The Correlation Between Static Fatigue Testing and the Quantitative Myasthenia Gravis Score and Activities of Daily Living Profile

Fatigue is a common symptom in myasthenia gravis (MG), but both objective and subjective measures of fatigue are poorly studied in the disease. We conducted a pilot study of static fatigue testing (SFT) in a group of MG patients, using an isometric quantified muscle analysis computer system. Results from sustained isometric contraction of 5 muscle groups in 77 patients were correlated to the Quantitative MG Score (QMG) and the Activities of Daily Living Profile (MG-ADL), two commonly used outcome measures. Pearson correlation coefficients for the SFT were highest (0.33) for hand grip for both the QMG and MG-ADL. Correlations were quite poor for the proximal muscle groups and ankle dorsiflexion. More work is needed to develop objective and subjective measures of fatigue in MG.

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Reliability and Validity of Turkish Myasthenia Gravis-Activities of Daily Living Scale

OTJR Occupation Participation and Health ◽

10.1177/1539449220961077 ◽

2020 ◽

pp. 153944922096107

Author(s):

Ecem Karanfil ◽

Yeliz Salcı ◽

Ayla Fil-Balkan ◽

Can Ebru Bekircan-Kurt ◽

Sevim Erdem Özdamar ◽

...

Keyword(s):

Construct Validity ◽

Myasthenia Gravis ◽

Activities Of Daily Living ◽

Daily Living ◽

Intraclass Correlation ◽

Reliability And Validity ◽

Life Questionnaire ◽

Good Test ◽

Retest Reliability ◽

Test Retest Reliability

Linguistic, reliable, and valid secondary efficacy measures are important in clinical settings and studies. The aim of the study is to report test–retest reliability and construct validity of Turkish version of Myasthenia Gravis-Activities of Daily Living Scale (MG-ADL-T) in Myasthenia Gravis (MG) patients. Fifty-two ocular and generalized individuals with MG, applying to rehabilitation center, were included in the study. MG-ADL-T, MG quality-of-life questionnaire (MG-QoL), MG composite (MGC), quantitative MG score (QMGS), and pulmonary function test were administered. Reliability was assessed with intraclass correlation coefficient (ICC) and Cronbach’s alpha. Spearman correlation test and receiver operating characteristic (ROC) analysis were performed for construct validity. MG-ADL-T had fair internal consistency (Cronbach’s α = .67), excellent test–retest reliability (ICC = 0.96) and moderate construct validity (MG-QoL, r = 0.59; QMGS, r = .58; MGC, r = .68). MG-ADL, a unique scale that evaluates activities of daily living (ADL), has good test–retest reliability and construct validity in Turkish MG patients.

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COMPARATIVE PERFORMANCE OF FOUR CLAIMS-BASED FRAILTY MEASURES IN THE UNITED STATES MEDICARE DATA

Innovation in Aging ◽

10.1093/geroni/igz038.2526 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S684-S685

Author(s):

Dae H Kim ◽

Elisabetta Patorno ◽

Ajinkya Pawar ◽

Hemin Lee ◽

Sebastian Schneeweiss ◽

...

Keyword(s):

United States ◽

Health Outcomes ◽

Activities Of Daily Living ◽

Gait Speed ◽

Daily Living ◽

Correlation Coefficients ◽

The United States ◽

Medicare Data ◽

C Statistic ◽

Age And Sex

Abstract Background: There has been increasing effort to measure frailty in the United States Medicare data. The performance of claims-based frailty measures has not been compared. Methods: This retrospective cohort study included 2,326 community-dwelling Medicare beneficiaries who participated in the 2008 assessment of the Health and Retirement Study. The claims-based frailty measures developed by Davidoff, Faurot, Segal, and Kim were compared against clinical measures of frailty (gait speed, grip strength) using correlation coefficients and health outcomes (e.g., mortality, hospitalization, activities-of-daily-living disabilities) over 2 years using C-statistics. Results: The Davidoff, Faurot, Segal, and Kim indices were negatively correlated with gait speed (-0.19, -0.33, -0.37, and -0.37, respectively), but age and sex adjustment variably attenuated the correlation to -0.17, -0.22, -0.18, and -0.33, respectively. The corresponding correlation coefficients with grip strength were -0.17, -0.27, -0.35, and -0.24, which attenuated to -0.09, -0.14, -0.05, and -0.23 after age and sex adjustment, respectively. The models that included age, sex, and each of Davidoff, Faurot, Segal, and Kim indices showed C-statistics of 0.67, 0.71, 0.71, 0.75 for mortality (versus C-statistic for age and sex: 0.66); 0.59, 0.64, 0.63, 0.70 for hospitalization (versus C-statistic for age and sex: 0.58); and 0.64, 0.63, 0.63, 0.70 for activities-of-daily-living disabilities (versus C-statistic for age and sex: 0.61), respectively. Conclusions: The choice of a claims-based frailty measure results in a meaningful variation in the identification of frail older adults at high risk for adverse health outcomes. Claims-based frailty measures that included demographic variables offer limited risk adjustment beyond age and sex.

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Physician- and self-assessed myasthenia gravis activities of daily living score

Muscle & Nerve ◽

10.1002/mus.25764 ◽

2017 ◽

Vol 57 (3) ◽

pp. 419-422

Author(s):

Hye Lim Lee ◽

Ju-Hong Min ◽

Jin Myoung Seok ◽

Eun Bin Cho ◽

Hye Jin Cho ◽

...

Keyword(s):

Myasthenia Gravis ◽

Activities Of Daily Living ◽

Daily Living

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Association between filial responsibility when caring for parents and the caregivers overload

Revista Brasileira de Enfermagem ◽

10.1590/0034-7167-2017-0133 ◽

2017 ◽

Vol 70 (4) ◽

pp. 767-774 ◽

Cited By ~ 4

Author(s):

Marinês Aires ◽

Duane Mocellin ◽

Fernanda Laís Fengler ◽

Idiane Rosset ◽

Naiana Oliveira dos Santos ◽

...

Keyword(s):

Activities Of Daily Living ◽

Financial Support ◽

Daily Living ◽

Correlation Coefficients ◽

Cross Sectional Study ◽

Bivariate Analysis ◽

P Value ◽

Filial Responsibility ◽

Cross Sectional ◽

Older Parents

ABSTRACT Objective: To analyze the association between filial responsibility and the overload of the children when caring for their older parents. Method: Cross-sectional study with 100 caregiver children of older adults. Filial liability was assessed by the attitudes of the responsible child (scale of expectation and filial duty) and by care behaviors (assistance in activities of daily living, emotional and financial support, and keeping company). The overload was assessed by the Caregiver Burden Inventory. To assess the associations, the correlation coefficients of Pearson and Spearman, Kruskal-Wallis Test, and Mann-Whitney were employed. Variables that presented p-value<0.20 in the bivariate analysis were inserted in a multivariate linear regression model. Results: The factors associated with overload were: formal employment (p=0.002), feelings regarding family life (p<0.001), financial support (p=0.027), and assistance with Activities of Daily Living (ADLs) (p<0.001). Conclusion: Children who were more involved with the ADLs and provided financial support showed higher levels of overload.

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Correlation between myasthenia gravis−activities of daily living (MG‐ADL) and quantitative myasthenia gravis (QMG) assessments of anti−acetylcholine receptor antibody−positive refractory generalized myasthenia gravis in the phase 3 regain study

Muscle & Nerve ◽

10.1002/mus.26152 ◽

2018 ◽

Vol 58 (2) ◽

pp. E21-E22 ◽

Cited By ~ 4

Author(s):

John Vissing ◽

Fanny O'Brien ◽

Jing Jing Wang ◽

James F. Howard

Keyword(s):

Myasthenia Gravis ◽

Activities Of Daily Living ◽

Acetylcholine Receptor ◽

Daily Living ◽

Phase 3 ◽

Receptor Antibody ◽

Acetylcholine Receptor Antibody ◽

Anti Acetylcholine

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Relationship Between Activities of Daily Living and Depression in Older Adults

Salmand ◽

10.32598/sija.13.10.180 ◽

2020 ◽

Vol 15 (2) ◽

pp. 200-211 ◽

Cited By ~ 2

Author(s):

Marzieh Mohamadzadeh ◽

◽

Vahid Rashedi ◽

Mitra Hashemi ◽

Vahidreza Borhaninejad ◽

...

Keyword(s):

Older Adults ◽

Activities Of Daily Living ◽

Elderly People ◽

Daily Living ◽

Pearson Correlation ◽

Depression Scale ◽

The Elderly ◽

Cluster Sampling ◽

Early Assessment ◽

Cross Sectional

Objectives: Physical disability to perform daily living activities is one of the major causes of depression in the elderly people. On the other hand, depression is associated with loss of interest in daily activities and lack of independence. The present study aimed to assess the relationship of depression with the ability to perform Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) in older adults in Iran. Methods & Materials: This cross-sectional study was performed on 148 elderly people aged ≥60 years who were selected by multi-stage cluster sampling method. Data were collected by using ADL, IADL, and 15-item Geriatric Depression Scale (GDS-15) questionnaires and were then presented by using descriptive statistics and analyzed by Chi-square test, Pearson correlation coefficient, and regression analysis. Results: Participants were 86 female (58.1%) and 62 male (41.9%); 109 (73.6%) aged 60-75 years, and the rest were older than 75 years; 71 (48%) had moderate or severe depression; 4(2.7%) and 61(41.2%) were dependent or in need of help performing ADL and IADL, respectively. Statistical analysis showed that depression has a significant negative correlation with ADL (r= -0.304, P<0.001) and IADL (r=-0.193, P>0.01); i.e. by increasing one of them, the depression decreases. Conclusion: The ability of the elderly people to perform ADL and IADL can be a good predictor of depression in them. With early assessment of their health and ability by health teams and family members, it is possible to prevent the development of their disability and depression.

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Responsiveness and Predictive Ability of the Chinese Version of the Action Research Arm Test in People with Cerebral Infarction

BioMed Research International ◽

10.1155/2019/8270187 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8

Author(s):

Jiang-Li Zhao ◽

Tao Zhang ◽

Zhi-Qin Xu ◽

Ming-Hui Ding ◽

Yan Leng ◽

...

Keyword(s):

Action Research ◽

Cerebral Infarction ◽

Activities Of Daily Living ◽

Daily Living ◽

Rank Correlation ◽

Correlation Coefficients ◽

Predictive Ability ◽

Chinese Version ◽

Rank Test ◽

Floor Effect

Purpose. To detect the responsiveness and predictive ability of the Chinese version Action Research Arm Test (C-ARAT) in participants within the first 3 months after cerebral infarction. Methods. Ninety-seven individuals (75 men, mean age 59.87 ± 10.94 years) with a first cerebral infarction were enrolled in this study. The participants were evaluated by two outcome measures: C-ARAT and the Barthel Activities of Daily Living Index (BI) at five time points: 0D, 3W, 3M, 6M and 1Y after enrolment. The standardised response mean (SRM) and the Wilcoxon signed rank test were used to analyse responsiveness. Predictive validity was determined by using Spearman’s rank correlation coefficients. The predicted performance of C-ARAT on activities of daily living (ADLs) was measured by linear regression model. Floor and ceiling effects were estimated by counting the proportion of subjects falling outside the 5% lower or upper boundary, respectively. Results. The C-ARAT showed moderate to large responsiveness in detecting changes over time (SRM = 0.58–0.84). The C-ARAT subscales showed small to large responsiveness (SRM = 0.44–0.90). The C-ARAT at 0D showed moderate to good correlation with the BI scores at 3W, 3M and 6M (ρ = 0.561–0.624, p<0.001), and exhibited fair correlation with the BI score 1Y after enrolment (ρ = 0.384, p<0.05). C-ARAT was a good predictor (adjusted R2 = 0.185–0.249) of BI within 3M follow-up. The C-ARAT total score showed a notable floor effect at 0D and 3W and a notable ceiling effect at 3M, 6M and 1Y. Conclusion. The results of this study support the use of the C-ARAT as a measurement of upper extremity function in individuals with a first cerebral infarction.

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Patterns of lower limb muscular activity and joint moments during directional efforts using a static dynamometer

BMC Biomedical Engineering ◽

10.1186/s42490-019-0035-7 ◽

2020 ◽

Vol 2 (1) ◽

Author(s):

Mathieu Lalumiere ◽

Cloé Villeneuve ◽

Cassandra Bellavance ◽

Michel Goyette ◽

Daniel Bourbonnais

Keyword(s):

Lower Limb ◽

Healthy Subjects ◽

Inverse Dynamics ◽

Pearson Correlation ◽

Activity Patterns ◽

Correlation Coefficients ◽

Muscular Activity ◽

Lower Limbs ◽

Joint Moments ◽

Muscle Groups

Abstract Background Strength and coordination of lower muscle groups typically identified in healthy subjects are two prerequisites to performing functional activities. These physical qualities can be impaired following a neurological insult. A static dynamometer apparatus that measures lower limb joint moments during directional efforts at the foot was developed to recruit different patterns of muscular activity. The objectives of the present study were to 1) validate joint moments estimated by the apparatus, and 2) to characterize lower limb joint moments and muscular activity patterns of healthy subjects during progressive static efforts. Subjects were seated in a semi-reclined position with one foot attached to a force platform interfaced with a laboratory computer. Forces and moments exerted under the foot were computed using inverse dynamics, allowing for the estimation of lower limb joint moments. To achieve the study’s first objective, joint moments were validated by comparing moments of various magnitudes of force applied by turnbuckles on an instrumented leg equipped with strain gauges with those estimated by the apparatus. Concurrent validity and agreement were assessed using Pearson correlation coefficients and Bland and Altman analysis, respectively. For the second objective, joint moments and muscular activity were characterized for five healthy subjects while exerting progressive effort in eight sagittal directions. Lower limb joint moments were estimated during directional efforts using inverse dynamics. Muscular activity of eight muscles of the lower limb was recorded using surface electrodes and further analyzed using normalized root mean square data. Results The joint moments estimated with the instrumented leg were correlated (r > 0.999) with those measured by the dynamometer. Limits of agreement ranged between 8.5 and 19.2% of the average joint moment calculated by both devices. During progressive efforts on the apparatus, joint moments and patterns of muscular activity were specific to the direction of effort. Patterns of muscular activity in four directions were similar to activation patterns reported in the literature for specific portions of gait cycle. Conclusion This apparatus provides valid joint moments exerted at the lower limbs. It is suggested that this methodology be used to recruit muscular activity patterns impaired in neurological populations.

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DISTINGUISHING SUBJECTIVE EXPERIENCE FROM OBJECTIVE FACTORS IN DECISION MAKING AND PERCEIVED EFFORT

Innovation in Aging ◽

10.1093/geroni/igz038.2292 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S616-S616

Author(s):

Richard Gonzalez ◽

Patricia Abbott ◽

James Ashton-Miller ◽

Jacqui Smith

Keyword(s):

Decision Making ◽

Activities Of Daily Living ◽

Daily Living ◽

Subjective Experience ◽

Objective Measures ◽

Subjective Measures ◽

Perceived Effort ◽

Set Up ◽

Fully Connected ◽

Fully Functioning

Abstract We use self-reported and behavioral data from the HomeLab to comment on the theoretical and methodological implications of integrating objective and subjective measures of experience. To illustrate, we will focus on two domains that vary in the nature of objective and subjective measurements examined. One domain will be decision making where subjective measures include subjective probability and utility and the respective objective measures include probability and actual outcomes. The second domain will be activities of daily living where the subjective measure is perceived effort and the objective measures include various data from sensor such as EDA (arousal) and EMG (muscle contraction). The presentation will discuss the benefits of conducting such research in a realistic standardized context such as the HomeLab, which is a fully connected, fully functioning apartment set up as a standardized lab in order to study activities of daily living.

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