scholarly journals Rhabdomyolysis as a manifestation of clomipramine poisoning

2013 ◽  
Vol 131 (6) ◽  
pp. 432-435 ◽  
Author(s):  
Nathalie Oliveira de Santana ◽  
Aécio Flávio Teixeira de Góis
Keyword(s):  
Eye Movement ◽  
Suicide Attempts ◽  
Rare Complication ◽  
Gastric Lavage ◽  
Antidepressive Agents ◽  
Electric Activity ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Refractory Hypotension ◽  
Serum Transaminases

CONTEXT: Tricyclic antidepressive agents are widely used in suicide attempts and present a variety of deleterious effects. Rhabdomyolysis is a rare complication of such poisoning. CASE REPORT: A 55-year-old woman ingested 120 pills of 25 mg clomipramine in a suicide attempt two days before admission. After gastric lavage in another emergency department on the day of intake, 80 pills were removed. On admission to our department, she was disoriented, complaining of a dry mouth and tremors at the extremities. An electrocardiogram showed a sinus rhythm with narrow QRS complexes. Laboratory results showed high creatine phosphokinase (CK = 15,094 U/l on admission; normal range = 26 to 140 U/l), hypocalcemia, slightly increased serum transaminases and mild metabolic acidosis. The patient's medical history included depression with previous suicide attempts, obsessive-compulsive disorder, hypothyroidism and osteoporosis. She presented cardiac arrest with pulseless electric activity for seven minutes and afterwards, without sedation, showed continuous side-to-side eye movement. She developed refractory hypotension, with need for vasopressors. Ceftriaxone and clindamycin administration was started because of a hypothesis of bronchoaspiration. The patient remained unresponsive even without sedation, with continuous side-to-side eye movement and a decerebrate posture. She died two months later. Rhabdomyolysis is a very rare complication of poisoning due to tricyclic drugs. It had only previously been described after an overdose of cyclobenzaprine, which has a toxicity profile similar to tricyclic drugs. CONCLUSIONS: Although arrhythmia is the most important complication, rhabdomyolysis should be investigated in cases of clomipramine poisoning.

Suicidality and Aggressive Behavior in Body Dysmorphic Disorder

2017 ◽  
Author(s):  
Katharine A. Phillips
Keyword(s):  
Suicidal Ideation ◽  
Physical Aggression ◽  
Body Dysmorphic Disorder ◽  
Suicide Attempts ◽  
Violent Behavior ◽  
Clinical Samples ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Completed Suicide ◽  
Increased Risk

This chapter reviews suicidality and aggressive/violent behavior in body dysmorphic disorder (BDD) and presents clinical cases, which reflect the extreme suffering that BDD often causes. Suicidal ideation and suicide attempts are common in BDD. This has been found in both clinical and epidemiologic samples and in adults as well as youth. More severe BDD symptoms are independently associated with an increased risk of suicidal ideation and suicide attempts. Suicidality appears more common in BDD than in obsessive-compulsive disorder and other clinical samples with which BDD has been directly compared. Although data are limited, the rate of completed suicide appears markedly elevated; indeed, individuals with BDD have many risk factors for completed suicide. Physical aggression and violence are less well studied but appear to commonly occur as a consequence of BDD. Surgeons, dermatologists, and other clinicians who provide cosmetic treatment may be at particular risk. Additional studies designed to investigate these topics are urgently needed.

Body Dysmorphic Disorder

1996 ◽  
Vol 169 (2) ◽  
pp. 196-201 ◽  
Author(s):  
David Veale ◽  
Ann Boocock ◽  
Kevin Gournay ◽  
Windy Dryden ◽  
Fozia Shah ◽  
...  
Keyword(s):  
Body Dysmorphic Disorder ◽  
Suicide Attempts ◽  
Age At Onset ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Primary Disorder ◽  
The Usa ◽  
Axis I ◽  
High Degree

BackgroundBody dysmorphic disorder (BDD) consists of a preoccupation with an ‘imagined’ defect in appearance which causes significant distress or impairment in functioning. There has been little previous research into BDD. This study replicates a survey from the USA in a UK population and evaluates specific measures of BDD.MethodCross-sectional interview survey of 50 patients who satisfied DSM–IV criteria for BDD as their primary disorder.ResultsThe average age at onset was late adolescence and a large proportion of patients were either single or divorced. Three-quarters of the sample were female. There was a high degree of comorbidity with the most common additional Axis I diagnosis being either a mood disorder (26%), social phobia (16%) or obsessive–compulsive disorder (6%). Twenty-four per cent had made a suicide attempt in the past. Personality disorders were present in 72% of patients, the most common being paranoid, avoidant and obsessive–compulsive.ConclusionsBDD patients had a high associated comorbidity and previous suicide attempts. BDD is a chronic handicapping disorder and patients are not being adequately identified or treated by health professionals.

Smooth-pursuit eye movement and saccadic intrusions in obsessive-compulsive disorder

1996 ◽  
Vol 40 (11) ◽  
pp. 1164-1172 ◽  
Author(s):  
Stefano Pallanti ◽  
Lorella Matia Grecu ◽  
Pier Franco Gangemi ◽  
Stefano Massi ◽  
Alessandro Parigi ◽  
...  
Keyword(s):  
Eye Movement ◽  
Obsessive Compulsive Disorder ◽  
Smooth Pursuit ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Smooth Pursuit Eye Movement ◽  
Saccadic Intrusions

Eye movement tracking in pediatric obsessive compulsive disorder

2019 ◽  
Vol 43 ◽  
pp. 9-16
Author(s):  
Anirban Ray ◽  
Aditi Subramanian ◽  
Harleen Chhabra ◽  
John Vijay Sagar Kommu ◽  
Ganesan Venkatsubramanian ◽  
...  
Keyword(s):  
Eye Movement ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Eye Movement Tracking ◽  
Movement Tracking

Pursuit eye movement dysfunction in obsessive-compulsive disorder

1992 ◽  
Vol 42 (1) ◽  
pp. 1-11 ◽  
Author(s):  
John A. Sweeney ◽  
Donna R. Palumbo ◽  
James P. Halper ◽  
M.Katherine Shear
Keyword(s):  
Eye Movement ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Eye Movement Dysfunction

The Relationship of Body Dysmorphic Disorder to Obsessive-Compulsive Disorder and the Concept of the Obsessive-Compulsive Spectrum

2017 ◽  
Author(s):  
Jessica Simberlund ◽  
Eric Hollander
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Body Dysmorphic Disorder ◽  
Suicide Attempts ◽  
Obsessive Compulsive ◽  
Major Depressive ◽  
Compulsive Disorder ◽  
Compulsive Behaviors ◽  
Genetic And Environmental Factors ◽  
Relationship Of ◽  
The Relationship

This chapter describes the relationship of body dysmorphic disorder (BDD) to obsessive-compulsive disorder (OCD) and the concept of the obsessive-compulsive spectrum. BDD is proposed to be part of an obsessive-compulsive spectrum of disorders, given its many similarities to OCD. OCD and BDD are both characterized by obsessions and compulsions, although in BDD individuals focus specifically on body image concerns, whereas in OCD they typically focus on concerns such as contamination, harm, and aggression. Distress that results from obsessions usually generates compulsive behaviors intended to reduce emotional discomfort. Individuals with BDD are more likely to have delusional beliefs and significantly poorer insight. Individuals with BDD report higher rates of major depressive disorder, substance use disorders, suicidal thoughts, and suicide attempts. OCD and BDD demonstrate familiality, indicating that they are likely related conditions. OCD and BDD are thought to be heterogeneous disorders that result from both genetic and environmental factors, some of which appear to be shared; for example, they appear to share some abnormalities involving the basal ganglia and limbic system (specifically the caudate nucleus).

A critical review of the contribution of eye movement recordings to the neuropsychology of obsessive compulsive disorder

2011 ◽  
Vol 124 (2) ◽  
pp. 87-101 ◽  
Author(s):  
N. Jaafari ◽  
F. Rigalleau ◽  
F. Rachid ◽  
P. Delamillieure ◽  
B. Millet ◽  
...  
Keyword(s):  
Eye Movement ◽  
Obsessive Compulsive Disorder ◽  
Critical Review ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Genetically predicted education attainment in relation to somatic and mental health

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shuai Yuan ◽  
Ying Xiong ◽  
Madeleine Michaëlsson ◽  
Karl Michaëlsson ◽  
Susanna C. Larsson
Keyword(s):  
Higher Education ◽  
Health Outcomes ◽  
Lower Risk ◽  
Suicide Attempts ◽  
Education Level ◽  
Cancer Type ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Cancer Breast ◽  
Artery Disease

AbstractA deeper understanding of the causal links from education level to health outcomes may shed a light for disease prevention. In the present Mendelian randomization study, we found that genetically higher education level was associated with lower risk of major mental disorders and most somatic diseases, independent of intelligence. Higher education level adjusted for intelligence was associated with lower risk of suicide attempts, insomnia, major depressive disorder, heart failure, stroke, coronary artery disease, lung cancer, breast cancer, type 2 diabetes and rheumatoid arthritis but with higher risk of obsessive–compulsive disorder, anorexia nervosa, anxiety, bipolar disorder and prostate cancer. Higher education level was associated with reduced obesity and smoking, which mediated quite an extent of the associations between education level and health outcomes. These findings emphasize the importance of education to reduce the burden of common diseases.

Sign in / Sign up

Export Citation Format

Share Document