scholarly journals The COVID-19 Pandemic: Defining the Clinical Syndrome and Describing an Empirical Response

2020 ◽  
Vol 7 (1) ◽  
pp. 37-44
Author(s):  
Mandalam Seshadri ◽  
Jacob John

The novel corona virus infectious disease, COVID-19, is a pandemic now and is raging through several continents, posing a challenge to health-care systems of all the countries and disrupting lives and livelihoods across the world. The facilities for virus testing are available for only limited numbers in each country and each country excludes a large number of potentially infected subjects because the lab test is done for only certain categories. Nearly 80 % of those infected will therefore go undiagnosed. There is an urgent need therfore to define the clinical syndrome so that practitioners at the primary and secondary levels can make a confident clinical diagnosis and proceed to manage patients early and effectively. Chloroquine and hydroxychloroquine, both antimalarials have shown promise in limited trials in France and China. They are inexpensive, have been around for several decades in the prevention and treatment of malaria, have well-known side-effects and in the short term safe for use . We propose that practitioners make a preliminary clinical diagnosis of the COVID-19 syndrome based on simple clinical criteria and  lab tests and proceed to manage patients and protect other family members and contacts by using isolation measures and short regimens of these anti malarial and other medications, anticipating results of more clinical trials.

Author(s):  
Adjoby Cassou Roland ◽  
◽  
Gbary-Lagaud Eleonore ◽  
Effoh Ndrin Denis ◽  
◽  
...  

The novel coronavirus (SARS-Cov-2) that appeared in December 2019 in China quickly spread to all countries around the world leading the World Health Organization (WHO) to declare a pandemic on 11 March 2020. This pandemic is particularly serious in that it severely undermines health care systems in all affected countries, including developing and resource-constrained countries, forcing them to adapt quickly. Current data on COVID-19 and pregnancy are limited. The first published Chinese data seem to show that the symptoms in pregnant women are substantially the same as those in the general population. Through the first 2 cases of COVID-19 observed during pregnancy at Angré University Hospital, the authors wanted to share their experience, under the conditions of a low-resources country.


Author(s):  
Adjoby Cassou Roland ◽  
◽  
Gbary-Lagaud Eleonore ◽  
Effoh Ndrin Denis ◽  
◽  
...  

The novel coronavirus (SARS-Cov-2) that appeared in December 2019 in China quickly spread to all countries around the world leading the World Health Organization (WHO) to declare a pandemic on 11 March 2020. This pandemic is particularly serious in that it severely undermines health care systems in all affected countries, including developing and resource-constrained countries, forcing them to adapt quickly. Current data on COVID-19 and pregnancy are limited. The first published Chinese data seem to show that the symptoms in pregnant women are substantially the same as those in the general population. Through the first 2 cases of COVID-19 observed during pregnancy at Angré University Hospital, the authors wanted to share their experience, under the conditions of a low-resources country


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Tina Drud Due ◽  
Thorkil Thorsen ◽  
Julie Høgsgaard Andersen

Abstract Background Attempts to manage the COVID-19 pandemic have led to radical reorganisations of health care systems worldwide. General practitioners (GPs) provide the vast majority of patient care, and knowledge of their experiences with providing care for regular health issues during a pandemic is scarce. Hence, in a Danish context we explored how GPs experienced reorganising their work in an attempt to uphold sufficient patient care while contributing to minimizing the spread of COVID-19. Further, in relation to this, we examined what guided GPs’ choices between telephone, video and face-to-face consultations. Methods This study consisted of qualitative interviews with 13 GPs. They were interviewed twice, approximately three months apart in the initial phase of the pandemic, and they took daily notes for 20 days. All interviews were audio recorded, transcribed, and inductively analysed. Results The GPs re-organised their clinical work profoundly. Most consultations were converted to video or telephone, postponed or cancelled. The use of video first rose, but soon declined, once again replaced by an increased use of face-to-face consultations. When choosing between consultation forms, the GPs took into account the need to minimise the risk of COVID-19, the central guidelines, and their own preference for face-to-face consultations. There were variations over time and between the GPs regarding which health issues were dealt with by using video and/or the telephone. For some health issues, the GPs generally deemed it acceptable to use video or telephone, postpone or cancel appointments for a short term, and in a crisis situation. They experienced relational and technical limitations with video consultation, while diagnostic uncertainty was not regarded as a prominent issue Conclusion This study demonstrates how the GPs experienced telephone and video consultations as being useful in a pandemic situation when face-to-face consultations had to be severely restricted. The GPs did, however, identify several limitations similar to those known in non-pandemic times. The weighing of pros and cons and their willingness to use these alternatives shifted and generally diminished when face-to-face consultations were once again deemed viable. In case of future pandemics, such alternatives seem valuable, at least for a short term.


2017 ◽  
Vol 127 (1) ◽  
pp. 37-40
Author(s):  
Krzysztof Włoch ◽  
Janusz Jaroszyński ◽  
Ewa Warchoł-Sławińska ◽  
Anna Jurek ◽  
Bartłomiej Drop ◽  
...  

Abstract Community System of Social Support is the basis of modern health care systems not only in Poland but all over the world in the prophylaxis-treatment-rehabilitation procedure. In Poland, family doctors, commune councils and territorial self-governments are involved in it. Family doctors perform a substantial function, whereas commune councils and territorial self-governments an administrative one. The principle of the system work is evaluation of its benefits. Its aim is the reduction of the number of patients who abuse alcohol and those who abuse alcohol despite treatment.


2020 ◽  
Vol 16 (8) ◽  
pp. 467-482 ◽  
Author(s):  
Eva Segelov ◽  
Craig Underhill ◽  
Hans Prenen ◽  
Christos Karapetis ◽  
Christopher Jackson ◽  
...  

Cancer has become a prevalent disease, affecting millions of new patients globally each year. The COVID-19 pandemic is having far-reaching impacts around the world, causing substantial disruptions to health and health care systems that are likely to last for a prolonged period. Early data have suggested that having cancer is a significant risk factor for mortality from severe COVID-19. A diverse group of medical oncologists met to formulate detailed practical advice on systemic anticancer treatments during this crisis. In the context of broad principles, issues including risks of treatment, principles of prioritizing resources, treatment of elderly patients, and psychosocial impact are discussed. Detailed treatment advice and options are given at a tumor stream level. We must maintain care for patients with cancer as best we can and recognize that COVID-19 poses a significant competing risk for death that changes conventional treatment paradigms.


Author(s):  
Bin Fang ◽  
Linlin Liu ◽  
Xiao Yu ◽  
Xiang Li ◽  
Guojun Ye ◽  
...  

AbstractAs the highly risk and infectious diseases, the outbreak of coronavirus disease 2019 (COVID-19) poses unprecedent challenges to global health. Up to March 3, 2020, SARS-CoV-2 has infected more than 89,000 people in China and other 66 countries across six continents. In this study, we used 10 new sequenced genomes of SARS-CoV-2 and combined 136 genomes from GISAID database to investigate the genetic variation and population demography through different analysis approaches (e.g. Network, EBSP, Mismatch, and neutrality tests). The results showed that 80 haplotypes had 183 substitution sites, including 27 parsimony-informative and 156 singletons. Sliding window analyses of genetic diversity suggested a certain mutations abundance in the genomes of SARS-CoV-2, which may be explaining the existing widespread. Phylogenetic analysis showed that, compared with the coronavirus carried by pangolins (Pangolin-CoV), the virus carried by bats (bat-RaTG13-CoV) has a closer relationship with SARS-CoV-2. The network results showed that SARS-CoV-2 had diverse haplotypes around the world by February 11. Additionally, 16 genomes, collected from Huanan seafood market assigned to 10 haplotypes, indicated a circulating infection within the market in a short term. The EBSP results showed that the first estimated expansion date of SARS-CoV-2 began from 7 December 2019.


2014 ◽  
Vol 83 (2) ◽  
pp. 156-160
Author(s):  
Katarzyna Hojan

Aim. Cancer rehabilitation is an important, but often underutilized treatment in the comprehensive care of the cancer patient. The lack of appropriate referral by physicians unfamiliar with the concept of rehabilitation was identified as primary barriers to optimal delivery of rehabilitation care. Therefore, the aim of this paper is to describe the current situation in the world of science of cancer rehabilitation and to describe availability of professional resources in the selected countries in the world. Material and methods. This paper is a review article to describe rehabilitation models in cancer services for patients in selected cases in the world.Results. Rehabilitation should be applied in various settings, depending on the level of disability, extent of disease, medical acuity level of the patient, and available services. However, the rehabilitation systems in the world differ depending on the various social security and health-care systems, but they are largely based on a similar, multidimensional and multidisciplinary understanding of cancer rehabilitation. Conclusions. On the basis of description of the bio-psycho-social models, it can be seen that rehabilitation must be an integral and continuous part of all cancer care. There is strong evidence that rehabilitation is a well-tolerated and safe adjunct therapy that can mitigate several common treatment-related side effects among cancer patients.


Author(s):  
Konstans Wells ◽  
Miguel Lurgi

AbstractThe rapid and pandemic spread of COVID-19 has led to unprecedented containment policies in response to overloaded health care systems. Disease mitigation strategies require informed decision-making to ensure a balance between the protection of the vulnerable from disease and the maintenance of global economies. We show that temporally restricted containment efforts, that have the potential to flatten epidemic curves, can result in wider disease spread and larger epidemic sizes in metapopulations. Longer-term rewiring of metapopulation networks or the enforcement of feasible long-term measures that decrease disease transmissions appear to be more efficient than temporarily restricted intensive mitigation strategies (e.g. short-term mass quarantine). Our results may inform balanced containment strategies for short-term disease spread mitigation in response to overloaded health care systems and longer-term epidemiological sizes.


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