BIOLOGICAL EFFECTS OF 131I AND 125I ISOTOPES OF IODINE IN THE RAT

1976 ◽  
Vol 71 (1) ◽  
pp. 109-114 ◽  
Author(s):  
I. DONIACH ◽  
D. J. SHALE
Keyword(s):  
Thyroid Function ◽  
Biological Effects ◽  
Female Rats ◽  
Long Term Effects ◽  
Significant Elevation ◽  
Radioiodine Uptake ◽  
Male And Female ◽  
Male And Female Rats ◽  
Serum Tsh

SUMMARY From the differences in radiation profiles between 131I and 125I isotopes of iodine it would be expected that they would show different effects on thyroid function. The differences should lead to lower rates of thyroid gland destruction with 125I and hence less post-irradiation hypothyroidism. This difference in biological effect has been demonstrated in rats by indirect assessment of thyroid function. In this report the long-term effects of a range of similar doses of 131I and 125I were compared, in male and female rats, by direct assessment of thyroid function. Seventeen months after receiving 25 and 125 μCi of 131I, male and female rats showed significant elevation of serum TSH concentration and a reduction in 3 h radioiodine uptake. Rats receiving 1 and 5 μCi of 131I and all doses of 125I showed no significant changes in thyroid function. These findings confirm the previously reported differences in effect between the 131I and 125I isotopes of iodine in the rat.

LONG-TERM EFFECTS OF ADRENALECTOMY AND GONADECTOMY ON THYROID FUNCTION IN THE RAT

1965 ◽  
Vol 48 (4) ◽  
pp. 556-560 ◽  
Author(s):  
Jerome A. Grunt ◽  
Russell D. Cunningham
Keyword(s):  
Replacement Therapy ◽  
Thyroid Function ◽  
Hormonal Replacement Therapy ◽  
Female Rats ◽  
Follicular Epithelium ◽  
Long Term Effects ◽  
Male And Female ◽  
Hormonal Replacement ◽  
Male And Female Rats

ABSTRACT Thyroid function has been evaluated in male and female rats which had been either sham operated, gonadectomized, adrenalectomized, or adrenalectomized and gonadectomized on day 25, and killed at 180 days of age. No hormonal replacement therapy was utilized. Animals without adrenals showed increased thyroid weights, increased cell heights of follicular epithelium and decreased resin binding of 131I labeled triiodothyronine without significant changes in BEI. Possible mechanisms for these changes in thyroid function are discussed.

Long-term effects of high-fat diets on peroxisomal β-oxidation in male and female rats

Lipids ◽  
1985 ◽  
Vol 20 (10) ◽  
pp. 668-674 ◽  
Author(s):  
M. S. Thomassen ◽  
J. Norseth ◽  
E. N. Christiansen
Keyword(s):  
Female Rats ◽  
Long Term Effects ◽  
High Fat ◽  
Male And Female ◽  
Male And Female Rats ◽  
High Fat Diets ◽  
Fat Diets

Long-term Effects of Alcohol Consumption in Male and Female Rats

2007 ◽  
Vol 7 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Mariann R. Piano ◽  
David L. Geenen ◽  
Dorie W. Schwertz ◽  
Shamim A. K. Chowdhury ◽  
Milina Yuzhakova
Keyword(s):  
Alcohol Consumption ◽  
Female Rats ◽  
Long Term Effects ◽  
Male And Female ◽  
Male And Female Rats

Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats

2006 ◽  
Vol 190 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Bruce A. Rasmussen ◽  
Jahn O’Neil ◽  
Kebreten F. Manaye ◽  
David C. Perry ◽  
Yousef Tizabi
Keyword(s):  
Sensorimotor Gating ◽  
Female Rats ◽  
Long Term Effects ◽  
Male And Female ◽  
Male And Female Rats

Protocol for chronic implantation of patch electrodes on the gastric muscle wall of the rat v1

2021 ◽  
Author(s):  
Robert Phillips ◽  
Deborah Jaffey ◽  
Terry Powley
Keyword(s):  
Body Weight ◽  
Electrical Stimulation ◽  
Female Rats ◽  
Long Term Effects ◽  
Male And Female ◽  
Post Surgery ◽  
Male And Female Rats ◽  
Gastric Muscle ◽  
And Behavior

Electrical stimulation is a potential therapy for gastric disorders. Here we describe our surgical procedure for the implantation of patch electrodes on the muscle wall of the stomach of both male and female rats for use in chronic studies looking at the long-term effects of stimulation on physiology and behavior. The surgery is well tolerated by the subjects as rats return to pre-surgical body weight and normal solid chow intake within 7 to 10 days post-surgery. In our hands, rats implanted using the methods described below have been continuously run in feeding and motility experiments for 8 to 12 weeks with minimal to no loss of subjects. When failure does occur, it is typically a result of back mount failure at the site of attachment of the overhead tether to the back mount.

scholarly journals Long-Term Effects of Intermittent Adolescent Alcohol Exposure in Male and Female Rats

2017 ◽  
Vol 11 ◽  
Author(s):  
Eva M. Marco ◽  
Sara Peñasco ◽  
María-Donina Hernández ◽  
Anabel Gil ◽  
Erika Borcel ◽  
...  
Keyword(s):  
Alcohol Exposure ◽  
Female Rats ◽  
Long Term Effects ◽  
Male And Female ◽  
Adolescent Alcohol ◽  
Male And Female Rats

scholarly journals EFFECTS OF NEURALTICATE DURING LONG-TERM INTRODUCTION ON BEHAVIOUR OF MALE AND FEMALE RATS IN THE «OPEN FIELD»

2019 ◽  
Vol 70 (2) ◽  
pp. 130-133
Author(s):  
L.I. Bugaeva ◽  
◽  
V.V. Bagmetova ◽  
Yu.V. Markina ◽  
A.A. Kolmakov ◽  
...  
Keyword(s):  
Open Field ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Evaluation of Some Male and Female Rats’ Reproductive Hormones Following Administration of Aspartame With or Without Vitamin C or E

2021 ◽  
Vol 45 (2) ◽  
pp. 14-20
Author(s):  
Omar H Azeez
Keyword(s):  
Vitamin C ◽  
Reproductive Hormones ◽  
Female Rats ◽  
Control Group ◽  
Male And Female ◽  
Group 4 ◽  
Male And Female Rats ◽  
Group 3 ◽  
Group 2

Aspartame (ASP) is a sugar substitute. Its use rose because it has been demonstrated to have deleterious effects after being metabolized. In the presence of antioxidant vitamins C or E, the effects of ASP on reproductive hormones of adult male and female Albino Wister rats were investigated. A total of eighty male and female rats were used in this study. The rats were divided into four groups: group 1, received no treatment; group 2, received ASP at 40 mg/kg BW; group 3, received ASP at 40 mg/kg BW with vitamin C at 150 mg/kg BW; and group 4, received ASP at 40 mg/kg BW and vitamin E at 100 mg/kg BW. All treatments were given orally by gavage needle once daily for consecutive 90 days. The levels of estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone hormone (TH) were measured after 90 days in blood plasma. In comparison with the control group, ASP treatment resulted in lower levels of E2, FSH, and LH in male and female rats. When the antioxidants vitamin C or E was given, the effects of ASP were reversed, and the levels of E2, LH, and FSH were increased. The testosterone hormone was likewise significantly increased by ASP, but testosterone hormone concentrations were decreased by vitamin C or E treatments. Long-term ASP consumption caused interfering with testicular and ovarian hormonal activity, while vitamins C and E on the other hand, overcome longstanding consumption ASP's effects.

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