walking (ITW), its prevalence and classification, and possible therapeutic approaches. In addition, this review aims to clarify the differences between idiopathic toe walkers and tiptoe walkers with underlying neurological or muscle deficiency as primary conditions. Understanding its causes and learning to make a differential diagnosis will help determine the adequate therapeutic approach. Methods: This is a review of different articles and case studies from 1967 to 2016. The information was gathered to update and unify all the information about ITW that has been published. Conclusion: The literature offers limited research regarding the possible etiology, prevalence, classification, and evaluation of ITW. This review puts together all the information regarding the etiology, prevalence, classifications, evaluation, and treatment of ITW. Levels of Evidence: Level IV

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Evaluating the role of formulation in counselling psychology: A systematic literature review

The European Journal of Counselling Psychology ◽

10.5964/ejcop.v7i1.146 ◽

2018 ◽

Vol 7 (1) ◽

pp. 47-68

Author(s):

Harriet Challoner ◽

Fani Papayianni

Keyword(s):

Systematic Review ◽

Clinical Practice ◽

Literature Review ◽

Therapeutic Approaches ◽

Regulatory Bodies ◽

The Subject ◽

Training Institutions ◽

Shed Light ◽

Counselling Psychology

Despite the importance placed upon the concept and act of formulation across multiple therapeutic approaches, there is a lack of literature from within the profession of counselling psychology directly on the role, use and practice of formulation, with existing literature predominantly emanating from the related yet distinct therapeutic fields of counselling, psychotherapy, clinical psychology or psychiatry. This, in conjunction with the controversies and lack of consensus on the subject, as well as the demands of the professional and regulatory bodies, have led to this paper. Our aim is to shed light on the role that formulation plays within the profession under the lens of counselling psychology’s philosophical underpinnings. More specifically, this systematic review investigates whether formulation may be considered as fact or opinion; whether formulations across therapeutic approaches may be cohesive or divisive within counselling psychology practice; whether formulations should be undertaken inclusively with clients and other professionals or exclusively by the practitioner. Such exploration uncovers key areas of debate and potential considerations for the profession regarding how formulation is approached, utilised in clinical practice and, taught by training institutions.

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A Systematic Literature Review of Current Therapeutic Approaches for COVID-19 Patients

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2020/v32i730455 ◽

2020 ◽

pp. 13-25 ◽

Cited By ~ 1

Author(s):

Saber Soltani ◽

Amir Mohammad Zakeri ◽

Mohammad Reza Karimi ◽

Sara Akhavan Rezayat ◽

Fateme Zomorodi Anbaji ◽

...

Keyword(s):

Literature Review ◽

Supportive Care ◽

Web Of Science ◽

Drug Research ◽

Treatment Options ◽

Antiviral Agents ◽

Therapeutic Approaches ◽

Improved Outcomes ◽

New Treatment ◽

Novel Coronavirus

Background: In December 2019, the pneumonia outbreak reported in Wuhan, Hubei Province, China. WHO introduced a novel coronavirus and the virus named Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) in January 2020. There are not any specific antiviral agents for coronavirus disease 19 (COVID‐19). Objective: Our review aimed to discuss treatment options and the efficacy of currently prescribed drugs and supportive care in COVID‐19 patients. Study Design: A literature review of the articles in the Web of Science, PubMed, Scopus and EMBASE conducted. Results: Lopinavir/ritonavir combination was the most frequently used drug, followed by Arbidol and Oseltamivir and Methylprednisolone. Lopinavir/Ritonavir outcome showed the fever and respiratory infection improve in day two and day eight, respectively. Also, negative PCR of SARS‐CoV‐2 in days six and 7day was seen and finally these patients discharged in 10 days. Conclusions: Lopinavir/Ritonavir was the most improving administrated antiviral combination, which might be a good option for COVID-19 due to its availability. Although supportive care such as O2 supplementary and IV fluid therapy has improved outcomes. There are not evidence for suggesting a new treatment or a new drug, which mean the necessity of further investigations for drug research in a clinical trial for a conclusion about the optimum treatment.

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Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review

Cells ◽

10.3390/cells9112412 ◽

2020 ◽

Vol 9 (11) ◽

pp. 2412

Author(s):

Gizem Kaykı-Mutlu ◽

Olga Papazisi ◽

Meindert Palmen ◽

A. H. Jan Danser ◽

Martin C. Michel ◽

...

Keyword(s):

Heart Failure ◽

Systematic Review ◽

Congestive Heart Failure ◽

Literature Review ◽

Dependent Manner ◽

Therapeutic Approaches ◽

System Activation ◽

And Function ◽

Circulating Levels

As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular α1-ARs in HF using 5 databases for our search. All three α1-AR subtypes (α1A, α1B and α1D) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of α1-ARs. Conflicting findings arise from different studies concerning the influence that HF has on α1-AR expression and function; in contrast to β-ARs there is no consistent evidence for down-regulation or desensitization of cardiac or vascular α1-ARs. Whether α1-ARs are a therapeutic target in HF remains a matter of debate.

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Pimecrolimus Cream 1% for the Treatment of Papulopustular Eruption Related to Epidermal Growth Factor Receptor Inhibitors: A Case Series and a Literature Review of Therapeutic Approaches

Dermatology ◽

10.1159/000277430 ◽

2010 ◽

Vol 220 (3) ◽

pp. 243-248 ◽

Cited By ~ 5

Author(s):

V. Nikolaou ◽

A. Stratigos ◽

C. Antoniou ◽

M. Kiagia ◽

C. Nikolaou ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Literature Review ◽

Case Series ◽

Growth Factor Receptor ◽

Therapeutic Approaches ◽

Epidermal Growth ◽

Papulopustular Eruption

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Undifferentiated pleomorphic sarcoma of the right atrium in an infant

Patologiya krovoobrashcheniya i kardiokhirurgiya ◽

10.21688/1681-3472-2020-2-119-123 ◽

2020 ◽

Vol 24 (2) ◽

pp. 119

Author(s):

I. S. Murashov ◽

V. E. Kliver ◽

T. A. Ageeva ◽

A. M. Volkov ◽

E. E. Kliver

Keyword(s):

Literature Review ◽

Conflict Of Interest ◽

Malignant Tumour ◽

Final Approval ◽

Therapeutic Approaches ◽

Immunohistochemical Examination ◽

Undifferentiated Pleomorphic Sarcoma ◽

Pleomorphic Sarcoma ◽

Critical Revision ◽

The Right

Undifferentiated pleomorphic sarcoma is a high-grade malignant tumour, accounting for one-third of all primary cardiac sarcomas. This paper describes a case of undifferentiated pleomorphic sarcoma in an infant using detailed morphological characterisation, immunohistochemical examination and a brief literature review. Taken together, these data will be useful not only for practicing pathologists but also for researchers of other biomedical fields for the development of procedures for differential diagnoses, investigation of the pathogenesis and development of therapeutic approaches for undifferentiated pleomorphic sarcoma.Received 4 February 2019. Revised 31 March 2020. Accepted 9 April 2020.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.Author contributions Drafting the article: I.S. Murashov, E.E. Kliver Literature review: V.E. Kliver, T.A. Ageeva Illustrations: V.E. Kliver, A.M. Volkov Critical revision of the article: I.S. Murashov, E.E. Kliver Final approval of the version to be published: I.S. Murashov, V.E. Kliver, T.A. Ageeva, A.M. Volkov, E.E. Kliver

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Immunological background for treatments with biologicals in CRSwNP

Archives of Asthma Allergy and Immunology ◽

10.29328/journal.aaai.1001026 ◽

2021 ◽

Vol 5 (1) ◽

pp. 022-029

Author(s):

Klimek L ◽

Hagemann J ◽

Casper I ◽

Huppertz T ◽

Bedbrook A ◽

...

Keyword(s):

Literature Review ◽

Inflammatory Disease ◽

Nasal Polyps ◽

Current Knowledge ◽

Cochrane Library ◽

Molecular Processes ◽

Therapeutic Approaches ◽

Phenotype Classification ◽

The Cochrane Library ◽

Structured Literature Review

Background: Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial inflammatory disease of the nasal and paranasal mucosa. To date, no internationally standardized uniform classification has been developed for this disease. Usually, a phenotype classification according to CRS with (CRSwNP) and without (CRSsNP) polyposis is performed. However, through a variety of studies, it has been shown that even within these phenotypes, different endotypes of CRS exist, each with a different underlying inflammatory pathophysiology. In this mini-review, we aim to outline the essential immunological processes in CRSwNP and to highlight the modern therapeutic options with biologics derived from this disease. Methods: Current knowledge on the immunological and molecular processes of CRS, especially CRSwNP, was compiled by means of a structured literature review. Medline, PubMed, national/international trial and guideline registries as well as the Cochrane Library were all searched. Results: Based on the current literature, the different immunological processes involved in CRS and nasal polyps were elaborated. Current studies on the therapy of eosinophilic diseases such as asthma and polyposis are presented and their results discussed. Conclusion: Understanding the immunological basis of CRSwNP may help to develop new personalized therapeutic approaches using biologics. Currently, 2 biologics (dupilumab, omalizumab) have been approved for the therapy of CRSwNP (polyposis nasi) in Europe.

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Unicystic ameloblastoma of the mandible clinical case presentation and literature review

Mexican Journal of Medical Research ◽

10.29057/mjmr.v2i3.1794 ◽

2014 ◽

Vol 2 (3) ◽

Author(s):

Almallely De la Paz López ◽

Norith Recendez Santillán ◽

Eduardo Varela Ibáñez ◽

Marco A. Escamilla-Acosta ◽

Georgina Romo-Hernández

Keyword(s):

Conservative Treatment ◽

Literature Review ◽

Male Patient ◽

Clinical Case ◽

Tumor Location ◽

Therapeutic Approaches ◽

Case Presentation ◽

Patient Referral ◽

Neoplastic Lesion ◽

Unicystic Ameloblastoma

Ameloblastoma is a neoplastic lesion that in its early stages does not present signs or symptoms; ages more common in which occurs this lesion are between 20 to 30 years of age, it has no predilection by any gender; their formation can be derived epithelial involved with the formation of teeth. The objective of this review is to present a clinical case of a 14-year-old male patient referral to the Hospital del Niño DIF Hidalgo, which presented volume increased in right hemiarch, diagnostic studies were conducted in which the result was an Unicystic Ameloblastoma of the Mandible, which was addressed through conservative treatment. It is intended that this review will update the knowledge and therapeutic approaches to this disease, assessing tumor location and patient age.

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Nanotheranostic agents for neurodegenerative diseases

Emerging Topics in Life Sciences ◽

10.1042/etls20190141 ◽

2020 ◽

Vol 4 (6) ◽

pp. 645-675

Author(s):

Parasuraman Padmanabhan ◽

Mathangi Palanivel ◽

Ajay Kumar ◽

Domokos Máthé ◽

George K. Radda ◽

...

Keyword(s):

Drug Delivery ◽

Neurodegenerative Diseases ◽

Cell Types ◽

Specific Cell ◽

Ageing Population ◽

Target Tissue ◽

Therapeutic Approaches ◽

Surface Receptors ◽

Theranostic Agents ◽

Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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