ANALYSIS OF THE TRADITIONAL RISK FACTORS INFLUENCE ON DEVELOPMENT OF ISCHEMIC HEART DISEASE IN FAMILIAL HYPERCHOLESTEROLEMIA

INTRODUCTION : Ischemic heart disease (IHD) is a leading cause of death in the world. Most of the subjects with IHD may have traditional risk factors including diabetes,smoking, hypertension,obesity. Rheumatoid Factor (RF) has been associated with an increased likelihood of developing IHD.Presence of RF in general population may identify the subjects with a similar immune pathology to patients with RA, who may also share an increased likelihood of developing IHD and that RF may have special role in the pathogenisis of IHD . MATERIALS AND METHODS: Cross sectional observational study done from September 2020 to August 2021 in Kamineni institute of medical sciences Narketpally, included 100 patients, who were all RF positive.During the study period they were evaluated for IHD by E CG and ECHO.Those who are included in the study were evaluated for traditional risk factors h/o Diabetes, smoking,family h/o IHD and hypertension,BMI for Obesity and features of RA. A resting 12 lead ECG was carried out for features of IHD.The following ch anges in the ECG were taken as marker of ischemia: 1)The combination of ST elevation in a set of leads and reciprocal ST depression in a set of leads.2) Inversion of T with ST still being elevated.3) Presence of pathological Q waves RESULTS : Of the 100 patients with RF positivity, there were 65 females and 35 males. Ischemic changes in ECG in presence of RF with traditional risk factor is n=12 (75%) M 8(50%) F-- 4(25%) and RF without traditional risk factor is n=4 (25%) M-4(25%) F-0.In the present study there were 16 patients who had RF positivity with Ischemic changes in ECG. 12 were males and 4 were females. CONCLUSIONS: RF per se can be considered as one of the risk factor for Ischemic heart disease in males. Ÿ RF associated with traditional risk factors increase the prevalence of IHD. Ÿ Though more female patients have positive RF, they are not vulnerable to IHD.

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Platelet polymorphisms and ischemic heart disease: moving beyond traditional risk factors∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(01)01478-4 ◽

2001 ◽

Vol 38 (4) ◽

pp. 1028-1032 ◽

Cited By ~ 7

Author(s):

David E Kandzari ◽

Pascal J Goldschmidt-Clermont

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Ischemic Heart ◽

Traditional Risk Factors

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Ischemic Heart Disease Risk Factors in Black Americans

PsycEXTRA Dataset ◽

10.1037/e375702004-001 ◽

1986 ◽

Cited By ~ 1

Author(s):

Shiriki K. Kumanyika ◽

Daniel D. Savage

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Disease Risk ◽

Black Americans ◽

Ischemic Heart ◽

Ischemic Heart Disease Risk ◽

Heart Disease Risk Factors ◽

Heart Disease Risk

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IMPACT OF RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE CORONARY SYNDROME, PLATELET ULTRASTRUCTURE, AND ASPIRIN RESISTANCE

Wiadomości Lekarskie ◽

10.36740/wiadlek201911107 ◽

2019 ◽

Vol 72 (11) ◽

Author(s):

Yulian H. Kyyak ◽

Olga Yu. Barnett ◽

Marta P. Halkevych ◽

Olha Ye. Labinska ◽

Hryhoriy Yu. Kyyak ◽

...

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Aspirin Resistance ◽

Ischemic Heart ◽

Coronary Syndrome

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IMPACT OF RISK FACTORS OF ISCHEMIC HEART DISEASE ON THE DEVELOPMENT OF ACUTE CORONARY SYNDROME, PLATELET ULTRASTRUCTURE, AND ASPIRIN RESISTANCE

Wiadomości Lekarskie ◽

10.36740/wlek201911107 ◽

2019 ◽

Vol 72 (11) ◽

Author(s):

Yulian H. Kyyak ◽

Olga Yu. Barnett ◽

Marta P. Halkevych ◽

Olha Ye. Labinska ◽

Hryhoriy Yu. Kyyak ◽

...

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Aspirin Resistance ◽

Ischemic Heart ◽

Coronary Syndrome

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Gender difference in risk factors associated with ischemic heart disease in Lahore

Journal of Fatima Jinnah Medical University ◽

10.37018/hjie6482 ◽

2020 ◽

Vol 14 (2) ◽

pp. 72-77

Author(s):

Muhammad Salman Tariq ◽

Iram Manzoor ◽

Qurat Ul Ain Zulfi ◽

Naeem Hussain ◽

Nimra Saleem ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Gender Difference ◽

Ischemic Heart Disease ◽

Ischemic Heart ◽

Public Health Issue ◽

Stressful Event ◽

Female Population ◽

High Tendency ◽

Factors Associated

Background: Ischemic heart disease (IHD) is one of the leading causes of mortality in Pakistan. With advancement in research, multiple causes have contributed in development of web of causation of this public health issue. The objective of this study was to assess gender differences in risk factors associated with ischemic heart disease in patients presenting at the biggest cardiology hospital of Lahore. Patients and methods: A comparative cross-sectional study was carried out in Punjab Institute of Cardiology, Lahore from January to August, 2018 on a sample of 296 diagnosed patients of IHD, through non-probability consecutive sampling technique. Data was collected on pretested questionnaire. The data was analyzed using SPSS version 22. Chi-Square test of significance was applied and a p-value ≤0.05 was considered statistically significant. Results: The mean age of participants was 45±12 years with predominance of male patients (71.3%). Frequency of risk factors for IHD included increase body mass index (83.8%), hypertension (61%), insufficient physical activity (43%), diabetes (38.5%) and smoking (23%). Increase serum cholesterol was reported in 95% and triglycerides in 99% of the participants. Gender difference was significant with females residing in urban population (p=0.054) and exercise routine (p=0.034). Males showed high tendency of IHD with smoking pattern (p<0.001) contrary to presence of diabetes in females (p=0.05), hypertension (p=0.054), BMI (p=0.0379) and stressful event in life (p=0.002). Males showed regular intake of medicines (p =0.045) after diagnosis as compared to female population. Conclusion: There is more frequency of ischemic heart disease in males as compared to females. Significant association was observed with residence in urban area, presence of diabetes, hypertension, high BMI and stressful event in life in occurrence of ischemic heart disease in female population.

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Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?

Journal of Clinical Medicine ◽

10.3390/jcm10112284 ◽

2021 ◽

Vol 10 (11) ◽

pp. 2284

Author(s):

Diana Gurzău ◽

Alexandra Dădârlat-Pop ◽

Bogdan Caloian ◽

Gabriel Cismaru ◽

Horaţiu Comşa ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Left Bundle Branch Block ◽

Left Ventricular ◽

Ischemic Heart ◽

Left Ventricular Ejection ◽

Bundle Branch Block ◽

Microvascular Angina ◽

Ventricular Ejection Fraction

Left bundle branch block is not a benign pathology, and its presence requires the identification of a pathological substrate, such as ischemic heart disease. Left bundle branch block appears to be more commonly associated with normal coronary arteries, especially in women. The objectives of our study were to describe the particularities of left bundle branch block in women compared to men with ischemic heart disease. Result: We included seventy patients with left bundle branch block and ischemic heart disease, with a mean age of 67.01 ± 8.89 years. There were no differences in the profile of risk factors, except for smoking and uric acid. The ventricular depolarization (QRS) duration was longer in men than women (136.86 ± 8.32 vs. 132.57 ± 9.19 msec; p = 0.018) and also men were observed to have larger left ventricular diameters. Left bundle branch block duration was directly associated with ventricular diameters and indirectly associated with left ventricular ejection fraction value, especially in women (R = −0.52, p = 0.0012 vs. R = −0.50, p = 0.002). In angiography, 80% of women had normal epicardial arteries compared with 65.7% of men; all these patients presented with microvascular dysfunction. Conclusion: The differences between the sexes were not so obvious in terms of the presence of risk factors; instead, there were differences in electrocardiographic, echocardiographic, and angiographic aspects. Left bundle branch block appears to be a marker of microvascular angina and systolic dysfunction, especially in women.

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