scholarly journals Clinical characteristics and surgical outcome of patients with temporal lobe tumors and epilepsy

2000 ◽  
Vol 58 (4) ◽  
pp. 1002-1008 ◽  
Author(s):  
CARMEN LISA JORGE ◽  
SUELY K. NAGAHASHI-MARIE ◽  
CHRISTIANE C. PEDREIRA ◽  
SÉRGIO ROSEMBERG ◽  
ROSA M.F. VALÉRIO ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Temporal Lobe ◽  
Pilocytic Astrocytoma ◽  
Clinical Characteristics ◽  
Pathological Diagnosis ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Precise Location ◽  
Histological Characteristics ◽  
Mri Characteristics

This is a retrospective study of 21 surgically treated patients with temporal lobe tumors and epilepsy. Evaluation included clinical data, EEG findings, structural scans, pathological diagnosis and post-surgical follow-up. There were 9 cases of ganglioglioma, 5 pilocytic astrocytoma, 3 ganglioneuroma, 2 dysembryoplastic neuroepithelial tumor, 1 pleomorphic xantoastrocytoma, and 1 meningioangiomatosis. Mean follow-up time was 22 months and outcome was evaluated according to Engel's classification; 76.2% were classified in class I and 23.8% in II and III. All patients classes II and III had been submitted to mesial and neocortical resections. There were no differences related to clinical characteristics, pathological diagnosis or duration of follow-up in patients seizure-free or not. All patients had abnormal MRI and ten of these had normal CT; the MRI characteristics were compared to pathological diagnosis and specific histological characteristics of the tumors were not discernible by MRI. We concluded that MRI was essential for the diagnosis and precise location of TL tumors. Ganglioglioma was the most frequent tumor and lesionectomy associated to mesial resection doesn't guarantee a better prognosis.

Control of temporal lobe epilepsy following en bloc resection of low-grade tumors

1993 ◽  
Vol 78 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Peter J. Kirkpatrick ◽  
Minal Honavar ◽  
Ivan Janota ◽  
Charles E. Polkey
Keyword(s):  
Temporal Lobe ◽  
Age At Onset ◽  
Tumor Resection ◽  
Temporal Lobectomy ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Low Grade ◽  
En Bloc ◽  
Content Type ◽  
Incomplete Removal

✓ Thirty-one patients with a mean age of 18.9 years (range 3 to 53 years) who underwent temporal lobe surgery for tumor-related epilepsy over a 14-year period are presented. All had suffered chronic drug-resistant temporal lobe seizures (mean age at onset 6.9 years, range 0 to 30 years; mean duration of condition 11.9 years, range 3 to 39 years). Preoperative interictal scalp electroencephalography tracings indicated unilateral localized epileptic foci in 90% of patients, and computerized tomography scans showed abnormalities within the temporal lobe in 87%. All patients underwent en bloc temporal lobectomy. No patient received adjuvant radiotherapy or chemotherapy. Review of the histological material showed dysembryoplastic neuroepithelial tumor in 27 (87%) of the specimens and microscopic evidence of incomplete removal of tumor in 22 (71%). At long-term follow-up evaluation (mean duration 5.8 years, range 1 to 14 years), 81% of patients were completely free of seizures (Engel grade I) and 10% were almost seizure free (Engel grade II) with no deaths reported in either early or late follow-up review. Only one patient in the series failed to benefit from the surgery. Four patients suffered permanent neurological deficit causing a mild disability. Psychological assessment showed no significant fall in verbal or performance intelligent quotient for the group, but a mild memory impairment was evident in 32%. Behavioral and social aspects improved in nearly all (94%) cases. Relief of seizures could not be predicted by intraoperative electrocorticography, and outcome was independent of the completeness of tumor resection. Postoperative electroencephalographic findings identified epileptiform potentials in 65% of patients, which were associated with a worse seizure-control outcome grade.

scholarly journals Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tie-Jun Shui ◽  
Chao Li ◽  
Hong-bing Liu ◽  
Xiaohua Chen ◽  
Bi-ke Zhang
Keyword(s):  
Polymerase Chain Reaction ◽  
Retrospective Study ◽  
Clinical Characteristics ◽  
Throat Swab ◽  
Antibody Detection ◽  
Controlled Trials ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Polymerase Chain

Abstract Background Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients. Methods The clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China. Results In total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/IgM RDT results, respectively. Conclusions Some patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation. Trial registration Current Controlled Trials ChiCTR2000033580, Jun 6th 2020. Retrospectively registered.

Abstract 2994: Atherosclerotic Plaque Histology Predicts Restenosis after Carotid Endarterectomy: a Prospective Cohort Study in 500 Patients.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Willem E Hellings ◽  
Frans L Moll ◽  
Jean-Paul P De Vries ◽  
Dominique De Kleijn ◽  
Gerard Pasterkamp
Keyword(s):  
Carotid Endarterectomy ◽  
Atherosclerotic Plaque ◽  
Vascular Remodeling ◽  
Odds Ratio ◽  
Clinical Characteristics ◽  
Adjusted Odds Ratio ◽  
Multivariable Logistic Regression Analysis ◽  
Lipid Core ◽  
Histological Characteristics

Introduction: Many studies have addressed clinical and angiographic risk factors for restenosis development after vascular interventions, but the composition of the atherosclerotic plaque at the intervention site has not been studied as a determinant of luminal re-narrowing after intervention. The aim of this study was to investigate the association between atherosclerotic plaque histology at baseline and restenosis development after carotid endarterectomy. Methods: Patients undergoing carotid endarterectomy were included in a longitudinal vascular biobank study. After surgical excision, the plaques were subjected to histological examination. The patients were prospectively followed-up with duplex ultrasound to assess restenosis (cut-off points: >50% and >70% renarrowing) one year after the intervention. The risk of restenosis was related to predefined plaque histological characteristics (macrophage and smooth muscle cell infiltration, collagen, calcifications, intra-plaque bleeding, luminal thrombus and lipid core size) adjusted for clinical characteristics (multivariable logistic regression analysis). Measurements of vessel diameter and intima-media thickness were performed using B-mode ultrasound in a subgroup of patients to discriminate between the roles of geometric vascular remodeling and neointima formation during follow-up. Results: In 500 consecutive patients (April 2002 – April 2007), plaque macrophage infiltration and a large lipid core were strongly associated with decreased risk of >50% restenosis (adjusted odds ratio = 0.43 [0.26 – 0.70]; 0.38 [0.19 – 0.70]) and >70% restenosis during follow-up (adjusted odds ratio = 0.36 [0.18 – 0.74]; 0.42 [0.17–1.03]), independent of clinical characteristics. The other histological characteristics were not related with restenosis. Duplex measurements (n=50) showed that vessels holding macrophage rich plaques revealed increased expansive geometric vascular remodeling during 1 year follow-up (+1.19 mm [0.03 – 2.36]). Conclusions: The absence of plaque macrophages and lipid core are powerful independent predictors of restenosis development after carotid endarterectomy. Plaque composition is linked with restenosis via geometric vascular remodeling.

scholarly journals Clinical characteristics of single human papillomavirus 53 infection: a retrospective study of 419 cases

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruizhe Chen ◽  
Yunfeng Fu ◽  
Bingbing You ◽  
Ying Li ◽  
Yeli Yao ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Retrospective Study ◽  
Clinical Characteristics ◽  
Intraepithelial Neoplasia ◽  
Low Grade ◽  
High Grade ◽  
Hpv Genotypes ◽  
Intraepithelial Lesion ◽  
Histological Results

Abstract Background Human papillomavirus (HPV) infection is the main cause of cervical cancer. Characteristics of HPV infections, including the HPV genotype and duration of infection, determine a patient’s risk of high-grade lesions. Risk quantification of cervical lesions caused by different HPV genotypes is an important component of evaluation of cervical lesion. Data and evidence are necessary to gain a deeper understanding of the pathogenicity of different HPV genotypes. The present study investigated the clinical characteristics of patients infected with single human papillomavirus (HPV) 53. Methods This retrospective study analyzed the clinical data of patients who underwent cervical colposcopy guided biopsy between October 2015 and January 2021. The clinical outcomes and the follow-up results of the patients with single HPV53 infection were described. Results 82.3% of the initial histological results of all 419 patients with single HPV53 infection showed negative (Neg). The number of patients with cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, vaginal intraepithelial neoplasia (VaIN)1, CIN1 + VaIN1, CIN1 + VaIN2, and CIN2 + VaIN2 was 45, 10, 2, 9, 6, 1, and 1, respectively. Cancer was not detected in any patient. When the cytology was negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL), we observed a significant difference in the distribution of histological results (P < 0.05). 95 patients underwent follow-up with cytology according to the exclusion criteria. No progression of high-grade lesions was observed during the follow-up period of 3–34 months. Conclusions The lesion caused by HPV53 infection progressed slowly. The pathogenicity of a single HPV53 infection was low.

Radiosurgery for dural carotid-cavernous sinus fistulas: Gamma Knife compared with XKnife radiosurgery

2010 ◽  
Vol 113 (Special_Supplement) ◽  
pp. 9-20 ◽  
Author(s):  
Hung-Chuan Pan ◽  
Ming-Hsi Sun ◽  
Jason Sheehan ◽  
Meei-Ling Sheu ◽  
Clayton Chi-Chang Chen ◽  
...  
Keyword(s):  
Clinical Improvement ◽  
Gamma Knife ◽  
Temporal Lobe ◽  
Treatment Modalities ◽  
Conformity Index ◽  
Index Number ◽  
The Mean ◽  
Instrument Accuracy ◽  
Group 1

Object In the modern era, stereotactic radiosurgery is an important part of the multidisciplinary and multimodality approach used to treat dural carotid-cavernous fistulas (DCCFs). Based on the ease of performance of techniques to fuse cerebral angiography studies with MR images or CT scans during the radiosurgical procedure, the Gamma Knife and XKnife are 2 of the most popular radiosurgical instruments for patients with DCCF. In this study, the authors compared the efficacy, neurological results, and complications associated with these 2 radiosurgical devices when used for DCCF. Methods Records for 41 patients with DCCF (15 treated using the XKnife and 26 with Gamma Knife surgery [GKS]) were retrieved from a radiosurgical database encompassing the period of September 2000 to August 2008. Among these patients, at least 2 consecutive MR imaging or MR angiography studies obtained after radiosurgery were available for determining radiological outcome of the fistula. All patients received regular follow-up to evaluate the neurological and ophthalmological function at an interval of 1–3 months. The symptomatology, obliteration rate, radiation dose, instrument accuracy, and adverse effects were determined for each group and compared between 2 groups. The data were analyzed using the Student t-test. Results The mean age of the patients was 63 ± 2.6 years, and the mean follow-up period was 63.1 ± 4.4 months (mean ± SD). Thirty-seven patients (90%) achieved an obliteration of the DCCF (93% in the XKnife cohort and 88% for the GKS cohort). In 34 of 40 patients (85%) with chemosis and proptosis of the eyes, these symptoms were resolved after treatment (4 had residual fistula and 2 had arterializations of sclera). All 5 patients with high intraocular pressure demonstrated clinical improvement. Ten (71%) of 14 patients with cranial nerve palsy demonstrated improvement following radiosurgery. Significant discrepancies of treatment modalities existed between the XKnife and GKS groups, such as radiation volume, conformity index, number of isocenters, instrument accuracy, peripheral isodose line, and maximum dosage. The XKnife delivered significantly higher radiation dosage to the lens, optic nerve, optic chiasm, bilateral temporal lobe, and brainstem. Few adverse events occurred, but included 1 patient with optic neuritis (GKS group), 1 intracranial hemorrhage (XKnife group), 1 brainstem edema (XKnife), and 3 temporal lobe radiation edemas (XKnife). Conclusions Radiosurgery affords a substantial chance of radiological and clinical improvement in patients with DCCFs. The Gamma Knife and XKnife demonstrated similar efficacy in the obliteration of DCCFs. However, a slightly higher incidence of complications occurred in the XKnife group.

Clinical Value of Computer-Assisted Taylor Three-dimensional External Fixation in the Treatment of Tibiofibular Fracture (Preprint)

2020 ◽  
Author(s):  
Hongfeng Sheng ◽  
Weixing Xu ◽  
Bin Xu ◽  
Hongpu Song ◽  
Di Lu ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Internal Fixation ◽  
External Fixation ◽  
External Fixator ◽  
Theoretical Basis ◽  
New Technology ◽  
Three Dimensional ◽  
Computer Assisted ◽  
Clinical Value

UNSTRUCTURED The retrospective study of Taylor's three-dimensional external fixator for the treatment of tibiofibular fractures provides a theoretical basis for the application of this technology. The paper collected 28 patients with tibiofibular fractures from the Department of Orthopaedics in our hospital from March 2015 to June 2018. After the treatment, the follow-up evaluation of Taylor's three-dimensional external fixator for the treatment of tibiofibular fractures and concurrency the incidence of the disease, as well as the efficacy and occurrence of the internal fixation of the treatment of tibial fractures in our hospital. The results showed that Taylor's three-dimensional external fixator was superior to orthopaedics in the treatment of tibiofibular fractures in terms of efficacy and complications. To this end, the thesis research can be concluded as follows: Taylor three-dimensional external fixation in the treatment of tibiofibular fractures is more effective, and the incidence of occurrence is low, is a new technology for the treatment of tibiofibular fractures, it is worthy of clinical promotion.

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