scholarly journals Leptospirosis patient with AIDS the first case reported

1994 ◽  
Vol 27 (1) ◽  
pp. 39-42 ◽  
Author(s):  
Elizabeth de Souza Neves ◽  
Martha Maria Pereira ◽  
Maria Clara Gutierrez Galhardo ◽  
Adriana Caroli ◽  
Jarbas Andrade ◽  
...  
Keyword(s):  
Clinical Course ◽  
Blood Cultures ◽  
Agglutination Test ◽  
Leptospira Interrogans ◽  
First Case ◽  
Positive Urine ◽  
Maximum Titer ◽  
Acquired Immunodeficiency ◽  
Low Levels ◽  
Immunodeficiency Syndrome

A case of renal icterohaemorrhagic leptospirosis involving a patient with acquired immunodeficiency syndrome (AIDS) is reported. Despite the low levels of CD4+ Tlymphocytes, the clinical course of leptospirosis was similar to that observed in non-immunodepressed patients, and no worsening of AIDS occurred due to the infebtion by the spirochete. Serologic conversion was observed in the microscopic agglutination test, with maximum titer of1:3,200. The patient had positive urine cultures for Leptospira interrogans for two months, whereas blood cultures were negative.

Plasmablastic Lymphoma of the Lung

2001 ◽  
Vol 125 (2) ◽  
pp. 282-285 ◽  
Author(s):  
Yuan Lin ◽  
Gilberto D. Rodrigues ◽  
John F. Turner ◽  
Mohammad A. Vasef
Keyword(s):  
Hodgkin Lymphoma ◽  
Acquired Immunodeficiency Syndrome ◽  
Lung Tumor ◽  
B Cell Lymphoma ◽  
Plasmablastic Lymphoma ◽  
Non Hodgkin Lymphoma ◽  
First Case ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Distinct Subtype

Abstract Non-Hodgkin lymphomas associated with acquired immunodeficiency syndrome are heterogeneous. Recently, a novel subtype of non-Hodgkin lymphoma occurring mostly in patients with acquired immunodeficiency syndrome has been described and designated as plasmablastic lymphoma. The histomorphologic and immunophenotypic findings of this distinct subtype of non-Hodgkin lymphoma have been characterized previously. Most patients present with oral cavity involvement. We report a case of plasmablastic lymphoma presenting as a lung tumor. To our knowledge, this is the first case report of this unusual subtype of diffuse large B-cell lymphoma in this location.

scholarly journals The First Case of Vestibulocochlear Neuritis in a Patient with Acquired Immunodeficiency Syndrome in Korea

2016 ◽  
Vol 48 (2) ◽  
pp. 132
Author(s):  
Hyun Joo Park ◽  
Chin Saeng Cho ◽  
Nak Min Kim ◽  
Su A Yun ◽  
Hee Jung Yoon
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
First Case ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

scholarly journals Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors

2021 ◽  
Vol 14 (9) ◽  
pp. 893
Author(s):  
Maria da Conceição Avelino Dias Bianco ◽  
Debora Inacio Leite Firmino Marinho ◽  
Lucas Villas Boas Hoelz ◽  
Monica Macedo Bastos ◽  
Nubia Boechat
Keyword(s):  
New Drugs ◽  
Viral Load Suppression ◽  
Pyrrole Derivatives ◽  
Highly Active ◽  
First Case ◽  
Combined Antiretroviral Therapy ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Anti Hiv Agents ◽  
Anti Hiv

Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and remains a global health problem four decades after the report of its first case. Despite success in viral load suppression and the increase in patient survival due to combined antiretroviral therapy (cART), the development of new drugs has become imperative due to strains that have become resistant to antiretrovirals. In this context, there has been a continuous search for new anti-HIV agents based on several chemical scaffolds, including nitrogenated heterocyclic pyrrole rings, which have been included in several compounds with antiretroviral activity. Thus, this review aims to describe pyrrole-based compounds with anti-HIV activity as a new potential treatment against AIDS, covering the period between 2015 and 2020. Our research allowed us to conclude that pyrrole derivatives are still worth exploring, as they may provide highly active compounds targeting different steps of the HIV-1 replication cycle and act with an innovative mechanism.

INFLUENCE OF HOST GENOTYPE ON PROGRESSION TO ACQUIRED IMMUNODEFICIENCY SYNDROME AMONG CHILDREN INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE 1

PEDIATRICS ◽  
1996 ◽  
Vol 98 (2) ◽  
pp. 348-348
Author(s):  
Joseph A. Church
Keyword(s):  
Clinical Course ◽  
Host Factors ◽  
Host Genotype ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Specific Factors ◽  
Immunodeficiency Syndrome ◽  
Clinical Pictures ◽  
Hla Genotype

The specific factors that determine the clinical course in individual patients with HIV infection are yet to be precisely defined. Variable virus subtypes are likely to produce different clinical pictures. This article documents that host factors, such as HLA genotype, are also important in clinical outcome. The relative importance of host versus viral characteristics is as yet undetermined.

Septate fungal invasion in masked mastoiditis: a diagnostic dilemma

2006 ◽  
Vol 120 (3) ◽  
pp. 250-252 ◽  
Author(s):  
G Kuruvilla ◽  
A Job ◽  
J Mathew ◽  
A P Ayyappan ◽  
M Jacob
Keyword(s):  
Diabetic Patient ◽  
Acquired Immunodeficiency Syndrome ◽  
Literature Search ◽  
English Literature ◽  
Diabetic Patients ◽  
Rare Entity ◽  
Diagnostic Dilemma ◽  
First Case ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Invasive fungal mastoiditis is a rare entity, seen almost entirely in immunocompromized patients. It has been reported primarily in patients with leukaemia and more recently with acquired immunodeficiency syndrome. A literature search revealed only a few reports in diabetic patients, in whom the invasive fungus was identified as mucormycosis in all cases. We report the first case in the English literature of invasive septate fungal mastoiditis in a diabetic patient with intact tympanic membranes.

scholarly journals Morvan’s syndrome treated successfully with rituximab and lacosamide

2019 ◽  
Vol 12 (2) ◽  
pp. e226832
Author(s):  
Olafur Sveinsson ◽  
Faiez Al Nimer ◽  
Fredrik Piehl
Keyword(s):  
Intensive Care ◽  
Clinical Course ◽  
Disease Course ◽  
Neurofilament Light ◽  
Nmda Receptor Encephalitis ◽  
First Case ◽  
Morvan’S Syndrome ◽  
Peripheral Nerve Hyperexcitability ◽  
Low Levels ◽  
Neuroaxonal Degeneration

We describe a woman with both central and peripheral nervous system symptoms consistent with Morvan’s syndrome who was successfully treated with immunosuppression including rituximab and the new antiepileptic drug lacosamide against peripheral nerve hyperexcitability. Despite being over 8 months in hospital and 4 months in an intensive care unit she recovered fully. It is also the first case where cerebrospinal fluid neurofilament-light (NfL) levels were followed during the disease course. The clinical course resembled that of anti-NMDA receptor encephalitis, where patients often recover surprisingly well despite severe symptoms and an extensive time in intensive care. A possible explanation is the comparatively low levels of NfL, indicating disease processes that are not characterised by extensive neuroaxonal degeneration.

Coccidioidomycosis Meningitis With Massive Dural and Cerebral Venous Thrombosis and Tissue Arthroconidia

2000 ◽  
Vol 124 (2) ◽  
pp. 310-314 ◽  
Author(s):  
B. K. Kleinschmidt-DeMasters ◽  
Michael Mazowiecki ◽  
Lian A. Bonds ◽  
David L. Cohn ◽  
Michael L. Wilson
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Coccidioides Immitis ◽  
Pathogenic Organism ◽  
The Past ◽  
First Case ◽  
Coagulation Defects ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Thrombotic Tendency

Abstract To our knowledge we report the first case of meningitis from Coccidioides immitis associated with massive dural and cerebral venous thrombosis and with mycelial forms of the organism in brain tissue. The patient was a 43-year-old man with late-stage acquired immunodeficiency syndrome (AIDS) whose premortem and postmortem cultures confirmed C immitis as the only central nervous system pathogenic organism. Death was attributable to multiple hemorrhagic venous infarctions with cerebral edema and herniation. Although phlebitis has been noted parenthetically to occur in C immitis meningitis in the past, it has been overshadowed by the arteritic complications of the disease. This patient's severe C immitis ventriculitis with adjacent venulitis appeared to be the cause of the widespread venous thrombosis. AIDS-related coagulation defects may have contributed to his thrombotic tendency.

scholarly journals Pseudoaneurysms of large arteries associated with AIDS

1999 ◽  
Vol 117 (4) ◽  
pp. 165-170 ◽  
Author(s):  
Carlos Eli Piccinato ◽  
Jesualdo Cherri ◽  
Takachi Moriya ◽  
Antônio Carlos Souza
Keyword(s):  
Popliteal Artery ◽  
Histopathological Examination ◽  
Vascular Complications ◽  
Femoral Prosthesis ◽  
Iliac Arteries ◽  
Large Arteries ◽  
First Case ◽  
Acquired Immunodeficiency ◽  
The Right ◽  
Immunodeficiency Syndrome

BACKGROUND: Several vascular complications are known to occur in association with the acquired immunodeficiency syndrome (AIDS) and recent publications have called attention to the development of pseudoaneurysms of large arteries in patients with AIDS. CASE REPORT: We report on 2 patients with AIDS aged 23 and 31 years with pseudoaneurysms of the abdominal aorta and common iliac arteries. After clinical and radiological evaluation by arteriography and computed tomography, the patients were submitted to aneurysmectomy, with the placement of a patch of dacron in the first case and the interposition of a right aorto-iliac and left femoral prosthesis in the second. The second patient developed new aneurysms of the right subclavian and left popliteal arteries 2 months after surgery. Proximal ligation of the right subclavian artery was performed to treat the first aneurysm and resection and interposition of a reversed saphenous vein was carried out to treat the pseudoaneurysm of the popliteal artery. Histopathological examination of the popliteal artery revealed necrotizing arteritis.

scholarly journals Antibody seronegative human T-lymphotropic virus type III (HTLV-III)- infected patients with acquired immunodeficiency syndrome or related disorders

Blood ◽  
1985 ◽  
Vol 66 (3) ◽  
pp. 742-744 ◽  
Author(s):  
JE Groopman ◽  
PI Hartzband ◽  
L Shulman ◽  
SZ Salahuddin ◽  
MG Sarngadharan ◽  
...  
Keyword(s):  
Virus Type ◽  
Acquired Immunodeficiency Syndrome ◽  
Blood Donation ◽  
Clinical Course ◽  
Accurate Diagnosis ◽  
T Lymphotropic Virus ◽  
Type Iii ◽  
Acquired Immunodeficiency ◽  
Virus Culture ◽  
Immunodeficiency Syndrome

Abstract The human T-lymphotropic virus type III (HTLV-III) is the primary cause of the acquired immunodeficiency syndrome (AIDS) and related disorders (ARC). Prior studies have reported that nearly all symptomatic patients with AIDS or ARC manifest antibody to HTLV-III. This observation has engendered efforts to screen for HTLV-III, especially prior to blood donation, with assays for antibody to HTLV-III. We report the first two cases, one with AIDS and one with ARC, that are HTLV-III virus positive but antibody negative. Accurate diagnosis of HTLV-III infection in some cases may require direct virus culture or tests for antigen. In addition, lack of HTLV-III antibody may indicate an atypical clinical course of AIDS.

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