scholarly journals Pneumocystis carinii: its incidence in rodents and enhancement of the infection by corticosteroids

1973 ◽  
Vol 71 (1-2) ◽  
pp. 87-93 ◽  
Author(s):  
Helly A. Lage ◽  
Suelena A. Lage

A survey was made on the incidence of Pneumocystis carinii in 361 rodents including sewer rats, albino rats, albino mice, guinea-pigs and rabbits. P. carinii was found in 4 of the 215 Rattus norvegicus examined (1,8%). These results accord with recent observations but disagree with investigations made by the researchers who first studied this parasite in the past when high indexes of infection were found. However, in 20 albino rats treated with corticosteroids (betamethazone) we found 8 positive (40%) and in 20 albino mice treated by the same way, 9 were positive for P. carinii (45%). These results confirm the opportunistic character of P. carinii in rodents already well demonstrated in man.

2020 ◽  
Vol 13 (6) ◽  
pp. 449-454
Author(s):  
Rekia Sidhoum ◽  
Mostapha Bachir bey ◽  
Latifa Halli ◽  
Othmane Yalaoui ◽  
Asma Belkadi

1970 ◽  
Vol 20 (2) ◽  
pp. 483-487
Author(s):  
LF Zitte ◽  
RS Konya

Antinociceptive is reducing sensitivity to painful stimuli for the individual. The objective of this study was to evaluate the antinociceptive potentials of graded doses of Pleurotus ostreatus (Oyster Mushroom) aqueous extract in Rattus norvegicus (Albino Rats) and its chemical pattern by comparing it with a standard drug and a control using the hot water based flick tail test. Thirty five adult rats of both sexes were used for the experiment which, were divided into five groups of seven rats per group. Group one was used as the control (with 1ml normal saline), while groups two, three and four were treated with 100, 200 and 400 mg/kg of Pleurotus ostreatus aqueous extracts and group five treated with 15 mg/kg Aspirin (a standard drug) as positive control. Hot water at 550C was used to determine the nociceptive responses of the animals to detect anti-nociceptive effects of Pleurotus ostreatus extracts as compared to the control in hot water inflicted pain. The results suggested that Pleurotus ostreatus aqueous extract exhibits antinociceptive properties against thermal stimulus at 550C. The diversity of individual animals’ pain tolerance threshold when immersed in hot water was also observed during the experiment. However, the extract indicated a high degree of anti-nociceptive effect at 30, 60, 90 and 120 minutes post treatment period, with a progressively longer threshold time for pain sensitivity. It was also found that at 90 minute period, the control portrayed a relatively short response time.KEY WORDS: Anti-nociceptive, threshold pain, Pleurotus ostreatus, hot water test flick tail.


1982 ◽  
Vol 50 (2) ◽  
pp. 421-422 ◽  
Author(s):  
M. A. Persinger ◽  
Jane Lundgren

Offspring of 6 wild, male (brown-coated) dump rats ( Rattus norvegicus) and laboratory albino females were compared with the offspring of albino rats on several tissue and muricide measures. At weaning, the 48 hybrid pups (all brown-coated), both vocalized and bit the experimenters' gloves; these behaviors were not apparent in the 40 albino pups. Adult hybrid rats did not kill significantly more mice than albino controls. Although hybrid rats had significantly lighter (ω2 = 55%) wet thyroid weights than albinos, they did not differ in spleen, thymus, adrenal, or body weights.


Lipids ◽  
2020 ◽  
Vol 55 (4) ◽  
pp. 341-351
Author(s):  
Annelies De Cuyper ◽  
Daniela Winkler ◽  
Thomas Tütken ◽  
Geert P.J. Janssens ◽  
Marcus Clauss

1957 ◽  
Vol 190 (3) ◽  
pp. 457-458 ◽  
Author(s):  
Charles G. Wilber

Guinea pigs were forced to swim to total exhaustion in water at various temperatures. Small animals (400 gm) showed peak performance at about 40°C, large ones (1000 gm) at about 35°C. Large animals swam longer at low temperatures but shorter at high temperatures than did small ones. At 35°C all guinea pigs swam for an average of about 150 minutes. In general this species shows much less capacity for swimming than do albino rats. The difference may be related to diet or to endocrine factors.


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