scholarly journals Pathological conditions in newborns against the background of undifferentiated connective tissue dysplasia in their mothers

2021 ◽  
pp. 25-31
Author(s):  
O.Yu. Chumak ◽  
◽  
A.P. Volokha ◽  
◽  
Keyword(s):  
Connective Tissue ◽  
Mode Of Delivery ◽  
Clinical Signs ◽  
Obstetric Complications ◽  
Moderate Correlation ◽  
Pathological Conditions ◽  
Group I ◽  
Connective Tissue Dysplasia ◽  
Group Ii ◽  
Newborn Children

Undifferentiated connective tissue dysplasia (UCTD) in pregnant women reduces the adaptive capacity of their newborns and is an unfavorable background for the development of certain pathological conditions of the perinatal period. At the same time, information on the spectrum of diseases in children born to mothers with clinical manifestations of UCTD is rather contradictory. Purpose — to study the nature and direction of the correlation between certain pathological conditions in newborns and clinical signs of UCTD in their mothers. Materials and methods. We examined 75 women in labor aged 16 to 44 years old and their 75 newborn children (38 boys and 37 girls) during 2018–2020. The number of girls and boys is approximately the same, the gender difference between children did not affect on the results of the study. The newborns gestational age (GA) was 28–42 weeks, and their birth weight (BW) was 1500–4070 g. Among them there were 51 (68%) full-term, and 24 (32%) — preterm infants. Anthropometric indices (AI), which were used to confirm dolichostenomelia as a UCTD marker, were calculated for mothers and their children. The integral indicator of dolichostenomelia (IID) was determined by summing the standardized values of these coefficients for each mother and child. The presence of neonatal encephalopathy, congenital pneumonia, interventricular septal defect (IVSD), intrauterine growth retardation (IUGR), respiratory distress syndrome, asphyxia at birth, grade I–II of intraventricular hemorrhage (IVH), and necrotizing enterocolitis were taken into account in children. As for mothers, the presence of complications of their pregnancy and labor associated with UCTD was taken into consideration, and in addition, hypermobility of the joints was assessed according to the Beighton scale. Women were divided into two groups: group I (n=45) consisted of women with >1 anthropometric marker of UCTD, group II (n=30) involved mothers who did not have any of these markers. Newborn children were divided into two groups, respectively: group I involved newborns from mothers with signs of UCTD, group II consisted of borned from mothers without signs of UCTD. Results. It was found that mothers with UCTD markers reliably more often had children weighing less than 2500 g (ϕс=0.251; р=0.029). According to the results of the morbidity analysis, it was clarified that children borned from mothers with UCTD manifestations, were more often suffering from congenital pneumonia (ϕс=0.218; р=0.049), IVSD (ϕс=0.241; р=0.037) and IUGR (ϕс=0.31; р=0.029). According to the results of the rank correlation analysis, a direct moderate correlation was established between the presence of progression of varicose veins in women during pregnancy and IID both in them (ρ=0.463; p<0.001) and in their children (ρ=0.369; p=0.001); a similar in degree and direction correlation of >3 UCTD associated obstetric complications with IID of mothers (ρ=0.305; p=0.008) and their children (ρ=0.326; p=0.004) was also found. At the same time, a positive weak correlation was established between mothers' IID and registration of placental dysfunction (ρ=0.231; p=0.046), polyhydramnios (ρ=0.234; p=0.043) in them. As for newborns, their IID had a direct moderate correlation with their mothers' IPD (ρ=0.364; p=0.001), and a weaker correlation with joint hypermobility in their mothers (ρ=0.258; p=0.025) and obstetric ruptures (ρ=0.230; p=0.047). Simultaneously, there were no statistically reliable differences between the groups of children by gender, their GA, age of their mothers and the mode of delivery. Conclusions. Consequently, children borned from mothers with clinical markers of UCTD are more often have low BW (p=0.029); during the neonatal period they have IUGR (p=0.029), congenital pneumonia (p=0.049) and IVSD (p=0.037) more often registered. It should also be noted that integral anthropometric markers of UCTD in newborn children have the most significant correlation with similar markers in their mothers (p=0.001), on the one hand, as well as with the progression of varicose disease in women during pregnancy (p=0.001) and a combination >3 UCTD associated obstetric complications (p=0.004), on the other hand. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: newborns, postpartum women, undifferentiated connective tissue dysplasia.

scholarly journals ВПЛИВ МІСЦЕВОЇ ТА ЗАГАЛЬНОЇ МЕТАБОЛІЧНОЇ ТЕРАПІЇ НА СТАН ЗОРОВОГО АНАЛІЗАТОРА В ДІТЕЙ ІЗ НАБУТОЮ МІОПІЄЮ, АСОЦІЙОВАНОЮ З СИНДРОМОМ НЕДИФЕРЕНЦІЙОВАНОЇ ДИСПЛАЗІЇ СПОЛУЧНОЇ ТКАНИНИ

2018 ◽  
Author(s):  
Т. Ye. Tsybulska ◽  
O. Ye. Pashkova
Keyword(s):  
Visual Acuity ◽  
Connective Tissue ◽  
Morphological Changes ◽  
Eye Drops ◽  
Metabolic Abnormalities ◽  
Supporting Function ◽  
Metabolic Therapy ◽  
Group I ◽  
Connective Tissue Dysplasia ◽  
Group Ii

Significant role in the formation of myopic refraction in children plays the syndrome of undifferentiated connective tissue dysplasia (SUCTD). On the background of metabolic abnormalities of the connective tissue occur morphological changes in the connective tissue of the sclera, which change its supporting function and contribute to the development and progression of myopia. This substantiates the expediency of the appointment of local and general metabolic therapy in the treatment of this category of children.The aim of the study – to evaluate the effect of local metabolic therapy on the state of the visual analyzer in children with acquired myopia associated with SU CTD.Materials and Methods. Оphthalmologic examination was performed on 65 children (130 eyes) from 7 to 12 years old with acquired myopia and phenotypic features of SU CTD . I group – 35 patients (70 eyes) received complex metabolic therapy for 2 months with the preparation "Cardonat", "Magnesium V6", and also eye drops "Tioretin A". The second group of observation included 15 children (30 eyes) with acquired myopia and SUDST who did not receive general and local therapy.Results and Discussion. After treatment in children of the group I, visual acuity is increased by an average of 0.15 c.u., obtained in 82.8 % of patients (58 eyes), reserves of absolute accommodation, reserve of relative accommodation by an average of 1.5 dpi and 2.5 dpi (p<0.05). In group II, on the contrary, the reduction of uncompressed visual acuity was determined at 0.09 c.u. (p<0.05), the indicators of accommodation function did not change significantly, remaining low. In the group I, only 17.1 % of patients (12 eyes) experienced an increase in clinical refraction by an average of 0.25–0.5 dpi, (p>0.05). In the group II, this indicator increased by an average of 0.42 dpi (p<0.05). The increase in the axial length of the eye was an average of 0.12 mm in the group I; 0.22 mm in the group II (p<0.05).Conclusions. Metabolic therapy by using Cardonate, Magnesium V6 and eye drops "Thioretin A" in children with myopia associated with SU CTD increases the visual acuity without correction on average by 1.8 times, increases the absolute accommodation and reserves of relative accommodation on average 2.1 and 1.9 times respectively.

scholarly journals DIAGNOSTIC CRITERIA FOR UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH ARTERIAL HYPERTENSION

2020 ◽  
pp. 49-54
Author(s):  
Ye. H. Zaremba ◽  
N. O. Rak ◽  
O. V. Zaremba ◽  
O. V. Zaremba-Fedchyshyn ◽  
M. M. Virna ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Arterial Hypertension ◽  
Control Group ◽  
Severe Dysplasia ◽  
Moderate Severity ◽  
Group Iii ◽  
Group I ◽  
Connective Tissue Dysplasia ◽  
Group Ii

The aim – to improve the diagnosis efficiency of patients with arterial hypertension (AH) combined with undifferentiated connective tissue dysplasia (UCTD) based on the study of clinical course, the severity of UCTD external and internal symptoms with determining the levels of IL-1, IL-6, TNF-a, free and general blood oxyproline. Material and Methods. The study implied examination of 90 patients (52 women and 38 men) with AH of stage 2 from first to third degrees with manifestations of UCTD, who were on inpatient treatment in the Cardiology Department of the Lviv City Communal Clinical Emergency Hospital. The mean age of patients was (61.14±2.58) years. Patients were divided into 3 groups depending on the stage and degree of hypertension. Group I (n=16) included patients with hypertension of the first degree, group II (n=35) – with AH of the second degree, group III (n=39) – with AH of the third degree. The control group consisted of 20 patients with hypertension without manifestations of CTD. Patients underwent clinical (checkup, palpation, percussion, auscultation), laboratory (determination of IL-1, IL-6, TNF-a, free and general oxyprolin blood levels) and instrumental studies (ECG, echocardiography, DBPM, ultrasound examination of internal organs and vessels of the lower extremities, ultrasound duplex examination of the carotid and vertebral arteries, radiological examination of the osteoarticular system), consultations of an ophthalmologist, neurologist, traumatologist and dentist. Results. As a result of the study, in the group I of patients (n=16) UCTD of slight degree of severity was revealed in 13 (81 %), of medium degree – in 3 (19 %) persons. In the group II of patients (n=35), UCTD of moderate severity was found in 30 (86 %), severe – in 5 patients (14 %). In the group III of patients (n=39), UCTD of moderate severity was found in 32 patients (82 %), severe – in 7 (18 %). In the study of the level of TNF-a, an increase compared to the control group was detected, particularly, in the group I of patients its level exceeded in 37.4 times, in the group II – in 39.6 times, in the group III – in 46.2 times (p<0.001). IL-1b increased by 2.6-fold (р<0.05) in the group I of patients compared to the control group, 3.1-fold (р<0.01) – in the group II, and by 3.7-fold, that was the foremost (р<0.001), in patients of the group III. In turn, IL-6 in the group I of patients exceeded the indicators of the control group by 4.3 times (p<0.001), in the group II – 4.8 times (p<0.001), in the group III – 5.7 times (р<0.001). The study of the level of free oxyproline revealed its increase in comparison with the control group, namely in the group I of patients exceeded in 6.12 times, in the group II – in 6.81 times, in the group III – by 7.56 times (р<0.01). The study of the general of bound oxyproline revealed its increase in comparison with the control group, namely in the group I of patients exceeded by 6.98 times, in the group II – by 7.79 times, in the group III – by 9.42 times (p<0.01), which indicates an increase in fibrillogenesis and more pronounced destructive and inflammatory processes in connective tissue. Conclusions. Patients with AH of the stage 2 from first to third degrees with manifestations of UCTD have increased levels of IL-1, IL-6 and TNF-a, which are not only sensitive markers of inflammation, but also play an important role in the pathogenesis and progression of vascular lesions, occurrence and destabilization of atherosclerotic plaques and thrombotic vessels occlusion. The determination of blood oxyprolin in patients with hypertension combined with UCTD confirms the presence of CTD, namely the decay of collagen is more pronounced in patients with severe dysplasia.

scholarly journals EPIDEMIOLOGY OF THE PREVALENCE OF PHENOTOPIC SIGNS UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME IN WOMAN WITH MISCARRIAGES

2021 ◽  
Vol 74 (4) ◽  
pp. 880-883
Author(s):  
Tunzala V. Ibadova ◽  
Volodymyr V. Maliar ◽  
Vitalii V. Maliar ◽  
Vasyl V. Maliar
Keyword(s):  
Preterm Birth ◽  
Connective Tissue ◽  
Pregnant Women ◽  
Premature Birth ◽  
Control Group ◽  
Cervical Insufficiency ◽  
Group I ◽  
Therapeutic Measures ◽  
Connective Tissue Dysplasia ◽  
Group Ii

The aim: Study of the relationship between cervical insufficiency and dysplastic stigma in miscarriages. Materials and methods: 80 pregnant women were examined at 23-27 weeks of gestation.) Group I included 40 pregnant women with the threat of premature birth, with habitual miscarriage and correction of cervical insufficiency (CI) by using pessary in the anamnesis. Group II consisted of 20 pregnant women with the threat of premature birth and correction of CI by using pessary without the burden of habitual miscarriage, the control group of 20 almost healthy pregnant women. Results: The studies revealed phenotypic signs of dysplastic stigmatization in 39 (97.5 + 2.5%) pregnant women of group I, in 18 (90.0 + 6.9%) group II and in 4 (20.0 + 9.2%) control, which indicates a high prevalence of connective tissue dysplasia in women with CI, which also has a laboratory reflection in the form of increased excretion per day of oxyproline and a decrease in total glycosaminoglycans in both groups at risk of preterm birth. Conclusions: The most common gestational complication in women with connective tissue dysplasia is the risk of premature birth. Improving existing and finding new diagnostic and therapeutic measures for women with UDСTD will reduce the risk of preterm birth.

scholarly journals Pathogenetic substantiation of preterm births prevention methods

2021 ◽  
Keyword(s):  
Preterm Birth ◽  
T Lymphocytes ◽  
Connective Tissue ◽  
Clinical Signs ◽  
Simultaneous Increase ◽  
Pronounced Increase ◽  
Group Iii ◽  
Healthy Pregnancy ◽  
Group I ◽  
Group Ii

The study of the pathogenesis of premature birth is one of the important issues of modern obstetrics. This could contribute developing a scientifically sound program for predicting and preventing this complication of pregnancy. The aim of the study was to investigate the blood variables of the immune system and connective tissue metabolism in women with preterm birth at 23-36 weeks of gestation. Materials and methods. A total of 227 pregnant women were examined, 190 of whom had clinical signs of threatened preterm birth. Group I included 48 women with a threatened preterm delivery resulted in childbirth between 23 and 27 weeks. In group II, 142 women at risk of preterm birth were observed from 28 to 36 weeks. Group III included 37 women with a healthy pregnancy, completed at 38-41 weeks. Result. The number of lymphocytes and their subpopulations, the content of connective tissue metabolites in the blood of the examined patients were studied. In women of group, I relatively to women of group III there was an evident (p < 0.001) decrease in blood level of CD3 + -marker of T-lymphocytes by an average of 23 %, which suggests the presence of immunodeficiency and considered as a stress response. In women with preterm birth at 28-36 weeks of gestation (group II), the relative level of CD3 + in the blood, on the contrary, slightly but probably (p = 0.014) increased compared to women with healthy pregnancy by an average of 13%. A significant decrease in the immunoregulatory index in women of group I is associated with the suppression of the T-helper component and emphasizes the presence of T-cell immunosuppression. The decrease in the index in women of group II occurred due to cytotoxic T-lymphocytes. Сonclusions. Thus, the work confirms the opinion of R. Romero on the role of immune "rejection" in the third trimester, associated with the HLA-incompatibility of mother and fetus. In women of group I, compared with women of group III, there was a more pronounced increase in serum free oxyproline - a marker of collagen breakdown than bound oxyproline - a marker of collagen synthesis. Group II women also had a simultaneous increase in the level of the two oxyproline fractions, but more pronounced for the protein-bound fraction. This suggests that the violation of the metabolism of connective tissue leads to the destruction of the collagen matrix of the cervix and its shortening. Studies suggest that cerclage or insertion of pessary should be used to prevent cervical incompetence in the second trimester due to metabolic disorders in the connective tissue. The use of progesterone is appropriate for prevention of "short cervix" syndrome, as well as the possible immunosuppressive effect of the latter. The established signs of autoimmune processes require screening for antiphospholipid syndrome and the appointment, if confirmed, of anticoagulants.

Comparative analysis of the effectiveness of surgical techniques for the treatment of Miller Class I gingival recessions

2021 ◽  
Vol 26 (2) ◽  
pp. 150-157
Author(s):  
R. R. Farkhshatova ◽  
L. P. Gerasimova ◽  
I. T. Yunusov
Keyword(s):  
Connective Tissue ◽  
Soft Tissues ◽  
Platelet Rich Plasma ◽  
Class I ◽  
Study Group ◽  
Connective Tissue Graft ◽  
Group I ◽  
Autologous Platelet Rich Plasma ◽  
Group Ii ◽  
Autologous Platelet

Relevance. It is currently relevant to study and compare the effectiveness of the autologous connective tissue grafts and the combination of collagen-based and autologous platelet-rich plasma in the surgical treatment of Miller Class I gingival recessions.Materials and methods. We examined and treated 48 (20 male (41.67%) and 28 female (58.33%)) patients aged from 25 to 40 years with Miller Class I gingival recessions. All gingival recessions were treated surgically using a modified twolayer tunnel technique. The patients were divided into two groups according to the graft type. Group I (24 patients (50%) had a connective tissue graft from the hard palate. Group II (24 patients (50%) used the combination of the autologous platelet-rich plasma and 3D collagen matrix Fibromatrix for the regeneration of oral soft tissues. We removed the sutures on the 14th day. The patients were followed up on the 7th and 14th days and in 1.3 months.Results. 48 Miller Class I gingival recessions were treated between 2018 and 2020. The depth of gingival recessions averaged 3.5 ± 1.13 mm before treatment. The level of the attached keratinized gingiva regarding the cementoenamel junction significantly (p < 0.001) improved in both groups after the surgery. The width and thickness of the keratinized gingiva best increased in group II. The mean effectiveness of gingival recession treatment was 84% in study group I and 96% – in study group II. Pain syndrome, fibrinous plaque and soft tissue edema were insignificant in group II.Conclusion. The combination of the autologous platelet-rich plasma and Fibromatrix, collagen 3D matrix, for the regeneration of the oral soft tissues is a more effective technique for the treatment of Miller Class I gingival recessions. This technique has several advantages. It is minimally invasive, less painful, soft tissue postoperative swelling is less and the received volume of the attached keratinized gums is larger than with a connective tissue graft. 

PECULIARITY OF ADAPTATION OF BABIES ARE BORN PREMATURELY FROM MOTHERS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

2021 ◽  
Vol 74 (10) ◽  
pp. 2566-2568
Author(s):  
Tunzala V. Ibadova ◽  
Vitalii V. Maliar ◽  
Volodymyr V. Maliar ◽  
Vasyl V. Maliar
Keyword(s):  
Connective Tissue ◽  
Premature Infants ◽  
Distress Syndrome ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Main Group ◽  
Phenotypic Markers ◽  
Group I ◽  
Neonatal Respiratory Distress ◽  
Connective Tissue Dysplasia

The aim: To evaluate the peculiarity of clinical manifestations of neonatal respiratory distress syndrome (NRDS) in deeply premature infants from mothers with phenotypic markers of undifferentiated connective tissue dysplasia (UCTD). Materials and methods: The study represent the results of a retrospective clinical and statistical analysis of 268 premature birth report card and newborn report sheet. .The main (1 group) included 50 pregnants with obvious phenotypic markers of UCTD, the comparison group (group 2) consisted of 50 pregnant women without phenotypic markers of UDCTD. Results: According to the study, in 12 (24%) pregnant women of the main group at the time of admission to the clinic had contractions,which required specific therapy. Cervical cerclage was performed in 38 (76%) patients of the main group due to the presence of cervical insufficiency (CI). In these cases, the severity of the CI on the Steinber scale was 7.2 &#177; 0.4 points in the main group against 4.4 &#177; 0.2 points in the comparison group (p &#60;0.05). Group I patients were more likely to have complications of labor such as:premature rupture of membranes, uterine contraction abnormalities and fetal distress, which required in most cases cesarean delivery (7% and 2%), respectively (p &#60;0.05). The incidence of neonatal complications requiring respiratory support was 67% in group I and 48% in group II. According to our observations, the clinical manifestations of bronchopulmonary dysplasia were twice as high in infants of the main group (66%) against (44%) of the comparison group (p &#60;0.05). Conclusions:1.Neonatal respiratory distress syndrome in premature infants is more often associated from mothers with UDCTD. 2. The high importance of steroid prophylaxis of NRDS and antioxidant therapy in reducing the frequency of mechanical ventilation and the development of bronchopulmonary pathology, especially in infants from mothers with UDCTD syndrome, has been proven. 3. The possibility of diagnosing disorders of functional maturation of the lungs in the fetal period using a non-invasive method of ultrasonography has been confirmed.

scholarly journals Mandibular movements in children with and without signs and symptoms of temporomandibular disorders

2004 ◽  
Vol 12 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Leonardo Rigoldi Bonjardim ◽  
Maria Beatriz Duarte Gavião ◽  
Luciano José Pereira ◽  
Paula Midori Castelo
Keyword(s):  
Clinical Signs ◽  
Mouth Opening ◽  
Signs And Symptoms ◽  
Lateral Movement ◽  
Mandibular Movement ◽  
Group I ◽  
Group Ii ◽  
The Right ◽  
Mandibular Movements ◽  
Digital Caliper

This research aimed to evaluate mandibular movements in children with and without signs and symptoms of temporomandibular dysfunction. The sample taken consisted of 99 children aged 3 to 5 years distributed in two groups: I - Absence of signs and/or symptoms of TMD (25 girls/40 boys); II - Presence of signs and symptoms of TMD (16 girls/18 boys). The symptoms were evaluated through an anamnesis questionnaire answered by the child's parents/caretakers. The clinical signs were evaluated through intra- and extraoral examination. Maximum mouth opening and left/right lateral movements were measured using a digital caliper. The maximum protrusive movement was measured using a millimeter ruler. The means and standard deviations for maximum mouth opening in Group I and Group II were 40.82mm±4.18 and 40.46mm±6.66, respectively. The values found for the left lateral movement were 6.96mm±1.66 for Group I and 6.74mm±1.55 for Group II, while for the right lateral movement they were 6.46mm±1.53 and 6.74mm±1.77. The maximum protrusion movements were 5.67mm±1.76 and 6.12mm±1.92, in Groups I and II, respectively. The mandibular movement ranges neither differed statistically between groups nor between genders. FAPESP Process 96/0714-6.

scholarly journals Disorders of social functioning and quality of life in patients with gastroesophageal reflux disease while combined with undifferentiated connective tissue dysplasia

2020 ◽  
Vol 3 (1) ◽  
pp. 11-16
Author(s):  
Iryna Romash
Keyword(s):  
Quality Of Life ◽  
Gastroesophageal Reflux Disease ◽  
Connective Tissue ◽  
Gastroesophageal Reflux ◽  
Social Functioning ◽  
Reflux Disease ◽  
Control Group ◽  
Group I ◽  
Group Ii

Introduction. It has been scientifically confirmed that the risk of developing gastroesophageal reflux disease (GERD) increases especially with generalized or regional disruption of connective tissue structure, which is widespread among the population. Patients with such comorbid pathology may have a wide range of symptoms that may go beyond the general symptoms of heartburn and regurgitation. The symptoms and complications of GERD affect general health, daily and social functioning, physical and emotional activity. It also affects the quality of life (QoL) associated with health through frequent breaks during sleep, work and social activities. Purpose. study the dynamics of the level of quality of life and social functioning in patients with gastroesophageal reflux disease in combination with the syndrome of undifferentiated connective tissue dysplasia. Methodology. A total of 120 patients were included in the study: 65 men and 55 women: in 75 of them (Group II) GERD occurred on the background of UCTD, in 45 (Group I) as an independent disease. The control group consisted of 12 healthy individuals. The study was comprehensive. The Medical Outcomes Study 36-Item Short-Form Health Status (SF-36),the Gastrointestinal Symptom Rating Scale (GSRS) and the scale of "Personal and social performance" (PSP) -  were used to study patients in detail. Results and Discussion. Analyzing the results obtained on the basis of the GSRS questionnaire (Table 1), in patients with GERD on the background of UCTD, compared with patients of group I and the control group, there is a significant increase in three and four from the five scales. QoL in patients of Group II on the scale "Abdominal pain" were 14.3 ± 0.4 points, in Group I - 5.6 ± 1.3 points, in the Control Group - 2.4 ± 0.8 points, on the scale "Reflux syndrome": 13.7 ± 0.9, 10.5 ± 1.3 and 3.1 ± 0.9, respectively. "Dyspeptic syndrome" - 15.3 ± 0.4 points in Group II, 12.2 ± 0.6- in Group I and 6.1 ± 0.3- in the control group. "Constipation syndrome" 9.5 ± 0.8, 5.6 ± 1.03 and 5.7 ± 0.4, respectively (p <0,05). Conclusions: In this research we investigated the effect of comorbid pathology on QoL in patients with GERD, which developed against the background of UCTD. The results confirm that patients with such combined pathology have a lower level of quality of life and social functioning, and the tactics of treatment of such patients should take into account these changes

scholarly journals CARDIAL MANIFESTATIONS OF NON-DIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA AND THEIR INFLUENCE ON PREGNANCY

2021 ◽  
pp. 14-22
Author(s):  
V. Yu. DOBRIANSKA ◽  
S. M. HERYAK ◽  
L. M. MALANCHUK ◽  
M. I. SHVED ◽  
I. V. KORDA
Keyword(s):  
Mitral Valve ◽  
Connective Tissue ◽  
Ventricular Arrhythmia ◽  
Pregnant Women ◽  
Mitral Valve Prolapse ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Adequate Treatment ◽  
Pregnancy And Childbirth ◽  
Connective Tissue Dysplasia

Among the visceral manifestations of NDST in pregnant women most often diagnosed mitral valve prolapse (20-25%) that accompanied by more cardiovascular and obstetric complications during pregnancy. It demonstrates the high clinical significance of the problem of connective tissue dysplasia with mitral valve prolaps for pregnancy and requires adequate treatment programs for prevention of complications and management of pregnant women with connective tissue dysplasia. Aim. Determination of the frequency of pregnancy pathology in women with clinical signs of NDST and MVP complicated by extrasystolic arrhythmia. Materials and methods. 138 pregnant women with MVP and concomitant signs of NDST and 54 healthy pregnant women were selected for analysis. Clinical manifestations of NDST, different variants of arrhythmias and the total number of complications of pregnancy and childbirth were evaluated. Results. In pregnant women with clinical signs of NDST and MVP complicated by extrasystolic arrhythmia, cases of frequent sinus extrasystole were significantly more often compared to frequent ventricular arrhythmia (47.8% vs. 18.1%, p<0.001) and cases of combination of frequent sinus extrasystole and ventricular arrhythmia (13.3 % vs. 1.5%, p <0.05). They significantly more often identified both symptoms of arrhythmological nature and symptoms that indicated a violation of autonomic status. The presence of NDST syndrome is more often accompanied by the development of complications of pregnancy and childbirth. These pregnant women have genetic and phenotypic risk factors for the development of pathological pregnancy and childbirth, birth trauma, disability of mother and newborn, which justifies such patients in a separate risk group for individualized programs of the prevention and treatment of visceral (cardiac) manifestations of NDST and possible complications of pregnancy and childbirth. Conclusions. 3.1% of pregnant women are diagnosed with phenotypic signs (stigma) of undifferentiated connective tissue dysplasia, and the most common visceral cardiac manifestation is mitral valve prolapse. The presence of mitral valve prolapse and extrasystolic arrhythmia in pregnant women with NDST is accompanied by significantly more frequent development of pregnancy and childbirth complications in these patients.

scholarly journals CLINICAL AND GENETIC FEATURES OF CONNECTIVE TISSUE DYSPLASIA SYNDROME IN CYSTIC FIBROSIS IN CHILDREN

2019 ◽  
Vol 21 (4) ◽  
pp. 203-207 ◽  
Author(s):  
Anastasia V. Goryainova ◽  
P. V. Shumilov ◽  
S. Yu. Semykin ◽  
G. Yu. Zobkova ◽  
A. E. Donnikov
Keyword(s):  
Cystic Fibrosis ◽  
Connective Tissue ◽  
Matrix Metalloproteinase ◽  
Clinical Signs ◽  
Respiratory Disorders ◽  
Matrix Metalloproteinase 3 ◽  
Genetic Features ◽  
Connective Tissue Dysplasia ◽  
Modifying Effect ◽  
Severe Pathology

The aim of the study was to determine the clinical and genetic features of the syndrome of undifferentiated connective tissue dysplasia (CTD) in cystic fibrosis (CF) children and the possible modifying effect of polymorphisms of connective tissue genes on the development of severe pathology of the bronchopulmonary system in CF cases. 188 patients with the moderate to severe course of СF, aged from 3 to 17 years were examined. In СF patients significant associations have been established between polymorphisms of matrix metalloproteinase 3, the phenotypic signs of CTD and severe clinical signs of respiratory disorders.

Sign in / Sign up

Export Citation Format

Share Document