scholarly journals Análise de protocolos com intervenção motora domiciliar para pacientes com doença de Alzheimer: uma revisão sistemática

2013 ◽  
Vol 16 (3) ◽  
pp. 615-631
Author(s):  
Julimara Gomes dos Santos ◽  
Larissa Pires de Andrade ◽  
Jessica Rodrigues Pereira ◽  
Angelica Miki Stein ◽  
Renata Valle Pedroso ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Physical Therapy ◽  
Physical Exercise ◽  
Physical Fitness ◽  
Web Of Science ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia ◽  
Home Based

A prática regular de atividade física é indicada como uma terapia não farmacológica ao tratamento da doença de Alzheimer por promover benefícios cognitivos, comportamentais e funcionais. Pouco se sabe, porém, sobre os protocolos com intervenção motora domiciliar para essa população. Pensando nisso, esta revisão teve como objetivo investigar e analisar os protocolos de intervenção motora domiciliar para idosos com doença de Alzheimer descritos em artigos científicos. Realizou-se busca sistemática, sem limite de data, nas seguintes bases de dados: Web of Science, PubMed, PsycINFO e Scopus. Utilizaram-se os seguintes operadores booleanos e palavras-chave: "home-based exercise" OR "home-based physical exercise" OR "home-based physical fitness" OR "home-based rehabilitation" OR "home-based physical therapy" OR "home-based physical activity" OR "home-based motor intervention" and "AD" OR "Alzheimer's disease" OR "Alzheimer" OR "Alzheimer's dementia". Realizou-se também uma busca manual nas listas de referência dos artigos selecionados. Dos cinco artigos que atenderam aos critérios de inclusão adotados, três realizaram um protocolo de intervenção motora domiciliar, conseguindo boa adesão ao programa, melhora geral da saúde e diminuição de sintomas depressivos. Os outros dois estudos limitaram-se a descrever os protocolos. Apesar de serem necessários mais estudos, com protocolos mais detalhados, esta revisão permitiu mostrar que protocolos de intervenção motora domiciliar também podem produzir efeitos positivos tanto para pacientes quanto para cuidadores.

scholarly journals Atividade física sistematizada e desempenho cognitivo em idosos com demência de Alzheimer: uma revisão sistemática

2009 ◽  
Vol 31 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Flávia Gomes de Melo Coelho ◽  
Ruth Ferreira Santos-Galduroz ◽  
Sebastião Gobbi ◽  
Florindo Stella
Keyword(s):  
Physical Activity ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Physical Therapy ◽  
Physical Education ◽  
Cognitive Performance ◽  
Web Of Science ◽  
Alzheimer’S Dementia ◽  
Alzheimer's Dementia

OBJETIVO : Apesar da crescente evidência dos benefícios do exercício físico para a cognição, existem controvérsias a respeito da prática de atividade física sistematizada em pacientes com doença de Alzheimer. Desta forma, o objetivo deste trabalho foi o de realizar uma revisão sistemática dos estudos que analisaram o efeito da atividade física sistematizada no desempenho cognitivo em idosos com doença de Alzheimer. MÉTODO : Efetuou-se uma pesquisa na PsycINFO, Biological Abstracts, Medline, Web of Science, Physical Education Index e SPORTDiscus, no período de 1990 a 2008, utilizando-se as seguintes palavras-chave: "physical activity", "physical therapy", "exercise", "fitness", "aerobic", "strength", "intervention", "cognition", "cognitive performance", "Alzheimer's disease", "Alzheimer's dementia", "Alzheimer", além de referências cruzadas dos artigos selecionados. RESULTADOS: Foram encontrados oito estudos que preencheram os critérios de inclusão adotados para o presente trabalho. Estes estudos mostraram que a atividade física sistematizada contribuiu para melhorar pelo menos temporariamente as funções cognitivas em paciente com doença de Alzheimer, particularmente, atenção, funções executivas e linguagem. CONCLUSÃO: Não foi possível estabelecer um protocolo de recomendações a respeito do tipo e intensidade da atividade física sistematizada necessária para produzir benefícios no funcionamento cognitivo. No entanto, a prática regular de atividade física sistematizada parece contribuir para a preservação ou mesmo melhora das funções cognitivas em pacientes com doença de Alzheimer.

scholarly journals The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense: Mitigating Disease Burden, With Focus on COVID-19 Consequences

2021 ◽  
Vol 12 ◽  
Author(s):  
Tayrine Ordonio Filgueira ◽  
Angela Castoldi ◽  
Lucas Eduardo R. Santos ◽  
Geraldo José de Amorim ◽  
Matheus Santos de Sousa Fernandes ◽  
...  
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Physical Fitness ◽  
Bed Rest ◽  
Multiple Organ ◽  
Immune Defense ◽  
Sitting Time ◽  
Low Grade ◽  
Home Based ◽  
Effective Therapeutic Strategy

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a fast spreading virus leading to the development of Coronavirus Disease-2019 (COVID-19). Severe and critical cases are characterized by damage to the respiratory system, endothelial inflammation, and multiple organ failure triggered by an excessive production of proinflammatory cytokines, culminating in the high number of deaths all over the world. Sedentarism induces worse, continuous, and progressive consequences to health. On the other hand, physical activity provides benefits to health and improves low-grade systemic inflammation. The aim of this review is to elucidate the effects of physical activity in physical fitness, immune defense, and its contribution to mitigate the severe inflammatory response mediated by SARS-CoV-2. Physical exercise is an effective therapeutic strategy to mitigate the consequences of SARS-CoV-2 infection. In this sense, studies have shown that acute physical exercise induces the production of myokines that are secreted in tissues and into the bloodstream, supporting its systemic modulatory effect. Therefore, maintaining physical activity influence balance the immune system and increases immune vigilance, and also might promote potent effects against the consequences of infectious diseases and chronic diseases associated with the development of severe forms of COVID-19. Protocols to maintain exercise practice are suggested and have been strongly established, such as home-based exercise (HBE) and outdoor-based exercise (OBE). In this regard, HBE might help to reduce levels of physical inactivity, bed rest, and sitting time, impacting on adherence to physical activity, promoting all the benefits related to exercise, and attracting patients in different stages of treatment for COVID-19. In parallel, OBE must improve health, but also prevent and mitigate COVID-19 severe outcomes in all populations. In conclusion, HBE or OBE models can be a potent strategy to mitigate the progress of infection, and a coadjutant therapy for COVID-19 at all ages and different chronic conditions.

Estrogen Signaling in Alzheimer’s Disease: Molecular Insights and Therapeutic Targets for Alzheimer’s Dementia

2020 ◽  
Vol 57 (6) ◽  
pp. 2654-2670 ◽  
Author(s):  
Md. Sahab Uddin ◽  
Md. Motiar Rahman ◽  
Md. Jakaria ◽  
Md. Sohanur Rahman ◽  
Md. Sarwar Hossain ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Targets ◽  
Alzheimer’S Dementia ◽  
Estrogen Signaling ◽  
Alzheimer's Dementia

Setting the Scene: The Evidence for Pre-clinical Change, Projections of the Impact of Intervention, and Implications for Public Health

2017 ◽  
Vol 41 (S1) ◽  
pp. S12-S12
Author(s):  
T.C. Russ ◽  
K. Ritchie ◽  
G.M. Terrera ◽  
C.W. Ritchie
Keyword(s):  
Public Health ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Alzheimer’S Dementia ◽  
Prevention Measures ◽  
Risk Models ◽  
Clinical Change ◽  
Alzheimer's Dementia ◽  
The Impact ◽  
Statistical Risk

Alzheimer's disease has long been considered a neurodegenerative disorder of late life for which there is currently no disease-modifying treatment. This view is now being revised as increasing evidence suggests a long pre-clinical phase extending back into mid-life during which there is exposure to multiple potentially reversible risk factors. Further thought is now being given to the possibility of both early life intervention programs and development of new drug treatments focusing on the pre-dementia period. But how can the impact of such treatments be measured at this early stage since overt dementia may not be diagnosed for decades? In the four talks in this symposium, we will discuss evidence for pre-clinical change, theoretical models which have been used to project the possible impact of risk factor modification in mid-life and their integration into a future public health strategies. The development of new statistical risk models to determine the impact of such prevention measures will be outlined. We will consider the possibilities for drug development targeting the pre-clinical period before presenting the PREVENT Project and EPAD (http://ep-ad.org/), a multi-million euro IMI-Horizon 2020 funded project for the development of pre-clinical proof of concept trials. Titles of the four presentations: 1. Setting the scene: the evidence for pre-clinical change, projections of the impact of intervention, and implications for public health (TCR) 2. New statistical risk models for determining the impact of prevention measures in the pre-dementia period (GMT) 3. The PREVENT Study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer's disease (KR) 4. The European Prevention of Alzheimer's Dementia (EPAD) Project: developing interventions for the secondary prevention of Alzheimer's dementia (CWR)Disclosure of interestThe authors have not supplied their declaration of competing interest.

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