scholarly journals Clinical Features and Follow-Up of SARS-Cov-2 Asymptomatic Carriers

2020 ◽  
Vol 5 (3) ◽  
Author(s):  
Liu L ◽  
Yuan MJ ◽  
Hong XQ ◽  
Yu Y ◽  
Su X ◽  
...  
Keyword(s):  
Clinical Features ◽  
Clinical Characteristics ◽  
Test Results ◽  
Laboratory Findings ◽  
Asymptomatic Carriers ◽  
Reverse Transcription Pcr ◽  
Laboratory Test Results ◽  
Polymerase Chain ◽  
Respiratory Coronavirus

In the current global coronavirus disease (COVID-19) pandemic, asymptomatic transmission of the causative agent, severe acute respiratory coronavirus-2 (SARS-CoV-2), poses a considerable challenge for disease control. Furthermore, information on the clinical characteristics of asymptomatic carriers is limited. Here, we aimed to clarify the clinical features and obtain follow-up data of asymptomatic carriers to assist in the clinical management of carriers. This retrospective study included all asymptomatic SARS-CoV-2 carriers diagnosed at the First People’s Hospital of Yueyang (Hunan, China) and Hunan Provincial People’s Hospital (Changsha, China) between January 22 and March 26, 2020. Data including the epidemiology, clinical characteristics, laboratory test results, and chest computed tomography status were collected, with a follow-up of these cases. A total of 24 asymptomatic carriers were enrolled at the First People’s Hospital of Yueyang and Hunan Provincial People’s Hospital between 22 January 2020 and 26 March 2020. All patients had previously been exposed to SARS-CoV-2. Over the monitored time, patients experienced no symptoms and most laboratory findings were normal. The median time from contact to diagnosis was 9.6 days (range: 1-38 days), while that from diagnosis to discharge was 14.4 days (range: 6-24 days). Following discharge, all patients remained asymptomatic. However, five patients (20.83%) were re-admitted because a polymerase chain reaction (PCR)-based re-test of their specimens (4 throat swabs and 1 feces) showed that they were positive for SARS-CoV-2. The time to re-testing positively varied from 23 to 53 days post-diagnosis. The time to re-testing negative for SARS-CoV-2 by real-time reverse transcription PCR after re-testing positive was 3 to 11 days. In conclusion, although asymptomatic carriers have favorable outcomes, they should be closely monitored. Also, clear guidelines need to be formulated and close surveillance is required for the management of asymptomatic carriers.

scholarly journals COVID-19 and pregnancy – where are we now? A review

2020 ◽  
Vol 48 (5) ◽  
pp. 428-434 ◽  
Author(s):  
Aleksandra Rajewska ◽  
Wioletta Mikołajek-Bedner ◽  
Joanna Lebdowicz-Knul ◽  
Małgorzata Sokołowska ◽  
Sebastian Kwiatkowski ◽  
...  
Keyword(s):  
Case Fatality ◽  
Fetal Distress ◽  
Delivery Mode ◽  
Test Results ◽  
Rt Pcr ◽  
Third Trimester ◽  
The Third ◽  
Laboratory Test Results ◽  
Protective Antibodies ◽  
Polymerase Chain

AbstractThe new acute respiratory disease severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly contagious. It has caused many deaths, despite a relatively low general case fatality rate (CFR). The most common early manifestations of infection are fever, cough, fatigue and myalgia. The diagnosis is based on the exposure history, clinical manifestation, laboratory test results, chest computed tomography (CT) findings and a positive reverse transcription-polymerase chain reaction (RT-PCR) result for coronavirus disease 2019 (COVID-19). The effect of SARS-CoV-2 on pregnancy is not already clear. There is no evidence that pregnant women are more susceptible than the general population. In the third trimester, COVID-19 can cause premature rupture of membranes, premature labour and fetal distress. There are no data on complications of SARS-CoV-2 infection before the third trimester. COVID-19 infection is an indication for delivery if necessary to improve maternal oxygenation. Decision on delivery mode should be individualised. Vertical transmission of coronavirus from the pregnant woman to the fetus has not been proven. As the virus is absent in breast milk, the experts encourage breastfeeding for neonatal acquisition of protective antibodies.

scholarly journals A case report: Type II Abernethy malformation complicated with congenital polydactyly and enlargement of all cardiac chambers.

2019 ◽  
Author(s):  
Cheng Zhu ◽  
Min Wang ◽  
Qian Hao
Keyword(s):  
Congenital Malformations ◽  
Portacaval Anastomosis ◽  
Test Results ◽  
Abernethy Malformation ◽  
Form And Function ◽  
Laboratory Test Results ◽  
Number Of Patients ◽  
Patient Reported ◽  
And Function

Abstract Background: Abernethy malformation is a kind of congenital malformation of portal vein system caused by abnormal portacaval anastomosis. It can be in combination with other congenital malformations. The major therapy of Abernethy malformation is surgery. There has been a limited number of patients since the first patient reported, leading to a limited view towards this kind of disease until now.Results: In August 2018 we treated a patient diagnosed with typeII Abernethy malformation complicated with both congenital polydactyly and enlargement of all cardiac chambers, which is extremely rare and can be a supplementary to the existing cases. Besides, the low white blood cell and platelet, the arrested megakaryocytic maturation and the positive platelet autoantibody in serum may result in misdiagnosis as immune thrombocytopenia, so we analyze the differential points between these two diseases. We treated this patient with silybin orally and advised him to make follow-up visits because of his mild liver function disorder, normal cardiac function and no other malformations or complications complicated. At the latest follow-up, we knew the condition of the patient was generally satisfactory, whether in terms of laboratory test results or his daily life experience.Conclusions: Because of some changes of spleen in form and function secondary to Abernethy malformation, in some cases, this disease has similarities with a part of blood diseases, which we should take into consideration for differential diagnosis, especially when other congenital malformations are found in combination at the same time. This case also suggests that simply conservative treatment with regular follow-up visits can be suitable for certain patients.

Significance of Abuse Chemical Contamination of Returnable Dairy Containers: Hazard Assessment

1978 ◽  
Vol 41 (12) ◽  
pp. 965-973 ◽  
Author(s):  
JOHN M. GASAWAY
Keyword(s):  
Hazard Assessment ◽  
Pesticide Residues ◽  
Daily Intake ◽  
World Health ◽  
Test Results ◽  
Chemical Contamination ◽  
Laboratory Findings ◽  
Laboratory Test Results ◽  
Health Organization ◽  
Water Contents

Certain pesticide residues reabsorbed into milk (or water) contents when stored in LEXAN® resin and polyethylene plastic returnable milk containers that had been exposed to diluted pesticide products, washed, and subsequently filled. The significance of these laboratory test results is comprehensively discussed by attempting to characterize the nature of exposure to pesticide residues from a washed returnable dairy container, as opposed to exposure to milk containing pesticide residues of non-container origin. Laboratory findings are compared to actual public use experience with returnable plastic dairy containers. A hazard assessment is presented, which includes a comparison of quantities of pesticide residues found extracting with existing Federal milk tolerance standards, food tolerance standards, unavoidable contaminant food additive regulations, World Health Organization and Safe Drinking Water Committee acceptable daily intake values. The probability of purchase of milk that is contaminated with pesticide residues, where the washed returnable dairy container is the source, is presented.

The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy

2016 ◽  
Vol 44 (3) ◽  
Author(s):  
Jane So ◽  
Elizabeth Young ◽  
Natalie Crnosija ◽  
Joseph Chappelle
Keyword(s):  
Severe Disease ◽  
Vital Signs ◽  
Retrospective Chart Review ◽  
Clinical Findings ◽  
Bivariate Analysis ◽  
Test Results ◽  
Quadrant Pain ◽  
Laboratory Findings ◽  
Abnormal Laboratory ◽  
Laboratory Test Results

AbstractPreeclampsia is the 2A retrospective chart review of women who presented for evaluation of hypertension in pregnancy during 2010. Demographic information, medical history, symptoms, vital signs, and laboratory results were collected. Bivariate analysis was used to investigate associations between predictors and the outcome.Of the 481 women in the sample, 22 were identified as having abnormal laboratory test results (4.6%). Women who reported right upper quadrant pain or tenderness had significantly increased likelihood of having laboratory abnormalities compared to those without the complaint.Only a small percentage of women evaluated were determined to have abnormal laboratory findings, predominantly among women with severe preeclampsia. Right upper quadrant pain or tenderness was positively correlated with laboratory abnormalities. The restriction of laboratory analysis in women with clinical evidence of severe disease may be warranted – a broader study should, however, first be used to confirm our findings.

scholarly journals Prevalence and Course of SARS-CoV-2 Infection among Immunocompromised Children Hospitalised in the Tertiary Referral Hospital in Poland

2021 ◽  
Vol 10 (19) ◽  
pp. 4556
Author(s):  
Karolina Kuczborska ◽  
Janusz Książyk
Keyword(s):  
Laboratory Test ◽  
Clinical Characteristics ◽  
Chronic Treatment ◽  
Clinical Symptoms ◽  
Referral Hospital ◽  
Test Results ◽  
Tertiary Referral ◽  
Tertiary Referral Hospital ◽  
Laboratory Test Results ◽  
Underlying Diseases

The aim of this retrospective study was the assessment of the prevalence, clinical characteristics, and the comparison of the course of SARS-CoV-2 infection in children with and without immunodeficiency that were admitted to the COVID-19 Subunit of the tertiary referral hospital in Warsaw, Poland. We analysed 313 children hospitalised in the COVID-19 Subunit. The analysis was performed on the total study group and subgroups of children with and without immunodeficiency. In each group, clinical data and laboratory test results were analysed. Of the 68 children with isolated fevers, only seven (11.76%) were diagnosed with COVID-19, whereas among those with the accompanying features of respiratory or gastrointestinal infection, only one (3.23%) and ten (16.95%) patients tested positive, respectively. In both groups, the course of the infection was mainly asymptomatic or mild. The children with immunodeficiencies had lower white blood cell and lymphocyte counts, lower haemoglobin levels, and higher urea levels but did not differ in other biochemical variables. To conclude, the most frequently reported symptoms of COVID-19 indicate that this disease among children is only a small percentage. In both groups, the responses to the infection were comparable in terms of the mild clinical symptoms and the laboratory test results. Therefore, SARS-CoV-2 infection should not alter the chronic treatment of underlying diseases.

scholarly journals Changes in liver function in patients with covid-19 and the demographics of the disease in a mid-sized city of Turkey: A retrospective analysis

2020 ◽  
Vol 7 (12) ◽  
pp. 739-744
Author(s):  
Huseyin Avni Demir
Keyword(s):  
Liver Function ◽  
Clinical Characteristics ◽  
Severe Disease ◽  
Close Monitoring ◽  
Test Results ◽  
Laboratory Findings ◽  
Icu Patients ◽  
Mortality And Morbidity ◽  
The Mean ◽  
Significant Mortality

Objective:  To define the clinical characteristics of patients hospitalized with COVID-19 in ICU and ward and to evaluate the significance of liver function test results. A new disease caused by SARS-CoV-2 has been devastating the world affecting millions of patients worldwide and leading the significant mortality and morbidity. Material and Methods: The demographic features of a cohort of 125 hospitalized patients between March 2020 and May 2020 were recorded. The clinical characteristics, laboratory findings, and mortality rates were analyzed. Results: A total of 125 patients hospitalized for COVID-19 diagnosis where 113 (90.4%) were followed-up in the ward and 12 (9.6%) were in ICU were included in the study. The mean age of the patients was 44.05±16.95 and 88 (70.4%) of the patients were male. The most common symptoms were in the following order: cough in 80 patients (64%), dyspnea in 40 (32%) and fever in 33 (26.4%). The leukocyte and neutrophil counts were significantly higher in ICU patients with COVID-19 compared to patients in the ward (p=0.002, p<0.05; respectively). The CRP and D-Dimer levels were found elevated in ICU patients with COVID-19 than in the ward (p<0.05; p<0.05, respectively). The AST level of patients with COVID-19 in ICU was significantly heightened than patients in the ward. Conclusion: The present study revealed that patients with elevated AST level were at great risk of progressing to severe disease those require close monitoring.

scholarly journals Evaluation of Children Referred to Pediatric Rheumatology Outpatient Clinic with Suspicious Laboratory Test Results

2021 ◽  
Author(s):  
Şerife Gül Karadağ ◽  
Hafize Emine Sönmez ◽  
Ayşe Tanatar ◽  
Nuray Aktay Ayaz
Keyword(s):  
Rheumatic Disease ◽  
Laboratory Test ◽  
Rheumatic Diseases ◽  
Outpatient Clinic ◽  
Pediatric Rheumatology ◽  
Connective Tissue Diseases ◽  
Test Results ◽  
Laboratory Findings ◽  
Laboratory Test Results ◽  
Rheumatology Outpatient

INTRODUCTION: We aimed to evaluate the patients who were referred to the pediatric rheumatology outpatient clinic with suspicious laboratory test results. METHODS: All patients who were referred to our outpatient clinic with suspicious laboratory test results between March 2018 and March 2019 were evaluated. RESULTS: A total of 273 new patients who were referred with suspicious laboratory test results were evaluated. Among them; 48% were girls and 52% were boys and they were referred mostly from the clinics of child health and diseases (70.3%). The most frequent indications for referrals were anti-streptolysin O (ASO) elevation (n=86) and anti-nuclear antibody (ANA) positivity (n=47), while 66% of the patients were not diagnosed with rheumatic disease. None of the patients without complaints but with suspicious laboratory test results (n=49) were diagnosed with rheumatic disease. While 64.6% of those diagnosed with rheumatic diseases had periodic fever syndrome, 17.1% had juvenile idiopathic arthritis, 8.5% had postinfectious arthritis, and the remaining 9.8% had connective tissue diseases, vasculitis and uveitis. DISCUSSION AND CONCLUSION: Laboratory findings alone in childhood rheumatic diseases are not significant in patients without complaints. The diagnosis of rheumatic diseases should be made with the patient’s complaints, history, family history and physical examination findings and supported by laboratory findings. With the rational use of laboratory tests; unnecessary health expenses can be prevented and referrals of patients with nonrheumatic diseases to pediatric rheumatology outpatient clinics can be prevented.

scholarly journals Clinical Characteristics of Non-Pneumonia COVID-19 Adults in Shanghai, China

2020 ◽  
Author(s):  
Haiying Ji ◽  
Lijuan Hu ◽  
Tao Li ◽  
Linjing Gong ◽  
Xu Wu ◽  
...  
Keyword(s):  
Incubation Time ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Diagnostic Classification ◽  
Test Results ◽  
Underlying Condition ◽  
Laboratory Test Results ◽  
Initial Symptoms ◽  
Local Residents ◽  
Taste Disorders

Abstract Background: Since December 2019, coronavirus disease 2019 (COVID-19) rapidly spread throughout the whole world , data have been needed on the clinical characteristics of the affected patients.Objectives: A total of 579 adult COVID-19 cases were enrolled in Shanghai from Jan 20 to Apr 15, 2020, in which 95 cases (16.41%) showed non-pneumonia on CT when confirmed. The characteristics of non-pneumonia cases have not been clearly described previously, and this might provide guidance to prevent and treatment of COVID-19.Method: We retrospectively collected the patient clinical dataset including demography, epidemiology, clinical manifestation, laboratory test results, diagnostic classification, treatment and clinical outcomes.Results: The average age of 95 COVID-19 cases was 31.45 ± 12.89 years old and 95.79% of them were less than 60 years old. They had mild clinical symptoms and/or laboratory abnormalities. 20 of the 95 cases occurred mild pneumonia during hospitalization, accompanied with lower lymphocyte counts, in which 60% cases were complicated with underlying condition and 15% cases were over 60 years old. All cases were cured. 16 of the 95 cases were local residents with clear epidemiological history and long incubation time, and mainly discovered as fever and respiratory symptoms. Other 79 cases were overseas imported, some had initial symptoms of diarrhea, smell or taste disorders and so on. They were mainly found at port of entry.Conclusions: Non-pneumonia COVID-19 predominantly occurred among young adults with mild clinical symptoms and possible long incubation time. The patients with underlying condition or at older age more likely developed mild pneumonia after diagnosis. Thereby, it is very important to pay attention to these patients and make reasonable diagnostic classification towards better prevention and treatment of COVID-19.

Sign in / Sign up

Export Citation Format

Share Document