scholarly journals Pulmonary adenocarcinoma in a captive ocelot (Leopardus pardalis): morphologic and immunophenotypic characterization - case report

2021 ◽  
Vol 73 (5) ◽  
pp. 1111-1116
Author(s):  
A.R. Oliveira ◽  
F.M.A.M. Pereira ◽  
D.O. Santos ◽  
T.P. Carvalho ◽  
L.L. Soares-Neto ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
Epithelial Mesenchymal Transition ◽  
Metastatic Carcinoma ◽  
Pulmonary Adenocarcinoma ◽  
Domestic Cats ◽  
Leopardus Pardalis ◽  
Mesenchymal Transition ◽  
Wild Felids ◽  
Conducting Airways ◽  
Alveolar Parenchyma

ABSTRACT Pulmonary adenocarcinoma is a malignant epithelial neoplasia that usually arises from conducting airways or alveolar parenchyma. It has rarely been described in wild felids, with no previous reports in ocelots. In domestic cats it is a very aggressive neoplasm with a high metastatic rate that usually evolves to death. This report aimed to describe a pulmonary adenocarcinoma in a captive and senile ocelot (Leopardus pardalis), with a thorough morphologic and immunophenotypically characterization, evidencing the epithelial-mesenchymal transition (EMT) phenomenon in a high metastatic carcinoma, an important feature rarely described in veterinary medicine, even in domestic cats.

scholarly journals Signaling Pathways Induced by Leptin during Epithelial–Mesenchymal Transition in Breast Cancer

2018 ◽  
Vol 19 (11) ◽  
pp. 3493 ◽  
Author(s):  
Monserrat Olea-Flores ◽  
Juan Juárez-Cruz ◽  
Miguel Mendoza-Catalán ◽  
Teresita Padilla-Benavides ◽  
Napoleón Navarro-Tito
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Epithelial Cells ◽  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Three Dimensional ◽  
Public Health Problem ◽  
Metastatic Carcinoma ◽  
Surrounding Tissue ◽  
Mesenchymal Transition

Leptin is an adipokine that is overexpressed in obese and overweight people. Interestingly, women with breast cancer present high levels of leptin and of its receptor ObR. Leptin plays an important role in breast cancer progression due to the biological processes it participates in, such as epithelial–mesenchymal transition (EMT). EMT consists of a series of orchestrated events in which cell–cell and cell–extracellular matrix interactions are altered and lead to the release of epithelial cells from the surrounding tissue. The cytoskeleton is also re-arranged, allowing the three-dimensional movement of epithelial cells into the extracellular matrix. This transition provides cells with the ability to migrate and invade adjacent or distal tissues, which is a classic feature of invasive or metastatic carcinoma cells. In recent years, the number of cases of breast cancer has increased, making this disease a public health problem worldwide and the leading cause of death due to cancer in women. In this review, we focus on recent advances that establish: (1) leptin as a risk factor for the development of breast cancer, and (2) leptin as an inducer of EMT, an event that promotes tumor progression.

Epithelial mesenchymal transition, stromal density, and chemo-resistance in breast cancer (BrCa)

2019 ◽  
Author(s):  
Andrew Redfern ◽  
Veenoo Agarwal ◽  
Lisa Spalding ◽  
Tony Blick ◽  
Alexander Dobrovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition
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