scholarly journals Helminth-induced immune response: A new perspective for the treatment of Multiple Sclerosis

2021 ◽  
Author(s):  
Karla Viana Rezende ◽  
Ayrton Senna do Brasil Amaral Alves ◽  
Juliana Carollyne Amorim ◽  
Maria Inês Vaz de Oliveira ◽  
Maria Paula Banhara Rodrigues ◽  
...  
Keyword(s):  
Immune Response ◽  
Clinical Evidence ◽  
Scientific Evidence ◽  
Great Hope ◽  
Pubmed Database ◽  
Long Time ◽  
Immunological Factors ◽  
New Perspective ◽  
Helminth Therapy

Background: Multiple Sclerole (MS) is a progressive neurodegenerative disease that, in its most common form, evolves in outbreaks and compromises the patient’s quality of life and functionality. In a long time, a way of attenuating symptoms and preventing the progression of this pathology has been studied, however, drug therapies, until now, have not shown good accuracy. In this context, the exogenous use of helminths as non-drug therapy for MS has been considered, therefore, this study aims to demonstrate the recent results of studies on such therapies and verify whether there is scientific evidence of a good clinical, immunological and exam response. image of patients with MS. Methods: Bibliographic review in the PUBMED database Results: The four large studies carried out on the topic demonstrated evidence that the immune response induced by helminths decreases the activity of the immunological factors that contribute to the progression of MS, however the small control groups and unfavorable environments impaired the conclusions of the studies . Conclusions: Although the studies have no yet to demonstrate reliable clinical evidence about exogenous helminth therapy, it is undeniable that the good immune response induced by the parasites is a great hope that motivates the continuation of studies in the area.

scholarly journals The Use of Evidence-Based Acupuncture: Current Evidence

2022 ◽  
Author(s):  
Dedi Ardinata
Keyword(s):  
Clinical Evidence ◽  
Scientific Evidence ◽  
Current Evidence ◽  
Systematic Research ◽  
Evidence Based ◽  
Clinical Expertise ◽  
Quality Of Evidence ◽  
Assessment Development ◽  
Evidence Quality

Evidence-based medicine (EBM), which emphasizes that medical decisions must be based on the most recent best evidence, is gaining popularity. Individual clinical expertise is combined with the best available external clinical evidence derived from systematic research in the practice of EBM. The key and core of EBM is the hierarchical system for categorizing evidence. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) system divides evidence quality into four categories: high, moderate, low, and very low. GRADE is based on the lowest quality of evidence for any of the outcomes that are critical to making a decision, reducing the risk of mislabeling the overall evidence quality, when evidence for a critical outcome is lacking. This principle is also used in acupuncture as a complementary and integrative treatment modality, but incorporating scientific evidence is more difficult due to a number of factors. The goal of this chapter is to discuss how to establish a clinical evidence system for acupuncture, with a focus on the current quality of evidence for a variety of conditions or diseases.

scholarly journals Het belang van sociaal tolken als instrument van tolerantie in het kader van de huidige vluchtelingen- en arbeidsmigratie

2020 ◽  
Vol 68 (5 Zeszyt specjalny) ◽  
pp. 83-94
Author(s):  
Pavlína Knap-Dlouhá ◽  
Kateřina Křížová
Keyword(s):  
Social Services ◽  
Western Europe ◽  
Quality Of Healthcare ◽  
Social Changes ◽  
The European Union ◽  
The Social ◽  
Long Time ◽  
Professional Profile ◽  
New Perspective

As a result of social changes in society in Western Europe at the end of the 20th century, it was recognised that a new perspective on interpreting science was needed. For a long time, community interpreting was ignored or considered inferior in comparison to the dominant interpreting mode, namely, conference interpreting. Intensifying trade contacts and labour migration within the European Union have, in combination with the current influx of refugees, led to a high demand for interpreting services in the field of social and legal interpreting. Additionally, there is only a limited number of qualified interpreters available on the market, especially in combinations of less widely-spoken languages. The lack of qualified community interpreters and translators has direct consequences for delays in the functioning of certain government bodies and social services. The same applies to the quality of healthcare provided and to the social climate. Increasing the scale of interpreting and translation assignments, changing the professional profile of the interpreter and raising the demand for the provision of language services in specific language combinations are clear signals for small philological departments to offer their students the opportunity to specialise in this area. For this reason, two projects are presented in this article, both of which aim at promoting know-how in the field of social interpreters and at developing modules in social interpreting and translation.

scholarly journals Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars

2016 ◽  
Vol 62 (9) ◽  
pp. 862-866 ◽  
Author(s):  
VINÍCIUS ZOLEZI DA SILVA ◽  
ANTONIO ALBACETE NETO ◽  
GRAZIELLE DE SOUZA HORÁCIO ◽  
GUILHERME AUGUSTO MAGALHÃES DE ANDRADE ◽  
LEANDRO DEBS PROCÓPIO ◽  
...  
Keyword(s):  
Scientific Evidence ◽  
Fat Grafting ◽  
Hypertrophic Scars ◽  
Autologous Fat Grafting ◽  
Range Of Movement ◽  
Autologous Fat ◽  
Current State ◽  
Pubmed Database ◽  
Low Levels

SUMMARY Introduction Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. The aim of this study was to review the current state of autologous fat grafting for the treatment of keloids and hypertrophic scars, their benefits and scientific evidences in the literature. Method A review in the Pubmed database was performed using the keywords “fat grafting and scar”, “fat grafting and keloid scar” and “fat grafting and hypertrophic scar.” Inclusion criteria were articles written in English and published in the last 10 years, resulting in 15 studies. Results These articles indicate that autologous fat grafting carried out at sites with pathological scars leads to a reduction of the fibrosis and pain, an increased range of movement in areas of scar contraction, an increase in their flexibility, resulting in a better quality of scars. Conclusion So far, evidences suggest that autologous fat grafting for the treatment of keloids and hypertrophic scars is associated with a better quality of scars, leading to esthetic and functional benefits. However, this review has limitations and these findings should be treated with reservations, since they mostly came from studies with low levels of evidence.

scholarly journals Sarcoid-like lesions in paracoccidioidomycosis: immunological factors*

2013 ◽  
Vol 88 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Vanessa Lucília Silveira de Medeiros ◽  
Lúcia Arruda
Keyword(s):  
Immune Response ◽  
Clinical Picture ◽  
Clinical Presentation ◽  
Skin Lesions ◽  
Host Immunity ◽  
Spontaneous Cure ◽  
Long Time ◽  
Immunological Factors ◽  
Different Levels ◽  
Active Disease

The clinical presentation of paracoccidioidomycosis is spectral. Spontaneous cure, state of latency or active disease with different levels of severity can occur after the hematogenous dissemination. The morphology and number of skin lesions will depend on the interaction of host immunity, which is specific and individual, and fungus virulence. Some individuals have natural good immunity, which added to the low virulence of the fungus maintain the presence of well-marked granulomas with no microorganism and negative serology for a long time, making the diagnosis a challenge. Factors inherent to the fungus, however, may modulate the immune response and modify the clinical picture over the time. We present a sarcoidosis-like clinical presentation and discuss the immunological factors involved.

Gaining a new perspective on the quality of parent–adolescent relationships from adolescent speech samples.

2020 ◽  
Vol 34 (8) ◽  
pp. 938-948
Author(s):  
Sarah McKenna ◽  
Alison Hassall ◽  
Richard O'Kearney ◽  
Dave Pasalich
Keyword(s):  
Adolescent Relationships ◽  
New Perspective

Tingkat Pemahaman Kompetensi Guru Pada Mahasiswa Pendidikan Geografi Sebagai Calon Guru Geografi

2020 ◽  
Vol 21 (1) ◽  
pp. 102-117
Author(s):  
Novia Zalmita ◽  
Muhajirah Muhajirah ◽  
Abdul Wahab Abdi
Keyword(s):  
Prospective Teachers ◽  
Prospective Teacher ◽  
Quantitative Description ◽  
Population Data ◽  
Geography Education ◽  
Teacher Competence ◽  
Education Department ◽  
Long Time

One that influences human resource indicators is education. The teacher is a profession as a job of academic specialization in a relatively long time in college. Understanding related to teacher competence is very important to have by a prospective teacher because it can affect the quality of performance as a professional teacher. The teacher's competence is known as pedagogic, professional, social and personality competencies. The issue in this study is how the competency of the teacher of the Department of Geography Education FKIP Unsyiah as a prospective teacher of geography? The purpose of this study was to determine the competence of teachers in the Department of Geography Education FKIP Unsyiah as prospective geography teachers. Quantitative description approach is used in this study to find answers to the issue. The population in this study were students of the Department of Geography Education FKIP Unsyiah class of 2015 and 2016 who had been declared to have passed the Micro Teaching and Magang Kependidikan 3 course totaling 50 people. Because the population is small and can be reached, the determination of the sample using total sampling techniques so that the sample in this study is the whole population. Data collection is done by distributing test questions to respondents. The data was analyzed using the descriptive statistics percentage formula. The results of the study indicate that the level of teacher competence of Geography Education Department students as prospective teachers is in the moderate category, namely as many as 22 respondents (44%). A total of 12 respondents (24%) were in the high category, 15 respondents (30%) were in the low category and 1 respondent (2%) were in the very low category.

Electrical Damage Due to Low Energy Plasma Processing of GaAs Structures

1991 ◽  
Vol 223 ◽  
Author(s):  
Hans P. Zappe ◽  
Gudrun Kaufel
Keyword(s):  
Chemical Processes ◽  
Low Energy ◽  
Electrical Behavior ◽  
Rapid Thermal Anneal ◽  
High Temperature Anneal ◽  
Significant Damage ◽  
Low Energies ◽  
Long Time ◽  
Physical Plasma

ABSTRACTThe effect of numerous plasma reative ion etch and physical milling processes on the electrical behavior of GaAs bulk substrates has been investigated by means of electric microwave absorption. It was seen that plasma treatments at quite low energies may significantly affect the electrical quality of the etched semiconductor. Predominantly physical plasma etchants (Ar) were seen to create significant damage at very low energies. Chemical processes (involving Cl or F), while somewhat less pernicious, also gave rise to electrical substrate damage, the effect greater for hydrogenic ambients. Whereas rapid thermal anneal treatments tend to worsen the electrical integrity, some substrates respond positively to long-time high temperature anneal steps.

PEMBENAHAN TERHADAP LEMBAGA PEMASYARAKATAN DAPAT MENIADAKAN OPSI HUKUMAN MATI BAGI NARAPIDANA DI INDONESIA (THE IMPROVEMENT OF QUALITY OF PENITENTIARY CAN ELIMINATE THE DEATH PENALTY OPTIONS OF CONVICTED CRIMINALS IN INDONESIA)

2020 ◽  
Vol 10 (2) ◽  
pp. 175
Author(s):  
Nomensen Freddy Siahaan
Keyword(s):  
Death Penalty ◽  
Deterrent Effect ◽  
Criminal Cases ◽  
Psychological Burden ◽  
The Real ◽  
The Public ◽  
Good Citizen ◽  
The People ◽  
Long Time

After a long time was not heard to the public area, lately death penalty toward the criminal cases that classified as extraordinary crime are appear. The author discovers electronic article about the execution of the death penalty which is the prosecutor prepares to execute death penalty toward the drugs dealer. The president of Republic of Indonesia stated that it is necessary to give a deterrent effect to the convicted  criminal and keep the morality of Indonesian teenagers. According to my opinion, the author argues that it will be better and wiser if we discuss about renovating all of the Penitentiary in Indonesia than debating whether death penalty could be done in Indonesia or not, because it will be displeasure many parties, death penalty infringed the human rights of the convicted criminals and cause psychological burden to them, families, the executor of the death penalty, and other parties. Because if we have to improve the quality of the Penitentiary, if the function of Penitentiary for fostering moralily has been optimal or properly enough to the convicted criminals, Indonesia will be no longer need the death penalty option as sanction to the convicted crimanals including for the extraordinary crime (especially for drugs trafficking in our country). Penitentiary is one of the public services which aims for fostering the people that initially have bad habits (commited to the crime), so that they will have the awareness to change their bad attitude into the be better ones, will not harm others, and positively contributed to the society. Already Penitentiary’s conditions should be designed in such a way and as good as possible, so that the inmates feels like at their own home (like having a second home after his own home), and feel humaner to spend their days in the Penitentiary. The author believes that if the Penitentiary has been improved and optimized its function well, then the real purpose of Penitentiary will definitely achieved. As stated in Law Number 12 Year 1995 regarding to Penitentiary Article 2 which states "sanction system are organized in order to fostering the convicted criminals in order to be the real man, aware of their fault, improve themselves, and not to repeat the criminal act so that they can be friendly received by the community, can actively participated in the development of our country, and can socialize themselves as good citizen."Article 3 on this regulation also intensifies the function of Penitentiary "the function of Penitentiary is to prepare convicted criminals to be able to properly integrated to the society, so they can be accepted again as members of the public who are free and responsible ones." 

OS CAMINHOS DAS ÁGUAS NO MUNICÍPIO DE CARIRÉ, CEARÁ, BRASIL

2019 ◽  
Vol 21 (2) ◽  
pp. 564-580
Author(s):  
Eloiza Rocha Queiroz ◽  
José Falcão Sobrinho
Keyword(s):  
Water Resources ◽  
Potable Water ◽  
Field Trips ◽  
Central Theme ◽  
Northeast Region ◽  
Brazilian Semiarid ◽  
Long Time ◽  
Short Rains ◽  
Two Stages

A região Nordeste do Brasil vem sendo alvo de medidas do Estado a mais de um século, na tentativa de solucionar o problema da falta de água em época de secas. O Estado do Ceará, por sua vez, apresenta boa parte de seu território inserido no semiárido brasileiro, uma região caracterizada pelo clima seco, com poucas chuvas e elevada evapotranspiração. A problemática da água existe há bastante tempo, principalmente o acesso em quantidade e qualidade suficientes para atender a população. O presente trabalho tem como tema central a questão dos recursos hídricos, com enfoque no abastecimento humano do município de Cariré, localizado na região noroeste do Ceará. Nosso objetivo consiste em apresentar um panorama de como atualmente a população carireense tem acesso à água potável. A metodologia adotada constitui-se em duas etapas: na primeira, realizamos levantamento de material bibliográfico e a segunda diz respeito a parte prática realizada em saídas a campo. Segundo a ONU, a água é um bem comum e que deve ser de acesso a todos, é um direito humano. Nesta perspectiva, o gerenciamento adequado dos recursos hídricos é essencial para a manutenção da qualidade de vida. Palavras-chave: Recursos Hídricos; Abastecimento Humano; Cariré-Ce. ABSTRACTThe pnortheast region from Brazil has been subject of measures for more than a century in attempts to solve the problems lack of water in dry season. The state of Ceará has a good part of its territorial inserted in Brazilian semiarid, a region characterized by dry climate, short rains and high evapotranspiration. The water issue has existed for a long time, mainly in a sufficient access of quantity and quality to serve the population. Then, this article has as a central theme the water resources focusing on water supply of the Cariré localized at Northeast region from Ceará. Therefore the purpose of the paper is to present a study about how the Carire’s population has had access to potable water currently. The methodology adopted to this research consists of two stages: Firstly it was carried out a survey of bibliographical material and secondly it concerned the practical part carried out in the field trips. In accordance to United nations, water is a commom good and it has to be available to everyone, it is a human rights. In that sense, the proper management of water resources is essential to keep the quality of life.Key-words: Human supply; Water resources; Cariré – Ce. RÉSUMÉLa région du nord-est du Brésil est la cible de mesures prises par l’État depuis plus d’un siècle pour tenter de résoudre le problème de la pénurie d’eau en saison sèche. L’État du Ceará, en revanche, présente une bonne partie de son territoire inséré dans le semi-aride brésilien, région caractérisée par un climat sec, avec peu de pluies et une forte évapotranspiration. Le problème de l'eau existe depuis longtemps, principalement l'accès en quantité et qualité suffisantes pour satisfaire la population. Le travail actuel a pour thème central la question des ressources en eau, en mettant l'accent sur l'approvisionnement humain de la municipalité de Cariré, située dans la région nord-ouest du Ceará. Notre objectif est de présenter un aperçu de la façon dont la population carioca a actuellement accès à l’eau potable. La méthodologie adoptée comporte deux étapes: dans le premier, nous procédons à une enquête sur le matériel bibliographique et le second à la partie pratique réalisée lors des visites sur le terrain. Selon l'ONU, l'eau est un bien commun et doit être accessible à tous, c'est un droit humain. Dans cette perspective, la gestion adéquate des ressources en eau est essentielle au maintien de la qualité de la vie.Mots-clés: Ressources en eau; Approvisionnement humain; Cariré-Ce.

Experience with the Relay Procedure for Tuning Controllers in Automatic Control of Chlorination

1993 ◽  
Vol 28 (11-12) ◽  
pp. 257-261
Author(s):  
M. Truett Garrett ◽  
Zaki Ahmad ◽  
Shelly Young
Keyword(s):  
Wastewater Treatment ◽  
Automatic Control ◽  
Time Constant ◽  
Wastewater Treatment Plants ◽  
Relay Feedback ◽  
Quality Of Control ◽  
Incomplete Mixing ◽  
Long Time ◽  
Chlorine Demand

The recent requirements by U.S.E.P.A. for dechlorination and biomonitoring have increased the importance of automatic control of effluent chlorination in wastewater treatment plants. Difficulties with the Ziegler-Nichols controller tuning procedure were reported at the Kyoto Workshop, 1990. Problems are caused by the noise of incomplete mixing, a long time constant, and the disturbances of changing flow and chlorine demand. The Astrom-Hagglund relay feedback procedure provides acceptable control while data is logged to determine the controller constants. Experiences in using the procedure in existing facilities (not redesigning the mixing point) and the quality of control are presented.

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