Protocol for chronic implantation of patch electrodes on the gastric muscle wall of the rat v1

2021 ◽  
Author(s):  
Robert Phillips ◽  
Deborah Jaffey ◽  
Terry Powley
Keyword(s):  
Body Weight ◽  
Electrical Stimulation ◽  
Female Rats ◽  
Long Term Effects ◽  
Male And Female ◽  
Post Surgery ◽  
Male And Female Rats ◽  
Gastric Muscle ◽  
And Behavior

Electrical stimulation is a potential therapy for gastric disorders. Here we describe our surgical procedure for the implantation of patch electrodes on the muscle wall of the stomach of both male and female rats for use in chronic studies looking at the long-term effects of stimulation on physiology and behavior. The surgery is well tolerated by the subjects as rats return to pre-surgical body weight and normal solid chow intake within 7 to 10 days post-surgery. In our hands, rats implanted using the methods described below have been continuously run in feeding and motility experiments for 8 to 12 weeks with minimal to no loss of subjects. When failure does occur, it is typically a result of back mount failure at the site of attachment of the overhead tether to the back mount.

BIOLOGICAL EFFECTS OF 131I AND 125I ISOTOPES OF IODINE IN THE RAT

1976 ◽  
Vol 71 (1) ◽  
pp. 109-114 ◽  
Author(s):  
I. DONIACH ◽  
D. J. SHALE
Keyword(s):  
Thyroid Function ◽  
Biological Effects ◽  
Female Rats ◽  
Long Term Effects ◽  
Significant Elevation ◽  
Radioiodine Uptake ◽  
Male And Female ◽  
Male And Female Rats ◽  
Serum Tsh

SUMMARY From the differences in radiation profiles between 131I and 125I isotopes of iodine it would be expected that they would show different effects on thyroid function. The differences should lead to lower rates of thyroid gland destruction with 125I and hence less post-irradiation hypothyroidism. This difference in biological effect has been demonstrated in rats by indirect assessment of thyroid function. In this report the long-term effects of a range of similar doses of 131I and 125I were compared, in male and female rats, by direct assessment of thyroid function. Seventeen months after receiving 25 and 125 μCi of 131I, male and female rats showed significant elevation of serum TSH concentration and a reduction in 3 h radioiodine uptake. Rats receiving 1 and 5 μCi of 131I and all doses of 125I showed no significant changes in thyroid function. These findings confirm the previously reported differences in effect between the 131I and 125I isotopes of iodine in the rat.

Long-term effects of high-fat diets on peroxisomal β-oxidation in male and female rats

Lipids ◽  
1985 ◽  
Vol 20 (10) ◽  
pp. 668-674 ◽  
Author(s):  
M. S. Thomassen ◽  
J. Norseth ◽  
E. N. Christiansen
Keyword(s):  
Female Rats ◽  
Long Term Effects ◽  
High Fat ◽  
Male And Female ◽  
Male And Female Rats ◽  
High Fat Diets ◽  
Fat Diets

LONG-TERM EFFECTS OF ADRENALECTOMY AND GONADECTOMY ON THYROID FUNCTION IN THE RAT

1965 ◽  
Vol 48 (4) ◽  
pp. 556-560 ◽  
Author(s):  
Jerome A. Grunt ◽  
Russell D. Cunningham
Keyword(s):  
Replacement Therapy ◽  
Thyroid Function ◽  
Hormonal Replacement Therapy ◽  
Female Rats ◽  
Follicular Epithelium ◽  
Long Term Effects ◽  
Male And Female ◽  
Hormonal Replacement ◽  
Male And Female Rats

ABSTRACT Thyroid function has been evaluated in male and female rats which had been either sham operated, gonadectomized, adrenalectomized, or adrenalectomized and gonadectomized on day 25, and killed at 180 days of age. No hormonal replacement therapy was utilized. Animals without adrenals showed increased thyroid weights, increased cell heights of follicular epithelium and decreased resin binding of 131I labeled triiodothyronine without significant changes in BEI. Possible mechanisms for these changes in thyroid function are discussed.

Long-term Effects of Alcohol Consumption in Male and Female Rats

2007 ◽  
Vol 7 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Mariann R. Piano ◽  
David L. Geenen ◽  
Dorie W. Schwertz ◽  
Shamim A. K. Chowdhury ◽  
Milina Yuzhakova
Keyword(s):  
Alcohol Consumption ◽  
Female Rats ◽  
Long Term Effects ◽  
Male And Female ◽  
Male And Female Rats

Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats

2006 ◽  
Vol 190 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Bruce A. Rasmussen ◽  
Jahn O’Neil ◽  
Kebreten F. Manaye ◽  
David C. Perry ◽  
Yousef Tizabi
Keyword(s):  
Sensorimotor Gating ◽  
Female Rats ◽  
Long Term Effects ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Long-Term Effects of Intermittent Adolescent Alcohol Exposure in Male and Female Rats

2017 ◽  
Vol 11 ◽  
Author(s):  
Eva M. Marco ◽  
Sara Peñasco ◽  
María-Donina Hernández ◽  
Anabel Gil ◽  
Erika Borcel ◽  
...  
Keyword(s):  
Alcohol Exposure ◽  
Female Rats ◽  
Long Term Effects ◽  
Male And Female ◽  
Adolescent Alcohol ◽  
Male And Female Rats

Effects of Dehydroepiandrosterone Acetate on Metabolism, Body Weight and Composition of Male and Female Rats

1986 ◽  
Vol 116 (10) ◽  
pp. 1977-1983 ◽  
Author(s):  
Anthony R. Tagliaferro ◽  
James R. Davis ◽  
Stephen Truchon ◽  
Nancy Van Hamont
Keyword(s):  
Body Weight ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Toxicity Evaluation of a Traditional Polyherbal Unani Formulation Jawarish Shahi in Rats

2018 ◽  
Vol 7 (5) ◽  
pp. 412-418
Author(s):  
Mohd Urooj ◽  
◽  
Mohammad Ahmed Khan ◽  
G. Thejaswini ◽  
Munawwar Husain Kazmi ◽  
...  
Keyword(s):  
Body Weight ◽  
Feed Intake ◽  
Clinical Signs ◽  
Female Rats ◽  
Control Group ◽  
Sprague Dawley ◽  
Male And Female ◽  
Salix Caprea ◽  
Male And Female Rats ◽  
Dose Levels

Jawarish Shahi (JS) is a compound polyherbal Unani pharmacopoeial formulation indicated for Khafqan (Palpitation), Nafkh-e-Shikam (Flatulence) and Waswas (Insanity; false perception and hallucinations). Jawarish Shahi contains herbs like Halela (Terminalia chebula), Amla (Emblica officinalis), Kishneez (Coriandrum sativum), Elaichi Khurd, (Elettaria cardamomum), and Bed Mushk (Salix caprea). The present study was carried out as per OECD 408 guidance to evaluate 90 days repeated oral dose toxicity in male and female Sprague Dawley rats. The study was performed at dose levels 1028 and 2000 mg/kg bw. No adverse effects were reported with respect to body weight, feed intake, behavior and clinical signs indicative of systemic toxicity. The expected growth pattern was observed in body weight and feed intake as compared to control group at both dose levels in male and female rats. There were few significant alterations with respect to hematology, and clinical biochemistry, however the results were within normal range thus considered toxicologically insignificant. The microscopic examination of different organ/tissue showed that no histopathological changes were observed. The findings of the study showed that No Observed Adverse Effect Level (NOAEL) for JS is greater than 2000 mg/kg body weight

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