Encephalitozoon cuniculi causes focal anterior cataract and uveitis in dogs

2015 ◽  
Vol 43 (05) ◽  
pp. 337-344 ◽  
Author(s):  
J. Csokai ◽  
A. Fuchs-Baumgartinger ◽  
G. Maaß ◽  
B. Nell
Keyword(s):  
Serum Antibody ◽  
Encephalitozoon Cuniculi ◽  
Anterior Lens Capsule ◽  
Positive Serum ◽  
Posterior Synechia ◽  
Antibody Titres ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Lens Material

SummaryThree mongrel dogs, aged 10 months (case 1), 14 months (case 2) and 7.5 years (case 3), were presented because of ophthalmologic disorders of 4 months, 6 months and 7 years duration, respectively. All three dogs were offspring of stray dogs from Hungary and Serbia and had positive serum antibody titres against Encephalitozoon (E.) cuniculi. The two young dogs showed unilateral, the older dog bilateral chronic anterior uveitis with posterior synechia and focal anterior cortical cataract. The fundi that could be evaluated developed focal tapetal hyporeflective lesions in the course of the disease. Dogs 1 and 2 underwent removal of the lens via phacoemulsification. PCR of the lens material was positive for E. cuniculi strains IV and II, respectively. In dog 2 findings suggestive of microsporidia were detected underneath the anterior lens capsule by immunohistochemical staining. In all cases medical treatment consisted of systemic fenbendazole, prednisolone, and topical anti-inflammatory drugs, and additional brinzolamid/timolol for dog 3. For the time being all cases (follow up 23 months, 6 months and 3 months, respectively) are still on topical anti-inflammatory therapy. It is concluded that E. cuniculi infections can cause cataract and chorioretinal lesions in dogs.

Anti-NMDAR encephalitis presenting after immature teratoma resection

2021 ◽  
Vol 14 (11) ◽  
pp. e244637
Author(s):  
Deandra Kimberly Chetram ◽  
Kelsey Pan ◽  
Aisha Elfasi ◽  
Merry Markham
Keyword(s):  
Cancer Diagnosis ◽  
Psychiatric Symptoms ◽  
Serum Antibody ◽  
Immature Teratoma ◽  
High Dose ◽  
Intravenous Methylprednisolone ◽  
Nmda Receptor Encephalitis ◽  
Positive Serum ◽  
Antibody Titres ◽  
Significant Clinical Improvement

This is a case of a young woman who developed neurological and psychiatric symptoms 3 days after resection of an immature teratoma. She was diagnosed with anti-NMDA receptor encephalitis via positive serum antibody titres, which was later confirmed with cerebrospinal fluid antibody titres. Given her cancer diagnosis, she underwent treatment with bleomycin, etoposide and cisplatin chemotherapy in addition to 5 days of high-dose steroids (1 g of intravenous methylprednisolone) for the encephalitis. This treatment regimen led to significant clinical improvement 3 weeks after completion of one cycle of chemotherapy.

scholarly journals ‘Dry’ Pericarditis with Rapid Progression to Tamponade as a Feature of COVID-19

2021 ◽  
Author(s):  
Ashwin Reddy ◽  
Sarah Nethercott ◽  
Rudolph Duehmke ◽  
Sunil Nair ◽  
Omar Abdul-Samad
Keyword(s):  
Pericardial Effusion ◽  
Severe Acute Respiratory Syndrome ◽  
Stable Condition ◽  
Full Recovery ◽  
Rapid Progression ◽  
Life Threatening ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Pericardial inflammation is a recognised feature of coronavirus disease (COVID-19). The authors herein present the case of a female with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection who developed a large and life-threatening pericardial effusion over a few days following the onset of pericarditis, despite prompt commencement of treatment. This was successfully drained, and she was discharged in stable condition on oral nonsteroidal anti-inflammatory drugs and colchicine.At 6-week follow-up she had made a full recovery, and repeat echocardiography demonstrated no recurrence of effusion or evidence of constrictive physiology.

scholarly journals Limber tail syndrome in German shepherd dog

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ghazanfar Abbas ◽  
Muhammad Saqib ◽  
Mudassar Niaz Mughal ◽  
Asif Ali But ◽  
Ghulam Muhammad
Keyword(s):  
Cold Water ◽  
Clinical Signs ◽  
Acute Onset ◽  
Water Recovery ◽  
German Shepherd ◽  
German Shepherd Dog ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Freeze Water

A 3-year-old intact female German shepherd dog weighing 25 kg was evaluated for acute onset of staggering gait and flaccid (dropped) tail following immersion in freeze water. Clinical signs included staggering gait, aggressive behavior, postural pain and flaccid tail. Clinical signs progressed in severity for 2-3 hours following immersion in freeze water. The dog was treated using anti-inflammatory medication along with warm fomentation of the affected portion of the tail and complete rest. Dog uneventfully recovered on day 7 of initiation of treatment and no reoccurrence was observed during one month follow up period. Limber tail syndrome is an uncommonly reported condition in German shepherd dogs that should be considered when sudden staggering gait and dropped tail is observed after immersion in too cold water. Recovery is possible with anti-inflammatory drugs and rest.

scholarly journals Meningitis due to non-steroidal anti-inflammatory drugs: an often-overlooked complication of a widely used medication

2019 ◽  
Vol 12 (11) ◽  
pp. e231619 ◽  
Author(s):  
Florian Desgranges ◽  
Nathalie Tebib ◽  
Olivier Lamy ◽  
Antonios Kritikos
Keyword(s):  
Complete Resolution ◽  
Viral Infections ◽  
Empirical Therapy ◽  
Neurological Sequela ◽  
Review Of The Literature ◽  
Acute Meningitis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Tension Type Headaches

A 40-year-old man developed aseptic meningitis after ibuprofen consumption for tension-type headaches. After a thorough diagnostic workup and lack of improvement on empirical therapy for common aetiologies of meningitis (bacterial and viral infections), we suspected non-steroidal anti-inflammatory drug (NSAID) induced meningitis due to the temporal relationship between drug administration and symptom onset. Two days after NSAID suppression, the evolution was progressively favourable with complete resolution of fever and symptoms. On follow-up, symptoms did not recur and there was no neurological sequela. This article summarises the clinical picture and the complementary exams that led to the difficult-to-make diagnosis of NSAID-induced acute meningitis, in parallel with a brief review of the literature.

Long-term follow-up of patients with hypersensitivity to nonsteroidal anti-inflammatory drugs reveals shortcomings in compliance and care

2011 ◽  
Vol 127 (1) ◽  
pp. 284-285 ◽  
Author(s):  
Timo Buhl ◽  
Heike C. Meynberg ◽  
Kjell M. Kaune ◽  
Peter Hünecke ◽  
Michael P. Schön ◽  
...  
Keyword(s):  
Long Term Follow Up ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Hydroxychloroquine-Induced Hyperpigmentation: A Case Report

2020 ◽  
Author(s):  
Mona Talaschian ◽  
Anahita Sadeghi ◽  
Sara Pakzad
Keyword(s):  
Skin Diseases ◽  
Antimalarial Agents ◽  
The Face ◽  
History Of ◽  
Inflammatory Drugs ◽  
Skin Discoloration ◽  
Anti Inflammatory ◽  
One Year ◽  
Rheumatoid Diseases

Antimalarial agents, including chloroquine and hydroxychloroquine, have been used for the treatment of various rheumatoid diseases and skin diseases because of their anti-inflammatory and immune-modulating properties. Cutaneous adverse effects such as exacerbation of psoriasis, pruritus, and hyperpigmentation have been reported as side-effects of antimalarial drugs. In this case, we report a middle-aged man with a history of rheumatoid arthritis who was treated with non-steroidal anti-inflammatory drugs and hydroxychloroquine. He complainedof hyperpigmentation of the face after one year of initiating the hydroxychloroquine. It was discontinued and methotrexate was started. Skin biopsy was confirmed drug reaction. Aftermore than 10 years of follow up, his skin discoloration had not been improved.

scholarly journals Long-term therapy with non-steroidal anti-inflammatory drugs for axial spondyloarthritis: focus on changes in liver function

2021 ◽  
pp. 152-157
Author(s):  
A. P. Rebrov ◽  
A. V. Aparkina ◽  
E. V. Kchondkaryan
Keyword(s):  
Liver Function ◽  
Liver Enzymes ◽  
Genetically Engineered ◽  
Term Therapy ◽  
Acute Liver Damage ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Long Term Therapy

The purpose of the study is to analyze the state of liver function in patients with spondyloarthritis taking non-steroidal anti-inflammatory drugs continuously for 24 months. Materials and methods of the study include 198 patients with spondyloarthritis. The prospective study involved 36 patients with spondyloarthritis who took non-steroidal anti-inflammatory drugs (NSAIDs) prescribed by a physician in the community for 24 months. The level of liver enzymes in blood serum at admission and in dynamics was studied. The increase of liver enzymes was detected in 12 (6.06%) of 198 patients with spondyloarthritis. Among them 6 (50%) patients took methotrexate, 1 (8.33%) - genetically engineered drug, 2 (16.67%) patients-sulfasalazine and 3 (25%) - nonsteroidal anti - inflammatory drugs. 19.4% of patients were registered with a periodic increase of transaminase levels on the background of NSAIDs for the last 24 months. At the same time, no cases of acute liver damage or progressive deterioration of liver function requiring discontinuation of therapy were recorded during the entire follow-up period.

Regular use of non-steroidal anti-inflammatory drugs increases the risk of adult-onset asthma: a population-based follow-up study

2009 ◽  
Vol 3 (2) ◽  
pp. 82-84 ◽  
Author(s):  
Simon Francis Thomsen ◽  
Kirsten Ohm Kyvik ◽  
Lars Rauff Skadhauge ◽  
Ida Steffensen ◽  
Vibeke Backer
Keyword(s):  
Population Based ◽  
Adult Onset ◽  
Follow Up Study ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Risk of Recurrent Peptic Ulcer Disease in Patients Receiving Cumulative Defined Daily Dose of Nonsteroidal Anti-Inflammatory Drugs

2019 ◽  
Vol 8 (10) ◽  
pp. 1722
Author(s):  
Chih-Ming Liang ◽  
Shih-Cheng Yang ◽  
Cheng-Kun Wu ◽  
Yu-Chi Li ◽  
Wen-Shuo Yeh ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Eradication Therapy ◽  
Case Control ◽  
Defined Daily Dose ◽  
Ulcer Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
H Pylori

The purpose of this population-based case–control study was to clarify the impact of cumulative dosage of nonsteroidal anti-inflammatory drugs (NSAIDs) on recurrent peptic ulcers among chronic users after Helicobacter pylori (H. pylori) eradication. We analyzed data of 203,407 adult peptic ulcer disease (PUD) patients from the National Health Insurance Research Database in Taiwan entered between 1997 and 2013. After matching for age/gender frequencies and the length of follow-up time in a ratio of 1:1, the matched case–control groups comprised 1150 patients with recurrent PUD and 1150 patients without recurrent PUD within 3 years of follow-up. More recurrent PUDs occurred in NSAID users than in the control group (75.30% versus 69.74%; p = 0.0028). Independent risk factors for recurrent PUD included patients using NSAIDs (adjusted OR (aOR): 1.34, p = 0.0040), H. pylori eradication (aOR: 2.73; p < 0.0001), concomitant H2 receptor antagonist (aOR: 1.85; p < 0.0001) and anti-coagulant (aOR: 4.21; p = 0.0242) use. Importantly, in the initial subgroup analysis, the risk ratio of recurrent PUD did not increase in NSAID users after H. pylori eradication compared with that in non-users (p = 0.8490) but a higher risk for recurrent PUD with the increased doses of NSAIDs without H. pylori eradication therapy (aOR: 1.24, p = 0.0424; aOR: 1.47, p = 0.0074; and aOR: 1.64, p = 0.0152 in the groups of ≤28, 29–83, and ≥84 cumulative defined daily doses, respectively). The current study suggested that H. pylori eradication therapy could decrease the risk of recurrent PUD among patients with high cumulative doses of NSAIDs.

Sign in / Sign up

Export Citation Format

Share Document