The JNC Generic URL Research Program - Providing a Knowledge Base to Support both Implementer and Regulator in Japan

2006 ◽  
Vol 932 ◽  
Author(s):  
Hiroyuki Umeki ◽  
Kazuhiko Shimizu ◽  
Toshihiro Seo ◽  
Akira Kitamura ◽  
Hirohisa Ishikawa
Keyword(s):  
Knowledge Base ◽  
Safety Assessment ◽  
Atomic Energy Commission ◽  
Phase 1 ◽  
Site Characterization ◽  
Crystalline Rock ◽  
Know How ◽  
Safety Regulations ◽  
Site Characteristics ◽  
Underground Research Laboratory

ABSTRACTIn accordance with the R&D framework specified by the Atomic Energy Commission of Japan in 2000 for the implementing phase of HLW disposal, the Japan Nuclear Cycle Development Institute (JNC) continues to be responsible for R&D activities aimed at enhancing the reliability of disposal technologies and safety assessment methodologies and associated databases. JNC has thus been actively promoting technical R&D with a view to contributing to both the implementation of disposal and the formulation of safety regulations.One of JNC's key roles is to establish and demonstrate site characterization methodologies based on investigations in two purpose-built generic URL (underground research laboratory) projects: one at Mizunami in crystalline rock and the other at Horonobe in sedimentary rock.Through the surface-based investigations in the Mizunami and Horonobe projects (phase 1), integration of work from different disciplines into a “geosynthesis” has been illustrated and is planned to be developed further in the underground facilities at these sites (phases 2 and 3). These projects also serve for developing and testing the tools and methodologies required for site characterization. Further know-how will be gained through participation in foreign underground laboratory projects, transfer of experience from these projects to Japan and tailoring it to Japanese conditions and requirements.This experience represents an important knowledge base, which is obviously important for the implementer but is also needed by the regulator, in order to assess how key site characteristics are derived and what uncertainties are associated with this process.

Technical Know-How for Modeling of a Geological Environment: Part 2—Geological Modeling

2010 ◽  
Author(s):  
Toshiyuki Matsuoka ◽  
Kenji Amano ◽  
Hideaki Osawa ◽  
Takeshi Semba
Keyword(s):  
Research And Development ◽  
Research Laboratory ◽  
Site Characterization ◽  
Initial Surface ◽  
Geological Environment ◽  
Know How ◽  
Environment Model ◽  
High Level ◽  
Underground Research Laboratory ◽  
The Impact

It is important for site characterization projects to manage the decision-making process with transparency and traceability and to transfer the technical know-how developed and accumulated during the research and development to the implementing phase as well as to future generations. The modeling of a geological environment supports efforts to clarify the degree of understanding regarding that geological environment, including uncertainty. Evaluation of the impact of uncertainties in a geological environment model is important to identify and prioritize key issues for further investigations. Therefore, a plan for site characterization should be made based on the results of the modeling. The aim of this study is to support the planning of initial surface-based site characterization based on the technical know-how accumulated from the Mizunami Underground Research Laboratory Project and the Horonobe Underground Research Laboratory Project. These projects are broad scientific studies of the deep geological environment that are a basis for research and development for the geological disposal of high-level radioactive wastes. In this study, the work-flow followed in developing the geological model, one of the geological environment models, and the related technical know-how acquired from literature data have been summarized.

Technical Know-How for Modeling of Geological Environment: Part 1—Overview and Groundwater Flow Modeling

2010 ◽  
Author(s):  
Hiromitsu Saegusa ◽  
Shinji Takeuchi ◽  
Keisuke Maekawa ◽  
Hideaki Osawa ◽  
Takeshi Semba
Keyword(s):  
Decision Making ◽  
Research And Development ◽  
Groundwater Flow ◽  
Research Laboratory ◽  
Site Characterization ◽  
Decision Making Process ◽  
Geological Environment ◽  
Flow Modeling ◽  
Know How ◽  
Underground Research Laboratory

It is important for site characterization projects to manage the decision-making process with transparency and traceability and to transfer the technical know-how accumulated during the research and development to the implementing phase and to future generations. The modeling for a geological environment is to be used to synthesize investigation results. Evaluation of the impact of uncertainties in the model is important to identify and prioritize key issues for further investigations. Therefore, a plan for site characterization should be made based on the results of the modeling. The aim of this study is to support for the planning of initial surface-based site characterization based on the technical know-how accumulated from the Mizunami Underground Research Laboratory Project and the Horonobe Underground Research Laboratory Project. These projects are broad scientific studies of the deep geological environment that are a basis for research and development for the geological disposal of high-level radioactive wastes. In this study, the work-flow of the groundwater flow modeling, which is one of the geological environment models, and is to be used for setting the area for the geological environment modeling and for groundwater flow characterization, and the related decision-making process using literature data have been summarized.

Technical Know-How of Site Descriptive Modeling for Site Characterization

2011 ◽  
Author(s):  
Hiromitsu Saegusa ◽  
Tadafumi Niizato ◽  
Ken-ichi Yasue ◽  
Hironori Onoe ◽  
Ryosuke Doke
Keyword(s):  
Site Characterization ◽  
Current Status ◽  
Initial Surface ◽  
Geological Environment ◽  
Implementation Phase ◽  
Know How ◽  
Long Duration ◽  
High Level ◽  
Underground Research Laboratory ◽  
Technical Basis

The site descriptive model covering the current status of characteristics of geological environment and the site evolution model for estimation of the long-term evolution of site conditions are used to integrate multi-disciplinary investigation results. It is important to evaluate uncertainties in the models, to specify issues regarding the uncertainties and to prioritize the resolution of specified issues, for the planning of site characterization. There is a large quantity of technical know-how in the modeling process. It is important to record the technical know-how with transparency and traceability, since site characterization projects generally need long duration. The transfer of the technical know-how accumulated in the research and development (R&D) phase to the implementation phase is equally important. The aim of this study is to support the planning of initial surface-based site characterizations based on the technical know-how accumulated from the underground research laboratory projects. These projects are broad scientific studies of the deep geological environment and provide a technical basis for the geological disposal of high-level radioactive wastes. In this study, a comprehensive task flow from acquisition of existing data to planning of field investigations through the modeling has been specified. Specific task flow and decision-making process to perform the tasks have been specified.

Preclinical Safety Assessment of a Recombinant Plague Vaccine (rF1V)

2013 ◽  
Vol 32 (5) ◽  
pp. 327-335 ◽  
Author(s):  
Jessica L. Price ◽  
T. Scott Manetz ◽  
Jeffry D. Shearer ◽  
Robert V. House
Keyword(s):  
Clinical Trial ◽  
Safety Assessment ◽  
Phase 1 ◽  
Control Material ◽  
Injection Volume ◽  
Phase 1 Clinical Trial ◽  
Human Use ◽  
Favorable Safety ◽  
Plague Vaccine ◽  
Preclinical Safety

A recombinant vaccine (rF1V) is being developed to protect adults 18 to 55 years of age from fatal pneumonic plague caused by aerosolized Yersinia pestis. A comprehensive series of studies was conducted to evaluate the general toxicity and local reactogenicity of the rF1V vaccine prior to first use in humans. Toxicity was evaluated in CD-1 mice vaccinated with control material and three dosage concentrations of rF1V with or without Alhydrogel® by intramuscular (IM) injection on Study Days 1, 29, 57 and 71 in a volume of 0.1 mL. Total immunizing protein given in each dose was 0, 20 or 60 μg/animal. Local reactogenicity was evaluated in mice at the dosages given and in New Zealand white (NZW) rabbits using the same injection volume and formulations (40, 80, 160 and 320 μg/mL total antigen and 0.3% (w/v) Alhydrogel®) intended for human use (0.5 mL). The rF1V vaccine produced no apparent systemic toxicity and only transient edema and erythema at the injection site. Together these results indicated a favorable safety profile for rF1V and supported its use in a Phase 1 clinical trial.

scholarly journals An Approach to Health and Safety Assessment in Industrial Parks

2020 ◽  
Vol 12 (9) ◽  
pp. 3646
Author(s):  
Fco. Javier García-Gómez ◽  
Cristina González-Gaya ◽  
Víctor Fco. Rosales-Prieto
Keyword(s):  
Risk Assessment ◽  
Safety Assessment ◽  
Safety Management ◽  
Health And Safety ◽  
Assessment Process ◽  
Management Systems ◽  
Fundamental Aspect ◽  
Know How ◽  
Industrial Parks ◽  
Design Construction

Safety is a fundamental aspect to take into account in the design, construction and operation of industrial parks. Therefore, it is important to know how to deal with safety in this type of facility, and how to deal with risk analysis. This document provides information related to the industrial park risk assessment process to improve the health and safety of workers in these places. A search and consultation of references related to occupational health and safety management systems is carried out, and it is found that, although there is adequate protection, both in relation to the safety of workers in industrial parks and the safety of personnel outside the facilities, it is helpful to establish a health and safety risk assessment to identify hazards and hazardous events, evaluate associated risks, and select techniques or strategies (opportunities) to manage those risks after prioritization. Following the implementation of the selected techniques, their effectiveness can then be monitored in order to avoid incidents. This document can be a model for future implementation of a health and safety management system based in ISO 45001:2018.

Management Development Knowledge Base in the Gulf, Transferability, and Adaptability

2015 ◽  
Vol 4 (1) ◽  
pp. 1-11
Author(s):  
Suhaila E. Alhashemi
Keyword(s):  
Knowledge Base ◽  
National Culture ◽  
Management Development ◽  
Development Programs ◽  
Careful Selection ◽  
Gulf Region ◽  
Fully Integrated ◽  
Know How ◽  
The Moment ◽  
Selection Of

Management development programmes and management in transition is taking its shape in the Gulf Region. The purpose of this paper is to address the key assumptions and knowledge base on which Gulf management development programs were built with special reference to images of managerial professionalism and its major issues bearing on the transferability of managerial know-how. Interviews conducted with managers in Bahrain and Oman revealed using some Western Theories may prove not to be successful when fully integrated with the national culture, and therefore there is a need to adapt. Change and transformation is taking place within the GCC, this necessitates careful selection of strategies and ways to implement management development and transferability. Some organizations have been successful in adaptability and transferability of knowledge, others are undergoing the process at the moment and it will be some time when the effect takes place.

Air traffic safety management: ANSP perspective

2021 ◽  
Vol 132 ◽  
pp. 19-28
Author(s):  
Dolores Gracja PIWEK
Keyword(s):  
Traffic Safety ◽  
Safety Assessment ◽  
Safety Management ◽  
Air Traffic ◽  
Hazard Identification ◽  
Assessment Methodology ◽  
Voluntary Reporting ◽  
Safety Regulations ◽  
Dynamic Growth ◽  
Navigation Service

The dynamic growth of air operations in the airspace is related to air traffic threats, which obliges aviation organizations to predict them and develop a proactive safety management strategy. The study aimed to analyze how the air navigation service provider (ANSP) implements the safety management system's assumptions in the event of a constant increase in air traffic and whether these activities contribute to achieving the assumed parameters (indicators) of safety. For this purpose, a critical analysis of the literature was carried out, supplemented with interviews conducted among these institutions' representatives. The best tools for implementing the safety management system's objectives, including hazard identification and risk management by ANSP, were identified. These are the safety assessment methodology for changes in functional systems SAM (Safety Assessment Methodology), the mandatory and voluntary reporting of aviation occurrences, and the RAMS risk assessment mark sheets. It should be noted, however, that the change management process concerns primarily planned changes. Simultaneously, there is insufficient information on how to deal with unplanned changes, and the safety culture requires intensified activities in the form of training of operational personnel. Besides, safety regulations require constant updating, and safety management models adapt to a continually changing environment.

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