Hemangiopericytoma in a female dog with direct invasion of abdominal cavity and pulmonary metastasis

An intact adult female Poodle dog was presented with a history of an increase in volume in the left and right mammary inguinal glands. The histopathological examination revealed a proliferation of spindle cells arranged in bundles with concentric arrangements surrounding blood vessels, occasionally collapsed. Three weeks after the surgery, the animal presented a recurrence of the tumor that extended from the left inguinal mammary gland to the vulva. Necropsy revealed direct invasion of the abdominal cavity by the tumor and pulmonary metastasis. The definitive diagnosis of hemangiopericytoma was made by histopathological and immunohistochemical examination. Pulmonary metastasis of CHP (canine hemangiopericytoma) is rare and there is no previous report of direct invasion to the abdominal cavity as observed in the present case.

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Pulmonary adenocarcinoma in cattle

Revista Mvz Córdoba ◽

10.21897/rmvz.97 ◽

2014 ◽

pp. 4358-4363 ◽

Cited By ~ 1

Author(s):

Diogo Sousa Z ◽

Luis Rivera C ◽

Didier Quevedo C ◽

Ana Claudia Gorino ◽

Simone Biagio C ◽

...

Keyword(s):

Epithelial Cells ◽

Tumor Cells ◽

Adult Female ◽

Histopathological Examination ◽

Abdominal Cavity ◽

Pulmonary Adenocarcinoma ◽

Immunohistochemical Examination ◽

Histopathological Findings ◽

Hematoxylin Eosin ◽

Neoplastic Epithelial Cells

ABSTRACTThe Macroscopic, histological and immunohistochemical aspects of lung acinar adenocarcinoma and the presence of nodules in the abdominal cavity of an adult female bovine are reported. In the necropsy analysis samples were collected from the: lung, heart, spleen, liver, pancreas, kidney, uterus, intestine, brain, and from nodules found in the lung and abdominal cavity, which were routinely processed to be stained by hematoxylin-eosin and for an immunohistochemistry exam with the antibodies: cytokeratin (dilution 1:200 μL) and vimentin (dilution 1:1000 μL). The histopathological examination revealed neoplastic epithelial cells with acini formation. The immunohistochemical examination of the tumor cells showed positive marking for cytokeratin and the absence of marking for vimentin. According to anatomical, morphological, and histopathological findings, as well as the result of the immunohistochemical examination, the tumor was characterized as lung acinar adenocarcinoma.

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Intramammary Metastasis in a Patient with a History of Renal Cell Carcinoma: A Case Report

Case Reports in Oncology ◽

10.1159/000489391 ◽

2018 ◽

Vol 11 (2) ◽

pp. 318-322

Author(s):

Miyuki Kitahara ◽

Yasuo Hozumi ◽

Rio Asada ◽

Aya Sawa ◽

Hitoaki Saito ◽

...

Keyword(s):

Breast Cancer ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Needle Biopsy ◽

Malignant Tumors ◽

Definitive Diagnosis ◽

Benign Tumors ◽

Immunohistochemical Examination ◽

History Of

Intramammary metastasis of renal cell carcinoma (RCC) is extremely rare, accounting for only 1.5% of all intramammary metastases. Distinguishing intramammary metastases from benign tumors and breast cancer is clinically problematic. Some patients undergo excessive surgery after a misdiagnosis of breast cancer instead of a mammary tumor. We performed a core needle biopsy (CNB) of a breast mass that developed in a 71-year-old woman after surgeries for bilateral RCC and breast cancer, leading to a diagnosis of intramammary metastasis of RCC. In this case, the CNB and immunohistochemical examination were critical for reaching a definitive diagnosis. We conclude that, when examining patients with mammary tumors, establishing their history of malignant tumors may help diagnose intramammary metastasis and select the best treatment strategy.

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Occurrence of an Abdominal Leiomyosarcoma in the Cyprinus carpio: Optical and Immunohistochemical Study

Asian Journal of Research in Zoology ◽

10.9734/ajriz/2021/v4i230109 ◽

2021 ◽

pp. 10-19

Author(s):

Luis Alberto Romano ◽

Virgínia Fonseca Pedrosa

Keyword(s):

Cell Proliferation ◽

Smooth Muscle ◽

Immunohistochemical Study ◽

Histopathological Examination ◽

Smooth Muscle Actin ◽

Swim Bladder ◽

Muscle Actin ◽

Immunohistochemical Examination ◽

Vortex Pattern ◽

Spindle Cells

A capsulated nodular neoplasm measuring 9 cm in diameter, located between the swim bladder and the kidney sample of Cyprinuscarpio, was in laboratory. The neoplasm had a solid consistency in one sector and very adherent to the capsule. Histopathological examination of the neoplasm revealed a monotonous proliferation of spindle cells, and pleomorphic, sometimes in a vortex pattern and interspersed with collagen fibers. Cells had numerous well-oriented myofibrils giving them a deep red. The cytoplasm is eosinophilic and the nuclei are hyperchromatic located in the center with blunt or "cigar-shaped" ends. In the immunohistochemical examination, the tumor cells were positive for desmin, smooth muscle actin and K-47, the latter antibody showing significant cell proliferation. Due to histopathological and immunohistochemical findings, diagnosis was made with leiomyosarcoma.

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Primary Cervical Leiomyoma with Remarkable Calcification and Ossification

Case Reports in Otolaryngology ◽

10.1155/2014/896275 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Takahiro Yamanishi ◽

Kaname Sakamoto ◽

Hiroyuki Watanabe ◽

Takaaki Yonaga ◽

Naoki Oishi ◽

...

Keyword(s):

Histopathological Examination ◽

Needle Aspiration ◽

Definitive Diagnosis ◽

Resected Specimen ◽

Submandibular Region ◽

Spindle Cells ◽

Nodular Lesions ◽

Upper Mediastinum ◽

Immunohistochemical Analyses

We encountered a patient with primary cervical leiomyoma with remarkable calcification and ossification. A 68-year-old man presenting with induration and swelling of the left submandibular region was found to have nodular lesions with calcifications in the left submandibular region and the upper mediastinum on CT. Fine needle aspiration biopsies (FNAB) of the left submandibular lesion revealed no malignancy. Resection was performed for definitive diagnosis and treatment. The resected specimen contained a solid tumor, which was markedly calcified and ossified on the cut surface. Histopathological examination showed proliferating spindle cells in a tangled and crossed arrangement. Immunohistochemically, the spindle cells were stained intensely withα-SMA and h-caldesmon, consistent with smooth muscle cells. These findings led to a definitive diagnosis of leiomyoma with calcification and ossification. This is extremely rare and the preoperative differentiation from other tumors of the head and neck was very difficult. By resection of the submandibular tumor, both definitive diagnosis of leiomyoma by histopathological and immunohistochemical analyses and treatment could be carried out. However, as the tumor in the upper mediastinum was most likely to be leiomyoma with calcification, he did not wish to undergo its biopsy and resection immediately. We have continued the follow-up.

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Giant primary retroperitoneal myxoid leiomyoma: A case report

Vojnosanitetski pregled ◽

10.2298/vsp1305522r ◽

2013 ◽

Vol 70 (5) ◽

pp. 522-525 ◽

Cited By ~ 3

Author(s):

Milan Radojkovic ◽

Miroslav Stojanovic ◽

Jasmina Gligorijevic ◽

Goran Stanojevic ◽

Predrag Kovacevic ◽

...

Keyword(s):

Smooth Muscle ◽

Case Report ◽

Histopathological Examination ◽

Abdominal Mass ◽

Abdominal Cavity ◽

S100 Protein ◽

Negative Results ◽

Smooth Muscle Tumors ◽

History Of ◽

One Year

Introduction. Leiomyomas are benign smooth muscle tumors that usually arise from the uterus. Case report. We present a patient with a 6-month history of vague abdominal discomfort, occasional nausea, vomiting and urinary incontinence. On examination, there was an extremely large firm unpainfull palpable abdominal mass. Laboratory investigation revealed mild leukocytosis and blood creatinine elevation. Abdominopelvic ultrasonography and computed tomography revealed a massive well bordered, encapsulated intraabdominal tumor, extending from the pelvis to epigastrium and almost completely fulfilling the pelvic and abdominal cavity. At laparotomy, tumor arising from the retroperitoneum was excised in toto. Histopathological examination disclosed that the tumor was composed mainly of smooth muscle cells and very rare fibrous connective tissue elements with myxomatous alteration and with no mitotic activity. The negative results of numerous additional parameters analyzed (pancytokeratin, epithelial membrane antigen, S100 protein, CD68, CD34, desmin, aktin) ruled out different origin of a tumor. One year after resection the patient had no complaints and no radiological evidence of tumor recurrence. Conclusion. Considering current limitations in radiological diagnosis, in toto resection of these tumors is necessary to rule out malignancy.

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CASE REPORT: HEMANGIOSARCOMA OF THE MESENTERY IN A FERRET (MUSTELA PUTORUS FURO)

Taiwan Veterinary Journal ◽

10.1142/s1682648515720038 ◽

2016 ◽

Vol 42 (01) ◽

pp. 35-39 ◽

Cited By ~ 1

Author(s):

Roh-Kyum Lee ◽

Yu-Lun Tsai ◽

Hui-Ju Wang ◽

Cheng-Chung Lin ◽

Shih-Chieh Chang ◽

...

Keyword(s):

Case Report ◽

Lymph Nodes ◽

Histopathological Examination ◽

Abdominal Mass ◽

Abdominal Cavity ◽

Clinical Signs ◽

Definitive Diagnosis ◽

Neoplastic Cells ◽

Swallowing Reflex ◽

Mitotic Figures

A three-year-old female intact albino ferret was presented with clinical signs of panting, hyperpnea, weakness in all four limbs, loss of the swallowing reflex, lockjaw and sudden paleness of the oral mucosa and extremities. An abdominal mass was discovered during palpation. The patient died suddenly after clinical signs were observed. At necropsy, hemoperitoneum was noted in the abdominal cavity and a [Formula: see text][Formula: see text]cm dark red moruloid mass was found in the mesentery of the ileum. Histopathological examination of the mass revealed multiple cavernous structures with significant blood accumulation. Oval to polygonal neoplastic cells with frequent mitotic figures were also noted. Furthermore, neoplastic cells were positively stained with antibodies of CD34 and Factor VIII, and had metastasized to the mesentery lymph nodes. The definitive diagnosis was visceral hemangiosarcoma in a ferret.

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Imaging and pathological findings of intramedullary inflammatory pseudotumour in a miniature dachshund: a case report

BMC Veterinary Research ◽

10.1186/s12917-019-2213-1 ◽

2019 ◽

Vol 15 (1) ◽

Author(s):

Masamichi Yamashita ◽

Tomohiro Osaki ◽

Yusuke Murahata ◽

Yuji Sunden ◽

Rinko Morita ◽

...

Keyword(s):

Spinal Cord ◽

Histopathological Examination ◽

Cervical Spinal Cord ◽

Cervical Vertebra ◽

Inflammatory Cells ◽

Preoperative Imaging ◽

Spindle Cells ◽

History Of ◽

Dorsal Laminectomy ◽

Intradural Space

Abstract Background Inflammatory pseudotumours (IPTs) are distinctive lesions consisting of myofibroblastic spindle cells and a variety of inflammatory cells. The aetiology of IPTs is unknown. Reports of IPTs in veterinary medicine have been scarse. Moreover, only one case of intradural extramedullary IPT has been previously reported. In this report, we introduce the first known case of canine IPT, which occurred in the parenchyma of the spinal cord. Case presentation A 10-year-old female Miniature Dachshund presented with a 2-month-long history of progressively worsening ataxia and tetraparesis. Neurological examination was consistent with a lesion involving the cervical spinal cord. Magnetic resonance imaging revealed an intradural space-occupying lesion in the region of the fourth cervical vertebra. Dorsal laminectomy and resection of the mass were performed. Histopathological examination revealed the proliferation of immature spindle cells (fibroblasts/myofibroblasts and glial cells) and a highly cellular mixture of neutrophils, macrophages and lymphocytic cells. The mass was located in the parenchyma of the spinal cord and was diagnosed as an IPT occurring in the parenchyma of the spinal cord. No causative pathogen was detected. The dog’s symptoms improved, during the first month after surgery. However, neurological symptoms, such as laboured breathing and dysuria, subsequently worsened and the dog died 42 days after surgery. Conclusions The present study describes a canine case of IPT occurring in the parenchyma of the spinal cord. The diagnosis and determination of the site of the mass was difficult solely based on preoperative imaging in the present case. The outcome of this case was poorer than that observed in cases of canine extramedullary IPT and human intramedullary IPT, in which the patients exhibited recovery. The prognosis after surgical resection cannot be decided from the present case alone. However, patients should be monitored for potential serious complications and recurrence.

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Mucormycosis - A catastrophic mycotic lesion

RGUHS Journal of Dental Sciences ◽

10.26715/rjds.11_2_12 ◽

2019 ◽

Vol 11 (2) ◽

pp. 64-70

Author(s):

Dr. Chandrakala J. ◽

Dr. Sahana Srinath ◽

Dr. Abhisikta Chakrabarty ◽

Dr. Satish T. Yadav ◽

Dr. S. K Srinath

Keyword(s):

Rare Case ◽

Fruits And Vegetables ◽

Soft Tissues ◽

Histopathological Examination ◽

Fungal Spores ◽

Severe Burn ◽

Mortality And Morbidity ◽

Direct Invasion ◽

Fungal Hyphae ◽

History Of

Mucormycosis (phycomycosis, zygomycosis) is an severe opportunistic infection 2 caused by a saprophytic fungus found in soil, bread molds, decaying fruits and vegetables. This disease is commonly found in immunodeficiency patients like diabetes, tuberculosis, renal failure, leukemia, Cirrhosis and in severe burn cases. The fungal spores enter paranasal sinuses through inhalation and infection spreads to orbital and intracranial structures via blood vessels or by direct invasion. These organisms invade the arteries leading to thrombosisand subsequently cause necrosis of hard and soft tissues. We report a rare case of mucormycosisinvolving extensive area of palate in a 48-year old male patient with a medical history of diabetes andliver cirrhosis and met with accident a month back. Histopathological examination of H&E stainedsections revealed fungal hyphae in a connective tissue stroma. Non-septate branching hyphae were better appreciated through Gomori methenamine staining. Early diagnosis andtimely treatment can reduce the mortality and morbidity of this fatal condition.

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Spindle Cell Lipoma Occurring in the Buccal Mucosa: An Unusual Location of This Benign Lipomatous Neoplasm

Case Reports in Pathology ◽

10.1155/2015/805730 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Noala Vicensoto Moreira Milhan ◽

Ana Sueli Rodrigues Cavalcante ◽

Yonara Maria Freire Soares Marques ◽

Yasmin Rodarte Carvalho ◽

Ana Lia Anbinder

Keyword(s):

Buccal Mucosa ◽

Smooth Surface ◽

Spindle Cell ◽

Histopathological Examination ◽

Immunohistochemical Analysis ◽

Final Diagnosis ◽

Spindle Cell Lipoma ◽

Mature Adipose Tissue ◽

Spindle Cells ◽

History Of

Spindle cell lipoma is a benign lipomatous neoplasm, which rarely occurs in the oral cavity. The aims of this paper are to report a case of spindle cell lipoma located in buccal mucosa and discuss the main clinical, histological, and immunohistochemical findings of this entity. Thus, we report a 4-year history of an asymptomatic smooth surface nodule in an elderly Caucasian man with clinical hypothesis of fibroma. The histopathological examination showed spindle cells, mature adipose tissue, and many mast cells in a stroma of connective tissue presenting ropey collagen fibers bundles. After immunohistochemical analysis, the final diagnosis was spindle cell lipoma.

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Non-Epitheliotropic Cutaneous Lymphoma with Systemic Dissemination in a Dog

Acta Scientiae Veterinariae ◽

10.22456/1679-9216.107597 ◽

2021 ◽

Vol 49 ◽

Author(s):

Laís Guedes Rosseto ◽

Beatriz Crepaldi Aléssio Pitol ◽

Paulo Antonio Terrabuio Andreussi ◽

Mariana Isa Poci Palumbo ◽

Adriana Ventura ◽

...

Keyword(s):

Lymph Nodes ◽

T Lymphocyte ◽

Cell Lymphoma ◽

Histopathological Examination ◽

Present Report ◽

Definitive Diagnosis ◽

Cutaneous Lymphoma ◽

Clinical Staging ◽

Immunohistochemical Examination ◽

Systemic Dissemination

Background: Cutaneous lymphoma is a highly malignant neoplasm, which can originate in the epidermis or dermis, as well as be disseminated to other organs such as lung, heart, arm, liver and bone marrow. It comes in the form of nodes of various sizes, erythematous and alopecic, itching may or may not occur. The diagnosis is made by cytological and histopathological examination of the compromised tissue. However, it is important to perform complementary tests for clinical staging and prognostic characterization. The objective is to report a case of non-epitheliotropic cutaneous lymphoma with systemic dissemination in a dog.Case: A female mixed bred adult canine was attended at the Veterinary Hospital of the Federal University of Mato Grosso do Sul with a history of progressive weight loss and the presence of alopecic and non-pruritic subcutaneous nodules in the torso, nasal plane and pelvic limbs, starting 4 months ago. After approximately 20 days, the presence of rapidly evolving ulcerated nodules was noted. On physical examination, generalized lymphadenomegaly was observed and among the dermatological findings were multiple nodules of varying sizes with the presence of ulceration in the center of the lesions, alopecia, erythema and raised edges, in the region of the nasal sinus, pelvic and thoracic limbs, tail, thoracolumbar and abdominal region. The animal also presented right pelvic limb edema with painful sensibility to manipulation CBC and biochemical tests (albumin, alanine aminotransferase, creatinine, urea, alkaline phosphatase, globulins, total proteins and fractions) were performed, being observed as normocytic normochromic type anemia alteration (erythrocytes: 2.78 106/µL; hemoglobin: 6.8 g/µL; globular volume: 18.8%), leukopenia (4,000/mm³) with presence of metamyelocytes (120/mm³) and rods (1,080/mm³) and lymphopenia (80/mm³). Three samples of the nodules were collected for histopathological examination and a definitive diagnosis of cutaneous lymphoma was obtained. The material was then submitted to immunohistochemical examination, which showed that it was a non-epitheliotropic cutaneous lymphoma of T immunophenotype. Due to the compromised quality of life and unfavorable prognosis, the owner opted for euthanasia of the animal. In the necropsy examination, lymph nodes, subcutaneous tissue, skeletal muscle, heart, pericardial sac, tongue and multifocal infiltrate of neoplastic cells were observed, findings suggestive of multicentric lymphoma or infiltrations by dissemination of cutaneous lymphoma.Discussion: Non-epitheliotropic skin lymphomas exhibit rapid progression and infiltration into lymph nodes and subsequent systemic involvement. The diagnosis is based on clinical-dermatological signs, fine needle cytology, histopathological and immunohistochemical examination. Normocytic normochromic anemia is the most observed alteration in patients with lymphoma, followed by leukocytosis, leukopenia, thrombocytopenia, neutrophilia and leukoerythroblastic reactions. Dogs with T-cell lymphoma have a worse prognosis for life span and disease-free intervals than those with B-cell lymphoma, so immunophenotyping is critical to determine prognosis. In the present report, histopathological and immunohistochemical examinations were decisive for the diagnosis of the present report, because the expression CD3 and the negativity for CD79a proved that the neoplasm is of T lymphocyte lineage. The definitive diagnosis was obtained by histopathology, however, immunohistochemistry determined the immunophenotype of the neoplasia as non-epitheliotropic T lymphocyte.

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