Tunnel Asset Management (TAM) Program Application for High Risk Structural Components

2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Hamed Zamenian ◽  
Dan D. Koo
1982 ◽  
Vol 10 (4) ◽  
pp. 417-428 ◽  
Author(s):  
Ana M. Cauce ◽  
Robert D. Felner ◽  
Judith Primavera

2019 ◽  
Vol 59 (2) ◽  
pp. 734
Author(s):  
How Boon Tay ◽  
Nicola Marshall ◽  
Andrew McColm ◽  
Michael Wood

Traditional health, safety and environment (HSE) reporting communicates the ‘what’ but not the ‘why’ of safety events. Organisations’ operations-data footprints are growing in volume and velocity but data are often siloed and can be of poor quality. This results in an inability to connect the dots and see through the ‘noise’, to identify patterns of high risk behaviour and root causes of high risk incidents to fully realise the true value of available data and deliver well informed decision making. Deloitte has been working with large organisations across the energy and resources industry, connecting traditional HSE data with contextual data, including employees, contractors, rosters, timesheets, training, and environmental and operational data to surface insights that would otherwise be hidden. By applying exploratory machine learning techniques to these datasets, the sector can gain new insights that were previously ‘hidden’ in data siloes. Drawing on lessons learnt, the paper explains how predictive analytical techniques can enable organisations to identify groups of employees at the highest risk of incidents and, critically, what differentiates these groups, to design tailored interventions and optimally allocate finite resources to manage HSE risk. The paper also describes key factors found to be driving high severity or repeat incidents and details how data conventionally used for asset management and operations optimisation can be analysed alongside HSE data to characterise potential control failures. The outcome is a framework that can be applied to provide continuous controls monitoring of material risks and critical assets.


Author(s):  
Thomas W. Secord ◽  
Frank Harewood ◽  
Cahal McVeigh ◽  
Behrooz Nadian ◽  
Evin Donnelly

Transcatheter heart valve replacement is rapidly becoming a viable option for patients who present as high risk surgical candidates. The emergence of these devices has prompted a need to understand their long term structural integrity as a function of boundary conditions, material behavior, and device geometry assumptions. In the case of transcatheter replacement heart valves, there is a shortage of clinical data from which to derive accurate use conditions. Therefore, structural analysis of these devices is enhanced by using a stochastic, rather than deterministic, framework.


Author(s):  
A. J. Tousimis

The elemental composition of amino acids is similar to that of the major structural components of the epithelial cells of the small intestine and other tissues. Therefore, their subcellular localization and concentration measurements are not possible by x-ray microanalysis. Radioactive isotope labeling: I131-tyrosine, Se75-methionine and S35-methionine have been successfully employed in numerous absorption and transport studies. The latter two have been utilized both in vitro and vivo, with similar results in the hamster and human small intestine. Non-radioactive Selenomethionine, since its absorption/transport behavior is assumed to be the same as that of Se75- methionine and S75-methionine could serve as a compound tracer for this amino acid.


Author(s):  
Nicholas J Severs

In his pioneering demonstration of the potential of freeze-etching in biological systems, Russell Steere assessed the future promise and limitations of the technique with remarkable foresight. Item 2 in his list of inherent difficulties as they then stood stated “The chemical nature of the objects seen in the replica cannot be determined”. This defined a major goal for practitioners of freeze-fracture which, for more than a decade, seemed unattainable. It was not until the introduction of the label-fracture-etch technique in the early 1970s that the mould was broken, and not until the following decade that the full scope of modern freeze-fracture cytochemistry took shape. The culmination of these developments in the 1990s now equips the researcher with a set of effective techniques for routine application in cell and membrane biology.Freeze-fracture cytochemical techniques are all designed to provide information on the chemical nature of structural components revealed by freeze-fracture, but differ in how this is achieved, in precisely what type of information is obtained, and in which types of specimen can be studied.


Author(s):  
Richard B. Vallee

Microtubules are involved in a number of forms of intracellular motility, including mitosis and bidirectional organelle transport. Purified microtubules from brain and other sources contain tubulin and a diversity of microtubule associated proteins (MAPs). Some of the high molecular weight MAPs - MAP 1A, 1B, 2A, and 2B - are long, fibrous molecules that serve as structural components of the cytamatrix. Three MAPs have recently been identified that show microtubule activated ATPase activity and produce force in association with microtubules. These proteins - kinesin, cytoplasmic dynein, and dynamin - are referred to as cytoplasmic motors. The latter two will be the subject of this talk.Cytoplasmic dynein was first identified as one of the high molecular weight brain MAPs, MAP 1C. It was determined to be structurally equivalent to ciliary and flagellar dynein, and to produce force toward the minus ends of microtubules, opposite to kinesin.


Author(s):  
J.L. Carrascosa ◽  
G. Abella ◽  
S. Marco ◽  
M. Muyal ◽  
J.M. Carazo

Chaperonins are a class of proteins characterized by their role as morphogenetic factors. They trantsiently interact with the structural components of certain biological aggregates (viruses, enzymes etc), promoting their correct folding, assembly and, eventually transport. The groEL factor from E. coli is a conspicuous member of the chaperonins, as it promotes the assembly and morphogenesis of bacterial oligomers and/viral structures.We have studied groEL-like factors from two different bacteria:E. coli and B.subtilis. These factors share common morphological features , showing two different views: one is 6-fold, while the other shows 7 morphological units. There is also a correlation between the presence of a dominant 6-fold view and the fact of both bacteria been grown at low temperature (32°C), while the 7-fold is the main view at higher temperatures (42°C). As the two-dimensional projections of groEL were difficult to interprete, we studied their three-dimensional reconstruction by the random conical tilt series method from negatively stained particles.


1982 ◽  
Vol 47 (4) ◽  
pp. 373-375 ◽  
Author(s):  
James L. Fitch ◽  
Thomas F. Williams ◽  
Josephine E. Etienne

The critical need to identify children with hearing loss and provide treatment at the earliest possible age has become increasingly apparent in recent years (Northern & Downs, 1978). Reduction of the auditory signal during the critical language-learning period can severely limit the child's potential for developing a complete, effective communication system. Identification and treatment of children having handicapping conditions at an early age has gained impetus through the Handicapped Children's Early Education Program (HCEEP) projects funded by the Bureau of Education for the Handicapped (BEH).


1983 ◽  
Vol 48 (1) ◽  
pp. 110-110

For the November 1982 JSHD article, "A Community Based High Risk Register for Hearing Loss," the author would like to acknowledge three additional individuals who made valuable contributions to the study. They are Marie Carrier, Gene Lyon, and Bobbie Robertson.


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