scholarly journals IS SUPERFICIAL COLORECTAL LESIONS WITH LOW AND HIGH GRADES INTRAEPITHELIAL NEOPLASMS MORE PREVALENT IN OLDER ABOVE 65 YEARS?

2019 ◽  
Vol 32 (4) ◽  
Author(s):  
Nildete Rodrigues DIGER ◽  
Luiz Fernando KUBRUSLY ◽  
Paulo Afonso Nunes NASSIF ◽  
Artur Adolfo PARADA ◽  
Giovana Tonello BOLSI ◽  
...  
Keyword(s):  
Age Groups ◽  
Intraepithelial Neoplasia ◽  
Cross Sectional Study ◽  
Colorectal Carcinogenesis ◽  
Low Grade ◽  
High Grade ◽  
Cross Sectional ◽  
Intraepithelial Neoplasms ◽  
Colon And Rectum ◽  
The Right

ABSTRACT Background: Colorectal cancer has a higher incidence in the rectum and sigmoid. However, with the expansion of the diagnosis of superficial lesions interest in the diagnosis and in the role they play in colorectal carcinogenesis has increased. Aim: To verify the behavior of superficial lesions of the colon and rectum, comparing the pathological and endoscopic findings, below and above 65 years. Methods: Cross-sectional study with prospective evaluation of standard protocol, where 200 patients with colorectal superficial lesions were evaluated; they were submitted to colonoscopy and mucosectomy of these lesions. They were divided in two age groups, below and above 65 years. Results: One hundred-and-eight were women (54%) and 92 men (46%). Most colon lesions were localized in the right colon (95%) and the remaining (5%) in the rectum. In endoscopy, 77.20% were granular lesions in patients under 65 years and 77.90% above. Colon histology showed low grade intraepithelial neoplasia, being 69.79% in patients under and 73.70% in above 65 years. In rectum, above 65 years the incidence of high-grade intraepithelial neoplasia was higher (66.70%). Conclusion: The superficial colorectal lesions have been more endoscopically diagnosed today, and the highest incidence is the granular type, both in the colon and rectum, regardless of age. Regardless the age, histologically colon lesions were more as low grade intraepithelial neoplasia. In rectum, there was distinction for both age groups, being more frequent high grade intraepithelial neoplasia in patients over 65 years.

scholarly journals HER2 / neu Overexpression in Urothelial Carcinoma and Its Association with Tumour Grading - A Cross Sectional Study from a Tertiary Care Hospital in Kerala

2021 ◽  
Vol 8 (9) ◽  
pp. 497-501
Author(s):  
Sebina Asmi A.T ◽  
Suma Madathiveetil
Keyword(s):  
Urothelial Carcinoma ◽  
Growth Factor Receptor ◽  
Cross Sectional Study ◽  
Low Grade ◽  
High Grade ◽  
Sectional Study ◽  
Tumour Grade ◽  
Cross Sectional ◽  
Epidermal Growth ◽  
Papillary Urothelial Carcinoma

BACKGROUND Human epidermal growth factor receptor-2 HER2 / neu, is a trans membrane tyrosine kinase receptor of epidermal growth factor receptor (EGFR) family and is involved in the pathogenesis of urinary bladder cancer. In this study we attempted to evaluate the HER2 / neu expression in urothelial carcinoma of bladder and its association with tumour grading. METHODS This was a cross sectional study with a sample size of 75. Routine 4 micrometre thick sections of formalin fixed paraffin embedded tissue blocks stained with haematoxylin & eosin were reviewed. Tumour grade was determined by using the World Health Organization (WHO) / International Society of Urological Pathologist criteria (ISUP). Immunohistochemistry was done by using HER2 / neu monoclonal antibody and its expression were observed. The membrane staining intensity and pattern were studied and scored. RESULTS In our study 75 cases of urothelial carcinoma were studied, of which 49 cases were papillary urothelial carcinoma low grade, 26 cases were papillary urothelial carcinoma high grade. Among these, 19 cases were infiltrating urothelial carcinoma. HER2 / neu positivity were observed in 27 (36 %) cases and overexpression in 8 (10 %) cases. Low grade urothelial carcinoma showed HER2 / neu positivity in 11 (22 %) cases and overexpression in 1 (2 %) case. High grade urothelial carcinoma showed HER2 / neu positivity in 16 (64 %) cases, among which 7 (28 %) cases showed overexpression. HER2 / neu positivity was seen in 13 (68 %) cases of infiltrating urothelial carcinoma with 4 (21 %) cases showing overexpression. A statistically significant difference in HER2 / neu expression was noted in high grade and invasive urothelial carcinoma compared to low grade and non-invasive urothelial carcinoma. CONCLUSIONS Urothelial carcinomas show overexpression of HER2 / neu and this over expression increases with increasing grade of tumour and muscle invasiveness. KEYWORDS Urothelial Carcinoma, HER2 / neu, Overexpression, Tumour Grade, Trastuzumab

scholarly journals Morphological study of weight of the ovary at different age group in Bangladeshi people

1970 ◽  
Vol 10 (4) ◽  
pp. 266-268
Author(s):  
MS Ahmed ◽  
H Rahman ◽  
ZG Ara ◽  
SZ Sultana ◽  
M Rahman
Keyword(s):  
Morphological Study ◽  
Minimum Weight ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Age Group ◽  
Cross Sectional ◽  
Weight Variation ◽  
Group A ◽  
Group B ◽  
The Right

Aims: The morphological study was aimed to finedout the ovarian weight in dif ferent age group in Bangladeshi people to increase the knowledge regarding weight variation in our population. Subject & Methods: This cross - sectional study was carried out on Sixty two postmortem tissue contain ovary and fallopian tube along with surrounding structures were collected from 62- female cadaver of different age group by block dissection and fixed in 10% formal saline solution. Gross and fine dissections were carried out to see the morphological parameter of weight of the ovary in different age groups. In the present study, findings were compared with findings of the other researchers. Results: Maximum mean weight of the right ovary is found in this study in group C (46-80) years is 5.78gm and minimum weight is found in group A (2-13 years ) is 3.36gm .But incase left ovary Maximum in group B(14-45)years is 5.01 and minimum group a (2-13)is 2.72gm. statistatical analysis significant different between two groups was calculated by using students "T"Test. In the present study it is observed that the weight of the ovary is not equal on both side of same individual. Key words: ovary,morphology; weight DOI: http://dx.doi.org/10.3329/bjms.v10i4.9498 BJMS 2011; 10 (4): 266-268

scholarly journals Prognostic Role of Matrix Metalloproteinase Expression in Meningioma: A Cross-Sectional Study.

2020 ◽  
Author(s):  
Maryam Ahmad Sharifuddin ◽  
Sharifah Emilia Tuan Sharif ◽  
Hasnan Jaafar
Keyword(s):  
Cross Sectional Study ◽  
Low Grade ◽  
High Grade ◽  
Sectional Study ◽  
Cross Sectional ◽  
Who Grade ◽  
Exact Test ◽  
Immunohistochemical Markers ◽  
Chi Squared ◽  
The Difference

Abstract Background: Meningioma is the most common intracranial tumor in adults. In addition to the extent of tumor surgical resection and WHO grade, angiogenesis is a prognostic factor that is influenced by MMP-2. Our study examined the association of these prognostic factors with MMP-2 expression in meningioma. Methods: A cross-sectional study of patients diagnosed with meningioma between January 2008 and December 2017 was conducted. All samples were re-reviewed and subjected to immunohistochemical staining for Ki67, MMP-2, and CD34. Pearson’s chi-squared test and Fisher’s exact test were used to examine the association of MMP-2 expression with the WHO grade and microvascular density (MVD). Results: The study included 99 patients aged 23–75. Most patients were female (73.7%). This study included 85 cases of low-grade meningioma (grade I) and 14 cases of high-grade meningioma (grade II, 11; grade III, 3). The most common subtypes were meningothelial, transitional, and fibroblastic. In total, 62 of 85 patients with low-grade meningioma and 10 of 14 patients with high-grade meningioma exhibited high MMP-2 expression, and the difference in the rates between the groups was not significant. Most patients in this study displayed MVD scores of 1+ (54/99) and 2+ (33/99). Of the 54 patients with an MVD score of 1+, 42 exhibited high MMP-2 expression. MMP-2 was expressed by all patients with meningioma. Conclusion: In the future, more samples are required, in high-grade tumors, to prevent bias, and more specific immunohistochemical markers should be used to evaluate angiogenesis.

scholarly journals Weight of the Human Kidney – A Study on 70 Autopsy Cases

2016 ◽  
Vol 4 (1) ◽  
pp. 31-34
Author(s):  
Fatema Zohora ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Dilruba Siddiqua ◽  
Hasna Hena ◽  
Hosna Ara Perven ◽  
...  
Keyword(s):  
Age Groups ◽  
Human Kidney ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Bangladeshi Population ◽  
Group B ◽  
The Right

Background: Variations in weight of the kidney in different populations and in different age groups are evident.Objective: The aim of the present study was to find out age related changes in weight of the kidney in a Bangladeshi population and compare with previous local and foreign studies.Materials and method: This cross-sectional study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, Bangladesh from July 2008 to June 2009, based on collection of 140 post mortem human kidneys collected from 70 unclaimed dead bodies which were in the morgue under examination in the Department of Forensic Medicine of same institute. All the samples were divided into three different age groups - A (10-19 years), B (20-39 years) and C (40-59 years), and the weight of each kidney was measured by using a digital balance and recorded.Results: The weight of the right and left kidneys were found 86.18±0.32 gm and 86.10±0.10 gm in group A, 102.25±7.64 gm and 101.96±7.27 gm in group B, 95.59±0.75 gm and 95.19±1.24 gm in group C respectively. No difference was found between the right and left kidneys in any group. However, statistically significant differences were evident among age groups.Conclusion: The weight of the kidney was found to increase up to 4th decade of life and then declined with further advancing age.Delta Med Col J. Jan 2016 4(1): 31-34

scholarly journals Clinical-Cytological-Grading and phenotyping in patients with chronic rhinosinusitis with nasal polyps: the relevance in clinical practice

2020 ◽  
Vol 90 (2) ◽  
Author(s):  
Matteo Gelardi ◽  
Giuseppe Porro ◽  
Vitaliano Quaranta ◽  
Nicola Quaranta ◽  
Michele Cassano ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Total Population ◽  
Cross Sectional Study ◽  
Low Grade ◽  
High Grade ◽  
Cross Sectional ◽  
Aspirin Intolerance ◽  
Careful Management

Chronic rhinosinusitis (CRS) includes two main phenotypes: without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP). CRSwNP may be associated with comorbidity, mainly concerning asthma, aspirin intolerance, and allergy. CRSwNP patients may also be evaluated by clinical-cytological grading (CCG). The current study investigated the prevalence and characteristics of the different CCG and phenotypes in CRSwNP outpatients examined in clinical practice. This retrospective cross-sectional study enrolled 791 consecutive CRSwNP outpatients (424 males, mean age 48.8 years). In the total population, asthma was a common comorbidity (30.8%) as well as aspirin intolerance (24.8%), and allergy (50.8%). As concerns CCG-grading, 210 (26.5%) outpatients had low-grade, 366 (46.3%) medium, and 215 (27.2%) high. As regards cytological phenotypes, 87 (11%) had neutrophilic type, 371 (46.3%) eosinophilic, 112 (14.2%) mast cell, and 221 (27.9%) mixed. High-grade CCG was significantly associated with more frequent asthma, aspirin intolerance, allergy, recurrent surgery, and mixed cytological phenotype. Low-grade CCG was characterized by fewer comorbidities and operations, and neutrophilic phenotype. Therefore, the present study confirmed that CCG is a useful tool in the management of outpatients with CRSwNP. CRSwNP is frequently associated with asthma, aspirin intolerance, and allergy comorbidity. High-grade CCG is frequently characterized by a mixed cytological phenotype, thus, by more severe progress. These real-world outcomes underline that CRSwNP deserves adequate attention for careful management and optimal identification of the best-tailored therapy; CCG and cytological phenotyping could be fruitful tools in clinical practice. Asthma and aspirin intolerance should be adequately investigated in all CRS patients.

scholarly journals Magnitude of refractive errors in children in tertiary care hospital of western Nepal

2020 ◽  
Vol 10 (2) ◽  
pp. 54-58
Author(s):  
Srijana Thapa Godar
Keyword(s):  
Family History ◽  
Refractive Error ◽  
Tertiary Care ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Low Grade ◽  
Refractive Errors ◽  
Care Hospital ◽  
Cross Sectional ◽  
History Of

Background: Refractive error is one of the most common causes of the visual impairment and second leading cause of treatable blindness. The objective of the study was to determine the mag­nitude of refractive errors in children. Methods: This was a hospital based cross-sectional study conducted on 254 children attending Ophthalmology OPD of Manipal Teaching Hospital, Pokhara. The children whose visual acuity was worse than 6/6 but improved with pinhole were included in this study. Vision test, retinoscopy and subjective refraction was done in all subjects and cycloplegic refraction was done when needed. Statistical analysis was carried out using Epi-info version 7. Results: The commonest type of refractive error was astigmatism (46.06%) followed by myopia (42.31%). Majority of children had low grade of refractive errors (46.85%). Among the children, “with the rule astigmatism” was maximum (27.56%). Majority of children were in the age between 11 to 15 years (77.95%). The refractive error was seen more in female (63.78%). Among the chil­dren of refractive errors, 29.13% had family history, 33.46% had given the history of wearing spec­tacles and 10.24% children had amblyopia. There was statistically significant association between refractive errors and age groups, history of wearing spectacles, amblyopia and grading of refractive errors. However, there was no statistically significant association of refractive error with gender, residence and family history. Conclusions: Astigmatism was the common type of refractive error followed by myopia. This study emphasizes the importance of detection of refractive error in children.

scholarly journals Reliability of Duo Chrome Test in Different Age Groups Considering Patient Satisfaction as Gold Standard

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Zehwa Mazhar ◽  
Rabia Manzoor ◽  
Shazia Kanwal ◽  
Ghazala Iqbal
Keyword(s):  
Age Groups ◽  
Cross Sectional Study ◽  
P Value ◽  
Age Group ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Group 2 ◽  
And Gender ◽  
The Right

Purpose:  To check the reliability of the duo-chrome test in different age groups after best correction. Study Design:  Descriptive, Cross Sectional Study. Place and Duration of Study:  College of Ophthalmology and Allied Vision Sciences. King Edward Medical University, Lahore from September 2019 – December 2019. Methods:  Forty two cooperative patients of both genders more than 15 years of age were included but patients with poor fixation, any opacity or any other ocular pathology were excluded. Equipment used was Trial box Trial frame Auto-refractor and Snellen Chart. Group 1 composed of 17 patients (15 – 35 years of age). Group 2 (36 – 60 years) had 15 patients and group 3 (age 61-80 years) comprised of 10 patients. Data was collected on self-designed Performa. Duo Chrome was dependent variable and gender was independent variable. Data was analyzed by using statistical package for social science (SPSS22.00) and chi square test was applied. Results:  Out 42, 21 patients reported red, 12 reported green and 9 patients reported equally clear in the right eye. P value=0.156 showed that duo chrome test was equally reliable in every age group in the right eye. Similar results with p = 0.755 showed that duo chrome test was equally reliable in every age group in the left eye. Test when performed bilaterally, showed similar results. Out of 42 patients, 32 were satisfied and 10 were not satisfied with the test. Conclusion: Red Green duo-chrome test is equally reliable in all age groups to confirm refraction. Key Words: Duo chrome test, Refraction, Myopia, Hypermetropia.

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